Articles tagged with Stem Cell Research
Cancer cells can hide and escape therapies leading to recurrence. Researchers identify three possible mechanisms: cancer stem cells, polyploidy, and senescence. Combination treatments involving chemoradiation-induced transitory senescence and senolytic therapies may be effective in preventing repopulation.
Researchers used a stem cell model to study the effects of Alzheimer's disease-associated mutations on early human brain development, finding that mutant spheres were larger and contained fewer mature neurons. The study highlights the need for tailored therapies and paves the way for studying Alzheimer's in its early stages.
Patients with GATA2 deficiency have impaired ability to produce immune cells, leading to increased risk of recurrent infections and blood cancers. The study's findings suggest that a zebrafish model may help develop new treatments to slow or reverse the disease.
Researchers have developed a new standard for preventing graft-versus-host disease (GVHD) after stem cell transplant, showing improved efficacy and reduced side effects compared to the current gold standard. The new regimen achieved higher rates of patient survival without GVHD complications, making it a more effective option for patie...
Researchers at the University of Colorado Anschutz Medical Campus have discovered a molecular mechanism contributing to congenital heart defects in infants with Down syndrome. The study found that an abnormal interferon response inhibits key molecular events required for heart development, leading to impaired cardiogenesis.
Researchers compared developmental time across six species, including humans and mice, to find that embryonic duration is a key factor. They also discovered correlations between evolutionary history and segmentation clock periods.
Scientists used CRISPR interference to study gene function in human and chimp stem cells, discovering genes essential for cell cycle regulation that are absent in humans. This approach sheds light on the evolution of human brain development and highlights the importance of studying gene interactions over DNA sequences.
Researchers found that the amyloid precursor protein (APP) regulates human neurogenesis, which could be linked to Alzheimer's disease. APP promotes a balance between stem cell proliferation and differentiation, suggesting its disruption may cause premature neurogenesis and cellular stress.
Researchers at City of Hope have developed a universal donor stem cell therapy that can treat degenerative brain diseases such as Canavan disease and Alzheimer's. The therapy, which uses an 'off-the-shelf' approach, has shown promising results in preclinical studies, reducing toxic accumulation of metabolites and improving motor function.
Researchers used infected stem cells to study COVID-19's impact on organs, identifying effective anti-viral drugs for treatment. The study found distinct antiviral profiles in heart and lungs, paving the way for new therapeutic options.
The USC Stem Cell team is developing artificial kidney organoids using human stem cells and synthetic biology. They aim to create a functional kidney that resembles the real thing in function but not in form.
Researchers have made progress in generating stem cell-derived beta cells, but current methods are costly and labor-intense. A recent study has found a simple method to address these issues, enhancing maturation and functionality of sBCs.
Researchers have developed a technique to measure the effectiveness of clemastine in repairing myelin, allowing for future therapies to be assessed. Patients with MS treated with clemastine experienced modest increases in myelin water, indicating myelin repair.
A powerful new stem cell technique has enabled large-scale studies of the relationship between human genetics and biology, accelerating research and potential personalized treatments.
A team of scientists has discovered that IL-17 protein plays a central role in skin ageing, leading to inflammation and deterioration. Temporary inhibition of IL-17 slows down the appearance of aging symptoms, offering new possibilities for treating skin conditions and facilitating recovery after surgery.
Scientists have successfully converted human pluripotent stem cells into purified pituitary cells that secrete adrenocorticotropic hormone (ACTH), a hormone normally produced by the pituitary gland. Transplantation of these cells into mice with hypopituitarism resulted in long-lasting improvement in ACTH levels.
Researchers at Northwestern University have discovered a way to soften stiff hair follicle stem cells, enabling them to grow hair again. By boosting the production of microRNA-205, they promote hair growth in both young and old mice, offering potential for human hair regrowth.
Researchers found that ropinirole is safe and effective in slowing ALS progression, with patients showing improved physical activity and muscle strength after treatment. The study suggests that the method of growing motor neurons from patient-derived stem cells could be used to predict a patient's response to the drug.
Scientists from Brigham and Women's Hospital have developed a new immuno-therapeutic approach using twin stem cells that can target brain metastatic melanomas. The therapy, which uses an engineered 'twin stem cell model,' activates the immune system to suppress tumor growth and prolong survival in representative preclinical models.
Researchers from Oregon Health & Science University have discovered how stem cell transplantation can kill the virus that causes AIDS. The study, published in the journal Immunity, reveals that two circumstances must co-exist for a cure to occur and documents the order in which HIV is cleared from the body.
