Articles tagged with Stem Cell Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The New York Stem Cell Foundation (NYSCF) has selected six early-career researchers to join its prestigious investigator program, which provides $1.5 million in funding over five years. The award aims to accelerate treatments and cures through cutting-edge research.
Ruben van Boxtel's research focuses on understanding the origins of late treatment effects in children with blood cancer, exploring the role of stem cells. His work aims to find solutions to prevent these effects and predict their likelihood.
A groundbreaking trial at UC Davis Health has successfully treated three babies with spina bifida using a stem cell treatment combined with fetal surgery. The procedure shows promise in improving mobility and reducing the severity of the birth defect, which affects 1,500 to 2,000 children in the US every year.
The USC COMPASS program aims to recruit and support students from historically underrepresented backgrounds to pursue careers in regenerative medicine. Scholars will receive a minor in Stem Cell Biology and Regenerative Medicine, as well as paid summer internships and mentorship opportunities.
Researchers have developed brain-like organoids that can be tested experimentally to uncover cellular and molecular causes of autism. The organoids, grown in a dish from human cells, self-organize into layers of cells reminiscent of the cerebral cortex, allowing scientists to study how complex neural structures arise.
The study found that a combination of NOX1, loss of function, and TNF leads to an abnormal increase in microfold cells, driving increased recruitment of immune cells. Reversing the defect with reactive oxygen species restored healthy gut balance. Further studies on reactive oxygen species-stem cell modulation therapy are proposed.
Researchers discover that oxytocin stimulates stem cells to migrate and develop into cardiomyocytes in zebrafish and human cell cultures. This could lead to the regeneration of damaged hearts after a heart attack. The study found that oxytocin also activates EpiPCs, which can replenish lost cardiomyocytes.
Scientists have developed guidelines to produce high-quality, well-structured mini-brain organoids that accurately mimic human brain tissues. By using early-stage stem cells and specific molecules, researchers can overcome challenges in uniformity and structure, enabling studies of neurological development, disease, and therapies.
Blastoids, derived from stem cells, mimic early embryonic development but may not develop into a fetus. Ethical considerations surround their use and regulation in research.
Researchers identified a specific gut bacterium responsible for antibiotic-induced GVHD after stem cell transplants. A sugar supplement was found to improve gut health by distracting the bacteria from attacking mucin in the intestinal lining, reducing complications such as GVHD.
Researchers found that proteins coalesce into a liquid droplet to process and relay information in stem cells, which could be a target for cancer therapies. The droplet's unique structure enables efficient processing of proteins, making it a crucial component in cancer development.
Researchers discovered that macrophages eliminate stressed stem cells with high levels of reactive oxygen species, while healthy cells are amplified. The study found that a specific marker, calreticulin, acts as an 'eat me' signal for stressed cells.
Researchers have discovered how a common blood stem cell mutation, DNMT3A R882, alters gene activity and produces abnormal blood cells that increase cancer risk. The study found that the mutant cells produce more red blood cells and platelets, leading to higher cardiovascular disease risks.
Researchers have successfully created dopaminergic neurons directly from the skin of patients with Parkinson's disease, preserving aged characteristics and cellular defects. This breakthrough allows for modeling PD-related neuronal defects in a larger cohort of patients, aiming to identify disease causes and potential therapies.
A new study finds that consistently losing an hour and a half of sleep per night can negatively impact immune stem cells, leading to increased inflammation and cardiovascular disease. Even after catching up on sleep, the effects of disrupted sleep remain long-lasting.
Research at Kumamoto University reveals that fetal liver blood cells are stem cell-independent, contrary to the long-held view that HSCs are essential for their production. The study provides new insights into the origin of HSCs and suggests a reconsideration of their role in embryo formation.
The study proposes a model to understand the complications caused by zika virus infection during pregnancy. The researchers found that zika virus alters protein expression in neural cells, affecting energy production and RNA metabolism, which can lead to defective myelination and microcephaly.
Researchers from the University of Copenhagen have identified a new mechanism in ARVC that could lead to a potential treatment strategy. They found that activating sirtuin-3 can slow down disease progression, and honokiol, a natural product extracted from the tulip tree, has been shown to work similarly.
Researchers at UNSW Sydney have made significant discoveries about embryonic blood stem cell creation that could one day eliminate the need for blood stem cell donors. Two studies have emerged from UNSW researchers in this area that shine new light on how precursors to blood stem cells occur in animals and humans, and how they may be i...
