Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Two genes, MTG8 and MTG16, regulate stem cell differentiation in the small intestine, supporting its fast replacement process. This discovery could help understand how the body maintains a healthy gut and inform research on stem cell differentiation outside of the small intestine.
Using human stem cell models, researchers identified deficits within cells damaged by glaucoma and found that correcting genetic mutations could slow disease progression. They also discovered dysfunction in autophagy, a process that removes damaged cells, which correlated with neurodegeneration.
Researchers at A*STAR in Singapore have identified a potential biomarker, GSTT1, to screen the quality of donor's stem cells before harvesting. This biomarker can help determine the growth capacity and potency of MSCs, which is crucial for effective stem cell therapies.
Researchers at Indiana University School of Medicine have successfully grown hairy skin from human stem cells using a 3D cell culture method. The study shows that skin generated from pluripotent stem cells can integrate into mouse skin, leading to potential applications in skin reconstruction and disease modeling.
The study mapped the molecular characteristics of the aortic microenvironment where Hematopoietic Stem Cells (HSCs) form. Researchers identified conserved regulators, such as ADM and RAMP2, involved in HSC production in vivo.
Researchers at Lund University have identified CXCR4 as essential for the survival of leukemia stem cells, which can be controlled by cutting off the gene using CRISPR technology. This discovery reveals a fundamental difference in how leukemia stem cells and normal blood stem cells are regulated.
A study published in Cell Reports reveals that human acute myeloid leukemia (AML) stem cells are dependent on the transcription factor RUNX1, which could lead to lasting remissions or even cures. The researchers used induced pluripotent stem cells from a patient with AML to recreate leukemia stem cell biology in the lab.
A study by NYSCF Research Institute creates human stem-cell-derived astrocytes that become toxic to neurons in disease-like environments. This phenomenon could lead to effective treatments for neurodegenerative diseases such as multiple sclerosis, Parkinson's, and Alzheimer's.
Researchers found that stem cells collected from human amniotic membrane can slow the progression of scarring in pulmonary fibrosis by controlling immune cell activity. This pre-clinical study could lead to new treatments for this deadly disease, affecting 13-20 out of every 100,000 people worldwide.
Researchers have found that reprogrammed stem cells between days 15 and 28 of maturation can successfully restore heart tissue. This 'window of opportunity' makes it possible to use stem cells that the body recognizes as its own, allowing for more effective regenerative medicine.
After allogeneic stem cell transplantation, a critical window of vulnerability exists for re-infection with HIV. New T-cell responses to HIV proteins from donor cells develop after this time, indicating a weak point that may explain incomplete removal of the virus.
Researchers at the University of Sheffield have discovered ways to reduce DNA damage and mutations in pluripotent stem cells, a crucial step for regenerative medicine. The findings may allow for safer use of these cells in patients and significantly reduce the risk of genetic mutations.
Researchers mapped out how gene networks change as muscle cells mature from embryonic development to adulthood. The roadmap could lead to better methods for creating muscle stem cells from stem cells, potentially treating muscular dystrophies and sarcopenia.
Researchers have found that stem cells in planarians can postpone their own death to respond to an injury, allowing them to gather around the site of the wound and mount a response. This unique ability has implications for cancer research and therapies, particularly when examining chemotherapy and surgery options.
Researchers demonstrate a potential solution to corneal scarring by using stem cells to regenerate the cornea's stroma. The study shows improved corneal transparency and vision with minimal inflammatory response.
Researchers at the University of Illinois used nanostimulators to boost stem cells' regenerative powers, increasing blood flow and oxygen levels in ischemic limbs. The treatment showed improvements in mobility and strength, offering a promising approach for muscle repair.
A UCLA-led research team has developed a new method for delivering DNA into stem cells and immune cells safely, rapidly and economically. The technique uses high-frequency acoustic waves to manipulate cells and insert cargo without damaging them, enabling the creation of gene therapies for various diseases.
Researchers successfully reversed diabetes in mice by using genetically edited stem cells derived from patients with a rare genetic form of insulin-dependent diabetes. The CRISPR-Cas9 gene-editing tool corrected a genetic defect that caused the disease, allowing the human stem cells to normalize blood sugar levels.
A team of researchers at the Francis Crick Institute identified early-commitment genes that trigger irreversible cell specialization in human embryos. These genes, which include GATA3, activate a positive feedback loop, ensuring cells remain differentiated and do not reverse back to a stem cell state.
Researchers discovered that microscopic alterations in stem cell niche can predict Crohn's disease recurrence. A therapeutic approach using dichloracetate (DCA) restored intestinal stem cell functionality and maintained the intestinal barrier.
