Articles tagged with Stem Cell Research
Researchers at LCSB and DKFZ successfully rejuvenated stem cells in the aging brain of mice, improving regeneration of injured areas. The study identified a molecule called sFRP5 that keeps neuronal stem cells inactive, but neutralizing it allowed them to proliferate again.
Researchers identified a novel group of stem cells controlled by mutations in the parade gene, leading to abnormally positioned pigment cells. The study showed that blood vessels play a crucial role in regulating these stem cells.
Researchers found that nicotine disrupts cell-to-cell communication, decreases cell survival and alters gene expression in human embryonic stem cells. This study offers new insights into the effects of nicotine on individual organs and cells within the developing fetus.
Researchers used a mouse model to isolate stem cells in rotator cuff muscles and calf muscles, finding that rotator cuff stem cells develop into fewer muscle cells and more fat cells. DNA-level studies revealed genes involved in fat metabolism were activated in rotator cuff muscle stem cells.
Scientists have identified a key role for protein Akna in regulating neural stem cells via microtubule organization, promoting differentiation and detachment from the niche. This mechanism also plays a crucial role in epithelial-to-mesenchymal transition.
Scientists have developed a new technique using CRISPR-Cas9 gene editing to create pluripotent stem cells that can avoid rejection by the immune system. These 'universal' stem cells can be manufactured more efficiently than individualized cells and bring promise to regenerative medicine.
A University of Minnesota Medical School research breakthrough highlights the potential of cell therapies for treating muscular dystrophy. The study identifies the molecular signature of muscle stem cells generated in vitro and their transformation upon transplantation into mice with muscular dystrophy.
Researchers at Stanford University School of Medicine developed an antibody-based treatment that gently eliminates diseased blood-forming stem cells in the bone marrow. This could circumvent the need for harsh chemotherapy or radiation to prepare people for transplant, expanding the number of patients who can benefit from the procedure.
Researchers have successfully generated functional, transplantable B cells from mice using mouse embryonic stem cells. The study demonstrates that these cells can secrete natural antibodies and maintain themselves for over six months after transplantation.
Scientists at University of California San Diego School of Medicine use single-cell RNA sequencing to define cell types in human testes, opening a path for new strategies to treat male infertility. The study identifies spermatogonial stem cells and biomarkers that could help develop protein cocktails to drive cell proliferation.
Researchers have successfully grown functional mouse kidneys inside rats from just a few donor stem cells, offering a promising solution to the global kidney shortage. The study, published in Nature Communications, used the blastocyst complementation method to generate human stem cell-derived organs.
University of California, Irvine researchers will receive $6 million in funding to support the development of a new treatment for Huntington's disease. The two-year study aims to achieve FDA approval and begin first-in-human clinical trials.
A new method of growing stem cells has been discovered using the tropoelastin protein, which could lead to significant cost savings in treatment options. This breakthrough discovery, published in PNAS, uses a cost-effective approach to encourage the growth and recruitment of mesenchymal stem cells.
Researchers found the immune system plays a crucial role in maintaining healthy intestinal stem cells and preventing bowel cancer by enhancing DNA repair mechanisms. The study discovered that cells of the innate immune system can recognize genotoxic environmental factors, such as glucosinolates, and send signals to epithelial stem cell...
Researchers at the Babraham Institute have identified two proteins, Dppa2 and Dppa4, as key factors responsible for activating the zygotic genome. These findings provide valuable insights into the molecular regulation of early development in mammals, shedding light on a previously unexplored area of human development.
A clinical trial has shown promise in using stem cells from donors to repair the surface of the eye in patients with limbal stem cell deficiency, a significant cause of sight loss. The trial also sheds light on the causes of sight disorders and offers clues about how eye tissue loss could be repaired.
Scientists from JNCASR and inStem successfully created a synthetic mimic of cytoskeletal networks with structural and temporal programming. The system was developed through reaction-driven controlled growth, enabling precise control over one-dimensional growth and self-repairing features.
Researchers at UCLA create mature T cells capable of killing tumor cells from pluripotent stem cells using artificial thymic organoids. This breakthrough technique has the potential to lead to new approaches to cancer immunotherapy and create a virtually unlimited supply of T cells.
Researchers identified a potential pathway for creating effective treatments against CMV, a common viral infection that can be deadly for stem cell transplant patients. A serum containing antibodies matched to the infecting viral strain prevented CMV reactivation after periods of dormancy.
Researchers have developed a breakthrough technology to grow human blood vessels as organoids in a petri dish, which can be used to study vascular diseases and identify potential treatments. The discovery has the potential to unravel causes of conditions such as Alzheimer's disease, cardiovascular diseases, and cancer.
