Articles tagged with Stem Cell Research
The study reveals that brain stem cells use a double-lock mechanism to protect genes that control cell identity, preventing unintended activation. This discovery has great therapeutic potential for reactivating stem cells and could lead to new treatments for neurological disorders.
Researchers used zebrafish and human cells to determine how blood stem cells receive Wnt signaling, discovering the crucial role of the epidermal growth factor receptor. This finding may advance laboratory development of blood stem cells, potentially leading to off-the-shelf treatments for patients with blood diseases.
A new study at the University of Copenhagen found that immature intestinal cells can develop into stem cells based on their surroundings. The discovery may lead to more effective stem cell therapy for non-healing wounds and tissue repair.
Researchers from the University of Edinburgh discovered a protein that switches on an immune response in stem cells, protecting them from viruses. This finding could help develop more efficient stem cell therapies to treat diseases like Parkinson's and diabetes.
Researchers discovered that stem cells with Fanconi anemia tend to use aerobic energy production, leading to diverse symptoms. A specific signaling pathway may be crucial to treating the disease, and a drug inhibiting this pathway is being explored as a potential treatment option.
Using stem cells from six people, researchers recreated retinal cells in the lab and found a specific genetic variation that contributes to AMD. The study suggests that reducing VEGFA expression may be a key factor in the development of AMD.
Researchers at Karolinska Institutet developed a stem cell-based model to study neuron resilience in ALS. The model identified genes contributing to the resilience of oculomotor neurons, which can withstand the disease.
Researchers at IST Austria identified PRC2 as a key protein regulating temporal maturation of stem cells, leading to correct neuron type production. Eliminating PRC2 activity resulted in incorrect neuronal cell type composition and reduced neuron numbers.
Researchers at Harvard University have improved the laboratory process of converting stem cells into insulin-producing beta cells, increasing purity to 80 percent. This breakthrough may improve beta cell transplants for patients with type 1 diabetes.
Researchers at the University of Maryland School of Medicine have discovered pigment-producing stem cells that can regenerate myelin sheaths in mice, potentially treating neurodegenerative diseases like multiple sclerosis. The discovery could offer a less invasive and simpler alternative to embryonic stem cells.
Researchers at Helmholtz Munich discover key molecules in the cell nucleus that orchestrate paraspeckles formation, a structure linked to ALS progression. The discovery provides new insights into pluripotency and differentiation processes, potentially leading to breakthroughs in regenerative medicine and therapeutic strategies for ALS.
Joanne Kurtzberg, MD, has been awarded the 2019 Bernard Sanberg Memorial Award for her groundbreaking work in pediatric hematology and regenerative medicine. The award recognizes her clinical trials that have led to positive results in treating adult ischemic stroke patients with cord blood therapy.
Researchers at Rutgers University have identified a new factor essential for maintaining stem cells in the brain and gut, whose loss contributes to anxiety and cognitive disorders. The study reveals that this gene product supports multiple types of adult stem cells, including those critical for cognitive function and intestinal renewal.
A team of scientists has discovered that the neuronal transport factor Staufen2 scans and binds to its target transcripts in a more complex manner than previously thought. This finding opens up new approaches to improve our understanding of RNA transport and synaptic plasticity, which is essential for memory and learning.
Researchers have discovered that human iPSC-derived MSCs (iMSCs) from aged individuals acquire a rejuvenation-associated 50-gene signature, which is also expressed in pluripotent stem cells. This finding highlights the potential of iMSCs to act via paracrine signalling and circumvent drawbacks associated with adult MSCs.
A new collaboration will create a centralized biobank of induced-pluripotent stem cells for Prader-Willi syndrome, enabling researchers to investigate the genetic basis of the disease and explore potential therapies. The biobank will provide high-quality cellular resources to accelerate research and development of new treatments.
Researchers at the University of Michigan developed a method to improve ovarian follicle development, increasing survival rates from less than 5% to 42-86%. The approach uses adipose-derived stem cells in a 3D scaffold to mimic the ovary environment.
Researchers at Newcastle University develop a potential revolutionary way to treat eye injuries and prevent blindness by using an enzyme to soften the tissue hosting stem cells. This approach has important implications for developing new ways to heal corneal damage, which affects almost 500,000 people worldwide.
Researchers from the University of Pennsylvania have found that a single population of stem cells generates new neurons throughout life in the hippocampus. This process is crucial for healthy learning, memory, and mood adjustment.
Researchers at Tufts University have successfully grown and maintained olfactory stem cells in culture, which can then be used to restore tissue in the nose. The discovery raises hope that future therapies could be developed to restore the sense of smell in individuals where it has been damaged by injury or degeneration.
