Articles tagged with Hiv Research
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A new study reveals that among billions of HIV variants, only a few lead to sexual transmission. The researchers used genetic analysis and mathematical modeling to identify precisely those viruses responsible for HIV transmission.
Researchers at PARC-MGH found that chronic viral replication leads to exhaustion of HIV-specific T cells. The study suggests that understanding the nature of CTL responses is crucial for designing effective vaccines against HIV. Persistent exposure to specific viral protein segments appears to be the key factor in CTL exhaustion.
Researchers have developed a new immunotherapy technique called OPAL therapy that stimulates immunity and controls virus levels in HIV-infected individuals. The treatment involves reinfusing fresh blood cells with overlapping peptides, showing promise in preventing AIDS progression.
Researchers at Stanford University have synthesized a compound that can be tailored to flush HIV out of hiding and into the crosshairs for targeted destruction. By synthesizing prostratin and DPP, two compounds found in plants, scientists can now tackle the virus more effectively.
A University of Minnesota study found that online interventions can help reduce HIV risk among young men who have sex with men. The research showed that meeting partners both online and offline increases the number of sexual partners and engagement in unprotected anal intercourse.
A new study has identified a human protein that can be targeted to block HIV infection, offering a potential breakthrough in the fight against AIDS. By inactivating this protein, called interleukin-2-inducible T cell kinase (ITK), researchers have found that HIV's ability to infect and replicate within immune cells is slowed or blocked.
The Wellcome Trust has announced a £20 million investment in research and training in Africa. Four major programmes will be established, focusing on strengthening social sciences research, clinical trials, and institutional infrastructure. This funding aims to support local researchers in tackling pressing problems in their region.
A computer-based program using a video doctor sharply reduces HIV-positive patients' sexual and drug risk behaviors, according to UCSF researchers. The Positive Choice program was tested at five San Francisco Bay Area outpatient clinics and showed significant reductions in risky behaviors among participants.
A study suggests that accelerating efforts to provide antiretroviral therapy (ART) in South Africa could prevent over 1.2 million AIDS-related deaths by 2012, with full access reducing projected deaths to 800,000. Current treatment capacity would lead to 2.4 million deaths.
Researchers have discovered a way to manipulate the lengths of genetic pulses in HIV, favoring latency over replication. This finding offers promise for developing new treatments, as the 'switch' is a key factor in determining whether the virus becomes active.
Researchers at The Miriam Hospital and Brown University developed a new tool, the 'Willingness to Use Microbicides' scale, to measure women's willingness to use microbicides. Women with past experience using protective methods and casual sexual partners were more willing to use microbicides compared to their peers.
A Canadian-US research team has solved a major genetic mystery: how a protein in some people's DNA guards against killer immune diseases like HIV. The discovery of FOX03a offers promise for HIV vaccine development and treatments for other immune diseases, such as cancer and rheumatoid arthritis.
A team of researchers identified a human gene called TRIM22 that can block HIV infection in cell culture by preventing virus assembly. The discovery shows the body has a natural defense mechanism against HIV, but research is needed to understand why it doesn't work in people infected with HIV.
Researchers create devices called glycodendrons to inhibit HIV transport and stimulate immune response against the virus. The approach targets a specific carbohydrate structure on the viral surface, mimicking an antibody that protects against HIV progression.
A Phase II study has shown that tenofovir gel is safe for daily use and most women adhere to the regimen, suggesting a potential new approach to preventing HIV transmission. The findings are significant for women who are at high risk of infection due to heterosexual intercourse.
A Phase II study found that the tenofovir gel was favorably self-applied and well-tolerated by HIV-negative women, with 80% following instructions to use the gel after sex. The researchers plan to proceed with larger studies to determine if the gel can prevent HIV infection.
The Omololu Falobi Award honors advocates for their work in community advocacy and international leadership in HIV prevention research. Srikrishnan Aylur Kailasam was recognized for his role in working with marginalized communities, while Lori Heise received the award for her leadership in microbicide research as a partner.
University of Minnesota researchers have determined the atomic structure of APOBEC3G, a protein that inhibits HIV-1 infection. This discovery will help researchers manipulate the protein to combat HIV and develop methods to neutralize Vif, which triggers the destruction of APOBEC3G.
Research suggests that beneficial bacteria Lactobacillus in the vagina can reduce HIV virus levels in genital secretions, making it harder for the virus to spread. The study found a link between Lactobacillus production of hydrogen peroxide and lower vaginal HIV levels.
