Articles tagged with Stem Cell Research
A study published in Nature Communications reveals that the type of macrophage present in a person's body may determine how likely they are to develop severe inflammation in response to COVID-19. The research found that an aggressive subset of macrophages, known as M1 macrophages, can cause a cascade of events leading to multi-organ fa...
Scientists found that lithium chloride can cause X-inactivation loss in female hESCs, leading to cell death. The study suggests a possible new model for regulating X-inactivation and warns against using GSK-3 inhibitors like lithium.
Researchers have developed a novel therapeutic strategy for treating glioblastoma using allogenic stem cells that can target and kill tumor cells. The therapy demonstrated profound efficacy in preclinical models, with 100% of mice living over 90 days after treatment.
A Johns Hopkins Medicine study found that a protein called STING responds to clean-up signals in brain cells damaged by Parkinson’s disease by creating a cycle of inflammation that accelerates the disease’s progression. In mice with deactivated STING proteins, there was less microglial activity and brain cell death.
A recent study published in NPJ Regenerative Medicine found that large bone injuries trigger a repair strategy recapitulating elements of skeletal formation in utero. The gene Sonic hedgehog (Shh) plays a necessary role in healing central regions, while small-scale fractures heal through a distinct program.
Researchers studied naked mole-rats' skin using single-cell RNA-seq to understand its remarkable stability against aging. They found no changes in epidermal gene expression with age and a unique keratinocyte differentiation trajectory that remained intact.
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
A receptor protein called insulin receptor is pivotal for brain stem cell longevity, according to a Rutgers study. The researchers also found that the same protein plays a crucial role in sustaining brain cancer cells.
Researchers have developed a process to convert non-neuronal cells into functioning neurons that can take up residence in the brain and restore capacities undermined by Parkinson's destruction of dopaminergic cells. In a proof-of-concept study, one group of experimentally engineered cells performs optimally in terms of survival, growth...
A new study maps the distinct differences among cells in the retina's retinal pigment epithelium (RPE), which nourishes and supports photoreceptors. The research identifies five subpopulations with varying levels of disease sensitivity, opening doors to more precise cell and gene therapies for specific degenerative eye diseases.
A molecular switch, p57, enables stomach stem cells to change allegiance from normal digestion to injury response, potentially leading to new treatments for gastric pathologies. The study's findings suggest that p57 is a key regulator of reserve stem cell state in gastric chief cells.
Researchers at NC State University have created a stem cell-derived model that sheds light on the effect of dopamine on gene activity in neurons, revealing gene desensitization in human cells. The study provides a blueprint for future research into the relationship between dopamine and addiction.
The May issues of American Psychiatric Association journals explore the cognitive impacts of long-term cannabis use, the intersection of climate change and mental health, and tools to address children's mental health. The American Journal of Psychiatry and Psychiatric Services feature research reports on these topics.
Scientists have created cilia-free human pluripotent stem cells that exhibit symptoms of ciliopathy, such as polycystic kidney disease. These cells can be used to study the cause of these diseases and guide therapy development.
Researchers at Cedars-Sinai have developed an AI tool that accurately predicts pancreatic cancer patients based on CT scan images. Lowering blood cholesterol has also been shown to slow the growth of prostate cancer by enhancing immune cell action. Additionally, a new study found that an ultrasound probe plugged into a smartphone can b...
Scientists have identified a retinoic acid-dependent hemogenic endothelial progenitor from human pluripotent stem cells, enabling the development of transcriptionally similar cells in tissue culture. This breakthrough method brings researchers closer to developing blood-forming stem cells for transfusions and cancer treatments.
A recent study published in Stem Cell Reports found that sleep deprivation negatively affects corneal stem cells, leading to increased rates of cell multiplication and reduced tear film antioxidants. This can result in serious effects on corneal health, such as thinning and ruffling of the cornea.
Researchers from Columbia University have developed a plug-and-play multi-organ chip, customized to the patient, consisting of engineered human heart, bone, liver, and skin linked by vascular flow. The model allows for long-term studies and can be optimized for personalized therapy optimization in cancer and systemic diseases.
Researchers at Kyoto University have produced induced pluripotent stem cells (iPSCs) from the endangered Grévy's zebra, showcasing similarities with human and mouse stem cells. The study's findings provide insight into evolutionary conservation between mammals and may help advance research on endangered species.
Researchers have engineered a tiny living heart chamber replica to study disease progression and test new treatments. The miniPUMP device mimics the real organ's mechanics, allowing for accurate tracking of how the heart grows in embryos and studying the impact of disease.
