Articles tagged with Animal Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at TIGR have completed the genetic sequence of Deinococcus radiodurans, a bacteria that can withstand extreme environmental conditions. The study reveals its unique genome composition and large redundancy of repair functions, which may contribute to its exceptional radiation resistance.
A new technique allows scientists to introduce desired genes directly into embryonic cells using the baculovirus, enabling the study of gene function in non-model organisms. This method has shown promising results in fruit flies, beetles, and other species, offering a breakthrough for understanding developmental processes.
Researchers at Ohio State University developed a method to predict the lethal combination of insecticide concentration, droplet size, and number for specific species. The new approach boosts insect mortality by 60-70% in laboratory experiments, showing promise for more effective pest control with reduced environmental risks.
Researchers at Cornell University developed new tests to measure the true bioavailability of aging toxins like DDT, which may overestimate the risk to living organisms. The new tests meet standards set by common earthworms and provide a more realistic reflection of potential harm.
A recent study found that alcohol consumption during pregnancy can cause early delivery, with potential health consequences including low birth weight and increased risk of death or long-term illness. Researchers believe a critical period for drinking may exist, and prevention is key to reducing premature births.
Researchers have discovered that environmental stimuli like smells can induce a neurochemical response in the brain that may reinstate alcohol-seeking behavior after withdrawal. This study suggests that understanding the mechanisms involved in relapse can lead to the development of medications that target specific critical neural systems.
Researchers develop implants that amplify weak signals traveling along the spinal cord, potentially restoring coordinated movements in paralyzed individuals. Clinical trials are planned within two years to help people with spinal injuries stand and exercise their legs.
A traditional Chinese diet high in vegetables and green tea may be protective against heart disease. Researchers found that westernized Chinese individuals consumed more animal fats and dairy products than those who followed a traditional diet.
A recent study of 4,462 male U.S. Army veterans with post-traumatic stress disorder (PTSD) found a higher rate of heart disorders, including past heart attacks, compared to other veteran subjects. The study's results suggest that long-term severe psychological distress may cause coronary heart disease.
Researchers at Johns Hopkins Medicine have identified a new neurotransmitter, D-serine, which activates key nerve cells in the brain. This discovery could lead to the development of new stroke treatments by inhibiting NMDA receptor activity.
Researchers are refining technologies to identify active genes in the central nervous system, accelerating understanding of diseases like Alzheimer's, depression, and schizophrenia. Two teams use distinct approaches: one detects proteins or RNA in intact neurons, while the other identifies genes involved in daily rhythms.
Yale researchers have found that Lonesome George, the last remaining male Galapagos tortoise, has close genetic affinities to subspecies on islands farthest from his home. The study suggests that these distant island tortoises may be a suitable mate for George, increasing the chances of successful breeding.
A study found that people with pets experienced half the increase in blood pressure under stress compared to those without pets. The researchers used medication to control high blood pressure and tested the effects of pets on stress reactivity.
The American Association of Pharmaceutical Scientists (AAPS) has released new research on the influence of direct-to-consumer advertising (DTCA) on doctors' prescribing habits. A study found that half of physicians feel pressure to prescribe products patients have seen advertised, with 77% linking patient requests to TV advertising. Ad...
A five-year clinical trial found that premenopausal women taking fenretinide had a lower risk of developing another breast cancer, while postmenopausal women showed no significant benefit. The study also detected a reduced risk of ovarian cancer in younger women treated with fenretinide.
Researchers identified two critical developmental genes, Dnmt3a and Dnmt3b, which control methylation patterns and are associated with ICF syndrome. Mutations in these genes may cause ICF, a rare condition characterized by immune system defects and facial abnormalities.
A new animal study suggests that soy isoflavones may slow prostate cancer growth by inhibiting cell proliferation and promoting apoptosis. The study also found lower levels of insulin-like growth factor 1, a hormone that stimulates tumor growth.
A new study found that male prairie voles' brains produce a compound called citrulline, which is associated with aggressive behavior in mice. However, the study suggests that this compound may not be present in monogamous male voles, which could help explain their unique mating behaviors.
Researchers found increased genetic diversity in cattails growing in the most polluted sites, contradicting previous studies on animal populations. The team's findings suggest that cattails may be an effective indicator of environmental stress.
The discovery provides a detailed picture of life during the earliest days of dinosaurs and mammals. The newly found fossils are from the Middle to Late Triassic period, around 230 million years ago, and include two new dinosaurs that appear to be older than previously recorded species.
