News on the use of animals, and their alternatives, in biomedical research. Covers animal models, primate studies, tissue chips, research ethics, and disease modeling.
Researchers transplanted gut microbes from a naturally obesity-resistant shrew to high-fat-diet-induced obese mice, improving microbiome diversity. This approach resulted in decreased weight gain in the obese mice, suggesting potential therapeutic benefits for human obesity.
A new study from McGill University and international collaborators investigates the role of temperature in determining animal species' current and potential habitats. The research reveals that temperature is less directly limiting for land animals like reptiles, amphibians, and insects than previously thought.
A new study from the University of Wisconsin-Madison suggests that reducing isoleucine intake can extend lifespan and improve health outcomes. Mice on a low-isoleucine diet lived 33% longer and showed better health markers than those on a balanced diet.
A collaborative effort between scientists from the Natural History Museum of Utah and cavers led to the discovery of fossils spanning over 3,000 years in Boomerang Cave. The findings revealed a faithful reflection of mammal diversity in the area, including species unknown to the region.
A new study found that sediment plumes from deep-sea mining can cause significant stress in midwater jellyfish, leading to excess mucus production and energetic costly responses. The researchers also discovered that the stress response is more severe than expected even for a four-degree rise in sea temperature.
Researchers discovered that cerebellar nuclei make a surprising contribution to associative learning by strengthening connections with mossy fibers. Optogenetic experiments also showed that the nuclei can support well-timed learning. The study's findings have implications for understanding cerebellum function and potential treatments f...
A recent study published in One Health found that feeding dogs raw meat significantly increases the risk of excreting antibiotic-resistant E. coli, a bacteria that can cause life-threatening infections. The researchers emphasized the importance of proper hygiene and sourcing high-quality meat to reduce this risk.
Researchers at Lund University mapped extensive colour variation in female bluetail damselflies, finding a specific genomic region drove the emergence of male-like females. This genetic variation has been maintained through balanced natural selection over long evolutionary time periods.
A new study has uncovered the molecular causes of a rare developmental brain condition in children, known as Autosomal Recessive ACBD6-related disorder. The research team identified defects in the acyl-CoA-binding domain-containing protein 6 (ACBD6) gene as the underlying cause, leading to delays in cognitive and motor skills development.
A new study from the University of Oxford found that bumblebees cannot taste pesticides in nectar, even at lethal concentrations. Bees rely on taste to avoid contaminated nectar, which poses a significant threat to their survival.
A team of researchers analyzed whole genomes of over 100 muskoxen to explore their evolutionary history. They found that the muskox lost a significant proportion of its genetic diversity in the last 20,000 years, with present-day populations having only about a third of the diversity of ancient Siberian genomes.
A genetic study found that grizzly bears' energy production follows a daily pattern even during hibernation, with a blunted amplitude and shifted peak. This suggests that the circadian rhythm helps bears conserve energy while still maintaining some metabolic function.
Researchers found that cultivating Euglena in tomato juice resulted in high cell densities and tightly packed chloroplasts, outperforming other beverages. The nutrient composition of tomato juice is suitable for Euglena growth, offering a promising solution to the shortage of animal protein and potential health benefits.
Researchers found rabies virus variants closely related to those in White-tufted marmosets in bats, highlighting potential for human transmission. Genetic sequencing revealed complex spillover dynamics between hosts, emphasizing the need for public health measures and animal conservation.
A study of house finches found that sick birds are more social than healthy ones, preferring to eat with their flock. This behavior may be driven by the benefits of group living for sick birds, but also poses a risk to healthy birds due to increased disease transmission.
A recent study by the Complexity Science Hub found that at least two-thirds of animal COVID-19 deaths were not reported to official sources. The researchers compiled a comprehensive list of 35 animal species susceptible to SARS-CoV-2, highlighting the need for improved data exchange and reporting.
Researchers developed 'tension-activated repair patches' that release anti-inflammatory molecules, helping discs regain tension and reverse herniation. The patch uses natural biomechanical movement to activate its release, offering a potential early intervention for preventing worsening pain related to disc degeneration.
A new study reveals a network of genes that evolve differently in long-lived and short-lived bivalves, associated with longevity in other animals. This shared molecular framework suggests a common genetic basis for extended longevity across diverse animal lineages.
A collaborative research project found that shelter dogs with brief outings or fostering stays were more likely to be adopted, increasing adoption outcomes by five and 14 times. Short-term fostering programs can improve a dog's life in the shelter and help them find forever homes.
