News on the use of animals, and their alternatives, in biomedical research. Covers animal models, primate studies, tissue chips, research ethics, and disease modeling.
A comprehensive digital database has been created to document over 20,000 species known to produce sounds underwater, including 729 confirmed and 21,911 likely producers. This inventory can revolutionize marine science by providing valuable insights into species interactions and environmental impacts.
Researchers revisited melatonin's effects on cancer in mice, finding that nighttime administration inhibits chemically induced mammary tumor development. The study highlights the importance of timing in using this freely available compound for cancer prevention and treatment.
Researchers found apes recognize photos of friends they haven't seen in over 25 years and respond more enthusiastically. The study demonstrates the longest-lasting social memory outside humans, suggesting a common ancestor link and potential for great ape culture evolution.
A new method can help estimate the prevalence of disease in free-ranging wildlife by accounting for animal clustering. This approach may reduce the number of samples needed to detect a disease. The researchers focused on Chronic Wasting Disease (CWD) in deer, which tends to cluster in family groups, making this method particularly useful.
A new genetic atlas details the gene expression programs that drive zebrafish development, revealing insights into human embryonic growth and the origins of diseases such as gastrointestinal disorders. The atlas provides a comprehensive resource for studying cell development and differentiation in vertebrates.
The giant bacterium Epulopiscium viviparus has modified its metabolism to make the most of its environment, using a rare method to produce energy and harvest nutrients from its host's gut. This unique approach allows it to thrive in extreme conditions, with similarities to how mitochondria function in more complex organisms.
Scientists at Niigata University successfully produced marmoset eggs and embryos from xenotransplanted ovaries, offering a new method for generating genetically modified marmosets. The novel egg production system is expected to facilitate research into human diseases and contribute to regenerative medicine.
A study by Waseda University explores the effects of different vascularization strategies on brain organoids, improving cell differentiation and transcriptome profiles. Vascularized cerebral organoids exhibit a gene expression profile closer to fetal human brains than non-vascularized ones.
A team of scientists has decoded the evolution of Marek's Disease Virus, a fatal disease in chickens, using ancient DNA from up to 1,000-year-old chicken bones. The study found that the virus was already widely distributed over 1,000 years ago and became increasingly aggressive due to global chicken farming and vaccine use.
A study on cockroaches reveals that they can transmit antimicrobial resistance genes to each other through direct contact and habitat interactions. The findings suggest that the transmission of AMR genes is not limited to antibiotic overuse, but also occurs between animals carrying genes in their microbiomes.
The Mount Sinai Hospital has received a $1.3 million grant from the National Institutes of Health to expand its New York City Virus Hunters program. The program engages high school students in virus surveillance and mapping, tracking circulating avian influenza and paramyxoviruses in wild birds.
Researchers discovered that Nectandrin B, a bioactive lignan compound from nutmeg, extends the lifespan of Drosophila melanogaster by as much as 42.6%. The study found that Nectandrin B reduces intracellular ROS levels and improves age-related symptoms such as locomotive deterioration and neurodegeneration.
A comprehensive review of targeted therapies for lupus nephritis discusses the challenges of current treatments and proposes strategies to overcome obstacles. Recent advancements in B-cell targeting and alternative approaches such as CAR-T cells are highlighted.
The study maps over 32 million cells in the mouse brain, describing their type, location, and molecular information. This atlas paves the way for a greater understanding of the human brain and development of precision therapeutics for mental and neurological disorders.
Researchers found evidence of domesticated yak dating back 2,500 years in the southern Tibetan Plateau, revealing insights into animal domestication pathways and human adaptation to high-altitude environments. The discovery was made using a combination of ancient DNA sequencing and zooarchaeological analysis.
A new study finds that a hormone produced by the fetus and a mother's sensitivity to it are the causes behind nausea and vomiting during pregnancy. Lowering GDF15 levels or pre-exposing women to the hormone may mitigate symptoms, providing potential ways to prevent extreme forms of pregnancy sickness.
Research reveals that an average of 1,000 times more birds are in the air close to fireworks on New Year's Eve, with effects strongest within the first 5 km. Larger birds like geese and ducks fly for hours at remarkable altitudes, risking accidents.
A new study reveals that female American Kestrels venture away from their nests to scout future territories, a behavior previously undocumented in the species. These movements, which cover large distances relative to home range size, suggest that females may be holding multiple summer homes and using better habitat after breeding.
Researchers at Northwestern University developed virtual reality goggles for mice, allowing them to study responses to overhead threats for the first time. The new system enabled more accurate and precise neural circuitry analysis by simulating natural environments, reducing training times compared to traditional VR systems.
