Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Researchers have found a possible target for ALS treatment in astrocyte abnormalities. Astrocytes, a subtype of cells in the central nervous system, are involved in motor neuron death, leading to muscle weakness and paralysis. The study offers hope for developing new drugs to block this process.
Researchers use stem cells from people with extra X chromosomes to identify key genes contributing to symptoms like infertility and intellectual disability. The study's findings could lead to new treatments for these conditions.
Researchers detect Sars-CoV-2 mRNA in human retina organoids, indicating infection of retinal cells. The virus also replicates in these cell types, with implications for 'Long Covid' pathologies.
A genome-wide functional screen identified critical regulators of naïve stem cell reprogramming, enabling the creation of high-quality, stable stem cell populations. The study also uncovered epigenetic factors that hinder or help reprogramming, including the essential PRC1.3 complex and inhibitory HDAC2 protein.
The American Association for Cancer Research (AACR) announced its newly elected class of Fellows of the AACR Academy, recognizing distinguished scientists who have propelled innovation and progress against cancer. The 2022 class consists of 33 luminaries from various scientific disciplines.
Researchers developed a transgene-free method to convert human pluripotent stem cells into 8-cell totipotent embryo-like cells, paving the way for advances in organ regeneration and synthetic biology. These cells can be used to regenerate human organs, study human embryonic development, and prevent pregnancy loss.
A team of researchers found that re-activating the Piezo1 protein allows muscle stem cells to repair broken down muscles in mice with Duchenne muscular dystrophy. The study opens doors for potential molecular-level treatments to slow or halt disease progression.
Researchers have discovered an essential role of LCOR in enabling cancer cells to present tumour antigens, making them visible to the immune system. This approach increases the success of immunotherapy in triple-negative breast cancer, a subtype with low treatment response rates.
A retinal stem cell patch has survived for two years after implantation and continues to function without triggering immune rejection. The patch, developed through a collaboration of researchers, is one step closer to securing FDA approval and potentially restoring vision to millions of people affected by age-related macular degeneration.
A clinical trial at UC Davis Health showed that cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy, stopping deterioration of upper limb and heart functions. The therapy appears to be safe and effective in improving skeletal muscle and cardiac function.
A Penn State-led team of researchers developed a new delivery system that improves the efficiency and lifespan of CRISPR gene-editing tools after delivery into stem cells. The method uses an enzyme called PiggyBac, which enables permanent integration of the editing tools into the cell's genetic code, resulting in 99% of mutated cells b...
Scientists have successfully produced fully functional pancreatic beta cells from stem cells for the first time, offering a breakthrough in treating type 1 diabetes. The study's findings demonstrate that these stem cell-derived beta cells can regulate insulin secretion and manage glucose metabolism in both cell cultures and mice studies.
Scientists have discovered the signature of genes expressed by hematopoietic stem cells that can produce healthy blood cells after being transplanted. This finding could enable scientists to expand these cells outside the body or convert other types of stem cells into functional blood cells.
Researchers at HKUST discovered a protein called CPEB1 that drives skeletal muscle stem cell activation to repair damaged muscle. The study reveals discordance between SC proteome and transcriptome during activation, showing post-transcriptional regulation.
Researchers discovered a new human embryonic stem cell population that closely resembles the 8-cell embryo stage, allowing them to map key genomic changes during early development. This model will help advance knowledge of genome activation errors in developmental disorders and embryo loss.
The five-year grant will be used to mentor junior scientists, leveraging City of Hope's expertise in cancer treatment and patient care. The program will provide students with hands-on experience in cell-based therapies, regulatory approval, and commercialization.
Researchers have identified a group of clinical signs that can be paired with genetic testing to better inform the timing of more aggressive treatment for leukemia patients. The study used a mouse model to understand how genetic mutations trigger bone marrow failure and life-threatening complications.
Researchers at RMIT University used high-frequency sound waves to turn stem cells into bone cells, overcoming challenges in mass production and pain associated with extraction. The innovative treatment is faster, simpler, and more efficient than existing methods.
A new test procedure using human stem cells identifies chemicals that may cause birth defects in humans. The method assesses the likelihood of toxicity by monitoring disturbances in precisely programmed signaling pathways.
Researchers at Gladstone Institutes have developed a novel method for identifying genetic variants that are likely to play important roles in congenital heart disease. The study leverages interactions between proteins to pinpoint candidate genes, including GLYR1, which is involved in turning other genes on and off.
