Articles tagged with Stem Cell Research
Researchers found that aged bone marrow niches restrict the function of rejuvenated hematopoietic stem cells, which can lead to leukemia. The study suggests that addressing the influence of an aged niche is crucial for sustaining the function of rejuvenated HSCs.
Researchers at Monash University developed a new technique to speed up bone implant recovery by altering the shape and nucleus of individual stem cells. The micropillar array 'tricks' the cells into becoming bone, increasing bone production by four times compared to current methods.
A new study by the Linda Crnic Institute for Down Syndrome identifies a higher-than-expected rate of clonal hematopoiesis in individuals with Down syndrome between the age of one to 20 years old. This precocious clonal hematopoiesis is linked to an increased risk of leukemia, with oncogenic mutations dominating the TET2 gene.
Harvard researchers identify how chronic stress impairs hair follicle stem cells, leading to delayed regeneration and hair loss. The study found that the stress hormone corticosterone delays stem cell activation, while Gas6 pathway activation promotes hair growth.
Researchers at the University of Southampton developed a new technique using gold nanoparticles to detect and enrich skeletal stem cells. The method is simpler, quicker, and up to 50-500 times more effective than existing methods, offering promising areas for bone disease treatment.
The research team identified vinculin as critical for maintaining the quiescent properties of hair follicle stem cells. Vinculin's loss leads to weak cell-cell junctions and dysregulated YAP1 pathway, causing increased cell proliferation and loss of quiescence.
A study by researchers at Warwick Medical School reveals that decidual precursor cells play a critical role in pregnancy and their depletion may lead to recurrent pregnancy loss. The study suggests that these cells can be harnessed to prevent pregnancy disorders, offering new hope for women struggling with miscarriage.
A UCLA-led research team identified a chemical cocktail that enables large numbers of muscle stem cells to be produced within 10 days. The approach shows promise for improving muscle regeneration and could lead to the development of stem cell-based therapies for muscle loss or damage due to injury, age, or disease.
The National Eye Institute's Data Commons now offers access to AREDS2 data, including thousands of participants with age-related macular degeneration. Researchers can analyze genomic and phenotypic data, as well as retinal images, to better understand the disease and develop new therapies.
Mouse embryos can now be grown outside the womb for up to six days, allowing researchers to observe early stages of development in unprecedented detail. The method, developed by Weizmann Institute of Science researchers, enables detailed study of embryonic development and potential insights into birth defects.
Researchers have created stem-cell-derived organoids that can produce mature tear products, shedding light on the biology of crying and dry-eye disease. The organoids can be transplanted into mouse tear glands and form functional duct-like structures, revealing new insights into potential treatments for Sjögren's syndrome.
Researchers found that astrocytes from patients with bipolar disorder secrete more IL-6, which worsens symptoms and negatively impacts neuronal activity. The study highlights the potential role of astrocyte-mediated inflammatory signaling in psychiatric diseases.
A team of bioethicists and scientists proposes a cautious, stepwise approach to studying human embryos beyond the 14-day limit, potentially unlocking insights into early development disorders and therapies for infertility. The proposed research aims to serve important goals that cannot be adequately met by other means.
Researchers successfully grow mouse stem cells into sperm in the body of rats, paving the way for efficient reproduction and future applications.
A new method called MutaSeq can distinguish cancer stem cells from healthy stem cells using single cell sequencing. This technology has the potential to identify drug targets that could eradicate leukemia at its source.
A study by University of Zurich researchers reveals that increasing lamin B1 levels in aging mice stem cell division improves, leading to increased new neurons. The findings offer hope for future therapies targeting neurogenesis in older individuals or those with degenerative diseases like Alzheimer's.
The JDRF Center of Excellence in New England will focus on accelerating gene editing approaches for beta cell replacement therapy, aiming to solve the problem of immune rejection of beta cells. The center will collaborate with leading Massachusetts-based experts to develop new technologies and strategies to prevent beta cell destructio...
A team of researchers led by Alysson R. Muotri used stem cells to create 'mini-brains' modeled after extinct Neanderthals, discovering a single genetic alteration that could explain key differences in brain development and function between modern humans and our closest relatives
Scientists at RIKEN Center for Biosystems Dynamics Research have identified a population of hair follicle stem cells and developed a recipe for normal cyclical regeneration. In the study, 81% of bioengineered hair follicles generated in NFFSE medium went through at least three hair cycles and produced normal hair.
Researchers at NYU Tandon and NYSF have developed a system to sculpt bone tissue with features smaller than a single protein, opening doors for disease modeling, cell research, and targeted therapies. The technology could revolutionize drug discovery and develop better orthopedic implants.