Researchers at the University of Delaware have developed a new artificial hip design that reduces stress shielding and prevents bone atrophy in younger patients. The design is based on an analysis of real loading conditions within the human hip region and has been shown to consistently perform better than conventional designs.
A team of scientists discovered the oldest known dinosaur fossils in Madagascar, dating back to 230 million years ago. The fossils were found by a young local boy named Mena who led researchers to a hill with a mound of bones, sparking an eight-year dig that yielded spectacular results.
Researchers Ally R. Harari and Jane Brockmann studied the behavior of Diaprepes abbreviatus beetles, finding that mounting females attracts larger males, improving female reproductive success. The beetle's behavior appears to suggest a different explanation for homosexual behavior than observed in domesticated animals.
A captive breeding program aims to replenish the nearly decimated population of white abalone by leveraging their unique reproductive needs. The mollusks require close proximity with an opposite sex for fertilization, hindering effective reproduction and making conservation efforts challenging.
Researchers at UT Southwestern Medical Center discovered that cocaine affects the central nervous system, causing vessel constriction, rapid heartbeat, and subsequent heart attacks. By blocking the sympathetic nervous system, they found a potential pathway to develop a life-saving antidote for cocaine overdoses.
Seven research centers will study tobacco use, prevention, and treatment using a transdisciplinary approach. The centers aim to accelerate development of effective tobacco control interventions and reduce tobacco-related deaths.
Researchers found that a muscle protein rapidly disappears from synapses when not receiving nerve signals, supporting the idea of rapid molecular changes in learning. This discovery may explain why withdrawal of certain agents can be fatal to patients on respirators.
Researchers at Cornell University will use acoustic monitoring to count forest elephants in Africa, providing crucial information on population numbers and health. The project aims to support conservation efforts by tracking endangered species such as gorillas and rhinos.
A study by Brown researchers has found that the brain releases a naturally produced cannabinoid called anandamide in response to pain. The substance produces analgesia and may provide a new approach to treating chronic pain, particularly in cases where opiates are ineffective.
A study of 2283 children aged 8-10 found that those living on farms were 3 times less likely to develop hay fever and asthma. Regular exposure to microbial antigens in stables may play a role in developing immune tolerance.
Researchers at the University of North Carolina have identified latent membrane protein 1 as a key contributor to Epstein-Barr virus-induced cancer. The study found that mice with this protein developed lymphoma, highlighting its role in cancer development and potential target for prevention.
Researchers at the University of Chicago are developing new therapies to induce immune tolerance for islet transplants and autoimmune diseases. The grants aim to improve the success of transplants and treatments for type 1 diabetes, lupus, and rheumatoid arthritis.
The NIAID is spearheading a collaborative network to develop new ways of inducing immune tolerance, promising improvements in transplant success rates and treatment for autoimmune diseases. Researchers will conduct clinical trials using 'tolerogenic approaches' to selectively modulate the immune system.
Researchers found that estrogen can reduce the risk of developing cataracts by up to 77%, with estradiol and estrone showing particular promise. The study used rats with induced ovarian failure to test the effects of different estrogens on cataract development.
Researchers at the University of Illinois have isolated and characterized an insulin gene from the marine mollusk Aplysia californica. The study reveals a unique peptide, the 'D' peptide, which is separated from the standard two-chain insulin structure by a 'C' peptide.
Researchers found that loss of the NEP enzyme fuels inflammation in mice with colitis, leading to increased substance P levels and bowel inflammation. Administering the NEP enzyme or blocking substance P can dramatically reduce inflammation, suggesting potential treatments for humans.
Researchers suggest that testosterone plays a key role in redistributing immune cells to the skin during stress, rather than suppressing the immune system. This redistribution hypothesis is supported by studies in rats and mice, which show improved wound healing rates with testosterone treatment.
A team of researchers has identified a genetic link on mouse Chromosome 19 that controls inherited susceptibility to testicular cancer. The discovery uses a new genetic technique called chromosome substitution, which may lead to improved understanding and treatment options for the disease.
A study found that tumor necrosis factor-alpha (TNF-alpha) plays a crucial role in early liver damage caused by alcohol consumption. The researchers used gene knockout technology to show that TNF-alpha mediates the development of liver injury, leading to potential new drug therapies for conditions affecting millions of Americans.
