Articles tagged with Stem Cell Research
Researchers at Mount Sinai have discovered a method to increase the potency of hematopoietic stem cells, which could improve bone marrow transplants. By manipulating lysosomal activity, they enhanced the potency of these stem cells by over 90-fold.
Researchers used gene-editing tools to introduce the Parkinson's mutation into marmoset monkey stem cells, creating a primate model for studying disease progression and testing therapies. The edited cells exhibited characteristics of Parkinson's, such as abnormal cellular chemistry and reduced connections with neighboring neurons.
Researchers at UCSF successfully transplanted stem cells into fetal mice carrying a genetic mutation that causes MPS7, a disorder affecting enzyme production. The treatment improved survival rates and helped sustain the fetus through birth, with potential benefits for related metabolic disorders.
The game, developed by Cambridge sociologists and stem cell scientists, aims to provide a flavor of the lives and labor behind biotechnological advances. Players must balance competing demands, grow cells, and navigate the scientific career ladder while managing relationships and reputation.
Researchers have found a combination of two existing medications that can trigger the release of stem cells from bone marrow, which can aid healing in spinal fractures. The study suggests using these drug combinations could speed up the repair process and potentially lead to new treatments for various bone fractures.
Scientists have successfully used CRISPR/Cas9 base-editing to cure cystic fibrosis in human stem cells, providing a promising new approach for treating genetic diseases. The technique, which repairs mutations without cutting DNA, shows great promise for the future treatment of various genetic disorders.
Researchers propose a new path forward for adipose-based cell therapies in reparative medicine, focusing on patient safety and evidence-based medical practice. The FDA argues that autologous cellular therapies need to demonstrate safety and efficacy before marketing.
Computer simulations visualize the molecular processes involved in converting adult cells into stem cells. The study reveals that a pioneer transcription factor called Oct4 plays a crucial role in opening chromatin to allow gene expression.
Researchers have identified high levels of ketone bodies in the plasma of patients with arrhythmogenic cardiomyopathy as a reliable predictor of disease progression. The biomarker could help track the progression of this inherited heart condition, which can be fatal without warning.
Researchers at the University of York discovered that mutations in stem cells can cause blood cancer by disrupting normal cell communication. The study used super-resolution microscopy to observe how cells receive instructions from signalling proteins, leading to uncontrolled signals and imbalance in healthy blood cells.
Researchers at Texas A&M University have developed biodegradable hydrogels that create a fertile environment for bone stem cells to grow and proliferate. The study found that the space created by degrading hydrogels enables stem cells to thrive, remodel their local environment, and form intricate cellular networks.
Researchers at UCLA and international partners have successfully treated nine patients with X-linked chronic granulomatous disease (X-CGD) using a stem cell gene therapy. Six patients are now in remission and have stopped other treatments, with no complications reported.
Researchers have created a computer algorithm called CytoTRACE that can identify the most dangerous cancer cells by analyzing gene expression. The tool may help target cancer-causing genes and improve treatment outcomes for patients with aggressive forms of breast cancer.
Researchers at the University of Sydney have successfully developed pain-killing neurons using human stem cells, providing lasting relief in mice without side effects. The next step is to conduct safety tests in rodents and pigs before moving to human trials within five years.
Scientists at the University of Pittsburgh School of Medicine have created a biodegradable nerve guide that can regenerate long sections of damaged nerves without stem cells or donor nerves. The technology has been tested in monkeys and shown promising results, including restored nerve conduction and replenished Schwann cells.
The ISSCR is updating its guidelines to address the use of pluripotent stem cells in modeling early human embryo development. The new guidelines outline principles and recommendations for researchers, including oversight by special committees and reporting to Embryo Research Oversight (EMRO) processes.
Dr. Allon M. Klein receives the Dr. Susan Lim Award for his groundbreaking contributions to stem cell and developmental biology, including novel approaches to adult stem cell self-renewal and a cell-isolation system for transcriptional analysis.
Dr. Fred H. Gage has made groundbreaking discoveries in stem cell biology, neuroscience, and human evolution. His work has broad implications for treating diseases like Alzheimer's, Parkinson's, and mental health disorders.
Dr. Mitinori Saitou has made groundbreaking contributions to understanding mammalian germ cell development and reproduction in vitro. His work has enabled the generation of functional gametes from pluripotent stem cells and improved germ-cell technology.
Dr. Margaret A. Goodell, a renowned hematopoietic stem cell researcher, has been awarded the Tobias Lecture Award by the International Society for Stem Cell Research (ISSCR). Her pioneering work on epigenetic regulators of normal hematopoietic stem cell function has greatly advanced our understanding of hematologic malignancies.
