Articles tagged with Stem Cell Research
Scientists at USC have created rudimentary kidney structures, known as organoids, that resemble the collecting duct system. These organoids can be used to study kidney disease and test potential therapeutic drugs.
Researchers identified a novel vascular cell maintenance system where BEH3 competes with other transcription factors to stabilize vascular stem cell multiplication and differentiation. They also found that BEH3 hinders the activity of other BES/BZR transcription factors, indicating its opposing function in regulating vascular stem cells.
Experts call for global regulation to prevent unproven stem cell treatments from putting patients' lives at risk. The authors propose establishing an advisory committee on regenerative medicine and promoting harmonization among regulatory standards.
Researchers used base editing to convert a pathogenic hemoglobin gene to a benign variant, rescuing disease symptoms in animal models and enabling long-lasting production of healthy blood cells. The treatment successfully edited up to 80% of the mutated gene in human blood stem cells and maintained its effects in mice for 16 weeks.
Researchers developed a nanofiber-integrated cell encapsulation device that protects insulin-secreting cells from the immune system, allowing them to secrete insulin and control blood sugar levels. The implant was successful in mice with diabetes for up to 200 days without suppressing the immune system.
Researchers developed a method called SARSeq that enables large groups to be tested for SARS-CoV-2 with the same sensitivity as regular PCR tests. The method processes up to 36,000 samples in less than 48 hours and is highly specific and scalable.
Scientists have found key trends in how proteins are localized in mesenchymal stem cells, which can be controlled by substrate stiffness. This discovery may guide the control of stem cell states for research and medical treatments.
Researchers developed cardioids, human self-organizing cardiac organoids that recapitulate heart chamber formation and function. The model reveals how signaling and transcription factors control cardioid chamber formation and triggers an in vivo-like accumulation of extracellular matrix proteins after injury.
A recent case study by Johns Hopkins Medicine researchers provides evidence that medical marijuana may be an effective treatment for patients with chronic itch. The team found that THC, a compound in cannabis, attaches to brain receptors and reduces inflammation, leading to a reduction in skin sensations such as itchiness.
Researchers used advanced imaging technology to film Zebrafish brains while they were alive, revealing that the activation of stem cells responsible for generating neurons is not random, but rather coordinated. This finding has important implications for understanding brain development and may lead to new treatments for neurodegenerati...
A new stem cell-based vaccine has demonstrated 75% protection against pancreatic cancer in a mouse study. The vaccine targets multiple antigens found on pancreatic cancer cells, potentially leading to a more durable immune response.
Researchers at the University of Exeter have discovered a method to recreate the early structure of the human embryo from stem cells in the laboratory. This approach enables the study of human fertility and reproduction, with potential benefits for infertility research and IVF procedures.
Researchers at NIH have devised a four-part small-molecule cocktail, CEPT, that protects induced pluripotent stem cells from stress and maintains normal stem cell structure and function. The cocktail enhances the potential therapeutic uses of stem cells in treating diseases like diabetes, Parkinson's disease, and spinal cord injury.
Researchers at Beth Israel Deaconess Medical Center have successfully created 3D organoid models of the human pancreas from human stem cells, including both acinar and ductal structures. The new platform could lead to the discovery of markers for early diagnosis and monitoring of pancreatic cancer.
A team of researchers has created the first-ever single-cell atlas of the human teeth, revealing cellular heterogeneity and stem cell populations with great regenerative potential. The study highlights the importance of microenvironmental specificity in functional differences between stem cells in various tooth compartments.
Researchers have made significant findings in the fight against COVID-19, including a link between long-term blood vessel problems and an increased risk of heart disease. Studies also suggest promising leads for antiviral treatments and potential therapies using stem cells, as well as changes in science education during the pandemic.
A new stem cell therapy strategy has shown promising results in treating intestinal bowel disease in premature infants. The treatment uses human placental-derived stem cells to repair damage caused by the disease and promote healing of the intestinal barrier.
Researchers successfully generate synthetic mouse embryos containing the three fundamental cell types normally found in pre-implantation embryos. The study provides strong evidence that the system is a good model for studying early embryo development, shedding light on the mechanisms of totipotency and the causes of early pregnancy loss.
WeHI researchers have developed a new single-cell technique, SIS-seq, to understand the programming behind stem cells making particular cell types. The research uncovered 30 new genes that program stem cells to make dendritic cells that kick-start the immune response.
Researchers found that aged bone marrow niches restrict the function of rejuvenated hematopoietic stem cells, which can lead to leukemia. The study suggests that addressing the influence of an aged niche is crucial for sustaining the function of rejuvenated HSCs.
