Articles tagged with Open Access
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
This article emphasizes the importance of addressing social determinants of health inequities. It highlights the limitations of reductionism in medicine and suggests that a systems biology approach could be valuable for clinical medicine, focusing on the holistic characteristics of a problem rather than its component parts.
The new open-access journal aims to increase the accuracy and completeness of evidence available for clinical decision-making. All randomized trials are rigorously peer-reviewed and reported accurately, regardless of outcome.
A natural experiment found that open-access articles in PNAS gained a significant citation advantage over non-OA articles, being twice as likely to be cited within 4-10 months and almost three times more likely between 10-16 months after publication. The study suggests that open access accelerates the dissemination of scientific research.
Researchers found that caterpillars respond to variations in plant volatile production to reduce encounters with parasitic wasps. The study demonstrates that plant volatiles, rather than light, control the daily behavior of caterpillars.
Researchers found that density of infected nymphs varies significantly from year to year, primarily influenced by fluctuations in acorn, mouse, and chipmunk abundance. Acorns emerge as the best predictor of Lyme disease risk due to their crucial role in supporting rodent populations.
Researchers found that high-dose CRF injections triggered intense bursts of sugar craving in response to a cue, but low doses or no injection had minimal effect. The study suggests a potential link between stress and binge behavior.
A recent disease outbreak in China, caused by Streptococcus suis, has resulted in 38 deaths and highlights the importance of occupational exposure to pigs. Researchers found that the pathogen was linked to outbreaks in local pig populations, but a new strain may be responsible for the severity of symptoms.
The Proceedings of the National Academy of Sciences (PNAS) journal has commemorated the late editor-in-chief Nicholas R. Cozzarelli, who improved the quality and reach of the journal through dynamic initiatives. He also championed open-access publishing, making research papers freely available to researchers and the public.
African stonechats exhibit spontaneous nocturnal activity echoing that of European stonechats, indicating the presence of Zugunruhe. The researchers propose that this migratory program may be a common avian feature, allowing birds to adapt to environmental changes.
A study of 216 individuals found that those living on the coast reported more health issues, with a mean symptom score of 14.1 compared to inland residents. The authors conclude that long-term effects of crude oil spills on local populations warrant further investigation.
Authors debate the benefits and harms of direct-to-consumer advertising of prescription drugs. Some argue it can promote underused, life-saving medications, while others claim it raises patients' expectations, increases the quality of care, but also delivers flawed information that may lead to premature adoption of new drugs.
Research shows brain activity persists and evolves with time after learning new information, integrating recent memories through dynamic processing. The findings challenge the idea that sleep is essential for strengthening memories.
Researchers in Hong Kong found that flu outbreaks increase hospital admissions for heart conditions, stroke, diabetes, and respiratory diseases. Influenza was responsible for 11.6% of respiratory disease admissions, comparable to temperate countries.
A study found that three pharmaceutical promotional brochures contained data that differed from the results of underlying studies. Of the 20 identified studies, 15 were deemed valid, while 16 had been funded by the pharmaceutical company producing the drug. This raises concerns about the accuracy of promotional marketing materials.
Researchers use functional magnetic resonance imaging to investigate the brain regions involved in illusory tactile perceptions. The study finds that the same sector of the brain is activated whether the sensation is real or illusory, suggesting a connection between conscious perception and somatotopic cortical processing.
Researchers found that Culex mosquitoes changed their feeding behavior from American robins to humans in the fall, leading to large-scale outbreaks of disease. The study's findings suggest a continent-wide phenomenon and may explain why West Nile virus outbreaks are more intense in the US than in Europe and Africa.
A study of 3,778 individuals found that 52.1% of those with circulatory disorders continued to smoke. Only 3.4% of smokers had received counselling in the past year.
In cluttered conditions, observers make more high-confidence errors due to increased background noise and reduced accuracy. The study's findings suggest far-reaching implications for complex cognitive tasks, including problem-solving and memory.
A study found that genes involved in the innate immune response are underexpressed in female mice during puberty, while those involved in the adaptive immune response are overexpressed. This difference is controlled by the Fas/FasL pathway, modulated by estrogen.
Between 2000 and 2003, Sweden reported an increasing number of MRSA infections, peaking at 544 cases in 2003. A significant portion, 433 cases, were acquired outside the country.