Susan Solomon, CEO of The New York Stem Cell Foundation (NYSCF) Research Institute, receives the 2020 ISSCR Public Service Award for her tireless efforts to support stem cell science and researchers. NYSCF has raised over $350 million for stem cell research projects.
Scientists at TU Dresden used a method to stimulate neural stem cells, leading to increased neurons and improved cognitive function in old mice. This study suggests that boosting stem cells may be a promising approach to rejuvenate the brain and counteract aging-related cognitive impairments.
Researchers at Osaka University discovered that ESAM, a surface marker for hematopoietic stem cells and vascular endothelial cells, is crucial for the development of definitive hematopoiesis, especially adult-type erythropoiesis. The study found that ESAM-deficient mice had impaired hematopoiesis-supporting ability.
Researchers have developed a new method to characterise the complex organ of bone marrow, revealing previously unknown cell types and their spatial organisation. The study identifies niche cells that regulate blood stem cells and provides insights into leukaemia treatments.
The Glenn Foundation for Medical Research and AFAR have announced the 2019 Research Grants for Junior Faculty, awarding fifteen early career scientists $1,450,000 to support research on aging processes and age-related diseases. The grants aim to translate basic biology into interventions that can extend healthspan with lifespan.
The study reveals how embryonic cells may be deviated from a default state and awoken to new developmental possibilities during gastrulation. Researchers used scNMT-seq and MOFA computational methods to analyze gene expression, DNA methylation, and chromatin accessibility in single cells from mouse embryos.
Researchers used gene editing and stem cell reprogramming to correct mutations in a human genetic skin disorder, RDEB, in mice. The corrected skin grafts exhibited significant collagen VII deposition and integration, similar to wild-type skin.
Researchers at Baylor College of Medicine have identified a new mechanism that contributes to adult bone maintenance and repair. Periosteal stem cells, previously poorly understood, play a major role in bone healing and respond to mechanical injury and inflammatory molecules, offering potential therapeutic applications for conditions l...
Researchers identified genetic mutations that predict patient outcomes after a stem cell transplant for acute myeloid leukemia (AML) in patients over age 60. Patients with specific gene mutations were classified into low, high, or intermediate-risk groups, enabling personalized treatment approaches.
A new study finds the 'conductor' gene TCX2 in plant root stem cells coordinates division of different types, ensuring harmonic communication for plant growth. The researchers used mathematical modeling and machine learning to identify TCX2's role in regulating stem cell networks.
Hematopoietic stem cells can be purified from zebrafish kidneys using a novel purification scheme that allows researchers to collect these elusive cells. The discovery opens up new avenues for studying blood-based diseases and developing medical treatments.
Scientists at UCLA have discovered a key protein that enables human blood stem cells to self-renew in laboratory conditions. Activating this protein, MLLT3, increases the number of blood stem cells by at least twelvefold, opening up new possibilities for treating blood disorders.
A team led by biomedical engineer Kam Leong has received a $3.2 million NIH grant to develop efficient, noninvasive gene editing methods for the brain. The goal is to overcome current inefficiencies in delivering CRISPR-based gene editing elements to the brain and treat devastating diseases like Alzheimer's.
A study by Stanford University researchers found that omega-3 fatty acids influence stem cell division and fat cell formation. The findings suggest that consuming healthy fats can help regulate body weight and insulin sensitivity.
Scientists at Gladstone Institutes used a machine-learning approach to discover new ways of controlling the spatial organization of induced pluripotent stem cells. The model predicted patterns that could lead to the creation of functional organs for research or therapeutic purposes, and was found to be correct in simulating desired arr...
Scientists at Columbia University have successfully grown fully functional lungs in mouse embryos using transplanted stem cells. The innovative technique has shown promising results, suggesting that it may eventually be possible to generate human lungs in animals for transplantation and studying new treatments.
Researchers from University of Copenhagen have discovered how stem cells can 'forget' their past and develop into specific cell types. The study reveals that transcription factors play a key role in regulating gene expression, rather than driving cellular development.
A study found that spaceflight affects human heart cells' gene expression, but these changes largely revert to normal upon return to Earth. The researchers used induced pluripotent stem cell-derived cardiomyocytes and observed significant changes in gene expression related to mitochondrial function.
Researchers have discovered that dental epithelial stem cells from young mice can regenerate mammary glands and produce milk-producing cells. This breakthrough highlights the exceptional plasticity of these stem cells, which can generate not only dental tissues but also other cell populations.