Abnormal stem cells in COPD patients drive key features of the disease, including mucins that block airways and fibrosis and inflammation. Researchers have identified specific cells responsible for COPD pathology and are screening them against drug libraries to discover new treatments.
Scientists have discovered a way to directly reprogram skin cells into light-sensing rod photoreceptors, enabling blind mice to detect light after transplantation. The technique, which took only 10 days to produce functional cells, has the potential to model eye disease and advance therapies for age-related macular degeneration.
A Stanford study found that exercise restores youthful properties to muscle stem cells of old mice, improving their repair capabilities. The researchers identified a molecular pathway involved in this process and suggest that drugs targeting this pathway could be an effective substitute for exercise.
Researchers at UC San Diego Health are developing a dedicated space stem cell orbital research laboratory within the International Space Station (ISS) to study microgravity's effects on human biology. The studies aim to understand aging, degenerative diseases, and cancers in space, with potential applications for therapeutics on Earth.
Scientists successfully incorporated noncanonical amino acids into human hematopoietic stem cells, enabling the production of ncAA-containing proteins in living organisms. The modified stem cells provided a tool for studying human proteins in cell culture and living systems.
Researchers at Karolinska Institutet have developed a new method to refine the production of retinal cells from embryonic stem cells using CRISPR/Cas9 gene editing. The modified cells can hide from the immune system, reducing the risk of rejection and potentially leading to a new treatment for age-related macular degeneration.
Scientists identified a new control mechanism that enables stem cells to adapt their activity in emergency situations by modifying protein blueprints. Alternative polyadenylation regulates the amount of protein produced and controls protein isoform formation, affecting stability and localization.
A team of researchers has developed a groundbreaking 'cardiac patch with bioink' to repair heart damage. The patch uses genetically engineered stem cells and 3D bioprinting technology to enhance vascular regeneration and improve myocardiocyte survival. The innovative method has shown promising results in treating myocardial infarction.
Researchers at University College London have developed a new way to increase the functionality of umbilical cord blood stem cells, making them more suitable for transplantation. This breakthrough could improve treatment options for patients with blood cancers and other blood disorders.
A new stem cell delivery system using mussel adhesive protein has been developed to efficiently deliver mesenchymal stem cells to damaged cardiac muscular tissues. The system enables prolonged transplantation and promotes rapid integration of transplanted stem cells into surrounding tissues.
Scientists at the Wellcome Sanger Institute discovered that astrocytes in mouse brains are organized into distinct layers with molecular forms depending on their location, redefining brain structure. This knowledge will have implications for understanding neurological disorders like Alzheimer's, multiple sclerosis, and autism.
Researchers discovered that blood stem cells can drive a rapid and efficient immune response if previously exposed to LPS, mimicking an infection. The cells store immune response circuits in their DNA using C/EBP? factor, enabling a more efficient response upon subsequent infections.
Researchers have uncovered mechanisms of healing after a heart attack using human cardiopoietic cells, which restored cardiac muscle to its pre-attack state. The study found that these cells reversed two-thirds of the changes caused by a heart attack, with 85% of cellular functional categories responding favorably to treatment.
Researchers aim to investigate leukaemia stem cells to gain a better understanding of acute myeloid leukaemia (AML) causes and therapies. The study will use isolated single cells from patient samples to analyze characteristic markers, mutations, functional data, and metabolic pathways.
Scientists have successfully turned back the biological hands of time by coaxing adult human cells to revert to a primitive state, unlocking their potential to replace and repair damaged blood vessels in the retina. The findings advance regenerative medicine techniques aimed at reversing diabetic retinopathy.
Researchers at UConn School of Dental Medicine have discovered a population of stem cells residing along vascular channels in bone that can generate new bone-forming cells. These perivascular cells may regulate bone formation and participate in bone mass maintenance.
A new computer model developed by MIT cognitive scientists can quickly generate a detailed scene description from an image, similar to the brain's ability. The model, known as efficient inverse graphics (EIG), reverses the steps used in computer graphics programs to generate images, allowing it to infer underlying features of a scene. ...
Researchers used gene-editing tools to introduce the Parkinson's mutation into marmoset monkey stem cells, creating a primate model for studying disease progression and testing therapies. The edited cells exhibited characteristics of Parkinson's, such as abnormal cellular chemistry and reduced connections with neighboring neurons.
Researchers at Mount Sinai have discovered a method to increase the potency of hematopoietic stem cells, which could improve bone marrow transplants. By manipulating lysosomal activity, they enhanced the potency of these stem cells by over 90-fold.
Researchers at UCSF successfully transplanted stem cells into fetal mice carrying a genetic mutation that causes MPS7, a disorder affecting enzyme production. The treatment improved survival rates and helped sustain the fetus through birth, with potential benefits for related metabolic disorders.