The International Society for Stem Cell Research (ISSCR) has launched a new podcast called The Stem Cell Report with Martin Pera, which delves into the inspiration and stories behind stem cell research. The podcast features interviews with leading researchers and experts in the field.
Researchers at Monash University developed a new technique to speed up bone implant recovery by altering the shape and nucleus of individual stem cells. The micropillar array 'tricks' the cells into becoming bone, increasing bone production by four times compared to current methods.
A new study by the Linda Crnic Institute for Down Syndrome identifies a higher-than-expected rate of clonal hematopoiesis in individuals with Down syndrome between the age of one to 20 years old. This precocious clonal hematopoiesis is linked to an increased risk of leukemia, with oncogenic mutations dominating the TET2 gene.
Harvard researchers identify how chronic stress impairs hair follicle stem cells, leading to delayed regeneration and hair loss. The study found that the stress hormone corticosterone delays stem cell activation, while Gas6 pathway activation promotes hair growth.
Researchers at the University of Southampton developed a new technique using gold nanoparticles to detect and enrich skeletal stem cells. The method is simpler, quicker, and up to 50-500 times more effective than existing methods, offering promising areas for bone disease treatment.
The research team identified vinculin as critical for maintaining the quiescent properties of hair follicle stem cells. Vinculin's loss leads to weak cell-cell junctions and dysregulated YAP1 pathway, causing increased cell proliferation and loss of quiescence.
A study by researchers at Warwick Medical School reveals that decidual precursor cells play a critical role in pregnancy and their depletion may lead to recurrent pregnancy loss. The study suggests that these cells can be harnessed to prevent pregnancy disorders, offering new hope for women struggling with miscarriage.
The National Eye Institute's Data Commons now offers access to AREDS2 data, including thousands of participants with age-related macular degeneration. Researchers can analyze genomic and phenotypic data, as well as retinal images, to better understand the disease and develop new therapies.
A UCLA-led research team identified a chemical cocktail that enables large numbers of muscle stem cells to be produced within 10 days. The approach shows promise for improving muscle regeneration and could lead to the development of stem cell-based therapies for muscle loss or damage due to injury, age, or disease.
Mouse embryos can now be grown outside the womb for up to six days, allowing researchers to observe early stages of development in unprecedented detail. The method, developed by Weizmann Institute of Science researchers, enables detailed study of embryonic development and potential insights into birth defects.
Researchers have created stem-cell-derived organoids that can produce mature tear products, shedding light on the biology of crying and dry-eye disease. The organoids can be transplanted into mouse tear glands and form functional duct-like structures, revealing new insights into potential treatments for Sjögren's syndrome.
Researchers found that astrocytes from patients with bipolar disorder secrete more IL-6, which worsens symptoms and negatively impacts neuronal activity. The study highlights the potential role of astrocyte-mediated inflammatory signaling in psychiatric diseases.
A team of bioethicists and scientists proposes a cautious, stepwise approach to studying human embryos beyond the 14-day limit, potentially unlocking insights into early development disorders and therapies for infertility. The proposed research aims to serve important goals that cannot be adequately met by other means.
Researchers successfully grow mouse stem cells into sperm in the body of rats, paving the way for efficient reproduction and future applications.
A new method called MutaSeq can distinguish cancer stem cells from healthy stem cells using single cell sequencing. This technology has the potential to identify drug targets that could eradicate leukemia at its source.
A study by University of Zurich researchers reveals that increasing lamin B1 levels in aging mice stem cell division improves, leading to increased new neurons. The findings offer hope for future therapies targeting neurogenesis in older individuals or those with degenerative diseases like Alzheimer's.
The JDRF Center of Excellence in New England will focus on accelerating gene editing approaches for beta cell replacement therapy, aiming to solve the problem of immune rejection of beta cells. The center will collaborate with leading Massachusetts-based experts to develop new technologies and strategies to prevent beta cell destructio...
A team of researchers led by Alysson R. Muotri used stem cells to create 'mini-brains' modeled after extinct Neanderthals, discovering a single genetic alteration that could explain key differences in brain development and function between modern humans and our closest relatives
Scientists at RIKEN Center for Biosystems Dynamics Research have identified a population of hair follicle stem cells and developed a recipe for normal cyclical regeneration. In the study, 81% of bioengineered hair follicles generated in NFFSE medium went through at least three hair cycles and produced normal hair.
Researchers at NYU Tandon and NYSF have developed a system to sculpt bone tissue with features smaller than a single protein, opening doors for disease modeling, cell research, and targeted therapies. The technology could revolutionize drug discovery and develop better orthopedic implants.
