Articles tagged with Stem Cell Research
Researchers have identified the molecular mechanisms underlying gastric carcinogenesis induced by H. pylori infections, highlighting the disruption of the Wnt/PCP signaling pathway. This study provides insights into the potential target for clinical interventions against H. pylori cagA+ infections.
A study published in Nature Cell Biology found that blood stem cell diversity arises during embryonic development and can be manipulated in childhood to improve overall health. The researchers used zebrafish and human pluripotent stem cells to demonstrate the potential of enhancing blood stem cell production.
A study by Gladstone Institutes researchers found that tight junctions between cells may play a critical role in gastrulation in human embryos. By suppressing tight junction formation, the team was able to create primordial germ cell-like cells, which are stem cells resembling human precursors of sperm and egg cells.
Scientists have created human brain organoids free of animal cells, which could greatly improve the study and treatment of neurodegenerative conditions. The novel method uses an engineered extracellular matrix to support stem cell growth, resulting in more accurate models of brain development.
A team of scientists at Harvard Medical School has identified six chemical cocktails that can restore cellular aging and rejuvenate human cells. The study builds upon the discovery of Yamanaka factors, which can convert adult cells into induced pluripotent stem cells, raising hopes for treating age-related diseases and injuries. The im...
Researchers developed a chest imaging protocol using photon-counting CT, allowing for simultaneous evaluation of lung structure, ventilation, vasculature, and perfusion. The protocol showed advantages over standard CT, providing high image quality at lower radiation doses and better spectral resolution.
A novel association of t(5;17) with t(8;21) has been reported in an acute myeloid leukemia (AML) patient, resulting in a RUNX1-RUNX1T1 rearrangement. The patient received chemotherapy and stem cell transplantation, highlighting the importance of this rare translocation.
Researchers at Sylvester Comprehensive Cancer Center found that the ancient retrovirus HML-2 alters stem cell programming by activating a gene-regulating protein called OCT4, contributing to glioblastoma formation and aggressiveness.
Researchers discovered that a tiny sea creature, Hydractinia, regenerates its entire body with help from aging cells, providing insights into the interconnectedness of healing and aging. The study suggests that senescence may have evolved as a regeneration mechanism in ancient animals.
Researchers from Kyoto University developed a microchip using human iPS cells to measure transport capacity of membrane proteins, potentially giving test animals respite. The model simulates glucose reabsorption and drug excretion in renal proximal tubules, enabling patient-specific disease modeling and personalized medicine studies.
A collaborative study by researchers at the University of Ottawa and McMaster University has made a groundbreaking discovery linking different types of cancers to their embryonic origins. The team found that drugs targeting specific embryonic pathways can effectively treat various tumors, including brain, colon, and leukemia cancers.
Researchers at the University of Cambridge have developed a stem cell-derived model of the human embryo, allowing for the experimental modeling of embryonic development during the second week of pregnancy. This breakthrough could help understand why and how pregnancies fail, and potentially lead to new treatments for genetic disorders.
A new drug delivery method utilizes polymer-stabilized crystals to deliver antioxidants to stem cells, minimizing variation in drug release and extending the duration of effectiveness. This technology can be applied to various cell cultures and potentially other hydrophilic drugs, disease models, and methods applications.
Researchers at DTU Health Tech created a multi-levelled scaffold that enables near-perfect bone healing in just eight weeks, without using growth factors or endocrine factors and cells. The scaffold combines essential bone minerals with mechanical properties matching human bone compressive strength.
Researchers discovered a protein, C/EBPα, that accelerates B lymphocyte-to-macrophage conversion by interacting with PU.1. This epigenetic mechanism may be targeted for cancer research and treatment.
Cancer cells can hide and escape therapies leading to recurrence. Researchers identify three possible mechanisms: cancer stem cells, polyploidy, and senescence. Combination treatments involving chemoradiation-induced transitory senescence and senolytic therapies may be effective in preventing repopulation.
Researchers have developed a new standard for preventing graft-versus-host disease (GVHD) after stem cell transplant, showing improved efficacy and reduced side effects compared to the current gold standard. The new regimen achieved higher rates of patient survival without GVHD complications, making it a more effective option for patie...
Researchers used a stem cell model to study the effects of Alzheimer's disease-associated mutations on early human brain development, finding that mutant spheres were larger and contained fewer mature neurons. The study highlights the need for tailored therapies and paves the way for studying Alzheimer's in its early stages.
