News on the use of animals, and their alternatives, in biomedical research. Covers animal models, primate studies, tissue chips, research ethics, and disease modeling.
Researchers found that synbiotics, a combination of prebiotics and paraprobiotics, improved the gut microbiome of Magellanic penguins, reducing inflammation and enhancing overall health. The study also revealed that parasynbiotics can modulate inflammatory responses in penguins.
A study predicts that climate change will lead to a major species turnover in North American cities by the end of the century. Cities with cooler and wetter climates are expected to gain new species, while warmer cities may lose many species.
A study using a xenotransplantation model has revealed that human microglia respond to amyloid-β plaques with a complex immune response, influencing the disease course. The research highlights the importance of considering genetic factors in microglia-targeted therapies for Alzheimer's disease.
Two Micrurus mipartitus coral snakes have been observed battling for a caecilian in the dense rainforests of western Colombia, showcasing a rare example of kleptoparasitism among Elapidae family members. The study highlights the elusive nature of these reptiles and challenges of observing them in their natural habitats.
Researchers found that chlorogenic acid enhances osteoblast proliferation and differentiation, while inhibiting RANKL-induced osteoclastogenesis. Administration of chlorogenic acid antagonizes ovariectomized-induced bone loss in rats.
A UK study found that majority of rabbit owners could identify pain and pain-free rabbits but lacked knowledge on subtle signs, highlighting the need for education and training.
Research shows that long-term declines in pronghorn productivity are associated with increased oil and gas development and woody encroachment. Manual removal of trees and controlled burning could help protect iconic rangeland species like pronghorn.
Researchers have identified PDE4B as a potential target for treating Alzheimer's disease, where reducing its activity shows promise in improving memory and glucose metabolism. The study suggests that this approach may also protect against other forms of dementia, such as Huntington's disease.
Two well-known killer whale ecotypes in the North Pacific Ocean have been identified as separate species through genetic and behavioral evidence. The resident and Bigg's killer whales have distinct physical characteristics, diets, and cultural habits, justifying their recognition as distinct species.
A large-scale animal study reveals that brain pH and lactate levels are a common feature across various neuropsychiatric conditions, including schizophrenia, bipolar disorder, autism, depression, epilepsy, and Alzheimer's disease. Changes in brain energy metabolism are linked to cognitive impairment, particularly working memory.
Researchers found that birders with disabilities face constraints such as lack of accessible features and safety concerns, but also expressed interest in access to high-quality birding locations and information. The study aims to promote broader social inclusion for people with disabilities through wildlife recreation.
Researchers found that individuals with a single mutated copy of the MUTYH gene have a modest increase in susceptibility to a subset of solid tumors, including adrenal gland cancers and pancreatic islet cell tumors. This suggests that MUTYH variants may be involved in a broader range of cancers than previously known.
A new study reveals a strong pattern of decline among moths of all sizes and life stages from rural to urban areas in Florida. Larger macromoths fared worse than smaller ones, likely due to increased metabolic stress in high temperatures.
Researchers from Project Seahorse analyzed 7,794 validated iSeahorse observations from 96 countries, revealing new information on sex ratio and pregnancy seasonality. The study found that many seahorse species have larger geographic ranges, more diverse habitats, and shallower depth ranges than previously known.
Researchers at the University of Tokyo discovered that Japanese tit birds use wing movements as a symbolic gesture to communicate with their mates, mirroring human-like behavior. The study found that the birds' wing-fluttering display prompted the mate to enter the nest box first, while the one who fluttered entered second.
Researchers simultaneously tagged many humpback whales from the same pod to analyze their vocalization and compare individual calls. This study provides new information about whale behavior and communication, crucial for informing future conservation efforts.
A team of scientists from Pohang University of Science & Technology developed an artificial vitreous body based on alginate to treat retinal detachment. The hydrogel maintains vision post-surgery and regulates fluid dynamics within the eye, preventing recurrence and air bubble formation.
Researchers successfully carried out pioneering fecal microbiota transplantations on Navy bottlenose dolphins, showing significant improvement and increased microbial diversity. The study's findings have important implications for marine mammal medicine, highlighting a non-antibiotic option to treat gastrointestinal diseases.
A study found that dogs activate a mental representation of an object when hearing its name, indicating they understand the meaning of those words. The discovery suggests that dogs may have a capacity to understand words in a referential way, similar to humans.
Researchers from Tokyo University of Science found that rose essential oil increases the transcript levels of PIR1 and PIN2, key plant defense genes, in tomato plants. The study also showed that REO reduces leaf damage caused by pests and attracts beneficial predators to protect against herbivores.