Researchers at NYSCF identified two growth media types that support effective expansion of mesenchymal progenitor cells for bone treatment and repair. MP cells have promise in treating blood, heart, and immune diseases as well as repairing damaged bone and cartilage.
Researchers have created a method for modifying blood stem cells to reverse the genetic mutation that causes IPEX, a life-threatening autoimmune syndrome. The approach adds a normal copy of the FoxP3 gene to blood stem cells, restoring proper immune regulation and eliminating symptoms in mice.
Researchers found defective astrocytes cause accumulation of toxic alpha-synuclein, leading to neuronal death and degeneration. Healthy astrocytes protect neurons from cell death through restored cellular degradation processes.
A recent USC-Stanford study reveals that successfully transplanted stem cells exhibit 'extreme behavior' due to radiation and chemotherapy, whereas healthy cells produce blood and immune cells more evenly. The research also shows that certain stem cells become dormant or biased towards producing specific immune cells.
Researchers at Johns Hopkins Medicine have identified a cellular protein signal that drives both bone and fat formation in stem cells. Harnessing this signal, WISP-1, could help fractures heal faster, speed surgical recovery and prevent bone loss due to aging or injury.
Researchers discover ADAR1 enzyme promotes cancer cell resistance to treatment by hyper-mutating tumor suppressor RNAs. This enzyme may provide a molecular radar for early detection of malignancies and represent a new therapeutic target for preventing cancer cell resistance.
Researchers discovered a novel mechanism for sperm stem cell number control, where cells migrate and compete for fibroblast growth factors (FGFs). This self-organized process regulates stem cell density in the testis, maintaining uniformity despite the absence of a canonical niche.
Scientists at the University of Edinburgh have created stem cells that can transform into brain cells and produce dopamine, a key neurotransmitter lost in Parkinson's. The gene-edited cells resisted developing Lewy bodies, a hallmark of Parkinson's disease.
Researchers have developed a new method to analyze cardiac muscle cells derived from human pluripotent stem cells, using a non-invasive fluorescence technique that enables faster and more accurate analysis. This breakthrough method uses CRISPR-Cas9 to generate a calcium-indicating reporter stem cell line, which allows for the examinati...
Researchers will continue their decade-long study exploring stem-cell therapies that show promise for both animals and humans with spina bifida. The therapy involves using stem cells taken from donor placentas on bioengineered scaffolds to help cover and close wounds, preventing damage to the spinal cords.
Researchers at Lund University have mapped the maturation process of natural killer cells, which play a key role in fighting cancer and infections. The study found that Notch signaling is essential for NK cell development and function, highlighting its potential as a target for immunotherapies.
Scientists at the University of Texas Health Science Center have engineered a novel human stem cell line for skeletal muscle, enabling faster and more efficient generation of muscle stem cells. The breakthrough could lead to disease modeling, gene correction, and potential cell therapy for patients with muscle disorders.
Researchers at Michigan State University have identified YAP1 and WWTR1 as crucial proteins in regulating the balance between pluripotent cells and placenta formation. This discovery sheds light on the natural process of creating embryonic stem cells, which could lead to advances in regenerative medicine and organoid technologies.
Researchers developed a rapid screening method to evaluate drug responses of leukemia stem cells and blast cells from individual patients. The study revealed unique drug susceptibility patterns, with promising targets identified for patient-specific therapies.
Researchers at the Hubrecht Institute found that adult hearts do not have stem cells that can regenerate lost heart muscle after a heart attack. Instead, connective tissue cells produce scar tissue to replace the lost cardiac muscle, which helps maintain heart integrity.
Researchers at Columbia University Irving Medical Center found that circulating white blood cells from donors contain matured cells that educate recipients' immune system to be tolerant of donated tissues. The study suggests new strategies for managing organ transplantation and reducing immunosuppression.
Scientists have mapped the signal determining pancreatic progenitor cell fate, enabling the manufacturing of insulin-producing beta cells from stem cells. The research facilitates combating type 1 diabetes by understanding how extracellular matrix interactions influence cell destiny.
Healthy blood stem cells exhibit a similar number of DNA mutations as those found in leukemic cells, suggesting that the location of these mutations is more relevant than their quantity. This study's findings have implications for understanding the origins of leukemia and developing targeted treatments.
Stem cells derived from fat tissue can now be used to produce functioning platelets in just 12 days. This breakthrough could provide a reliable and safe supply of platelets for patients with cancer and other disorders, reducing the reliance on donated platelets.
A liquid nitrogen storage tank failure at a fertility center resulted in the loss of over 4,000 frozen eggs and embryos. Researchers argue that a ruling in favor of a couple's wrongful death lawsuit could lead to limits on abortion, stem cell research, and IVF.