Researchers have discovered a series of bird footprints from the Early Cretaceous period in Victoria, Australia, indicating that diverse birds lived in southern polar environments during this time. The discovery provides new insights into the distribution and dispersal of early birds across landmasses.
New research reveals Indian Ocean seabirds face no hotspots where predators feast on prey, highlighting the need for ocean-wide protection. The study's findings suggest that international action is necessary to safeguard these birds' survival due to human activities like overfishing and pollution.
A new alvarezsaurid dinosaur from Mongolia has provided insights into the sleeping behavior of non-avian dinosaurs. The discovery suggests that these ancient creatures may have slept in a similar position to modern birds.
Researchers have summarized recent advances in enzyme-activated near-infrared fluorescent probes for non-invasive visualization of enzyme dynamics and disease status. These probes offer high specificity, sensitivity, and biocompatibility, making them valuable assets in biomedical research and healthcare.
Research from the University of Bristol found that conflict with rival groups increases pup survival rate when threat levels are higher. This challenges the common belief that intergroup conflict has negative consequences on reproductive success.
A new UniSA study reveals that over-represented sharks in 'creature feature' films contribute to excessive fear of sharks. Dr. Brianna Le Busque warns that safety measures should balance people's safety with access to the ocean, rather than exacerbating fear.
Jenny Wilkerson receives $1.94 million grant to develop novel models and investigate antinociceptive profiles of basal sex hormone alterations in patients with chronic post-op pain. The study aims to answer questions about the impact of altered sex hormone levels on recovery times, drug effectiveness, and long-term health.
Researchers found that older fish deviate from a youthful fasting and refeeding cycle, entering a permanent fasting state despite eating. Genetic activation of AMP kinase's γ1 subunit restored benefits of refeeding in old killifish, improving health and longevity.
A new conservation tool, Lion Localizer, helps authorities track the origin of illegally traded lion parts by analyzing mitochondrial DNA. The tool provides critical information on population impact and resource allocation, supporting efforts to protect tiny West African lion populations.
A single infusion of CRISPR-based gene-editing therapy significantly reduced LDL cholesterol levels in people with heterozygous familial hypercholesterolemia, a condition that increases heart attack risk. The treatment has shown potential as a long-term or permanent option for high LDL-C control.
A new study suggests that hormonal birth control used by adolescents may influence the development of their brain, leading to altered risk assessment. The researchers found increased myelination and decreased immune cells in the brains of treated rats, while also exhibiting signs of impulsivity in behavior tests.
Researchers from the University of Konstanz and Tübingen have found genetic evidence of a woolly rhinoceros's presence in southern Germany during the late Middle Palaeolithic period. The analysis of hyena coprolites reveals that the animals preyed on and consumed woolly rhinoceroses, providing insights into prehistoric ecosystems.
In cooperative bird societies, mothers lay larger eggs for more help with nestling care, allowing them to focus on prenatal investment. This strategy enables helpers to contribute indirectly, benefiting offspring development.
A drug currently in clinical trials as a cancer therapy can also stimulate pancreatic beta cells to secrete insulin, revealing a new mechanism for insulin regulation in type 2 diabetes. The preclinical discovery provides a new chemical tool for probing the biology of diabetes and could lead to better treatments.
Researchers discovered two new strategies used by hummingbirds to transit small gaps, including a sideways scooch and tuck-and-glide technique. These adaptations enable the birds to maneuver through dense environments with improved accuracy and control.
Research by the University of Bern reveals that poison dart frog personality traits impact mating success, clutch numbers, and offspring survival. These traits are present in tadpoles and remain stable after metamorphosis.
A study published in mSystems found that mice fed a broccoli sprout diet had milder disease symptoms and richer gut microbial communities compared to those not exposed. The researchers suggest that broccoli sprouts could be used as a treatment strategy for patients with IBD.
Researchers tracked endangered thick-billed parrots using solar-powered satellite transmitters, revealing new critical habitat and migratory routes. Less than 20% of the newly identified habitat is protected from timber industry, highlighting the urgent need for conservation efforts.
Researchers found that mothers increase egg size when they have more female helpers to feed their chicks. The study suggests that helpers allow mothers to invest more in offspring at the egg stage by lightening maternal workloads at the chick-feeding stage.
A new analysis of European Red List species reveals that 19% are at risk of extinction, including a large proportion of invertebrates. Agricultural land-use change poses a significant threat to these species, highlighting the need for conservation efforts to counter biodiversity loss.
A newly developed labeling method allows for visualization of intraregional synaptic connections between inhibitory interneurons and excitatory engram cells. Researchers have identified the role of inhibitory interneurons in memory expression, suggesting that they suppress fear expression by inhibiting fear engram cells.