A recent study reveals a catastrophic collapse in orangutan populations due to massive deforestation and palm oil plantations. The genetic analysis indicates that the decline occurred within the past hundred years, coinciding with the acceleration of deforestation efforts.
Researchers analyze cost-effectiveness of different screening strategies to prevent cases through contaminated blood products. Screening only during mosquito season is deemed unnecessary in states with low WNV infection rates, while creating a 'supersafe' pool of blood for vulnerable individuals may be an effective solution.
A study found that patients prefer receiving both their GP letter and patient letter, as they provide valuable information. The letters were also compared for accuracy, with GPs preferring the structured format of their own letters.
Researchers discovered that adult interneurons in the visual cortex can dynamically change their branch tips through growth, retraction, and new additions. This finding highlights the complex dynamic properties of cortical neurons, which may underlie observed functional reorganizations.
A study of 1627 patients found that 53% stopped treatment early, with 36% citing ineffective treatment or worsening symptoms. Patients who experienced an early response to medication were 80% more likely to complete treatment, highlighting the importance of early symptom control and discussing treatment expectations.
Dr. Raz examines inconsistencies in antidepressant data for treating child and adolescent depression, highlighting the need for stronger evidence and questioning the safety of SSRIs for this age group.
A new study suggests that declining biodiversity in pollination networks may threaten plant community persistence. The experimentally manipulated plant and pollinator interactions show increased pollination efficiency with complementary insect and flower pairings.
A study of 80 medical school applicants found that assessors couldn't accurately predict happiness with a career in medicine from application forms. Higher educational qualifications were associated with perceived happiness, but didn't actually predict it.
A new study found that racial and ethnic minorities are just as willing, if not more willing, to participate in health research than non-Hispanic whites. However, they were less likely to be invited to participate in these studies, highlighting the need for improved access and inclusivity.
Researchers found that human cells without securin protein can recover from widespread chromosome losses over time, suggesting compensatory mechanisms at play. This discovery has implications for cancer treatment, as mathematical models often assume cell populations cannot recover from chromosomal instability.
A gene variant in Complement Factor H is associated with an increased risk of soft drusen, a precursor to advanced age-related macular degeneration. The study found that the CFH variant contributes to the development of soft drusen but does not determine who will progress to advanced AMD.
Researchers found that progressive loss of two types of hypothalamic neurons, Pomc and Agrp, leads to altered food intake patterns in mice. This discovery provides a potentially informative model for studying human age-related obesity and the regulation of energy homeostasis.
A study found significant differences in genetic effects between Chinese and non-Chinese studies on gene-disease associations. The researchers identified 161 Chinese studies on 12 topics, but only 20 were indexed in PubMed. This bias may lead to skewed evidence depending on language and publication sources.
A recent study found that nearly one-third of clinicians surveyed do not feel confident in counselling patients who report intimate partner violence. The study also revealed that only 10% of reports documented the clinician's level of documentation, highlighting a need for improved training and protocols.
Researchers found that only a third of high-risk patients were prescribed aspirin in 2003, despite its cost-effectiveness and recommended use for people with diabetes. The study suggests that physicians prioritize statins over aspirin due to advertising and preference.
A 1960s tool, adapted for influenza planning, identifies strengths and opportunities for improvement in Thailand's preparedness efforts. The Haddon matrix lends itself to rapid decision making necessary for effective pandemic response.
A study of Norwegian medical students found that nearly 70% self-prescribed medication in their first year after graduation, a trend that continued into their fourth and ninth years. The most commonly self-prescribed medications were antibiotics, contraceptives, and analgesics.
A short course of repetitive transcranial magnetic stimulation (rTMS) increases finger sensitivity by 15% immediately after treatment, with effects lasting up to two hours. The brain map representing the index finger also enlarges in response to rTMS, corresponding to increased sensory perception.
The new study found that full open-access journals face significant financial pressures over the longer term, with 41% reporting shortfalls. In contrast, subscription journals tend to be more profitable, with 81% of HighWire and AAMC journals reporting a profit.
Researchers observed western gorillas using sticks to test water depth and create a bridge in the wild. This discovery provides valuable insights into the evolution of tool usage in great apes and their abilities.