The discovery of human embryonic stem cells in 1998 revolutionized regenerative medicine, with 29 clinical trials underway globally. The field has grown exponentially, enabling large-scale production of pure cells for research, and nearly $1.43 billion spent on NIH stem cell research over the past 20 years.
Researchers found that reproductive stem cells boost production of non-coding RNA elements to suppress jumping gene activity and activate DNA repair processes, enabling normal egg development. Temperature influences sterility in fruit flies, with a specific temperature range controlling jumping gene invasion intensity.
Researchers at the University of Houston have developed a new environment for repairing eyes using hyaluronic acid. By creating an ideal substrate layer with high concentrations of hyaluronic acid, they aim to improve the treatment of patients with limbal stem cell deficiency, which can lead to opaque corneas.
The new law allows investigational stem cell treatments for patients with certain severe chronic diseases or terminal illnesses, sparking debate over increased access vs. unproven treatments.
A team of scientists has identified a key protein that triggers the activation of mammary stem cells during puberty, leading to the rapid expansion of the mammary gland. FoxP1 plays a crucial role in switching off proteins that keep mammary stem cells dormant, allowing them to divide and drive growth.
Researchers at Stanford University discovered that adult mouse skeletal stem cells revert to an earlier developmental stage when tasked with regenerating large portions of bone and tissue. This process, called de-differentiation, allows the cells to become more primitive and express genes typically found in early embryonic development.
A new method developed by MIT researchers helps blood cells regenerate faster after radiation therapy, which can help leukemia and lymphoma patients recover from bone marrow irradiation. The technique involves stimulating stem cells to secrete growth factors that aid in the differentiation of precursor cells into mature blood cells.
The New York Stem Cell Foundation has selected six promising researchers for its 2018 class of NYSCF-Robertson Investigators. These scientists will receive $1.5 million in funding to pursue high-risk, high-reward research projects in stem cell biology and neuroscience.
Researchers find that the autonomic nervous system directly controls stem cell proliferation in the intestinal lining and potentially other parts of the body. This discovery opens up new avenues for targeting cancer stem cells or inducing desired tissue growth through targeted drug delivery.
A study published in Nature Communications sheds light on how intercellular communication influences the differentiation of embryonic stem cells. Researchers discovered a potential mechanism to control the rate of differentiation without affecting the overall patterning of resulting multicellular tissues.
Researchers have successfully produced healthy mice with two mothers, who go on to have normal offspring of their own. In contrast, mice with two fathers only survived for a couple of days. The breakthrough uses haploid embryonic stem cells and targeted gene editing to overcome genomic imprinting barriers.
Researchers used human retinal tissue grown from stem cells to discover how cone photoreceptors develop, leading to insights into eye diseases like color blindness. Thyroid hormone signaling regulated the growth of blue-detecting cones first, followed by red- and green-detecting ones.
Researchers at the Gladstone Institutes have developed a new method to study the earliest stages of human development, mimicking how cells self-organize into distinct populations. By silencing specific genes in human pluripotent stem cells, they created ring patterns that influence cell behavior and future identity.
Researchers at the University of Minnesota Medical School have discovered a subset of muscle stem cells that are located close to blood vessels and are likely to be the more potent stem cell population in maintaining muscle health. This groundbreaking study uses 3D technology to study the interaction between stem cells and blood vessel...
Researchers report on the most in-depth study to date of how human stem cells can be turned into heart cells, revealing unique patterns of gene activity associated with cardiac cell development. The findings provide new insights into how the heart builds itself and may lead to new approaches for repairing damaged hearts.
USC Stem Cell scientist Andy McMahon and collaborators aim to identify key proteins enabling organs to communicate with each other. By using a tiny molecule as a tag, the team hopes to develop a new tool to enhance knowledge of normal physiology and disease.
A unique source of stem cells in blood helps build blood vessels in embryos, contradicting previous theories. This finding brings scientists closer to using stem cells to repair damaged blood vessels and treat heart and circulatory diseases.
Researchers developed a novel method to enhance native stem cell bioelectric signals, achieving ultra-high current levels two-orders of magnitude higher than previous methods. The new method uses 2D-molybdenum disulphide sheets, demonstrating improved commercialization and therapeutic safety for future stem cell-based therapies.
Researchers at Cincinnati Children's Hospital Medical Center successfully grew human esophageal organoids using pluripotent stem cells, enabling the study of diseases like esophageal cancer and gastroesophageal reflux disease. The bioengineered tissues were compared to patient biopsies and showed striking similarities in composition.
The discovery of the human skeletal stem cell could lead to treatments for regenerating bone and cartilage in people. The researchers created a family tree of stem cells important to the development and maintenance of the human skeleton.