Patients with GATA2 deficiency have impaired ability to produce immune cells, leading to increased risk of recurrent infections and blood cancers. The study's findings suggest that a zebrafish model may help develop new treatments to slow or reverse the disease.
Researchers at the University of Colorado Anschutz Medical Campus have discovered a molecular mechanism contributing to congenital heart defects in infants with Down syndrome. The study found that an abnormal interferon response inhibits key molecular events required for heart development, leading to impaired cardiogenesis.
Scientists used CRISPR interference to study gene function in human and chimp stem cells, discovering genes essential for cell cycle regulation that are absent in humans. This approach sheds light on the evolution of human brain development and highlights the importance of studying gene interactions over DNA sequences.
Researchers compared developmental time across six species, including humans and mice, to find that embryonic duration is a key factor. They also discovered correlations between evolutionary history and segmentation clock periods.
Researchers found that the amyloid precursor protein (APP) regulates human neurogenesis, which could be linked to Alzheimer's disease. APP promotes a balance between stem cell proliferation and differentiation, suggesting its disruption may cause premature neurogenesis and cellular stress.
Researchers at City of Hope have developed a universal donor stem cell therapy that can treat degenerative brain diseases such as Canavan disease and Alzheimer's. The therapy, which uses an 'off-the-shelf' approach, has shown promising results in preclinical studies, reducing toxic accumulation of metabolites and improving motor function.
Researchers have made progress in generating stem cell-derived beta cells, but current methods are costly and labor-intense. A recent study has found a simple method to address these issues, enhancing maturation and functionality of sBCs.
Researchers used infected stem cells to study COVID-19's impact on organs, identifying effective anti-viral drugs for treatment. The study found distinct antiviral profiles in heart and lungs, paving the way for new therapeutic options.
The USC Stem Cell team is developing artificial kidney organoids using human stem cells and synthetic biology. They aim to create a functional kidney that resembles the real thing in function but not in form.
Researchers have developed a technique to measure the effectiveness of clemastine in repairing myelin, allowing for future therapies to be assessed. Patients with MS treated with clemastine experienced modest increases in myelin water, indicating myelin repair.
A powerful new stem cell technique has enabled large-scale studies of the relationship between human genetics and biology, accelerating research and potential personalized treatments.
Scientists have successfully converted human pluripotent stem cells into purified pituitary cells that secrete adrenocorticotropic hormone (ACTH), a hormone normally produced by the pituitary gland. Transplantation of these cells into mice with hypopituitarism resulted in long-lasting improvement in ACTH levels.
A team of scientists has discovered that IL-17 protein plays a central role in skin ageing, leading to inflammation and deterioration. Temporary inhibition of IL-17 slows down the appearance of aging symptoms, offering new possibilities for treating skin conditions and facilitating recovery after surgery.
Researchers at Northwestern University have discovered a way to soften stiff hair follicle stem cells, enabling them to grow hair again. By boosting the production of microRNA-205, they promote hair growth in both young and old mice, offering potential for human hair regrowth.
Researchers found that ropinirole is safe and effective in slowing ALS progression, with patients showing improved physical activity and muscle strength after treatment. The study suggests that the method of growing motor neurons from patient-derived stem cells could be used to predict a patient's response to the drug.
Scientists from Brigham and Women's Hospital have developed a new immuno-therapeutic approach using twin stem cells that can target brain metastatic melanomas. The therapy, which uses an engineered 'twin stem cell model,' activates the immune system to suppress tumor growth and prolong survival in representative preclinical models.
Researchers from Oregon Health & Science University have discovered how stem cell transplantation can kill the virus that causes AIDS. The study, published in the journal Immunity, reveals that two circumstances must co-exist for a cure to occur and documents the order in which HIV is cleared from the body.
Researchers at Weill Cornell Medicine have successfully converted human stomach stem cells into insulin-secreting cells, offering a promising approach to treating type 1 and severe type 2 diabetes. The transplants reversed disease signs in mouse models, suggesting good durability.
Researchers from Kyoto University successfully induced meiotic oocytes from cynomolgus monkey embryonic stem cells. Single-cell transcriptome analysis revealed similarities and differences in gene expression between in vitro and in vivo oocytes, providing insights into the primate germ cell differentiation process.
Increased expression of Musashi 1 on breast cancer cells has significant implications for understanding dormancy and survival in bone marrow. Msi 1 knockdown led to a reduction in cancer stem cells with undetectable PD-L1, suggesting a potential therapeutic target.
Scientists create a subcellular omics toolkit to study organelle diversity and communication in stem cells. The tool enables the identification of similar cell types, leading to more precise therapies for various diseases.