Better education for cat owners and veterinarians is key to reducing antimicrobial use, which contributes to rising resistance. The study's findings highlight the need for faster, cheaper diagnostic testing and better training of pet owners and vets.
Researchers created an immunodeficient mouse model of physiological ovarian aging, mirroring female fertility decline with age. The study found decreased oocyte quality, impaired follicle activation and growth, and increased mitochondrial dysfunctions in Old mice.
Researchers found that sharks and other large predatory fish visit the mesopelagic zone, a critical habitat for these species. The study suggests these animals dive to this area for reasons beyond feeding, potentially involving navigation or avoidance of predators.
Research reveals crickets and other calling animals utilize the ground for acoustic efficiency gains. The study challenges traditional theories that the ground impedes animal communication.
Researchers from Tohoku University developed a model that simulates fish tail fin motion and reveals the underlying mechanisms behind synchronized swimming. The study found that synchronizing fin movements reduces energy dissipation, but the optimal timing may not always lead to conservation of energy.
Frogs from the genus Eleutherodactylus are geologically the oldest Caribbean vertebrates to be found in Florida. They arrived in North America much earlier than previously thought, with evidence suggesting they reached the peninsula through overwater dispersal on flotsam or other buoyant debris.
Researchers at Nagoya University found that field mice store and transport seeds from once-in-a-century flowering sasa bamboo plants, spreading them throughout the forest. The study reveals that mouse body size affects seed caching behavior, with larger mice carrying seeds to safer locations.
Researchers developed an imaging sensor capable of detecting UV light, using it to differentiate between cancer cells and normal cells with 99% confidence. The technology leverages the unique tiered structure of butterfly photoreceptors and perovskite nanocrystals.
Researchers from Ritsumeikan University developed a low-cost, self-powered biosensor for monitoring organic wastewater in freshwater lakes and rivers. The biosensor uses a microbial fuel cell to detect the level of organic contamination in water samples, providing an early warning system for water quality management.
Researchers at Ohio State University will investigate the role of microglia cells in chronic inflammation and neuronal dysfunction after TBI, with a focus on preventing long-term consequences. The $7.7 million award aims to develop innovative healthcare solutions for traumatic brain injury survivors.
Researchers shed light on TIMP2's role in regulating hippocampal plasticity and function, which decreases with age. Targeting the extracellular matrix may improve plasticity in the brain, offering new directions for mitigating neurodegenerative disorders.
The study has shed light on how cats evolved into different species and how genetic changes relate to survival abilities like smell detection. It also revealed that cat genomes tend to have fewer complex genetic variations than other mammal groups, such as primates.
Researchers from the Institute for Basic Science developed a novel approach to healing muscle injury using conductive hydrogels and robot-assisted rehabilitation. The injectable tissue prosthesis enhances gait in rodent models without nerve stimulation, while improving long-term muscle tissue regeneration.
Researchers found that as cats gained weight, their gastrointestinal transit time decreased, reducing nutrient extraction. The study also revealed changes in gut microbial composition, with an increase in Bifidobacterium and a decrease in Collinsella, opposite to what has been seen in overweight humans.
A new study found that high-pressure conditions in deep-sea environments preserve organic matter and nutrients, supporting a vast array of microorganisms. Researchers simulated these conditions using pressure tanks, demonstrating the importance of this process in maintaining life at extreme depths.
Researchers at Duke University developed an innovative antibody approach to target and kill tumor-promoting molecules found in cancer cells. The study revealed notable reductions in tumor growth and minimal side effects, making it a promising new treatment option for various types of cancer.
A new study found that killer whales' diets, rather than location, are more important for pollutant exposure. The research analyzed blubber samples from 162 North Atlantic killer whales and discovered varying diet compositions caused striking differences in contaminant concentrations.
A recent study led by ecologists from the Hebrew University of Jerusalem investigated how desert isopods select burrow sites amidst looming predators. Larger female isopods displayed a preference for safer burrows, emphasizing the importance of size and safety in their breeding site choices.
A study published in PLOS ONE found that roosters can recognize their mirror image and respond accordingly. The researchers tested 58 roosters and found that they emitted alarm calls when seeing themselves in the mirror, but not when seeing a conspecific. This suggests that roosters may have some level of self-awareness.
A species of Asian mosquito, Anopheles stephensi, is responsible for a sharp expansion of malaria cases in Africa, particularly in urban areas. The mosquito's ability to thrive in dry conditions and adapt to new breeding sites has made it a significant threat to public health.