A fungus-based biopesticide is less lethal to mammals than synthetic insecticides but can wipe out colonies of wasps that benefit plants by feeding on pests and performing pollination. The study found that infected wasps are not detected by nestmates, potentially threatening the survival of these species.
Researchers found SARS-CoV-2 viruses persisting in lung cells for up to 18 months post-infection, despite undetectable upper respiratory tract presence. The study suggests a link between innate immunity failure and virus persistence.
A small molecule drug compound has shown promise in treating multiple sclerosis by targeting the glutamate system, reducing MS-like symptoms and repairing damaged myelin. The results come from a CAMH-led pre-clinical study published in Science Advances.
A research paper reveals a suburban backyard is home to 1,150 unique species of animals, plants, and fungi. The study's authors discovered unexpected diversity, including 436 moth and butterfly species, 56 spiders, and eight reptiles.
Researchers found that honeyguides in Tanzania and Mozambique discriminate among human calls, responding more readily to local than foreign calls. This complex communication system benefits both species by increasing their chances of accessing calorie-dense honey and beeswax.
A recent Cornell University study found that wasps which can recognize individual faces tend to have better social interactions and exhibit stronger cognitive abilities than those who cannot recognize individuals. This suggests an evolutionary link between facial recognition and cooperation.
A study on ruff (Calidris pugnax) found a surprisingly low mutation load in the supergene controlling male mating strategies, forcing a reevaluation of supergene evolution. The researchers propose two potential scenarios to resolve this paradox: recent acquisition of recessive lethality or introgression from another species.
Scientists at ETH Zurich successfully navigate gas-filled microbubbles through the brain's blood vessels using ultrasound, offering a potential breakthrough in delivering medications to specific areas. This technology could revolutionize treatments for cancer, stroke, and neurological conditions.
In parts of Africa, humans communicate with greater honeyguides to locate bee colonies, sharing knowledge about the location of nests. The bird benefits by eating leftover honeycomb, while people gain access to honey and beeswax. Researchers found that honeyguides learn distinct vocal signals used by different honey-hunting communities.
Researchers analyzed skeletal remains of ancient Egyptian baboon mummies from the site of Gabbanat el-Qurud, finding lesions and deformations indicative of malnutrition and lack of sunlight. The findings provide insights into how baboons were kept in captivity before their eventual mummification.
Eurasian jays wait for higher-quality food when alone but choose low-quality reward with competitor birds present. Researchers studied delayed gratification in New Caledonian crows and Eurasian jays.
Scientists developed an AI method to track neurons in moving and deforming animals using convolutional neural networks with targeted augmentation. This breakthrough reduces manual annotation efforts by three times, enabling faster analysis of brain activity in model organisms like Caenorhabditis elegans.
Researchers from Nagoya University found that electric eel discharges can genetically modify small fish larvae, demonstrating the potential for electroporation in nature. The study's findings suggest that electric fields can affect gene transfer in organisms, leading to new insights into genetic modification.
Researchers found that mice require significant external sensory cues to recognize changes in their reflection and can detect visual differences, but not tactile ones. The study identified a subset of neurons involved in developing self-image, highlighting the neural mechanisms behind self-recognition in mice.
Researchers have uncovered the intricate molecular mechanism used by parasitic phytoplasma bacteria to manipulate plants. The discovery sheds light on a peculiar phenomenon in nature, where plants exhibit 'zombie-like' effects due to bacterial infection.
A new study compiled over 600,000 records from US and Canadian wildlife rehabilitation centers to investigate the threats facing more than a thousand species by region, highlighting human activities such as climate change and extreme weather events
Researchers developed a robot prototype inspired by a snail's ability to collect food particles at the water-air interface. The device uses an undulating motion to suck in microplastics from the surface of oceans and seas.
A study published in Science Advances found that abnormal cell stress in the placenta's syncytiotrophoblast layer may lead to preeclampsia. Researchers also developed a mouse model to demonstrate the effects of this stress, showing similar signs of high blood pressure and kidney damage.
Researchers found that specific algae from the genus Breviolum help Caribbean octocorals withstand heat waves and bleaching events. The study provides clues for the future of coral reefs and highlights the need for further research to better understand the ecosystem.
Researchers found a significant increase in extracellular vesicles released by aged keratinocytes, which were also enriched with specific microRNAs. These EVs impaired young keratinocyte proliferation and organogenesis, mimicking aged skin defects.