A study by Kyoto University Professor Misao Fujita found that Japan's Act on the Safety of Regenerative Medicine lacks key provisions to prevent unproven treatments from being administered to patients. The lack of scientific verification and clear definitions for medical innovations and interventions are major concerns.
Researchers from Johns Hopkins Medicine and Dana Farber Cancer Institute found that irisin reduces levels of a protein linked to Parkinson's disease and halts movement problems in mice. Irisin also speeds up the transport and degradation of alpha synuclein via fluid-filled sacs called lysosomes in brain cells.
Researchers have developed a mouse embryo model using only embryonic stem cells, achieving a high level of developmental stages including beating hearts and brain formation. This advancement opens up new avenues for understanding human pregnancy loss and developing organs in culture.
Researchers developed a more efficient process to apply CRISPR-Cas9 systems in human pluripotent stem cells, improving delivery efficiency by around 90% compared to plasmid DNA. The new approach also reduces off-target activity and allows for faster understanding of genetic disorders.
Researchers have created a stem cell-based model of the human liver, allowing for the study of how Ebola virus infects liver cells. The infected cultures showed that viral infection directly disrupts liver function, while immune cells can transfer the virus to other cells.
A novel stem cell-gene therapy has been shown to be safe in humans, with no serious side effects reported in the first trial. The treatment targets motor neurons that die in patients with amyotrophic lateral sclerosis (ALS), a fatal neurological disorder.
A study published in Cell Stem Cell found that mitochondrial dynamics regulate the dormant state of adult muscle stem cells, which are essential for tissue stability. The researchers discovered that the protein OPA1 regulates this process and its depletion leads to severe muscle stem cell defects.
Hereditary spastic paraplegia is a rare disease affecting approximately 77,000 Europeans, causing leg spasms and weakness. Researchers have discovered that the disease is linked to reduced calcium regulation, disrupting transport processes in brain cells.
Researchers at KU Leuven have developed a new model of human extraembryonic mesoderm cells, which closely resemble their natural counterparts in early embryos. This breakthrough enables scientists to study processes previously inaccessible during development.
A study by HKU Dentistry found that 'positive stress' can induce good changes in tooth stem cells, making them more resistant to injury and disease. The research team developed a preconditioning protocol that modified the cells genetically to mimic low oxygen conditions, which activated protective mechanisms.
Researchers at Brigham and Women's Hospital have developed a highly efficient method to generate human kidney cells, including principal and intercalated cell lines. This breakthrough could lead to new therapies for treating congenital abnormalities of the kidney and urinary tract, such as polycystic kidney disease.
Researchers at UBC develop new process to produce T cells, the most essential human immune cells, in the lab with improved efficiency. The breakthrough could lead to cost-effective production of cancer-fighting cells for CAR T therapy, a treatment with an efficacy rate of close to 50%.
A KAUST-led research team identified two drug treatments that boost the activity of molecules involved in cell adhesion, enhancing the ability of blood-forming stem cells to enter the bloodstream and produce new blood. This breakthrough could lead to improved bone marrow transplant success for leukemia patients.
Researchers at the University of Cambridge have successfully grown a model embryo with a brain, beating heart, and all other organs using mouse stem cells. This breakthrough could help understand why some pregnancies fail and develop a new approach for repairing synthetic human organs.
Researchers have developed a model mouse embryo that has beating hearts, foundations for a brain, and all the organs in a mouse body. This breakthrough could help understand why some embryos fail and provide insights into repairing synthetic human organs.
Researchers found that cells in diseased connective tissue lose their ability to reorder DNA information correctly, leading to cell dysfunction. The study suggests that epigenetic treatments could restore healthy genome organization and may be effective treatments for conditions affecting dense tissues.
Researchers have identified a group of latent stem cells in the central nervous system of mice that respond to injury by dividing, migrating towards damaged areas, and differentiating into astrocytes. If similar cells exist in humans, they could provide a new therapeutic approach for treating spinal cord injuries.
Researchers have successfully engineered human immune cells to model an infection common among immunocompromised people, paving the way for new drug testing and treatments. The immune cell type created played a key role in infection, inflammation, and regeneration, but also served as a natural host for germs.
Researchers have developed a tiny EEG cap for brain organoids, enabling 3D recording from the entire surface. This innovation expands what can be accomplished with organoids and holds promise for reducing animal testing in chemical toxicity studies.
A new study reveals a previously unrecognized level of heterogeneity and specialization of endothelial and mesenchymal cells in the bone marrow. By integrating single-cell gene expression data, researchers identified 14 endothelial and 11 mesenchymal subclusters, providing insights into blood stem cell self-renewal and differentiation
A new study published in Nature reveals that microglia cells change their molecular state to match neighboring neurons, influencing neural circuit function. The researchers found that different types of cortical neurons recruit specific numbers of microglia, which then adapt to the neuron's environment.