A new vaccine developed by UCLA researchers demonstrates high protection against melioidosis, a tropical disease that causes 89,000 fatalities annually. The vaccine was tested in mice and found effective even against a highly lethal strain of the bacteria.
A study from Lund University found that a ceramic bone substitute injection improves the strength of bone anchors and enhances peri-implant bone formation. The treatment combination shows promising results in increasing bone tissue density by up to 10% six months after surgery.
Researchers studied a subpopulation of transient killer whales that prey on marine mammals in the open ocean. They found two distinct foraging behaviors: independent diving and coordinated groups hunting along submarine canyons.
Researchers found that ageing reduces the ability of regulatory T cells to enhance myelin regeneration, which can have profound consequences for neurological functions. The study suggests that the loss of function may be reversible, and two new molecules, ITGA2 and MCAM, have been identified as potential therapeutic targets.
The study reveals Brat's role in regulating wing imaginal discs regeneration by modulating downstream growth factors. Flies with reduced Brat demonstrated improved wing regeneration but also exhibited deficiencies in cell-fate specification, highlighting the delicate balance required for proper regeneration.
A new UCLA study discovered a brain circuit that makes mice pursue fatty foods even when not hungry. People may possess the same cells, which could offer new insights into eating disorders. The research suggests that food-seeking neurons drive cravings for high-calorie foods, rather than hunger.
Researchers have identified a crucial interface in a mutated protein that drives lung cancer growth, which could act as a target for more effective treatments. The study used advanced laser imaging techniques to provide unprecedented details of the protein's structure and interactions.
Researchers have discovered that neurochemicals influence neural activity, blood flow, and fMRI measurements. The study found that certain neurochemicals can cause constrictions in blood vessels, leading to negative fMRI signals.
A recent study found that urban hawks are vulnerable to a range of threats, including collisions with windows and direct killing by humans. The researchers used GPS transmitters to track the movements of 158 female Cooper's hawks in Albuquerque, New Mexico, and found that 88 died over the course of 11 years.
Female Diadem butterflies have evolved colours and patterns that closely match those of toxic African Queens, making them appear toxic to predators. This convergent evolution allows the Diadems to avoid being eaten by birds and other predators.
Researchers discovered that wild animal hair undergoes seasonal changes to insulate against extreme temperatures. The inner microscopic details of the hairs change, allowing animals to survive in their environment.
A new study has discovered that Streptococcus anginosus bacteria play a significant role in causing stomach cancer. The research showed that S. anginosus infection led to gastric inflammation, cell damage, and the growth of stomach cancer cells, doubling tumour size and weight in some cases.
Researchers have solved the long-standing question of what triggers the alarm response in fish by identifying two distinct chemical signals: Daniol sulphate and Ostariopterin. These substances convey separate pieces of information that must be detected simultaneously to trigger a flight-or-freeze response.
Researchers from Nagoya University discovered that tree frogs create foam nests on the ground to protect their eggs from low temperatures, increasing hatchability rates.
A study by Hokkaido University and Aarhus University reveals a 'nocturnal' surge in vocalization activity among little auks in Arctic summer, contrary to expectations. The findings provide valuable insights into avian behavior under continuous daylight environments.
Researchers studied female Assamese macaques for eight years, finding that social networks decrease with age due to physical limitations and a desire to protect themselves from predators. The study's findings shed light on the biological roots of social aging in humans.
Research finds pythons convert feed into weight gain efficiently compared to conventional livestock like chickens and cattle. Pythons outperform mainstream agricultural species in terms of food and protein conversion ratios.
A recent study in the Journal of Dairy Science found that training dairy cows with positive reinforcement can improve their emotional state and overall welfare. The researchers trained Holstein dairy heifers using food rewards and observed increased anticipatory behaviors and play, indicating a positive experience for the animals.
A new study on wild chimpanzees reveals that mother-chimp play is crucial for their offspring's physical and social development, even during times of food stress. The research suggests that the persistence of mother-child play is important for chimp development, and sets primates apart from other mammals in terms of play behavior.
Researchers have identified a subset of T-cells that acts like stem cells and continuously generates effector T-cells that attack transplanted organs. Targeting the transcription factor IRF4 may lead to innovative therapies for patients with chronic infections, cancers, autoimmune diseases and transplanted organs.
Researchers used single-cell RNA sequencing to analyze the effects of APC treatment on AD transgenic mice, revealing alterations in glial cells and upregulated genes associated with AD progression. APC treatment downregulates inflammatory processes and recovers nervous system functions.