Researchers discovered bottlenose dolphins' ability to detect weak electric fields, which helps them search for fish hidden in sediment. This newfound sense also enables dolphins to navigate the globe using magnetic maps by sensing the planet's magnetic field at varying speeds.
A recent study found that flocks of birds in North America, Europe, and Asia responded equally strongly to the alarm call of an unfamiliar dusky-throated antshrike. This suggests that sentinel calls may contain a universal signal that allows birds to recognize them across different species and continents.
Researchers have developed a new mixture, organ agar, that enables them to screen bacteria more efficiently than traditional methods. This innovation allows for the testing of over 1,700 mutants of the UTI-causing bacteria Proteus mirabilis using only a quarter of the mice typically required.
Researchers have developed new tools to assess disease progression of Alzheimer's disease in animal models, providing a translational approach for studying the disease. The tools use neuroimaging and network modeling techniques to analyze metabolic changes in the brain, confirming previous clinical findings.
Researchers found that brittle stars, brainless marine creatures, can associate darkness with food and react accordingly, demonstrating classical conditioning. They retained this association even after a break from training, suggesting potential learning capabilities in these animals.
Researchers discovered ancient bird-like footprints in Southern Africa that date back over 210 million years, 60 million years before the earliest known bird fossil. The tracks were found at multiple sites and show a mix of dinosaur and bird-like characteristics.
The study found that England's only resident population of bottlenose dolphins has declined to just 48 individuals due to various human impacts. The researchers call for urgent measures to protect the population and its habitats.
Researchers have combined 14 studies on piglet gut bacteria to uncover common patterns in microbiome development over time. The analysis revealed predictable trajectories and important details at a fine time scale, with an accuracy of 70% in predicting animal age based on microbiomes.
A Victorian collector, Morton Allport, traded human and animal remains from Tasmania for scientific recognition. The research highlights the entwined costs of colonialism with practices of natural history, revealing a 'quid pro quo' arrangement to meet demand for these remains.
Four retinoids (RPalm, RP, HPR, and ROL) show anti-photoaging activities in vitro, while RPalm and RP are superior in a UVB-induced mice model. Topical application of these retinoids shows satisfactory biosafety without significant side effects.
A study of ancient elephants suggests that moving into open land grazing helped develop their coiling and grasping trunks. This adaptation enabled some groups, like Platybelodon, to survive in greater numbers in open environments.
Researchers found that 1,5-AF activated AMPK, leading to upregulation of the PGC-1α/BDNF pathway and alleviating aging-related decline in motor cognitive function. The study suggests that 1,5-AF can induce endogenous neurovascular protection, potentially preventing aging-associated brain diseases.
Researchers at the CNIC in Madrid have discovered a connection between stress kinases and the development of ventricular fibrillation. The study found that activation of these enzymes alters the electrical properties of cardiomyocytes, triggering arrhythmias.
Researchers found that honeybees' cluster behavior is a survival strategy against cold temperatures, not insulation. The study suggests that beekeepers should reconsider their hives' design and materials to reduce heat loss.
Researchers conducted extensive surveys and collected data from local communities, but found no evidence of Arabian leopards in Saudi Arabia. The study concludes that human-designed breeding programs and reintroductions are necessary for the recovery of leopard populations.
Researchers found that genetically identical Amazon mollies exhibit differences in offspring size and reproductive output, indicating varying levels of biological fitness. The study suggests that epigenetics, stochasticity, and micro-environmental factors play a role in the emergence of individuality.
Researchers at the University of Konstanz developed an AI-powered method to objectively characterize embryonic development tempo and stages. The Twin Network trained on over 3 million zebrafish embryo images accurately identified developmental stages, temperature dependence, and malformations.
Researchers from Kyoto University found that two species of land snails exhibit opposite behaviors in response to predator-like stimuli. The species K gainesi accelerates its forward movement to escape predators, while its nocturnal relative K editha retreats into its shell.
Researchers analyzed bones from 52 sacrificed animals at the well-preserved site of Casas del Turuñuelo, revealing a pattern of repeated mass animal sacrifice in Iron Age Spain. The study sheds light on ritual protocols and intentional selection of adult horses over young animals.
A new study published in PLOS ONE reveals the earliest known fossil of the modern European common hippopotamus, dating back to the Middle Pleistocene period. The analysis of a fossil skull from Italy confirms the identity of the species and provides insights into its dispersal history.
Researchers have unlocked the developmental mechanism of a unique reproductive process in Japanese green syllid worms. The stolon, a detached body part with gametes, swims autonomously and spawns after developing eyes, antennae, and swimming bristles.