A new strategy to treat sickle cell disease and beta thalassemia has been developed using CRISPR-Cas9 gene editing, with the goal of achieving durable therapeutic effects. The approach targets blood stem cells and enables efficient production of functional hemoglobin.
Researchers found that aging contributes to a decline in intestinal stem cells, which can lead to disorders of the gastrointestinal tract. Boosting these cells with a compound called nicotinamide riboside (NR) reverses this effect and provides protection against age-related damage.
A research team at Korea Brain Research Institute has developed a technology to produce dorsal cortical neurons utilizing induced pluripotent stem cells and tropical fish collagen. The breakthrough could lead to the treatment of brain diseases such as Parkinson's Disease by mass producing neurons using stem cells.
Researchers have found that modulating blood-forming stem cells' stiffness could help drive them out of the bone marrow and into the blood, but they need to be stiff to stay put. The study, published in Cell Stem Cell, suggests that altering cell biomechanics can improve mobilization regimens for stem cell-based therapy.
Chronic inflammation, not aging, is the main reason why bones heal more slowly with age. Researchers found that exposure to older mice's blood serum reduces stem cell multiplication and increases inflammation. Treatment with anti-inflammatory drugs restored skeletal stem cell function and bone healing ability in aged mice.
Researchers at Tel Aviv University developed a novel biosensor that can isolate and target leukemic stem cells, the most malignant of all leukemic cells. The sensor uses genetic encoding to identify and characterize these cells, which have high regenerative potential and escape targeted therapies.
Researchers have discovered a role for programmed cell death in wound healing and tissue regeneration, potentially paving the way to novel regenerative medicine therapies. Adult stem cells undergo apoptosis, a type of programmed cell death, which can impact their function and fate.
A team of researchers has identified specific factors in stem cell secretions that help protect neurons and reduce the severity of spinal cord injuries linked to spina bifida. The study's findings could pave the way for a cell-free treatment for the birth defect, which can cause lifelong disabilities.
Researchers at LCSB and DKFZ successfully rejuvenated stem cells in the aging brain of mice, improving regeneration of injured areas. The study identified a molecule called sFRP5 that keeps neuronal stem cells inactive, but neutralizing it allowed them to proliferate again.
Researchers identified a novel group of stem cells controlled by mutations in the parade gene, leading to abnormally positioned pigment cells. The study showed that blood vessels play a crucial role in regulating these stem cells.
Researchers found that nicotine disrupts cell-to-cell communication, decreases cell survival and alters gene expression in human embryonic stem cells. This study offers new insights into the effects of nicotine on individual organs and cells within the developing fetus.
Researchers used a mouse model to isolate stem cells in rotator cuff muscles and calf muscles, finding that rotator cuff stem cells develop into fewer muscle cells and more fat cells. DNA-level studies revealed genes involved in fat metabolism were activated in rotator cuff muscle stem cells.
Scientists have identified a key role for protein Akna in regulating neural stem cells via microtubule organization, promoting differentiation and detachment from the niche. This mechanism also plays a crucial role in epithelial-to-mesenchymal transition.
Scientists have developed a new technique using CRISPR-Cas9 gene editing to create pluripotent stem cells that can avoid rejection by the immune system. These 'universal' stem cells can be manufactured more efficiently than individualized cells and bring promise to regenerative medicine.
A University of Minnesota Medical School research breakthrough highlights the potential of cell therapies for treating muscular dystrophy. The study identifies the molecular signature of muscle stem cells generated in vitro and their transformation upon transplantation into mice with muscular dystrophy.
Researchers at Stanford University School of Medicine developed an antibody-based treatment that gently eliminates diseased blood-forming stem cells in the bone marrow. This could circumvent the need for harsh chemotherapy or radiation to prepare people for transplant, expanding the number of patients who can benefit from the procedure.
Researchers have successfully generated functional, transplantable B cells from mice using mouse embryonic stem cells. The study demonstrates that these cells can secrete natural antibodies and maintain themselves for over six months after transplantation.
Scientists at University of California San Diego School of Medicine use single-cell RNA sequencing to define cell types in human testes, opening a path for new strategies to treat male infertility. The study identifies spermatogonial stem cells and biomarkers that could help develop protein cocktails to drive cell proliferation.
Researchers have successfully grown functional mouse kidneys inside rats from just a few donor stem cells, offering a promising solution to the global kidney shortage. The study, published in Nature Communications, used the blastocyst complementation method to generate human stem cell-derived organs.
University of California, Irvine researchers will receive $6 million in funding to support the development of a new treatment for Huntington's disease. The two-year study aims to achieve FDA approval and begin first-in-human clinical trials.