Scientists at Michigan Medicine have developed a new way to grow tiny models of organs, called organoids, using a simple suspension culture. This breakthrough improves the understanding of human development and could lead to new insights into disease.
Researchers at the University of Illinois Chicago found a promising treatment for neurodegenerative diseases by stopping nerve cell degeneration. A peptide has been identified that inhibits mitochondrial fission and lets nerve cells grow normally.
A new study suggests that infusing healthy hematopoietic stem and progenitor cells into mice with sepsis can improve bacterial clearance, reduce tissue damage, and prolong survival. The infusion also boosts immunomodulatory cells, which regulate immune responses and decrease inflammation.
Research reveals YME1L protein balances cellular proliferation and quiescence in neural stem cells. Defects lead to premature conversion of stem cells into neurons, impairing long-term neural regeneration.
Scientists at University of Helsinki found that older mitochondria determine cell fate, controlling daughter cell differentiation and self-renewal. Studying cellular respiration, researchers identified key metabolic changes influencing stem cell identity.
A team of scientists has developed a three-dimensional airway model made from patient-derived stem cells to study COVID-19 infection. The model replicates the initial stages of infection and can be used to test potential antiviral drugs, with results showing that multi-ciliated airway cells are the primary entry point for the virus.
Researchers at Johns Hopkins Medicine found that certain stem cells have built-in tracers made of sugars that can track their movement in living tissues. The discovery could streamline and advance restorative research for diseases of the brain.
Researchers used 3D mini-brain models to study the effects of three autism risk genes on neural formation and development. The study found that despite unique molecular mechanisms, the genes converged on affecting specific types of neurons, suggesting potential therapeutic targets for autism treatment.
Researchers have developed a machine learning framework called dynamo that can predict a cell's path over time, including its fate and genetic changes. The tool uses data from individual cells to create mathematical equations describing the cell's trajectory.
Researchers have developed a personalized dosing regime for anti-thymocyte globulin (ATG) to improve the success of stem cell transplants in children with leukemia. The new approach led to better immune recovery and higher survival rates compared to standard treatment.
A new study reveals that histone H3.3 plays a crucial role in maintaining the balance between self-renewal and differentiation of blood stem cells, leading to abnormalities when deleted. The protein anchors key epigenetic marks at developmental genes and endogenous retroviruses, contributing to an inflammatory response and skewed produ...
Breakthrough research reveals Tuberous Sclerosis Complex arises from human-specific progenitor cells, explaining its pathology. Human-derived cerebral organoid models shed light on complex brain development and potential mechanisms for other diseases.
Researchers at Boston Children's Hospital have developed an organoid platform that identifies drugs that enhance enteroendocrine cell action, potentially reversing diabetes, obesity and gastrointestinal conditions. The system identified three chemicals that drive the formation of EE cells and hormone production.
A recent study by Gladstone Institutes researchers found that mouse stem cells can spontaneously transition from heart cell precursors to brain cell precursors when a specific gene is removed. This discovery upends current understanding of how stem cells differentiate into adult cells and maintain their identity. The study's findings h...
Researchers at RIKEN have developed a new retinal transplant technique by engineering human-derived retina sheets to lose bipolar cells, allowing better connections to host retinas and improved responses to light. The technique has shown substantial functional improvement in animal studies and is now poised for human clinical trials.
Researchers discovered that old neurons can block neurogenesis in mice, highlighting excessive senescence as a driving factor behind aging. By destroying senescent cells, the study showed enhanced hippocampal neurogenesis and cognitive function in middle-aged mice.
Scientists have developed a novel CRISPR-Cas3 editor from the bacteria Neisseria lactamica that improves editing efficiency and is more easily produced. The tool enables 50% editing efficiency in stem cells and 95% efficiency in other human cell lines, paving the way for research in genetic diseases and developmental biology.
Researchers at University of Helsinki have developed a faster and more reliable method for converting adult skin cells into pluripotent stem cells, known as induced pluripotent stem cells (iPS). The new technique uses CRISPRa gene-editing and produces high-quality iPS cells with improved accuracy and reliability.
Scientists create artificial liver cells that function like real ones, but excrete less urea, until they induce aquaporin 9, enabling them to break down ammonia into urea. The new model is being used to test OTC chaperones for therapies.
Researchers identified 40 peptide pairs with potential cross-reactivity between BCG vaccination and SARS-CoV-2, offering a new strategy to complement existing COVID-19 vaccines. These peptides can induce T cell responses and INF-γ production, providing long-lasting immunity against viral infections.