Researchers at the University of Cambridge have developed a new method called Multi-Organoid Patterning and Fusion (MOrPF) to grow miniature versions of organs. The technique enables faster assembly of organoids into airway tubes with uninterrupted passageways, retaining their shape even in the absence of external support.
Researchers found that a widely used cell type for brain research was misidentified as an endothelial cell, but could be reprogrammed to resemble one using gene expression manipulation. This study highlights the importance of rigorously evaluating stem cell models before embracing them.
Researchers at North Carolina State University found that treating mesenchymal stem cells with TGF-β2 reduces the immune response in recipients. This could lead to simplified treatment options for ligament and tendon injuries in horses, as well as potential human therapies.
In mice, blood vessel cells produce factor that stimulates blood stem cells, maintaining their self-renewal capacity. However, production of this factor ceases with aging, leading to loss of self-renewal ability and weakening of the immune system.
Researchers have discovered that two anti-viral enzymes, APOBEC3C and ADAR1, fuel the transition from pre-cancer stem cells to leukemia stem cells. Inhibiting these enzymes with existing medications may help prevent cancer, including leukemia.
Researchers at Inselspital and the University of Bern discovered that metoclopramide inhibits the proliferation of leukemia stem cells, a key target in CML treatment. The study identifies CD93 as a specific regulator responsible for leukemia stem cell growth, paving the way for potential new therapies.
Researchers successfully transplanted human cadaver-derived retinal pigment epithelium (RPE) into non-human primate models, showing promise for treating macular degeneration and blindness. The study demonstrates the safety and feasibility of this approach, paving the way for potential human clinical trials.
A mathematical model developed by researchers predicts that autologous gene-edited stem cell transplants could achieve viral control after antiretroviral therapy withdrawal. The conditions required for this include a sufficient dose of edited stem cells and allowing them to repopulate the blood before ART is stopped.
Researchers identified five novel toxin-antidote pairs in nematode species Caenorhabditis tropicalis and C. briggsae. The study found that these elements can delay reproduction or kill non-carriers, causing defects in over 70% of progeny from a single cross.
A randomized trial shows UC-MSC infusions safely reduce risk of death and quicken time to recovery for severe COVID-19 patients. The treatment, like smart bomb technology, restores normal immune response and reverses life-threatening complications.
Researchers found that umbilical cord-derived mesenchymal stem cell infusions safely reduce the risk of death and quicken recovery time for severe COVID-19 patients. Patient survival at one month was 91% in the treatment group versus 42% in the control group.
Baylor College of Medicine researchers found that long-term exposure to IFNγ exhausts blood stem cells by triggering proliferation and excessive differentiation. Modulating BST2 expression on these cells may provide a means to regulate their activation during chronic infections.
Researchers have discovered that brain stem cells in the hippocampus of mice can divide repeatedly over several months, leading to new insights into the formation of nerve cells. This finding has significant implications for future therapeutic approaches to conditions such as depression and Alzheimer's disease.
Researchers at Kyushu University identified eight transcription factors that can convert mouse stem cells directly into oocyte-like cells. These findings offer a simple route for generating specialized substances unique to oocytes for use in reproductive biology and medicine.
New research from the University of Exeter's Living Systems Institute has found that human embryonic stem cells do not acquire cancer-causing mutations when grown in their most primitive state. The study provides a significant breakthrough in understanding the genetic stability of human pluripotent stem cells.
A team of researchers has successfully grown structures similar to parts of a mouse embryo using a special gel and 3D cell culturing technique. This allows for the investigation of pharmacological agents on a scale that would not be possible in living organisms.
Researchers have discovered a protein that can expand typically scarce blood stem cells, potentially leading to new methods for growing a large quantity of these cells inside and outside the human body. The findings could benefit patients with inherited blood disorders and certain types of blood cancers.
New research suggests that testing for tumor DNA in DLBCL patients' stem cells or blood can help predict relapse risk. Patients with positive results may benefit from alternative treatments like CAR T cell therapy and prompt interventions to prevent relapse.
Scientists have identified a key gene mechanism controlling cellular aging and rejuvenation in mesenchymal stem cells. The GATA6/SHH/FOXP1 pathway regulates MSC aging and rejuvenation, offering insights into developing treatments for age-related diseases.
Scientists create a system to quickly and easily convert human stem cells into various cell types, including neurons and blood vessels. The researchers identified 290 DNA-binding proteins that reprogram stem cells into target cells within four days.
A new study by Crick researchers reveals that stem cells protect their chromosome ends through a unique t-loop structure, distinct from the TRF2-dependent mechanism in somatic cells. This discovery opens up new questions about the evolution of telomere protection and its implications for premature aging and cancer.