A new method of growing stem cells has been discovered using the tropoelastin protein, which could lead to significant cost savings in treatment options. This breakthrough discovery, published in PNAS, uses a cost-effective approach to encourage the growth and recruitment of mesenchymal stem cells.
Researchers found the immune system plays a crucial role in maintaining healthy intestinal stem cells and preventing bowel cancer by enhancing DNA repair mechanisms. The study discovered that cells of the innate immune system can recognize genotoxic environmental factors, such as glucosinolates, and send signals to epithelial stem cell...
Researchers at the Babraham Institute have identified two proteins, Dppa2 and Dppa4, as key factors responsible for activating the zygotic genome. These findings provide valuable insights into the molecular regulation of early development in mammals, shedding light on a previously unexplored area of human development.
A clinical trial has shown promise in using stem cells from donors to repair the surface of the eye in patients with limbal stem cell deficiency, a significant cause of sight loss. The trial also sheds light on the causes of sight disorders and offers clues about how eye tissue loss could be repaired.
Scientists from JNCASR and inStem successfully created a synthetic mimic of cytoskeletal networks with structural and temporal programming. The system was developed through reaction-driven controlled growth, enabling precise control over one-dimensional growth and self-repairing features.
Researchers at UCLA create mature T cells capable of killing tumor cells from pluripotent stem cells using artificial thymic organoids. This breakthrough technique has the potential to lead to new approaches to cancer immunotherapy and create a virtually unlimited supply of T cells.
Researchers identified a potential pathway for creating effective treatments against CMV, a common viral infection that can be deadly for stem cell transplant patients. A serum containing antibodies matched to the infecting viral strain prevented CMV reactivation after periods of dormancy.
Researchers have developed a breakthrough technology to grow human blood vessels as organoids in a petri dish, which can be used to study vascular diseases and identify potential treatments. The discovery has the potential to unravel causes of conditions such as Alzheimer's disease, cardiovascular diseases, and cancer.
Researchers at NYSCF identified two growth media types that support effective expansion of mesenchymal progenitor cells for bone treatment and repair. MP cells have promise in treating blood, heart, and immune diseases as well as repairing damaged bone and cartilage.
Researchers found defective astrocytes cause accumulation of toxic alpha-synuclein, leading to neuronal death and degeneration. Healthy astrocytes protect neurons from cell death through restored cellular degradation processes.
Researchers have created a method for modifying blood stem cells to reverse the genetic mutation that causes IPEX, a life-threatening autoimmune syndrome. The approach adds a normal copy of the FoxP3 gene to blood stem cells, restoring proper immune regulation and eliminating symptoms in mice.
A recent USC-Stanford study reveals that successfully transplanted stem cells exhibit 'extreme behavior' due to radiation and chemotherapy, whereas healthy cells produce blood and immune cells more evenly. The research also shows that certain stem cells become dormant or biased towards producing specific immune cells.
Researchers at Johns Hopkins Medicine have identified a cellular protein signal that drives both bone and fat formation in stem cells. Harnessing this signal, WISP-1, could help fractures heal faster, speed surgical recovery and prevent bone loss due to aging or injury.
Researchers discover ADAR1 enzyme promotes cancer cell resistance to treatment by hyper-mutating tumor suppressor RNAs. This enzyme may provide a molecular radar for early detection of malignancies and represent a new therapeutic target for preventing cancer cell resistance.
Scientists at the University of Edinburgh have created stem cells that can transform into brain cells and produce dopamine, a key neurotransmitter lost in Parkinson's. The gene-edited cells resisted developing Lewy bodies, a hallmark of Parkinson's disease.
Researchers discovered a novel mechanism for sperm stem cell number control, where cells migrate and compete for fibroblast growth factors (FGFs). This self-organized process regulates stem cell density in the testis, maintaining uniformity despite the absence of a canonical niche.
Researchers have developed a new method to analyze cardiac muscle cells derived from human pluripotent stem cells, using a non-invasive fluorescence technique that enables faster and more accurate analysis. This breakthrough method uses CRISPR-Cas9 to generate a calcium-indicating reporter stem cell line, which allows for the examinati...
Researchers will continue their decade-long study exploring stem-cell therapies that show promise for both animals and humans with spina bifida. The therapy involves using stem cells taken from donor placentas on bioengineered scaffolds to help cover and close wounds, preventing damage to the spinal cords.
Researchers at Lund University have mapped the maturation process of natural killer cells, which play a key role in fighting cancer and infections. The study found that Notch signaling is essential for NK cell development and function, highlighting its potential as a target for immunotherapies.
Scientists at the University of Texas Health Science Center have engineered a novel human stem cell line for skeletal muscle, enabling faster and more efficient generation of muscle stem cells. The breakthrough could lead to disease modeling, gene correction, and potential cell therapy for patients with muscle disorders.