Prof. Ebisuya's stem cell zoo allows for systematic comparison of embryonic development across species, shedding light on species-specific differences in pregnancy length. Her research aims to uncover the biophysical basis behind these variations.
Human brain organoids, grown in labs from stem cells, raise questions about personhood. Researchers propose a legal framework to understand their potential personhood and uses.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
Researchers developed a self-organizing system that models key cellular processes involved in embryogenesis, shedding light on the self-organization of ectodermal cells during neurulation. The study could inform ways to prevent or counteract central nervous system birth defects by optimizing human ectodermal development.
A multi-institutional phase 3 clinical trial found that a cancer stem cell test can accurately decide more effective treatments and lead to increased survival for patients with recurrent glioblastoma. ChemoID, a CLIA-accredited diagnostic test, was used to select chemotherapy treatments, resulting in significantly lower risk of death a...
Cincinnati Children's scientists have successfully grown functional human intestinal organoids that mimic key development stages of the human fetus. These lab-grown tissues accurately replicate the formation of specific cell types and tissue structures, providing a valuable resource for studying fetal intestine development and potentia...
Researchers discovered that gamma delta T cells can effectively combat triple-negative breast cancer by targeting stress-induced molecules and phosphoantigens. Counteracting metabolic changes with zolendronate makes immunotherapy more efficient.
Researchers have created a novel bioadhesive material to facilitate stem cell transplantation into damaged cartilage. The adhesive, derived from mussel protein and hyaluronic acid, enables the secure encapsulation of stem cells, promoting cartilage regeneration.
Scientists have created a detailed map of human spinal cord cell formation, shedding light on how injuries and diseases arise. The study's findings hold promise for developing new therapies for spinal cord injuries and diseases like ALS.
Scientists found that dopamine-containing nerve cells from Parkinson's patients have poorer ability to form extensions, leading to severe dopamine deficiency. Researchers also discovered a medication that makes these cells better at forming nerve extensions.
A new method, CloneTracer, distinguishes between cancerous and healthy stem cells in acute myeloid leukemia (AML). The study reveals two distinct stem cell compartments and shows that progenitor cells respond better to therapy. This finding paves the way for developing new techniques to predict patient response to chemotherapy.
Researchers identified an ancient mechanism for wound repair, triggered by low oxygen levels and IL24 protein. This pathway coordinates tissue repair without the need for infection, and may be involved in other organs featuring epithelial layers.
New research suggests neural crest cells retain adaptability even after differentiation, enabling them to 'change their mind' and differentiate anew. This hyper-flexibility has significant implications for regenerative medicine, as these cells have immense potential as treatments to replace and repair damaged body tissue.
Cedars-Sinai investigators have discovered a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using human induced pluripotent stem cells. The new approach uses cells derived from iPSCs that are renewable, scalable, and can delay disease progression in rodents.
Researchers at The Mount Sinai Hospital have created versatile disease models of acute myeloid leukemia (AML), allowing for accurate study of the cancer's progression and response to drugs. These models, derived from induced pluripotent stem cells, can mimic different stages of AML and are nearly identical to those found in patients.
Cedars-Sinai Medical Center is launching a historic Ax-2 mission that aims to produce induced pluripotent stem cells in microgravity for the first time. The upcoming mission will utilize astronauts to generate these stem cells, paving the way for potential treatments and research opportunities.
Researchers used prime editing to correct the mutation that causes sickle cell disease, restoring normal blood parameters in mice. The approach showed promising results with up to 41% conversion of mutated cells to healthy ones.
Researchers developed a novel approach that promotes bone regeneration in mice without implantation of bone tissue or biomaterials. By carefully stretching the skull along its sutures, they activated skeletal stem cells that reside in these wiggly seams, repairing damage to the skull that would not have healed on its own.
Researchers at Duke-NUS Medical School have achieved significant vision recovery in experimental models of damaged retinas using stem cells. The study marks a promising step towards potentially restoring vision in eye diseases characterized by photoreceptor loss.
Researchers have developed a new technology to sequence individual mitochondria in single cells, allowing for unbiased analysis of full-length mtDNA. This has revealed complex patterns of pathogenic mtDNA mutations and the potential risks of off-target mutations in genetic editing strategies.
Researchers at Vanderbilt University Medical Center have discovered a new way to measure the growth rate of precancerous clones of blood stem cells using a technique called PACER. The findings suggest that drugs targeting the gene TCL1A may be able to suppress clonal growth and associated cancers.