Researchers found that a widely used cell type for brain research was misidentified as an endothelial cell, but could be reprogrammed to resemble one using gene expression manipulation. This study highlights the importance of rigorously evaluating stem cell models before embracing them.
Researchers at the University of Cambridge have developed a new method called Multi-Organoid Patterning and Fusion (MOrPF) to grow miniature versions of organs. The technique enables faster assembly of organoids into airway tubes with uninterrupted passageways, retaining their shape even in the absence of external support.
Researchers at North Carolina State University found that treating mesenchymal stem cells with TGF-β2 reduces the immune response in recipients. This could lead to simplified treatment options for ligament and tendon injuries in horses, as well as potential human therapies.
In mice, blood vessel cells produce factor that stimulates blood stem cells, maintaining their self-renewal capacity. However, production of this factor ceases with aging, leading to loss of self-renewal ability and weakening of the immune system.
Researchers have discovered that two anti-viral enzymes, APOBEC3C and ADAR1, fuel the transition from pre-cancer stem cells to leukemia stem cells. Inhibiting these enzymes with existing medications may help prevent cancer, including leukemia.
Researchers at Inselspital and the University of Bern discovered that metoclopramide inhibits the proliferation of leukemia stem cells, a key target in CML treatment. The study identifies CD93 as a specific regulator responsible for leukemia stem cell growth, paving the way for potential new therapies.
Researchers successfully transplanted human cadaver-derived retinal pigment epithelium (RPE) into non-human primate models, showing promise for treating macular degeneration and blindness. The study demonstrates the safety and feasibility of this approach, paving the way for potential human clinical trials.
A mathematical model developed by researchers predicts that autologous gene-edited stem cell transplants could achieve viral control after antiretroviral therapy withdrawal. The conditions required for this include a sufficient dose of edited stem cells and allowing them to repopulate the blood before ART is stopped.
Researchers identified five novel toxin-antidote pairs in nematode species Caenorhabditis tropicalis and C. briggsae. The study found that these elements can delay reproduction or kill non-carriers, causing defects in over 70% of progeny from a single cross.
Researchers found that umbilical cord-derived mesenchymal stem cell infusions safely reduce the risk of death and quicken recovery time for severe COVID-19 patients. Patient survival at one month was 91% in the treatment group versus 42% in the control group.
A randomized trial shows UC-MSC infusions safely reduce risk of death and quicken time to recovery for severe COVID-19 patients. The treatment, like smart bomb technology, restores normal immune response and reverses life-threatening complications.
Baylor College of Medicine researchers found that long-term exposure to IFNγ exhausts blood stem cells by triggering proliferation and excessive differentiation. Modulating BST2 expression on these cells may provide a means to regulate their activation during chronic infections.
Researchers have discovered that brain stem cells in the hippocampus of mice can divide repeatedly over several months, leading to new insights into the formation of nerve cells. This finding has significant implications for future therapeutic approaches to conditions such as depression and Alzheimer's disease.
Researchers at Kyushu University identified eight transcription factors that can convert mouse stem cells directly into oocyte-like cells. These findings offer a simple route for generating specialized substances unique to oocytes for use in reproductive biology and medicine.
New research from the University of Exeter's Living Systems Institute has found that human embryonic stem cells do not acquire cancer-causing mutations when grown in their most primitive state. The study provides a significant breakthrough in understanding the genetic stability of human pluripotent stem cells.
A team of researchers has successfully grown structures similar to parts of a mouse embryo using a special gel and 3D cell culturing technique. This allows for the investigation of pharmacological agents on a scale that would not be possible in living organisms.
Researchers have discovered a protein that can expand typically scarce blood stem cells, potentially leading to new methods for growing a large quantity of these cells inside and outside the human body. The findings could benefit patients with inherited blood disorders and certain types of blood cancers.
New research suggests that testing for tumor DNA in DLBCL patients' stem cells or blood can help predict relapse risk. Patients with positive results may benefit from alternative treatments like CAR T cell therapy and prompt interventions to prevent relapse.
Scientists create a system to quickly and easily convert human stem cells into various cell types, including neurons and blood vessels. The researchers identified 290 DNA-binding proteins that reprogram stem cells into target cells within four days.
Scientists have identified a key gene mechanism controlling cellular aging and rejuvenation in mesenchymal stem cells. The GATA6/SHH/FOXP1 pathway regulates MSC aging and rejuvenation, offering insights into developing treatments for age-related diseases.