Researchers identified a PU.1-promoting subset of microglia that suppresses inflammation and protects cognitive function in mice with Alzheimer's disease. This discovery opens a new avenue for immunotherapies targeting microglial activity.
Researchers induced senescence in worms by manipulating transcription factor TFEB, mimicking mammalian aging. Key growth factors insulin and TGFbeta were identified as crucial signaling molecules in circumventing senescence.
A combination of Rapamycin and Trametinib therapies significantly prolongs the life of mice by up to 30%, reducing chronic inflammation and delaying cancer onset. The unique combination achieves novel effects on gene expression, offering a potential geroprotector approach to extend human lifespan.
Researchers have discovered a unique group of nerve cells in the brain that regulates body weight and is linked to obesity. Removing specific receptors in these cells leads to increased food intake and weight gain in mice.
A group of nerve cells called POMC neurons are responsible for dessert cravings, releasing a feel-good opiate when mice eat sugar. This pathway is activated even before eating, and blocking it reduces sugar consumption in full animals.
Researchers at Max Planck Institute discover that liver mitochondria adapt to food presence via nerve cells, leading to improved insulin sensitivity. This finding could pave the way for new type 2 diabetes treatments.
Researchers found that rapamycin extends lifespan by regulating the activity of protein S6K, which influences the endolysosomal system. This leads to improved immune function and clearance of bacterial infections at old age.
Researchers found that older fish deviate from a youthful fasting and refeeding cycle, entering a permanent fasting state despite eating. Genetic activation of AMP kinase's γ1 subunit restored benefits of refeeding in old killifish, improving health and longevity.
Researchers found that liraglutide improves associative learning in people with obesity by restoring brain activity to normal-weight levels. The study showed that participants with obesity had reduced ability to associate sensory stimuli and decreased brain activity compared to those with normal weight.
Researchers found that dieting amplifies neural signals of hunger in the brain, leading to increased food intake and weight gain. This long-term change could be a key target for developing therapies to prevent the yo-yo effect.
Researchers found that eating small amounts of high-fat and sugar foods regularly rewires the brain to prefer these types of foods. The brain's dopaminergic system is activated, leading to a subconscious preference for rewarding food.
Researchers found that rapamycin increased autophagy in female intestinal cells, leading to longer lifespan and reduced age-related diseases. In contrast, male intestinal cells showed no further increase in autophagy activity after rapamycin treatment.
Researchers discovered a gene mutation that causes faulty RNA processing in worms, leading to increased longevity. The PUF60 gene affects the mTOR signalling pathway, which regulates cell metabolism and has been a target for anti-aging drugs.
Researchers found that brief rapamycin exposure in early adulthood can prevent age-related decline and extend lifespan. The study used fruit flies and mice to test the effects of short-term drug administration, showing protection against intestinal pathology and increased health span.
Researchers found that older killifish have less diverse circulating antibodies compared to younger fish, contributing to reduced immune function. This decrease in antibody diversity may lead to a reduced ability to respond to infections.
Researchers discovered that pathogens can hijack mitochondrial defense mechanisms by mimicking host proteins, effectively disarming the mitochondria. This allows the pathogen to acquire essential nutrients and evade the host's immune response.