The New York Stem Cell Foundation (NYSCF) has announced the 2019 class of NYSCF - Robertson Investigators, including Ya-Chieh Hsu, Evangelos Kiskinis, Florian Merkle, Nicholas Bellono, Lauren O'Connell and six others. The award provides $1.5 million over five years to outstanding young scientists.
Binghamton University researchers aim to develop islet-like organoids that can produce insulin, addressing the shortage of usable islets in current treatments. The project uses induced pluripotent stem cells and oxygen-releasing materials to create microenvironments for controlled cell differentiation.
A research team has created a better way to grow an organoid model of the liver, bile duct and pancreas using human pluripotent stem cells. The resulting organoid bears a striking resemblance to its corresponding organs and demonstrates the potential for personalized modeling in studying organ development and disease.
Researchers found that Viagra, combined with Plerixafor, rapidly mobilizes blood stem cells from the bone marrow into the bloodstream in mice. This approach is nearly as effective as the current standard protocol and may be a more attractive option for patients who are very ill or elderly or have undergone chemotherapy.
Researchers at the Hubrecht Institute have created a new method called GateID that allows for the purification of cell types to high purity without using antibodies or genetic reporters. This enables the detailed study of individual cell types, such as stem cells and tumor cells, which are crucial for understanding their properties and...
Researchers develop novel therapies to reverse or prevent myelin loss in PMD patients, identifying iron toxicity as a key factor and discovering a potential treatment using an FDA-approved agent. Clinical trials are planned to test the effectiveness of this treatment in slowing or halting disease progression.
Researchers at the National Institutes of Health have developed a new and improved viral vector that can deliver therapeutic genes more efficiently than conventional vectors. The new vector shows promising results in animal models, with up to 10 times higher efficiency and six times higher carrying capacity.
Researchers at UCLA have identified a molecular process controlling nerve growth, which could inform therapies accelerating peripheral nerve recovery. The study shows that manipulating this process can increase nerve regeneration rate by 15% in mice.
Researchers from the University of Copenhagen and Memorial Sloan Kettering Cancer Center have discovered six proteins essential for directing PRC2 to specific areas in the genome. These findings provide insight into how cells maintain their identity, normal embryonic development, and may impact cancer treatment.
A recent study published in Stem Cells found that bone marrow cells treated patients showed enhanced recovery compared to those who received conventional treatment. Additionally, serial diffusion tensor imaging revealed the repair of motor nerve tracts in some patients, suggesting potential therapeutic benefits for stroke recovery.
Researchers at USC have developed a new method for repurposing cells, which they found to be significantly more reliable than existing techniques. The approach uses enzymes to untangle DNA and has been proven to work in mice and humans with near-perfect efficiency.
Researchers have found a group of antihistamines that can induce differentiation in leukaemic stem cells, leading to cell death. The discovery offers a potential new approach to treating Acute Myeloid Leukaemia (AML), a disease with a high rate of recidivism.
A study of institutional 'report cards' found that although a growing number of women are training in the sciences, they are underrepresented in senior roles and face inadequate policies. The researchers suggest that retaining and promoting women scientists is key to achieving gender parity in STEM.
A four-year study of over 500 research institutions found that promotion, recruitment, and retention of women to senior roles are lacking in STEM. Despite efforts by some institutions to implement supportive policies, the report suggests a persistent need for action to achieve gender equity.
Researchers create a 'clock in a dish' to study human developmental timing, replicating a genetic mutation linked to spondylocostal dysotosis. This breakthrough provides insight into the hard-wired timing within cells and may accelerate cell development for clinical benefit.
Scientists have identified two types of gastric isthmus stem cells with different roles and characteristics in the upper and lower glands. The discovery was made through a joint research project involving South Korea, Austria, and the UK, using advanced techniques such as single-cell transcriptional analysis.
Researchers used a machine learning algorithm to analyze electrical patterns from lab-grown brains and compared them to premature babies' brain activity. The study found that the lab mini-brains produced similar electrical patterns as premature babies, with similar levels of electric activity following a similar pattern.
A new Emmy-Noether Independent Junior Research Group is exploring the mechanisms behind certain bacteria causing disease in some people but not others. The team aims to develop strategies for preventing symptoms and restoring gut health.
Researchers found that Id4 controls whether stem cells remain in a state of rest or enter cell division, with increasing age leading to hyperactive signaling pathway inhibiting cell division.
Research finds that ketone bodies activate Notch signaling pathway, enhancing intestinal stem cell regeneration and function. A ketogenic diet boosts stem cell proliferation and repair damaged intestinal tissue.
Researchers grew 'miniature kidneys' in a lab from patient skin cells to better understand how kidney diseases develop and test potential treatments. The mini kidneys, or organoids, showed promise for personalized therapy approaches.