News on the use of animals, and their alternatives, in biomedical research. Covers animal models, primate studies, tissue chips, research ethics, and disease modeling.
The tawny owl's pale grey plumage is linked to crucial functions aiding survival in cold environments, including energy homeostasis and fat deposition. Genetic analysis reveals a 70-100% accuracy in predicting grey coloration through specific genetic variants.
A study of human-animal co-burials from ancient Italy suggests that the practice may have been related to enduring companion relationships or religious beliefs. Researchers found that the people buried with animals did not share common traits, leaving multiple interpretations for this phenomenon.
A study published in Nature tracked neural activity of freely moving macaques using wireless eye tracking and neural monitoring. The research found that the visual cortex plays an active role in social behavior by providing signals to the prefrontal cortex, enabling the decision to cooperate.
A new study finds that red-colored agricultural nets are more effective at deterring onion thrips than traditional black or white nets. The use of red nets resulted in a 25-50% reduction in insecticide applications, making them a promising solution for sustainable agriculture.
A recent study published in Biological Conservation reveals that NY bobcat populations remain critically low, with occupancies below detectable limits. Researchers used trail cameras to monitor wildlife populations in central and western NY state, tracking white-tailed deer, red fox, coyote, eastern wild turkey, and gray fox numbers.
A Johns Hopkins Medicine-led study found rapid antigen tests for detecting SARS-CoV-2 can be used at home with accuracy comparable to clinician-administered tests. The study involved nearly 1,000 patients and showed that self-administered rapid tests rivaled clinician-administered tests in both sensitivity and specificity.
A new study from the University of Ottawa proposes using vanoxerine, a drug initially developed for cocaine addiction, to potentially treat advanced colon cancer. Vanoxerine has been found to suppress cancer stem cell activity in colon cancer patients' tissues and tumours implanted in laboratory animals. The drug works by interfering w...
A recent study found that polar bears, closely observed by scientists, struggled to maintain weight when their preferred seal prey was out of reach during longer ice-free seasons. Despite trying various strategies, including resting and foraging, nearly all the bears lost weight rapidly, highlighting their vulnerability to climate change.
Researchers found Joro spiders can thrive near busy roads, attacking simulated prey 59% of the time, despite slight differences in attack rates, without compromising their health or body mass. The species' ability to tolerate urban vibrations and sounds is likely a key factor in its exponential growth
The study reveals that the superior colliculus is vital in the transition from seeing individual flashes to smooth motion, and may be a key component in creating the continuity illusion. Different methods of measuring the Flicker Fusion Frequency threshold suggest other parts of the brain also play a role in this process.
Two new EU-funded projects, PollinERA and WildPosh, will investigate the toxicological and ecological impacts of chemical pollution on terrestrial biodiversity and pollinators. The projects will improve risk assessment tools and characterise exposure routes to pesticides in four European regions.
Researchers identified blood proteomic markers associated with hepatocellular carcinoma (HCC) in patients with cirrhosis. The study found a set of biomarkers, including TGF-β driven mechanistic biomarkers and Myostatin and Pyruvate Kinase M2, which may stratify risk for HCC.
Researchers have created the DEBBIES dataset to enhance understanding of cold-blooded animals' responses to novel environmental shifts. The dataset contains estimates of eight life history traits for 185 ectotherm species, allowing users to develop general predictions on animal responses using a few key characteristics.
Detailed CT scans reveal the worm-lizard's skull anatomy, including sutured bones and a singular central tooth. Researchers also discovered sexual dimorphism in one species, confirming their findings through powerful jaw muscles.
ATH-1105, a small molecule positive modulator of the neurotrophic HGF system, demonstrates significant neuroprotective effects and extends survival in preclinical models of ALS. The study highlights the therapeutic potential of ATH-1105 in slowing or stopping neurodegeneration.
Scientists at UC Riverside have discovered a tiny worm species that can control crop pests in warm, humid environments. The new Steinernema adamsi nematode is nearly invisible and can kill insects with a low dose, making it a potential alternative to pesticides.
Researchers found elevated PROX1 levels in advanced colon adenocarcinoma, correlating with poor prognosis. PROX1 modulates CRC cell behavior, influencing invasiveness and survival outcomes. The combined PROX1/α-SMA gene set emerges as a potential CRC prognostic marker.
A new study published in the Journal of Dairy Science explores the use of spent hemp biomass as a feed ingredient for lactating dairy cows. The research shows that hemp biomass is safe and does not negatively affect milk production or animal health, despite being less palatable due to its characteristic smell. The study suggests potent...
A recent study published in Nature sheds light on how the brain's internal compass guides behavior, using fruit flies as a model organism. Three distinct groups of neurons enable communication between the compass and steering regions, translating signals into behavior to keep the fly moving in the right direction.