Researchers developed a new technique to track single blood stem cells in live organisms and describe their ultrastructure using electron microscopy. This allows for better understanding of cell-cell interactions and potential therapeutics for blood diseases and cancers.
Scientists have identified a critical source of essential molecules that enables the intestine's self-renewal and regeneration after injury. The study reveals that lymphatic endothelial cells play a key role in maintaining stem cell activity and tissues in the intestine.
Researchers generated rat sperm cells inside sterile mice using blastocyst complementation, achieving a proof-of-principle for producing gametes from one animal species in another. This breakthrough may speed up the production of transgenic rats for biomedical research and potentially support animal species conservation efforts.
A study published in Stem Cell Reports found that manipulating two signaling pathways, MAPK and PI3K-AKT, enhances the maturation of human-induced pluripotent stem cell-derived cardiomyocytes. This breakthrough discovery has significant implications for the development of cell therapy for heart disease.
Researchers from FSU College of Medicine and FAMU-FSU College of Engineering have developed a promising strategy to produce therapeutic particles in stem cells, which could help patients with neurological diseases such as stroke or multiple sclerosis. The new technique combines three-dimensional growing platforms with wave motion, lead...
Scientists at Cincinnati Children's develop a 'plug-and-play' method to consistently produce large numbers of lab-grown small intestines, colons, and stomachs. The new process overcomes the bottleneck of inconsistent organoid production, enabling faster and more accessible research.
Researchers investigate astrocyte production in the brain, discovering distinct dynamics in different parts of the cortex. The study suggests that early exposure to specific genes regulates stem cell behavior, leading to variations in astrocyte generation.
Scientists reprogrammed stem cells to create models of diseased eye cells, analyzing DNA, RNA, and proteins to pinpoint genetic signatures. The study identified 439 molecular signatures associated with AMD, including potential new gene variants that target mitochondrial proteins.
Researchers have identified a key chemical controlling hair follicle cell division and death, shedding light on a potential cure for baldness. The discovery also holds promise for speeding up wound healing by harnessing the regenerative properties of stem cells found in hair follicles.
A team of researchers has discovered a protein called NOVA1 that displays pathological characteristics in ALS patients at an early stage. This finding could lead to the development of new therapy concepts and potentially enable early detection of the disease.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
Researchers at Tokyo Institute of Technology have revealed that zinc (Zn) content is essential for the methionine-mediated regulation of pluripotent stem cells (PSCs). The team developed a protocol to convert PSCs into insulin-producing β cells, overcoming diabetes treatment challenges.
Researchers at UCLA have developed a roadmap detailing how stem cells become sensory interneurons, which enable sensations like touch and pain. The study identifies protocols for producing all types of sensory interneurons in the laboratory, paving the way for cell therapies to restore sensation in people with spinal cord injuries.
Research by Jeremy Wang at the University of Pennsylvania has discovered that DOT1L, a stem cell self-renewal factor, is essential for mice to produce sperm throughout their adult lives. The team found that mice lacking DOT1L fail to maintain spermatogonial stem cells and lose the ability to continuously produce sperm.
A groundbreaking study by Hebrew University researchers has discovered the most primitive blueprint for embryo cell creation. The team identified 14,000 sites in the DNA that control the development of all embryonic organs.
Researchers used human heart muscle cells and machine learning to predict arrhythmias in patients, achieving over 90% accuracy. The study lays the foundation for safer and more effective medicines by generating patient risk profiles and drug toxicity testing.
Scientists uncovered a biophysical mechanism steering stem cells in the intestine, shedding light on their behavior and renewal process. The findings suggest that location plays a crucial role in determining which cells act as stem cells, with more frequent movements in the small intestine leading to increased stem cell activity.
A new strategy using nanoparticles restores damaged stem cells, enabling them to grow new tissues again. The approach, which uses specially formulated 'backpacks' to deliver medicine, shows promise for treating gestational diabetes and other pregnancy complications.
Researchers generated simple kidney-like structures called organoids and used them to identify potential drugs for adult-onset polycystic kidney disease. They found nine compounds that inhibited cyst growth without stunting overall growth.
Researchers using 'blastoids' - in vitro models of the blastocyst - discovered that early embryonic signals induce placental development and prepare the uterus. The findings may contribute to a better understanding of human fertility and potentially improve IVF procedures, fertility drugs, and contraceptives.