Researchers found moose pregnancy rates fell from 90% in 1966 to 75% today, indicating limited food availability. The abundance of willows limits the number of moose, not wolves and grizzly bears, according to the study.
A study by Anthony Ricciardi and Joseph Rasmussen reveals freshwater species are dying out five times faster than terrestrial species. At this rate, many at-risk species will disappear within the next century, with non-native species and dams identified as major threats.
A groundbreaking study reveals differences in the human brain's neural architecture compared to apes and monkeys. Researchers found a uniquely human feature in the magnocellular pathway of the primary visual cortex, which may help understand diseases like dyslexia.
Researchers at MGH discovered TGF-beta-1 inhibits blood vessel growth associated with metastatic gallbladder cancer. The study's results may lead to anti-angiogenesis agents for cancer treatment.
Scientists created a new mouse strain with a genetic deletion that affects stress hormones and behavior. The mice exhibit anxiety-like behavior consistently, not just in response to external stimuli, offering insights into the role of CRH-binding protein in depression and anxiety disorders.
Researchers at Yale University have found that healthy bullfrog tadpoles can distinguish the odors given off by infected animals and keep their distance. This ability may be widespread among animals, enabling them to avoid diseases and reducing the spread of infection.
Researchers at UB used a fluorescent probe to track the uptake of AN-152, a cancer drug linked to a peptide hormone carrier, by human breast-cancer cells. The study provides evidence that AN-152 directly enters cancer cells, accumulates in the nucleus and associates with chromosomes.
Researchers aim to uncover principles of coordinated group motion and apply them to designing autonomous underwater or airborne robots. They will create a database recording fish school movements and test robotic versions of biological models.
Researchers at UT Southwestern Medical Center have identified casein kinase I (CKI) as a novel component of the Wnt-signaling cascade, essential for proper animal development. The discovery may lead to new approaches for influencing developmental processes and developing cancer treatments.
Researchers at UCSF have identified a protein enzyme that plays a key role in pain signaling, suggesting a possible target for broad-based pain therapy. The finding applies to inflammatory pain syndromes, such as arthritis and colitis, and has potential implications for post-operative pain relief.
Scientists have found a possible way to induce new blood vessels without gene therapy, by lowering an individual's heart rate, according to a University of Iowa Health Care study.
Fire ant attacks have been reported in US healthcare facilities and homes, resulting in severe medical complications, including death. The medical complications of fire ant stings can range from mild irritation to death from a generalized allergic reaction, depending on the number of stings and the physical condition of the victim.
A study published in the Journal of Comparative Neurology found that moderate fetal alcohol exposure can cause the corpus callosum to be larger than normal, contradicting previous research. This could have significant implications for our understanding of fetal alcohol syndrome and its effects on brain development.
The discovery of a new tomb at Teotihuacan's Pyramid of the Moon has provided critical evidence for reconstructing the city's 2,000-year-old history. The tomb contains human skeletons, animal bones, and offerings that differ from previous discoveries, suggesting a significant cultural shift between two phases of pyramid construction.
Researchers at Wistar Institute find parallels between PRD1 and human adenovirus coat protein structures, suggesting an evolutionary relationship. The discovery may lead to new research areas and therapies.
Researchers at Oregon State University have discovered a male pheromone that calms female salamanders during courtship, making them more receptive to mating. The study highlights the complex role of pheromones in animal behavior and suggests potential applications in human reproduction.
A new research study found that animals fed a blueberry extract diet showed fewer age-related motor changes and outperformed their counterparts on memory tests. The antioxidants in blueberries may help protect the body against oxidative stress, a process implicated in aging and neurodegenerative diseases.
The Wake Forest University School of Medicine has been awarded $400,000 for a new MicroPET scanner, which will enable researchers to conduct PET studies in nonhuman primates and rodents. The scanner's higher resolution allows for more detailed brain structure imaging.
Researchers at the University of North Carolina will use a novel vaccine method to develop a safe and effective HIV vaccine. Early tests on monkeys show promise, with vaccinated animals showing significant cellular and humoral immunity and reduced virus load.
Researchers have discovered a new drug, pifithrin-alpha, that can protect healthy tissues from radiation damage and reduce side effects. The treatment strategy may allow for higher doses of therapy to be administered, improving cure rates.
Researchers at Harborview Medical Center are exploring a new approach to treat depression by introducing extra copies of the gene for 5-HT1b receptors into serotonin neurons. Preliminary results suggest that this technique may allow for faster and more effective treatment of depression.