Survival rates for adult patients with relapsed acute lymphoblastic leukemia (ALL) after hematopoietic cell transplantation have increased significantly over the past two decades. The two-year overall survival rate rose from 27.8% in 2000-2004 to 54.8% in 2015-2019, despite a significant increase in patient age at relapse.
Researchers have created a human stem cell model of albinism using patient-derived stem cells, allowing for the study of how lack of pigmentation affects retinal development and function. This model will enable high-throughput screening of potential therapies to treat eye conditions associated with albinism.
The European Research Council has awarded Kai Kretzschmar a Starting Grant to systematically characterise oral epithelial stem cells. This will help decipher the mechanisms underlying the diversity of the oral epithelium and its contribution to oral squamous cell carcinomas.
Researchers discovered that human lung stem cells can undergo abnormal differentiation in response to injury from diseases like COVID-19 and pulmonary fibrosis. This aberrant process prevents the restoration of normal lung function, but the study also identified a potential therapeutic target for reversing damage.
Researchers at Cedars-Sinai have identified opportunities to use microgravity in space for large-scale stem cell production, disease modeling, and biofabrication. This could lead to breakthroughs in regenerative medicine and the development of new treatments.
The reNEW Center aims to harness therapeutic potential in stem cell medicine for incurable diseases, with a focus on translation and collaboration. Scientists will work together to develop new treatments and therapies.
Researchers at UC Davis Health developed a new treatment that simultaneously blocks IL-6 and TNF cytokines, providing superior protection against acute graft-versus-host-disease severity and mortality. The dual-cytokine blockade approach did not impair beneficial graft-versus-tumor effects.
Researchers grew 'mini-brains' from stem cells of patients with and without schizophrenia, finding reduced gene expression in patient samples that stymied brain cell development. Replacing the missing genes restored normal brain cell production, suggesting a potential target for therapy.
Researchers developed a dish-based model that replicates the characteristics of dry age-related macular degeneration, allowing them to screen over 1,200 drugs for their ability to slow or halt disease progression. Two drugs, Aminocaproic acid and L745, showed promise in inhibiting key phenotypes associated with AMD.
Researchers at NTU Singapore have developed a new use for e-waste plastics by repurposing them as an alternative to laboratory cell culture containers. The team found that over 95% of human stem cells seeded on e-waste plastics remained healthy after a week, comparable to cells grown on conventional plates.
Researchers discovered that blood stem cells use high-energy fatty acids from the body's fat stores to power up their response to infection. This finding could lead to new approaches in treating bacterial infections, particularly in vulnerable and older individuals.
A team of scientists led by Vimal Selvaraj has developed a way to preserve the genetic diversity of fast-disappearing native cattle breeds using stem cells. This technology could be used to clone extinct breeds or to produce animals with desirable traits, such as disease resistance and extreme weather tolerance.
Microglia, the brain's immune cells, migrate to the retina using blood vessels as pathways and require neurogenesis for colonization. The study provides insights into microglial migration and its implications for neurodegenerative diseases.
Researchers will investigate how cells collect and interpret signals to make differentiation decisions, using live cell imaging and mathematical frameworks. The goal is to reveal the mechanisms behind cells' earliest decisions and improve stem cell fate prediction.
Researchers created a disease map of genes involved in eye disorders, shedding light on how individual cells respond to external factors like injury. The study paves the way for regenerative medicine and cell replacement therapies for eye diseases.
Researchers have discovered molecules that could be candidates for contraceptives or fertility enhancers using human blastoid models. These models also show promise in improving the self-organization of stem cells during IVF procedures.
Researchers have created reconstructable uterus-derived materials (RUMs) to aid in the recovery of damaged uteruses. The materials, which can be formed into different states and shapes, prevent intrauterine adhesion and promote angiogenesis, endometrial regeneration, and muscle collagen rebuilding.
Researchers at the University of Helsinki have developed a method to precisely and rapidly correct genetic alterations in cultured patient cells. The new technique combines two Nobel Prize-winning approaches to produce genetically corrected autologous pluripotent stem cells, paving the way for potential therapeutic applications.
Scientists at Kobe University have successfully generated testosterone-producing Leydig cells from human iPS cells, a significant step towards developing a regenerative medicine treatment for late-onset hypogonadism. The induced cells expressed genes specific to Leydig cells and produced functional testosterone.
A new study reveals that a high-sugar and high-fat diet can disrupt the natural adaptation of the digestive system by accelerating the division and differentiation of intestinal stem cells. This can lead to an increased risk of obesity, type 2 diabetes, and gastrointestinal cancer.