The game, developed by Cambridge sociologists and stem cell scientists, aims to provide a flavor of the lives and labor behind biotechnological advances. Players must balance competing demands, grow cells, and navigate the scientific career ladder while managing relationships and reputation.
Researchers have found a combination of two existing medications that can trigger the release of stem cells from bone marrow, which can aid healing in spinal fractures. The study suggests using these drug combinations could speed up the repair process and potentially lead to new treatments for various bone fractures.
Scientists have successfully used CRISPR/Cas9 base-editing to cure cystic fibrosis in human stem cells, providing a promising new approach for treating genetic diseases. The technique, which repairs mutations without cutting DNA, shows great promise for the future treatment of various genetic disorders.
Researchers propose a new path forward for adipose-based cell therapies in reparative medicine, focusing on patient safety and evidence-based medical practice. The FDA argues that autologous cellular therapies need to demonstrate safety and efficacy before marketing.
Computer simulations visualize the molecular processes involved in converting adult cells into stem cells. The study reveals that a pioneer transcription factor called Oct4 plays a crucial role in opening chromatin to allow gene expression.
Researchers have identified high levels of ketone bodies in the plasma of patients with arrhythmogenic cardiomyopathy as a reliable predictor of disease progression. The biomarker could help track the progression of this inherited heart condition, which can be fatal without warning.
Researchers at the University of York discovered that mutations in stem cells can cause blood cancer by disrupting normal cell communication. The study used super-resolution microscopy to observe how cells receive instructions from signalling proteins, leading to uncontrolled signals and imbalance in healthy blood cells.
Researchers at Texas A&M University have developed biodegradable hydrogels that create a fertile environment for bone stem cells to grow and proliferate. The study found that the space created by degrading hydrogels enables stem cells to thrive, remodel their local environment, and form intricate cellular networks.
Researchers at UCLA and international partners have successfully treated nine patients with X-linked chronic granulomatous disease (X-CGD) using a stem cell gene therapy. Six patients are now in remission and have stopped other treatments, with no complications reported.
Researchers have created a computer algorithm called CytoTRACE that can identify the most dangerous cancer cells by analyzing gene expression. The tool may help target cancer-causing genes and improve treatment outcomes for patients with aggressive forms of breast cancer.
Researchers at the University of Sydney have successfully developed pain-killing neurons using human stem cells, providing lasting relief in mice without side effects. The next step is to conduct safety tests in rodents and pigs before moving to human trials within five years.
Scientists at the University of Pittsburgh School of Medicine have created a biodegradable nerve guide that can regenerate long sections of damaged nerves without stem cells or donor nerves. The technology has been tested in monkeys and shown promising results, including restored nerve conduction and replenished Schwann cells.
The ISSCR is updating its guidelines to address the use of pluripotent stem cells in modeling early human embryo development. The new guidelines outline principles and recommendations for researchers, including oversight by special committees and reporting to Embryo Research Oversight (EMRO) processes.
Dr. Margaret A. Goodell, a renowned hematopoietic stem cell researcher, has been awarded the Tobias Lecture Award by the International Society for Stem Cell Research (ISSCR). Her pioneering work on epigenetic regulators of normal hematopoietic stem cell function has greatly advanced our understanding of hematologic malignancies.
Susan Solomon, CEO of The New York Stem Cell Foundation (NYSCF) Research Institute, receives the 2020 ISSCR Public Service Award for her tireless efforts to support stem cell science and researchers. NYSCF has raised over $350 million for stem cell research projects.
Dr. Allon M. Klein receives the Dr. Susan Lim Award for his groundbreaking contributions to stem cell and developmental biology, including novel approaches to adult stem cell self-renewal and a cell-isolation system for transcriptional analysis.
Dr. Fred H. Gage has made groundbreaking discoveries in stem cell biology, neuroscience, and human evolution. His work has broad implications for treating diseases like Alzheimer's, Parkinson's, and mental health disorders.
Dr. Mitinori Saitou has made groundbreaking contributions to understanding mammalian germ cell development and reproduction in vitro. His work has enabled the generation of functional gametes from pluripotent stem cells and improved germ-cell technology.
Scientists at TU Dresden used a method to stimulate neural stem cells, leading to increased neurons and improved cognitive function in old mice. This study suggests that boosting stem cells may be a promising approach to rejuvenate the brain and counteract aging-related cognitive impairments.
Researchers at Osaka University discovered that ESAM, a surface marker for hematopoietic stem cells and vascular endothelial cells, is crucial for the development of definitive hematopoiesis, especially adult-type erythropoiesis. The study found that ESAM-deficient mice had impaired hematopoiesis-supporting ability.