Researchers at KU Leuven and UHasselt have created a 3D model with human dental stem cells that can produce enamel components, paving the way for biological dental enamel repair. This natural alternative has the potential to reduce risk of tooth necrosis and improve patient outcomes.
Researchers at Duke University discovered that SARS-CoV-2, the virus causing COVID-19, can directly infect and damage specific types of kidney cells. The virus hijacks the cell's machinery to replicate, leading to structural damage and increased production of viral particles.
Scientists at Johns Hopkins Medicine have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice. The self-renewing stem cells were created by reprogramming laboratory-grown human skin cells, which then differentiated into specific cell types using a nutrient-rich broth.
A UCLA-led team has created a roadmap tracing each step in human blood stem cell development, providing a blueprint for producing fully functional blood stem cells. The map could help expand treatment options for blood cancers and inherited disorders.
Researchers at Massachusetts General Hospital identified genes that play a crucial role in maintaining healthy kidney repair, including FANCD2 and Rad51. Activating a DNA repair mechanism may help preserve kidney function in people with chronic kidney disease.
Researchers at Mount Sinai have developed a reproducible method to advance the maturation of human pluripotent stem cell-derived cardiomyocytes, which support heart muscle contraction. The new protocol enables efficient energy generation from both carbohydrates and fatty acids, improving disease modeling and regenerative therapies.
Researchers discovered that Viagra and a common over-the-counter drug TUDCA restored mitochondrial processes, which drive heart failure in HLHS patients. This could lead to new therapies for treating heart failure without relying on heart transplants.
The article highlights the need for a more diverse approach to stem cell policy, including consideration of Muslim contexts and perspectives. Researchers argue that this could lead to a more nuanced understanding of bioethics and potentially expand the use of embryonic stem cells in research.
Researchers discovered newborn neurons and immature astroglia in patients with epilepsy, which could lead to new anti-seizure medications. The study suggests that targeting immature astroglia may be an effective approach to controlling seizures without aggressive brain surgery.
Researchers discovered that a genetic mutation causing odd-shaped nuclei may lead to earlier diagnosis and treatment of certain leukemias. The study found that the loss of nuclear Lamin B1 induces defects in nuclear morphology and genome instability, setting the stage for cancer.
Researchers have successfully generated large numbers of virus-resistant immune cells from monkeys using CRISPR/Cas9 gene editing. This breakthrough could lead to the development of a new treatment for HIV/AIDS by providing an alternative to current therapies that require lifelong medication and can cause side effects.
Researchers have discovered a novel nano-therapy that prevents bronchopulmonary dysplasia (BPD) in premature babies. The therapy uses tiny particles released by mesenchymal stromal cells, which travel to the brain and lungs, reducing damage and improving lung and brain health.
Researchers have found a possible target for ALS treatment in astrocyte abnormalities. Astrocytes, a subtype of cells in the central nervous system, are involved in motor neuron death, leading to muscle weakness and paralysis. The study offers hope for developing new drugs to block this process.
Researchers use stem cells from people with extra X chromosomes to identify key genes contributing to symptoms like infertility and intellectual disability. The study's findings could lead to new treatments for these conditions.
Researchers detect Sars-CoV-2 mRNA in human retina organoids, indicating infection of retinal cells. The virus also replicates in these cell types, with implications for 'Long Covid' pathologies.
A genome-wide functional screen identified critical regulators of naïve stem cell reprogramming, enabling the creation of high-quality, stable stem cell populations. The study also uncovered epigenetic factors that hinder or help reprogramming, including the essential PRC1.3 complex and inhibitory HDAC2 protein.
The American Association for Cancer Research (AACR) announced its newly elected class of Fellows of the AACR Academy, recognizing distinguished scientists who have propelled innovation and progress against cancer. The 2022 class consists of 33 luminaries from various scientific disciplines.
Researchers developed a transgene-free method to convert human pluripotent stem cells into 8-cell totipotent embryo-like cells, paving the way for advances in organ regeneration and synthetic biology. These cells can be used to regenerate human organs, study human embryonic development, and prevent pregnancy loss.
A team of researchers found that re-activating the Piezo1 protein allows muscle stem cells to repair broken down muscles in mice with Duchenne muscular dystrophy. The study opens doors for potential molecular-level treatments to slow or halt disease progression.