Researchers at Virginia Tech have developed a simple, noninvasive, rapid screen to detect cancer in dogs using urine analysis. The test is more than 90% accurate and provides a preliminary understanding of whether a dog has cancer markers in minutes.
The Komodo Dragon's teeth develop and replace rapidly, with up to five replacement teeth per position in its jaws. This allows it to quickly respond to prey capture or injury, making it an ideal model for studying theropod dinosaur life history and feeding strategies.
Researchers discovered surprising secrets about how fruit flies adapt their senses to different environments through gene expression patterns. Thousands of genes had undergone significant changes in expression, shaping unique olfactory landscapes of different fly species.
A standard quality test for raw organic milk is insufficient to distinguish between specific groups of bacteria, highlighting the need for updated criteria at processing plants. Distinguishing between non-sporeforming and spore-forming thermoduric bacteria is crucial to reducing troubleshooting time and improving milk quality.
Researchers at the University of Bristol have discovered how ermine moths produce ultrasonic warning sounds using an 'aeroelastic tymbal'. The mechanism involves the snap-through buckling of a corrugated membrane, amplifying sound production through resonance. This study sheds light on the biomechanics behind moth defense mechanisms.
Researchers at the University of Sydney have developed a method to shield plants from herbivorous mammals by fooling them with artificial odors, mimicking plants they naturally avoid. This approach is more humane and low-cost than current methods, and shows promise for protecting valuable plants globally.
Researchers observed that clown anemonefish colonies display the most aggressive behavior towards fish with three bars like themselves. The fish also recognize different anemonefish species based on the number of vertical white bars, leading to strict social hierarchies and upholding dominance.
A combination of two cancer drugs has shown promise in treating malignant peripheral nerve sheath tumors (MPNSTs), a type of cancer that is notoriously hard to treat. The study found that the combination therapy of SHP2 inhibitors and CDK4/6 inhibitors suppressed tumor growth and triggered cell death in mouse models.
A team of neuroscientists has discovered that oligodendrocytes, myelin-forming cells, accelerate glucose consumption to deliver energy-rich molecules to rapidly firing axons. This communication is mediated by potassium signals and maintains axonal health.
A survey of 2,002 Danish dog owners found that 38% used cannabinoids, primarily CBD, to treat their pets' pain, behavioral issues, and allergies. 77% of these owners reported positive effects on their dogs' mental or physical health.
Researchers at the University of Arkansas System Division of Agriculture have developed a new hybrid technique for creating detailed 3D images of the chicken brain. The method, which combines histochemistry and diceCT imaging, allows for quality images resembling MRI technology at a lower cost.
Researchers found an adaptive increase in cerebellum size in fossil vertebrates, enabling powered flight. The study combined PET scans with fossil data, revealing increased brain activity in the cerebellum and optic flow pathways during flight.
Researchers found that individual Balearic shearwaters are adapting to climate change by shifting their migratory range northwards, with a speed of 25km per year. However, this flexibility comes with constraints, as the birds have further to fly back in the autumn, and the impact on breeding success and survival is still unclear.
Scientists mapped genetic blueprints for 51 vertebrate species, including cats, dolphins, and birds, using novel algorithms and computer software. This discovery has huge implications for understanding human health and evolution, as it allows researchers to compare complete genomes and identify DNA sequence divergence.
A new CRISPR-based technology, TRED-I, has been developed to increase visibility of cancer cells to the immune system by augmenting MHC class I molecules. This technology has shown promising results in animal cancer models, reducing tumor sizes and enhancing treatment efficacy when used with existing immunotherapy.
Researchers identified two probiotic strains that promote weight loss in obese dogs. The strains, Enterococcus faecium IDCC 2102 and Bifidobacterium lactis IDCC 4301, reduced body fat percentage and improved intestinal microflora balance in dogs fed a high-fat diet.
A study by Konstanz biologists reveals that the moths use visual feedback to move and correct the movement of their proboscis, similar to humans grasping objects. The animals' efficient way of working is also great models for applied research in robotics and understanding the visual control of appendages.
A new review of international research highlights the dangers of forced separation from pets in crisis situations like domestic violence, homelessness, or natural disasters. The study found a lack of support services puts people and animals at risk of distress and harm.
Researchers have identified two distinct brain regions involved in regulating salt and water intake, which can help prevent excessive consumption. The parabrachial nucleus plays a crucial role in feedback mechanisms that reduce thirst and salt appetite after ingesting water or salt.
Researchers used fMRI to assess brain responses to lights stimulating only cone cells in dogs with different types of retinal diseases. The study found that gene augmentation therapy restored response in cortex to black and white stimulation, making this disease a promising one for photoreceptor cell replacement treatment.