Researchers at Weill Cornell Medicine have successfully converted human stomach stem cells into insulin-secreting cells, offering a promising approach to treating type 1 and severe type 2 diabetes. The transplants reversed disease signs in mouse models, suggesting good durability.
Researchers from Kyoto University successfully induced meiotic oocytes from cynomolgus monkey embryonic stem cells. Single-cell transcriptome analysis revealed similarities and differences in gene expression between in vitro and in vivo oocytes, providing insights into the primate germ cell differentiation process.
Increased expression of Musashi 1 on breast cancer cells has significant implications for understanding dormancy and survival in bone marrow. Msi 1 knockdown led to a reduction in cancer stem cells with undetectable PD-L1, suggesting a potential therapeutic target.
Scientists create a subcellular omics toolkit to study organelle diversity and communication in stem cells. The tool enables the identification of similar cell types, leading to more precise therapies for various diseases.
Prof. Ebisuya's stem cell zoo allows for systematic comparison of embryonic development across species, shedding light on species-specific differences in pregnancy length. Her research aims to uncover the biophysical basis behind these variations.
Researchers developed a self-organizing system that models key cellular processes involved in embryogenesis, shedding light on the self-organization of ectodermal cells during neurulation. The study could inform ways to prevent or counteract central nervous system birth defects by optimizing human ectodermal development.
Human brain organoids, grown in labs from stem cells, raise questions about personhood. Researchers propose a legal framework to understand their potential personhood and uses.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
A multi-institutional phase 3 clinical trial found that a cancer stem cell test can accurately decide more effective treatments and lead to increased survival for patients with recurrent glioblastoma. ChemoID, a CLIA-accredited diagnostic test, was used to select chemotherapy treatments, resulting in significantly lower risk of death a...
Researchers discovered that gamma delta T cells can effectively combat triple-negative breast cancer by targeting stress-induced molecules and phosphoantigens. Counteracting metabolic changes with zolendronate makes immunotherapy more efficient.
Cincinnati Children's scientists have successfully grown functional human intestinal organoids that mimic key development stages of the human fetus. These lab-grown tissues accurately replicate the formation of specific cell types and tissue structures, providing a valuable resource for studying fetal intestine development and potentia...
Researchers have created a novel bioadhesive material to facilitate stem cell transplantation into damaged cartilage. The adhesive, derived from mussel protein and hyaluronic acid, enables the secure encapsulation of stem cells, promoting cartilage regeneration.
Scientists have created a detailed map of human spinal cord cell formation, shedding light on how injuries and diseases arise. The study's findings hold promise for developing new therapies for spinal cord injuries and diseases like ALS.
Scientists found that dopamine-containing nerve cells from Parkinson's patients have poorer ability to form extensions, leading to severe dopamine deficiency. Researchers also discovered a medication that makes these cells better at forming nerve extensions.
Researchers identified an ancient mechanism for wound repair, triggered by low oxygen levels and IL24 protein. This pathway coordinates tissue repair without the need for infection, and may be involved in other organs featuring epithelial layers.
A new method, CloneTracer, distinguishes between cancerous and healthy stem cells in acute myeloid leukemia (AML). The study reveals two distinct stem cell compartments and shows that progenitor cells respond better to therapy. This finding paves the way for developing new techniques to predict patient response to chemotherapy.
New research suggests neural crest cells retain adaptability even after differentiation, enabling them to 'change their mind' and differentiate anew. This hyper-flexibility has significant implications for regenerative medicine, as these cells have immense potential as treatments to replace and repair damaged body tissue.
Cedars-Sinai investigators have discovered a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using human induced pluripotent stem cells. The new approach uses cells derived from iPSCs that are renewable, scalable, and can delay disease progression in rodents.
Cedars-Sinai Medical Center is launching a historic Ax-2 mission that aims to produce induced pluripotent stem cells in microgravity for the first time. The upcoming mission will utilize astronauts to generate these stem cells, paving the way for potential treatments and research opportunities.
Researchers used prime editing to correct the mutation that causes sickle cell disease, restoring normal blood parameters in mice. The approach showed promising results with up to 41% conversion of mutated cells to healthy ones.
Researchers at The Mount Sinai Hospital have created versatile disease models of acute myeloid leukemia (AML), allowing for accurate study of the cancer's progression and response to drugs. These models, derived from induced pluripotent stem cells, can mimic different stages of AML and are nearly identical to those found in patients.