Researchers have discovered an essential role of LCOR in enabling cancer cells to present tumour antigens, making them visible to the immune system. This approach increases the success of immunotherapy in triple-negative breast cancer, a subtype with low treatment response rates.
A retinal stem cell patch has survived for two years after implantation and continues to function without triggering immune rejection. The patch, developed through a collaboration of researchers, is one step closer to securing FDA approval and potentially restoring vision to millions of people affected by age-related macular degeneration.
A clinical trial at UC Davis Health showed that cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy, stopping deterioration of upper limb and heart functions. The therapy appears to be safe and effective in improving skeletal muscle and cardiac function.
A Penn State-led team of researchers developed a new delivery system that improves the efficiency and lifespan of CRISPR gene-editing tools after delivery into stem cells. The method uses an enzyme called PiggyBac, which enables permanent integration of the editing tools into the cell's genetic code, resulting in 99% of mutated cells b...
Scientists have successfully produced fully functional pancreatic beta cells from stem cells for the first time, offering a breakthrough in treating type 1 diabetes. The study's findings demonstrate that these stem cell-derived beta cells can regulate insulin secretion and manage glucose metabolism in both cell cultures and mice studies.
Scientists have discovered the signature of genes expressed by hematopoietic stem cells that can produce healthy blood cells after being transplanted. This finding could enable scientists to expand these cells outside the body or convert other types of stem cells into functional blood cells.
Researchers at HKUST discovered a protein called CPEB1 that drives skeletal muscle stem cell activation to repair damaged muscle. The study reveals discordance between SC proteome and transcriptome during activation, showing post-transcriptional regulation.
Researchers discovered a new human embryonic stem cell population that closely resembles the 8-cell embryo stage, allowing them to map key genomic changes during early development. This model will help advance knowledge of genome activation errors in developmental disorders and embryo loss.
The five-year grant will be used to mentor junior scientists, leveraging City of Hope's expertise in cancer treatment and patient care. The program will provide students with hands-on experience in cell-based therapies, regulatory approval, and commercialization.
Researchers have identified a group of clinical signs that can be paired with genetic testing to better inform the timing of more aggressive treatment for leukemia patients. The study used a mouse model to understand how genetic mutations trigger bone marrow failure and life-threatening complications.
Researchers at RMIT University used high-frequency sound waves to turn stem cells into bone cells, overcoming challenges in mass production and pain associated with extraction. The innovative treatment is faster, simpler, and more efficient than existing methods.
A new test procedure using human stem cells identifies chemicals that may cause birth defects in humans. The method assesses the likelihood of toxicity by monitoring disturbances in precisely programmed signaling pathways.
Researchers at Gladstone Institutes have developed a novel method for identifying genetic variants that are likely to play important roles in congenital heart disease. The study leverages interactions between proteins to pinpoint candidate genes, including GLYR1, which is involved in turning other genes on and off.
Scientists at Michigan Medicine have developed a new way to grow tiny models of organs, called organoids, using a simple suspension culture. This breakthrough improves the understanding of human development and could lead to new insights into disease.
A new study suggests that infusing healthy hematopoietic stem and progenitor cells into mice with sepsis can improve bacterial clearance, reduce tissue damage, and prolong survival. The infusion also boosts immunomodulatory cells, which regulate immune responses and decrease inflammation.
Researchers at the University of Illinois Chicago found a promising treatment for neurodegenerative diseases by stopping nerve cell degeneration. A peptide has been identified that inhibits mitochondrial fission and lets nerve cells grow normally.
Research reveals YME1L protein balances cellular proliferation and quiescence in neural stem cells. Defects lead to premature conversion of stem cells into neurons, impairing long-term neural regeneration.
Scientists at University of Helsinki found that older mitochondria determine cell fate, controlling daughter cell differentiation and self-renewal. Studying cellular respiration, researchers identified key metabolic changes influencing stem cell identity.
A team of scientists has developed a three-dimensional airway model made from patient-derived stem cells to study COVID-19 infection. The model replicates the initial stages of infection and can be used to test potential antiviral drugs, with results showing that multi-ciliated airway cells are the primary entry point for the virus.
Researchers at Johns Hopkins Medicine found that certain stem cells have built-in tracers made of sugars that can track their movement in living tissues. The discovery could streamline and advance restorative research for diseases of the brain.
Researchers used 3D mini-brain models to study the effects of three autism risk genes on neural formation and development. The study found that despite unique molecular mechanisms, the genes converged on affecting specific types of neurons, suggesting potential therapeutic targets for autism treatment.