A new study highlights the link between depression and risky behavior among juvenile offenders. The research suggests that depression screenings should be included in the juvenile intake process to identify appropriate mental health interventions. This could lead to positive health outcomes for high-risk youth who have an arrest history.
Researchers have developed a new laboratory mouse model that can be used to test the efficacy of pre-exposure antiviral drugs to prevent HIV infection. The BLT mice have human blood cells, liver, and thymus tissue, making them susceptible to vaginal infection with HIV.
Researchers at UCLA have identified a key protein in dendritic cells that can stop HIV from 'budding', a crucial step in its life cycle. DC-SIGN and DC-SIGNR demonstrated strong inhibition of viral production, rendering released particles uninfectious.
A large-scale randomized trial of nearly 4,500 men found no significant differences in sexual satisfaction and performance between circumcised and non-circumcised individuals. The study's findings support the use of circumcision as an effective way to reduce HIV transmission
A new UCLA AIDS Institute study found that newly homeless youth are more likely to engage in risky sexual behavior if they lack supervision and social support. Drug use also plays a significant role in this behavior, particularly among females living in nonfamily settings.
The amfAR Mathilde Krim Fellowship program awards $1 million to bright young scientists working on prevention and treatment solutions for HIV/AIDS. Recipients include researchers studying HIV Tat-mediated transfer, TRIM5 modulation, biophysical studies of integrase-DNA complex, and morphogenesis of HIV-1 particles.
New research identifies a second gene, TRIM22, that exhibits rapid evolutionary adaptation to defeat retroviruses, suggesting alternate defense mechanisms over time. The study suggests that both TRIM5 and TRIM22 have played roles in protecting humans against retroviral infections.
Researchers from University of Missouri and Imperial College London found that chemical markers on cancer and HIV-infected cells can fool the immune system, making it ineffective against vaccines. The study suggests that vaccines may be unlikely to work due to these shared sequences.
Researchers at Brown University have created a 10-minute animated video explaining rapid tests for HIV, aiming to educate patients and healthcare providers. The video's effectiveness was tested in pilot trials, showing that it can improve comprehension of rapid HIV testing fundamentals.
Researchers call for GPs to be more proactive in offering HIV testing to higher-risk groups, citing low rates of early diagnosis and serious consequences. The study found that half of surveyed HIV-positive Africans were diagnosed late, despite above-average use of healthcare services.
Researchers found that newly HIV-infected men in the US dramatically shifted their behavior to choosing only unprotected sex with other infected individuals. This change reflects a systematic shift among men, mostly gay, to protect their partners from HIV infection.
A new investigational drug, tesamorelin, significantly improved symptoms of HIV lipodystrophy by reducing deep abdominal fat deposits and improving lipid abnormalities. Participants reported significant improvements in body image and reduced distress.
Researchers developed an HIV prevention program for adolescent runaways using a Strengths-Based Case Management model. The program focused on the youth's strengths and future goals, empowering them to realize their potential and preventing health risks.
A new study reveals HIV epidemic among men who have sex with men (MSM) is widespread and severe in low- and middle-income countries. MSM are 19 times more likely to be infected than the general population, with rates up to 100 times higher in some countries.
CONRAD has received a $28.5 million grant from the Bill & Melinda Gates Foundation to develop microbicides for HIV prevention, supporting combination microbicide research and testing of novel candidates.
The National Institutes of Health (NIH) recognizes the contributions of researchers and managers in the fight against HIV/AIDS. Since the first cases of AIDS were reported, NIH has established a comprehensive trans-NIH research effort to understand HIV biology, develop effective therapies, and prevent new infections.
A Harvard Medical School and PIH study found that integrating HIV testing into primary medical care reduced diagnosis delays. In a single clinic, 85% of patients diagnosed on first visit, and median delay was just 62 days.
Two studies led by Johns Hopkins Bloomberg School of Public Health researchers suggest that HIV subtype E is more virulent than other subtypes, leading to significantly shorter survival rates in Thailand. The studies found a median survival time from infection to death of 7.8 years for Thai men, compared to 11 years globally.
A qualitative study found critical failures in South Africa's Prevention of Mother to Child Transmission (PMTCT) programme, including inadequate HIV testing and lack of nevirapine administration. The research highlights the need for strengthened HIV testing and a revised antiretroviral drug regimen to improve uptake.
Researchers found that suppressing herpes simplex virus type 2 (HSV-2) significantly reduces levels of HIV in the blood and rectal secretions, making patients less likely to transmit the virus. This reduction in HIV levels could have a significant impact on transmission of HIV.