AZojomo is the first open-access publishing system to reward authors and peer reviewers with revenue sharing, providing a more inclusive and accessible way for scientists to publish research papers. Peer-reviewed by internationally renowned materials science experts, AZojomo ensures the credibility of published content.
Physicians can serve as investigators in bioterrorism cases, collecting forensic evidence like in a sexual assault investigation. They should also document the patient's medical history and physical exam. This helps prevent further attacks and achieves justice.
Limiting free antiretroviral medicine access to only treatment-naïve patients puts patients at risk of adverse effects and can slow treatment enrollment. Human rights issues arise when some individuals are denied medication due to financial constraints, potentially leading to their demise.
A study published in PLoS Medicine found that a computer monitoring system can alter doctors' behavior, making them more likely to stop prescriptions or order further tests when alerted to potential problems. This could lead to significant reductions in adverse drug events and hospital costs.
Research studies with smaller sample sizes are more prone to false results. Additionally, scientific fields with smaller postulated effects tend to have higher rates of false positive claims. Financial interests and prejudices can also influence the accuracy of research findings.
The Beilstein Journal of Organic Chemistry is a peer-reviewed online journal that covers all aspects of organic chemistry and related disciplines. It invites submissions from organic chemists worldwide, offering efficient refereeing, rapid publication, and high visibility, with no publication charges or copyright restrictions.
Researchers studied over 13,000 people from five diverse sites to investigate dementia incidence. The study found no convincing evidence of variation in dementia incidence across sites or age groups, challenging previous proposals for public health policy.
A novel coronavirus, HCoV-NL63, is strongly associated with croup in children under three years old. The study found that 43% of patients with high viral load and no co-infection had croup, compared to 6% of those without the virus.
Children in southern Italy face a constellation of risks including high school dropout rates and low youth employment. The region also struggles with low vaccination uptake rates, leaving kids vulnerable to preventable diseases.
A study found that health-related adverts accounted for approximately half of all adverts in mainstream women's magazines, but only a quarter in black and Hispanic magazines. The disparity highlights existing health inequalities among different ethnic groups.
Researchers found that mosquitoes were significantly more attracted to children with infectious stages of malaria, whereas treatment with antimalarial drugs showed no difference in attractiveness.
The study found age-related changes in gene expression in the human brain's cortex, but not in non-brain tissues. The results support a theory that DNA damage and protein degradation contribute to aging, with more metabolically active tissues showing greater gene activity reduction.
The media's role in spreading health messages is being reevaluated by experts. Journalists have a responsibility to mirror society's needs and issues comprehensively and proportionally. They must investigate and report possible conflicts of interest among sources, citing earlier research and seeking independent expert opinions.
Cats have no way to recognize carbohydrates, resulting in a diet high in meat and fat. This is due to the pseudogenization of sweet-receptor genes, which prevents cats from tasting sweetness.
Researchers have identified new genes that regulate aging, with effects on insulin signaling, metabolism, and dietary regulation. Inhibiting these genes increases lifespan in certain organisms, suggesting potential therapeutic applications for age-related diseases.
A study of Nigerian healthcare professionals found discriminatory attitudes towards patients with HIV/AIDS, including refusal to care for or admit them. The authors highlight inadequate education and resource shortages as contributing factors, and call for targeted interventions to address these issues.
A study by Professor Chris McManus found a decline in postgraduate medical exam scores between 1997 and 2001, with a sharper drop in 2001 compared to 1996. This decline had implications for medical education, prompting further studies on performance in other exams.
Stephen P Goff, a prolific scientist with over 250 publications, was recognized for his outstanding research and mentorship. He developed the Moloney murine leukemia virus as a genetic system and made significant contributions to the development of antitumor drug Gleevec.
The International Campaign to Revitalise Academic Medicine proposes three possible futures for academic medicine: one driven by the private sector, another by public engagement, and a third by global networks. The scenarios offer insights into how academic medicine should evolve, with potential benefits including improved efficiency, i...
A new study in PLoS Biology confirms the genetic link between Polynesians and indigenous Taiwanese populations, revealing three unique mitochondrial DNA mutations. The findings suggest that Taiwanese aboriginal populations have been genetically isolated from mainland Chinese for 10,000 to 20,000 years.