Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Researchers have created a method for modifying blood stem cells to reverse the genetic mutation that causes IPEX, a life-threatening autoimmune syndrome. The approach adds a normal copy of the FoxP3 gene to blood stem cells, restoring proper immune regulation and eliminating symptoms in mice.
A recent USC-Stanford study reveals that successfully transplanted stem cells exhibit 'extreme behavior' due to radiation and chemotherapy, whereas healthy cells produce blood and immune cells more evenly. The research also shows that certain stem cells become dormant or biased towards producing specific immune cells.
Researchers at Johns Hopkins Medicine have identified a cellular protein signal that drives both bone and fat formation in stem cells. Harnessing this signal, WISP-1, could help fractures heal faster, speed surgical recovery and prevent bone loss due to aging or injury.
Researchers discover ADAR1 enzyme promotes cancer cell resistance to treatment by hyper-mutating tumor suppressor RNAs. This enzyme may provide a molecular radar for early detection of malignancies and represent a new therapeutic target for preventing cancer cell resistance.
Researchers discovered a novel mechanism for sperm stem cell number control, where cells migrate and compete for fibroblast growth factors (FGFs). This self-organized process regulates stem cell density in the testis, maintaining uniformity despite the absence of a canonical niche.
Scientists at the University of Edinburgh have created stem cells that can transform into brain cells and produce dopamine, a key neurotransmitter lost in Parkinson's. The gene-edited cells resisted developing Lewy bodies, a hallmark of Parkinson's disease.
Researchers have developed a new method to analyze cardiac muscle cells derived from human pluripotent stem cells, using a non-invasive fluorescence technique that enables faster and more accurate analysis. This breakthrough method uses CRISPR-Cas9 to generate a calcium-indicating reporter stem cell line, which allows for the examinati...
Researchers will continue their decade-long study exploring stem-cell therapies that show promise for both animals and humans with spina bifida. The therapy involves using stem cells taken from donor placentas on bioengineered scaffolds to help cover and close wounds, preventing damage to the spinal cords.
Researchers at Lund University have mapped the maturation process of natural killer cells, which play a key role in fighting cancer and infections. The study found that Notch signaling is essential for NK cell development and function, highlighting its potential as a target for immunotherapies.
Scientists at the University of Texas Health Science Center have engineered a novel human stem cell line for skeletal muscle, enabling faster and more efficient generation of muscle stem cells. The breakthrough could lead to disease modeling, gene correction, and potential cell therapy for patients with muscle disorders.
Researchers at Michigan State University have identified YAP1 and WWTR1 as crucial proteins in regulating the balance between pluripotent cells and placenta formation. This discovery sheds light on the natural process of creating embryonic stem cells, which could lead to advances in regenerative medicine and organoid technologies.
Researchers developed a rapid screening method to evaluate drug responses of leukemia stem cells and blast cells from individual patients. The study revealed unique drug susceptibility patterns, with promising targets identified for patient-specific therapies.
Researchers at the Hubrecht Institute found that adult hearts do not have stem cells that can regenerate lost heart muscle after a heart attack. Instead, connective tissue cells produce scar tissue to replace the lost cardiac muscle, which helps maintain heart integrity.
Researchers at Columbia University Irving Medical Center found that circulating white blood cells from donors contain matured cells that educate recipients' immune system to be tolerant of donated tissues. The study suggests new strategies for managing organ transplantation and reducing immunosuppression.
Stem cells derived from fat tissue can now be used to produce functioning platelets in just 12 days. This breakthrough could provide a reliable and safe supply of platelets for patients with cancer and other disorders, reducing the reliance on donated platelets.
Scientists have mapped the signal determining pancreatic progenitor cell fate, enabling the manufacturing of insulin-producing beta cells from stem cells. The research facilitates combating type 1 diabetes by understanding how extracellular matrix interactions influence cell destiny.
Healthy blood stem cells exhibit a similar number of DNA mutations as those found in leukemic cells, suggesting that the location of these mutations is more relevant than their quantity. This study's findings have implications for understanding the origins of leukemia and developing targeted treatments.
A liquid nitrogen storage tank failure at a fertility center resulted in the loss of over 4,000 frozen eggs and embryos. Researchers argue that a ruling in favor of a couple's wrongful death lawsuit could lead to limits on abortion, stem cell research, and IVF.