Researchers used genome-wide profiling to study the epigenetic landscape of human stem cells, revealing important information about gene regulation. They found differences in chromatin structures between long-term and short-term stem cells, which could improve understanding of cancer cell behavior and stem cell therapy.
Researchers identified Sestrin as a key regulator of stem cell function and lifespan in response to dietary amino acids. Increasing Sestrin levels extended fruit fly lifespan and protected against negative diet effects.
Scientists have developed a novel approach to reprogram T cells into long-lived, highly active 'super immune cells' that can fight multiple types of cancer. This breakthrough could lead to more effective and durable anti-cancer responses with existing treatments.
A new study from UCLA researchers found that smoking cigarettes causes more severe COVID-19 infection in the airways by blocking immune system messenger proteins. The study used a model of airway tissue created from human stem cells to understand how SARS-CoV-2 virus affects smokers.
Researchers at Duke University have discovered a mechanism by which mesenchymal stem cells (MSCs) modulate the inflammatory response, extending their beneficial effects even after being cleared from the system. The study sheds light on how MSCs suppress T cell activation and reprogram disease-fighting cells to promote healing.
Researchers describe a rare case of frosted branch angiitis, a unique presentation of florid retinal vasculitis, in a woman treated for leukemia-lymphoma with allogeneic human stem cell transplant. The condition led to immune activation and required corticosteroids to suppress inflammation.
Researchers discovered that stem cells have smaller and weaker centromeres compared to differentiated cells. This finding highlights a possible mechanism for the errors in cell division that limit the potential of stem cells in regenerative medicine.
A study published in STEM CELLS revealed that fibulin 5 plays a crucial role in the development of Schwann cells, which produce the myelin sheath surrounding neuronal axons. The research suggests that fibulin 5 may be used to treat Charcot-Marie-Tooth disease and other demyelinating disorders.
Scientists have identified a subgroup of stem cells that retains regenerative capacity well beyond geriatric age, suggesting new avenues for improving muscle health in elderly individuals. The discovery provides insight into the FoxO signalling pathway and its role in maintaining youthful gene expression.
Scientists successfully created airway basal stem cells in vitro from induced pluripotent stem cells, which may lead to new treatments for airways and lungs damaged by various diseases. The study's findings could also enable the development of disease models and targeted drug approaches.
The New York Stem Cell Foundation (NYSCF) has announced the 2020 class of NYSCF - Robertson Investigators, recognizing six outstanding stem cell researchers and neuroscientists. The program provides critical seed funding to support cutting-edge research with the potential to accelerate treatments and cures.
Researchers found that certain chemotherapeutic agents can promote tissue overgrowth in normal tissues, while an innate immune signaling pathway in fibroblasts causes stem cells to proliferate. This discovery has broad implications for diseases associated with the immune system, including psoriasis and cancer.
Researchers from Kyoto University and Tokai University have developed a new apparatus to study terahertz radiation's effects on human stem cells. The findings reveal that terahertz pulses activate genes involved in motor neuron survival and mitochondrial function, while deactivating those involved in cell differentiation.
A research team at Pohang University of Science & Technology has developed a technology that allows for the rapid harvesting of human bone marrow-derived mesenchymal stem cell sheets using poly(N-isopropylacrylamide) (PNIPAAm) nanotopography. This breakthrough reduces the harvest time from one week to just two days, making it possible ...
Forsyth researchers discovered a way to reverse periodontal disease by stimulating stem cells with Maresin-1 and Resolvin-E1, two synthetic lipid mediators. This finding offers new therapeutic possibilities for treating systemic diseases associated with inflammation.
Researchers at Karolinska Institutet discovered that stem cells in the mouse spinal cord can form new oligodendrocytes, essential for neuronal signal transmission, to help repair damaged tissue. This finding indicates a conceptually new strategy for stimulating repair after nervous system damage.
A new study from Kanazawa University finds that combining antibiotics with antibiotic-laden stem cells effectively treats implant-related bone infections. The researchers used mesenchymal stem cells to deliver ciprofloxacin, which showed strong antimicrobial effects and improved outcomes in animal models of osteomyelitis.
A US survey of 430 Americans found 82% supportive of at least some parts of human-animal chimeric embryo research. Support varied by organ type, with highest for heart and liver, while concerns about animal welfare and human dignity were cited.
Researchers have designed a multifunctional cell therapy system to treat ulcerative colitis, with encouraging results obtained in animal models. The system incorporates stem cells, biomaterials, and microparticles that release interferon, aiming to improve cell persistence and biosafety.