Female whales of certain species experience menopause, living up to 40 years longer than their peers by prioritizing family care over breeding. This unique trait allows them to support their offspring and grandchildren without overlap with their daughters' reproductive cycles.
Researchers found thousands of nematodes in the lake's reef-like structures, previously thought to be inhabited only by brine shrimp and flies. The discovery suggests bacteria can help these worms adapt to highly saline conditions, opening new lines of inquiry into the Great Salt Lake's web of life.
A new study on sea anemones sheds light on the complex relationships between predators and prey in marine ecosystems. The research found that a native population of anemones lacking a key neurotoxin exhibited weakened defensive abilities, while its presence attracted natural predators of grass shrimp.
Spending time with dogs increases alpha-band oscillations, associated with relaxed wakefulness, and beta-band oscillation strength, linked to heightened concentration. Participants reported reduced fatigue, depression, and stress after dog-related activities.
Researchers at Johns Hopkins Medicine have developed a novel approach to target group 3 medulloblastoma tumors in mice, reducing tumor growth by 40-50% and extending survival by up to 84 days. The therapy uses antisense oligonucleotides to block lnc-HLX-2-7 from binding to the HLX promoter region.
A new study predicts that climate change will lead to a significant reduction in natural snow cover days globally, with popular ski hubs moving to remote areas. The European Alps, Australian Alps, and Japanese Alps are expected to experience the most decline, threatening local livelihoods and ecosystems.
Researchers found that secreted products from certain bacteria strains can reduce inflammation in gut-derived cell lines and improve airway health in mice with cystic fibrosis. The study suggests probiotics could be beneficial for kids with CF, providing a potential proof of concept.
A Photovoice project documented the lives of Seattle-area pet owners experiencing homelessness, revealing the benefits of human-animal bonds on mental and physical health. The study also identified barriers to services and recommendations for improved policies.
Researchers have successfully created a transgenic cow capable of producing human insulin in its milk. This breakthrough could lead to the mass production of insulin without the need for complex facilities or infrastructure. With further testing and FDA approval, this technology has the potential to revolutionize insulin production and...
Researchers from the University of South Australia discovered that eating faeces helps birds absorb lost or deficient nutrients and adjust to seasonal variations in food sources. This coprophagy enables them to adapt to new environments and is especially important for long-migratory birds.
Researchers developed a protein-based vaccine candidate called SpyCage that induces an immune response in rodent models, clearing COVID-19 infections more quickly than controls. The platform has the potential to prevent infection and transmission of respiratory viruses like SARS-CoV-2 by inducing a mucosal immune response.
A minimal metadata set (MNMS) is established to enable in vivo data reuse and improve the sharing and reproducibility of research data. The MNMS is designed to contribute to making data from living animals compliant with the FAIR data concept, which emphasizes Easy-to-Find, Accessible, Interoperable, and Reusable data.
A recent study by the University of Bonn and TU Munich found that banners with information on animal welfare had no effect on purchasing decisions in a virtual supermarket. Researchers invited test subjects to shop in a simulated environment, but even prominent labeling did not change buying behavior.
Researchers at Aarhus University have found a way to spot Alzheimer's disease before it develops into dementia using an advanced blood test analysis. The study suggests that activating the body's immune system at an early stage of the disease may slow down its progression.
A new project aims to improve the efficiency of livestock operations by utilizing precision farming techniques, including AI-powered monitoring systems. The goal is to optimize feeding behaviors and reduce costs through data-driven insights.
Researchers developed a custom-built, low-cost mesoscope that can adapt to different neuroimaging experiments in live mice and rats. The system offers excellent spatial and temporal resolutions, achieved through its reversible tandem lens configuration, which enables flexible experimentation.
Researchers at UNIST have developed a groundbreaking technology that enables the real-time display of colors and shapes through changes in nanostructures. Utilizing block copolymers, they achieved the self-assembly of photonic crystal structures on a large scale, mimicking natural phenomena observed in butterfly wings and bird feathers.
Researchers have created 3D images of over half of the world's animal groups using CT scans, making them accessible to scientists, researchers, students, teachers, and artists. The open-source repository MorphoSource allows users to share findings and improve access to material critical for scientific discovery.
Researchers studied cicadas' jet-like urination to challenge insect pee paradigms. They found that larger animals like cicadas can emit jets due to gravity and inertial forces, unlike smaller ones that typically produce droplets. This discovery has far-reaching implications for bio-inspired engineering and monitoring applications.