Researchers developed a novel approach that promotes bone regeneration in mice without implantation of bone tissue or biomaterials. By carefully stretching the skull along its sutures, they activated skeletal stem cells that reside in these wiggly seams, repairing damage to the skull that would not have healed on its own.
Researchers have developed a new technology to sequence individual mitochondria in single cells, allowing for unbiased analysis of full-length mtDNA. This has revealed complex patterns of pathogenic mtDNA mutations and the potential risks of off-target mutations in genetic editing strategies.
Researchers at Duke-NUS Medical School have achieved significant vision recovery in experimental models of damaged retinas using stem cells. The study marks a promising step towards potentially restoring vision in eye diseases characterized by photoreceptor loss.
Researchers at Vanderbilt University Medical Center have discovered a new way to measure the growth rate of precancerous clones of blood stem cells using a technique called PACER. The findings suggest that drugs targeting the gene TCL1A may be able to suppress clonal growth and associated cancers.
A study found that cell competition between neural progenitor cells regulates brain size in mice, with top performers producing 30%-40% of neurons and losers producing only 1%-2%. The researchers identified Axin2 and p53 as key drivers of this process.
Researchers at Trinity College Dublin have discovered a new process that explains why cells have unique identities. By studying Polycomb protein complexes, the team found that different forms of these proteins recruit distinct complexes to DNA, shedding light on cellular identity and its potential impact on cancer treatments.
Researchers created the integrated-gut-liver-on-a-chip platform to examine how gut and liver cells interact, particularly in relation to non-alcoholic fatty liver disease. The study showed significant changes in gene expression and DNA damage when free fatty acids were introduced, leading to cell death similar to severe cases of NAFLD.
A team of investigators created embryo-like structures from monkey embryonic stem cells and transferred them into female monkeys, which implanted and elicited a hormonal response similar to pregnancy. The study provides new tools and perspectives for exploring primate embryos and reproductive medical health.
Researchers at the University of Washington School Medicine have engineered stem cells that do not generate dangerous arrhythmias. These 'MEDUSA' cardiomyocytes can engraft in the heart, mature into adult cells and beat in sync with natural pacemaking without generating dangerous heart rates.
A study by Linköping University researchers found that blood stem cells from leukemia patients remain in the bone marrow, but become defective over time, leading to long-term effects on blood formation. This discovery may explain why many leukemia survivors experience blood cell function disorders later in life.
Researchers have identified a promising new combination of drugs to treat juvenile myelomonocytic leukemia (JMML), a rare form of blood cancer affecting children. The combination of 5-azacitidine and MEK inhibitor PD0325901 reduced cancerous stem cells and improved blood cell abnormalities.
Researchers at TUM have developed a method to create mini-hearts in Petri dishes using stem cells. The resulting organoids mimic the earliest stages of human heart development and can be used to investigate congenital heart defects, potentially leading to new treatment methods.
Researchers discover ZBTB12, a molecular barrier that prevents dedifferentiation in human pluripotent stem cells, and shed light on the core differentiation mechanism.
Researchers at the University of Missouri have developed a process for marking transplanted donor bone marrow cells, allowing them to target only cancerous cells. This breakthrough offers new hope for bone marrow transplant patients with blood cancers such as lymphoma and leukemia.
Scientists at the University of Helsinki have discovered that genetic mutations can significantly impact the accuracy of stem cell-based disease models. The researchers found that somatic mutations in genes like BCOR can affect the differentiation process and gene expression, leading to variations in the model's reliability.
Scientists from USC Stem Cell laboratory discovered a mechanism linking leukemic mutations to varying disease potentials, identifying RNA splicing regulator Rbm25 as a critical factor. The study found that over-contributing clones of blood stem cells produce excessive myeloid cells, leading to potential leukemia development.
Researchers at the Francis Crick Institute have discovered a key role for autophagy in controlling intracellular infections like TB. By boosting this natural process, they hope to create new treatments that can combat antibiotic-resistant bacteria.
The study successfully generated functional patient-specific T-cells and thymic epithelial cells from human pluripotent stem cells using thymus organoids. This breakthrough provides a new experimental model system to investigate thymic insufficiency and function, potentially leading to cell-based treatments for thymic defects.
Researchers developed a neural implant that restored limb function to amputees and paralysed individuals by integrating with the brain and nerve. The biohybrid device combines electronic components with reprogrammed muscle cells, preventing scar tissue formation and improving signal extraction.