A recent study published in Nature Plants reveals that O-glycosylation of the transcription factor SPATULA promotes Arabidopsis style development. The experimental study sheds new light on the mechanisms underlying plant organ symmetry.
Researchers found that male antechinus reduce their sleep by 3 hours per night for 3 weeks to focus on mating and reproduction. The study suggests that the marsupials may have a unique ability to thrive with reduced sleep, but the exact mechanisms behind this adaptation are unclear.
Research in Kenya's Ol Pejeta Conservancy reveals invasive big-headed ants have reduced lions' effectiveness at killing zebras. Lions now primarily target African buffalo instead, maintaining population stability.
A University of Kentucky team studied macrophages in spiny mice to see how they contribute to regenerative healing. They found that specific proteins released by these cells promote tissue rebuilding and growth, suggesting a potential key to triggering regeneration in humans. The study's findings may lead to new treatments for injuries...
Researchers found that intrinsically-photosensitive retinal ganglion cells (ipRGCs) use both microvillous and ciliary signaling mechanisms simultaneously. This discovery reveals a new pathway for transmitting light signals to the brain, which may have ancient origins on the evolutionary scale.
Researchers developed an mRNA therapeutic that combats ovarian cancer by producing functional p53 protein, shrinking and killing tumors. The treatment is effective against metastases and has shown promise in preclinical studies.
Researchers at São Paulo State University found a link between a protein-poor diet during pregnancy and an increased risk of prostate cancer in offspring. The study detected changes in the expression of over 700 genes in offspring, including the gene ABCG1, which is associated with prostate cancer.
A new mobile phone-based facial recognition application for dogs has been developed to improve rabies vaccination efforts in endemic areas. The app was tested at a clinic in rural Tanzania and proved remarkably accurate, identifying 76.2% of vaccinated dogs and 98.9% of unvaccinated dogs.
Research reveals humpback whales shift their daily singing patterns away from shore, returning to nearshore in the evening to minimize interference. This dynamic behavior may help increase the efficiency of their acoustic display.
A gene expression atlas has been developed to map the complex cellular and molecular interactions that drive ovulation in mice. The findings reveal a previously unknown layer of selection that determines which follicles will release eggs, and highlight the importance of early differentiation markers for fertility management.
The study's findings highlight serious failures in animal welfare protection during transportation, with all countries falling short of guaranteeing adequate protection. The researchers propose updating the regulations to address major risk factors such as excessively long journeys and hot weather, drawing key future directions for new...
A recent study found that exposure to multiple toxicants across generations can amplify health problems, such as obesity and kidney diseases. The study, published in Environmental Epigenetics, showed that epigenetic changes were greatly altered with each new generation of exposed animals.
A study of 370 documented cases found that almost half of hedgehogs injured by electric gardening tools did not survive. The data also show a growing conservation problem due to declining hedgehog populations in Germany.
Researchers at State University of Campinas discovered genes favoring colossal growth in whales also inhibit cancer development. The study found that certain regulatory regions influence both size and cancer suppression, offering new insights into the evolution of cetacean gigantism.
Researchers discovered a complex network of gene duplications and losses associated with tardigrade extremotolerance, highlighting the intricate genetic landscape driving modern tardigrade ecology. The study sheds light on the evolution of anhydrobiosis in tardigrades, revealing two independent transitions from marine to limno-terrestr...
A recent study from the University of Wisconsin School of Veterinary Medicine has uncovered new information about orofacial development in mice that researchers believe could one day help reduce the risk of these birth defects in humans. DNA methylation is a process where molecules are added to DNA that change gene expression without a...
Researchers at the University of Bristol have discovered a 200-million-year-old flying reptile, Kuehneosaurs, in Somerset. These small animals had gliding wings made from skin stretched over their side ribs and likely fed on insects.
Researchers found a significant connection between anxiety disorders and the brain receptor TACR3, as well as low testosterone levels. Testing showed that inhibiting TACR3 resulted in increased receptors on the cell surface, blocking long-term synaptic strengthening.
Researchers discovered that a specific phase of neck motor neuron activation in roundworms adjusts their trajectory toward higher salt concentrations. This finding highlights the neural mechanisms underlying navigation and sensory-motor integration, shedding light on how even simple animals adapt to environmental changes.
Researchers at Washington State University have discovered a key protein in prostate cancer cells' resistance to docetaxel. Blocking this protein, CHRM1, with dicyclomine restored the effectiveness of docetaxel and reduced tumor growth.
Researchers at Northwestern University have discovered that toxic short RNAs contribute to neuron death and DNA damage in Alzheimer's disease. Studies found that older individuals with superior memories have higher amounts of protective short RNA strands in their brains.