The STEP study, sponsored by Merck & Co., Inc. and the National Institute of Allergy and Infectious Diseases, has discontinued vaccinations due to lack of efficacy. Volunteers will now be informed about receiving either the vaccine or placebo and continue to participate in ongoing risk reduction counseling and study-related tests.
A recent study found that early and routine testing for HIV is key to curbing the spread of the disease among teenagers. Teens who have previously been tested are more likely to get re-tested, highlighting the importance of making testing readily available.
Researchers have identified a potential new way of fighting against HIV infection by targeting human endogenous retroviruses (HERV). A vaccine containing HERV antigens could stimulate T-cells that target cells expressing HERV, potentially protecting people from becoming infected or limiting damage caused by HIV.
A new UCLA study reveals that people seeking antiretroviral medications after high-risk sexual encounters are likely to complete the full treatment regimen. The research also shows a strong demand for publicly available post-exposure prophylaxis among high-risk populations in Los Angeles County.
The NIH has awarded $15 million over the next five years to the UCSF-GIVI Center for AIDS Research, doubling its previous support. The center provides strategic services and infrastructure to HIV/AIDS researchers, focusing on translational research and collaborations across disciplines.
A new study suggests that HIV/AIDS originated in Africa and traveled to the US through Haiti around 1969. Most US viruses descended from a single common ancestor originating from Haiti. The research used genetic analysis of archived blood samples to pinpoint the virus's entry point, shedding light on its early spread.
Local scientists play a crucial role in the fight against HIV, requiring adequate resources to conduct high-quality trials and develop treatments. Western governments must commit to sharing technology and expertise with developing countries on a long-term basis.
UF researchers tracked HIV genetic journey from birth to death in four children with HIV, finding the deadly X4 form emerges just before AIDS. The study reveals thymus as key location for viral replication and development of a 'program' of virus evolution over time.
The NIH grant will support innovative research into HIV transmission and early infection, with a focus on understanding the interactions between HIV and the immune systems of newly infected patients. The study aims to provide new clues for developing a vaccine and improving therapeutic outcomes.
A regulatory protein called CTLA-4 inhibits the action of HIV-specific CD4 T cells, leading to immune system breakdown in AIDS patients. Elevated CTLA-4 expression correlates with disease progression and reduced CD4 counts, suggesting a potential treatment target.
A mathematical model predicts that daily PrEP pills could prevent 3.2 million new HIV infections in southern sub-Saharan Africa in 10 years. The strategy is most effective when targeted towards high-risk individuals.
A new systematic review found that 'abstinence-plus' programs, which present safer sex as an option when abstinence fails, can increase abstinence, condom use, and reduce unprotected sex among North American youth. The study also suggests limited evidence of reduced pregnancy rates among teenage girls.
Dr. Michael Bruce Zwick is honored by the American Society for Microbiology (ASM) for his groundbreaking work in developing an HIV vaccine. He has published numerous papers and received several prestigious awards, including the ICAAC Young Investigator Awards.
American Society for Microbiology honors Jason T. Blackard for his groundbreaking research on HIV and hepatitis C co-infections, including extrahepatic replication of HCV in HIV-infected women.
The University of South Florida's global health initiative will expand its research training partnerships in India to fight AIDS among adolescents. The program, valued at $1.36 million, will partner with Vadodara Medical College to train Indian physicians and healthcare professionals.
A new UCLA study reveals that unstable lifestyles and lack of organization in HIV patients' lives can act as a barrier to regular medical care. The researchers developed a six-item scale to gauge the level of chaos in an adult's life, which found those with more chaos scored higher on the scale and had lower mental health status.
A Harvard study found that socioeconomic status influences antiretroviral treatment effectiveness, even among those adhering to treatment schedules. Lower education levels were associated with faster regimen failure, while higher adherence self-efficacy reduced this risk.
Researchers studied the molecular mechanisms of successful HIV antibodies and found that Fc receptors play a crucial role in preventing infection. The study's findings may lead to the design of tailor-made vaccines that have never been done before.
The Africa Centre for Health and Population Studies will receive £15 million over five years to improve health status, focusing on HIV infection. Researchers will study the impact of ART programs and develop interventions to prevent transmission.
A study in Kabul found alarmingly high rates of risky injecting and sexual behaviors among injection drug users, with 50% sharing syringes and 76% engaging in paid sex. The incidence of Hepatitis C infection was also high, potentially foreshadowing an increase in HIV rates.
Researchers found that HIV reduced population growth in worst-affected areas by two-thirds, but the overall population continues to grow, with a higher crude death rate and lower birth rate in the presence of HIV.