Researchers found that reproductive stem cells boost production of non-coding RNA elements to suppress jumping gene activity and activate DNA repair processes, enabling normal egg development. Temperature influences sterility in fruit flies, with a specific temperature range controlling jumping gene invasion intensity.
The discovery of human embryonic stem cells in 1998 revolutionized regenerative medicine, with 29 clinical trials underway globally. The field has grown exponentially, enabling large-scale production of pure cells for research, and nearly $1.43 billion spent on NIH stem cell research over the past 20 years.
Researchers at the University of Houston have developed a new environment for repairing eyes using hyaluronic acid. By creating an ideal substrate layer with high concentrations of hyaluronic acid, they aim to improve the treatment of patients with limbal stem cell deficiency, which can lead to opaque corneas.
The new law allows investigational stem cell treatments for patients with certain severe chronic diseases or terminal illnesses, sparking debate over increased access vs. unproven treatments.
A team of scientists has identified a key protein that triggers the activation of mammary stem cells during puberty, leading to the rapid expansion of the mammary gland. FoxP1 plays a crucial role in switching off proteins that keep mammary stem cells dormant, allowing them to divide and drive growth.
Researchers at Stanford University discovered that adult mouse skeletal stem cells revert to an earlier developmental stage when tasked with regenerating large portions of bone and tissue. This process, called de-differentiation, allows the cells to become more primitive and express genes typically found in early embryonic development.
A new method developed by MIT researchers helps blood cells regenerate faster after radiation therapy, which can help leukemia and lymphoma patients recover from bone marrow irradiation. The technique involves stimulating stem cells to secrete growth factors that aid in the differentiation of precursor cells into mature blood cells.
The New York Stem Cell Foundation has selected six promising researchers for its 2018 class of NYSCF-Robertson Investigators. These scientists will receive $1.5 million in funding to pursue high-risk, high-reward research projects in stem cell biology and neuroscience.
Researchers find that the autonomic nervous system directly controls stem cell proliferation in the intestinal lining and potentially other parts of the body. This discovery opens up new avenues for targeting cancer stem cells or inducing desired tissue growth through targeted drug delivery.
A study published in Nature Communications sheds light on how intercellular communication influences the differentiation of embryonic stem cells. Researchers discovered a potential mechanism to control the rate of differentiation without affecting the overall patterning of resulting multicellular tissues.
Researchers used human retinal tissue grown from stem cells to discover how cone photoreceptors develop, leading to insights into eye diseases like color blindness. Thyroid hormone signaling regulated the growth of blue-detecting cones first, followed by red- and green-detecting ones.
Researchers have successfully produced healthy mice with two mothers, who go on to have normal offspring of their own. In contrast, mice with two fathers only survived for a couple of days. The breakthrough uses haploid embryonic stem cells and targeted gene editing to overcome genomic imprinting barriers.
Researchers at the Gladstone Institutes have developed a new method to study the earliest stages of human development, mimicking how cells self-organize into distinct populations. By silencing specific genes in human pluripotent stem cells, they created ring patterns that influence cell behavior and future identity.
Researchers report on the most in-depth study to date of how human stem cells can be turned into heart cells, revealing unique patterns of gene activity associated with cardiac cell development. The findings provide new insights into how the heart builds itself and may lead to new approaches for repairing damaged hearts.
Researchers at the University of Minnesota Medical School have discovered a subset of muscle stem cells that are located close to blood vessels and are likely to be the more potent stem cell population in maintaining muscle health. This groundbreaking study uses 3D technology to study the interaction between stem cells and blood vessel...
USC Stem Cell scientist Andy McMahon and collaborators aim to identify key proteins enabling organs to communicate with each other. By using a tiny molecule as a tag, the team hopes to develop a new tool to enhance knowledge of normal physiology and disease.
A unique source of stem cells in blood helps build blood vessels in embryos, contradicting previous theories. This finding brings scientists closer to using stem cells to repair damaged blood vessels and treat heart and circulatory diseases.
Researchers developed a novel method to enhance native stem cell bioelectric signals, achieving ultra-high current levels two-orders of magnitude higher than previous methods. The new method uses 2D-molybdenum disulphide sheets, demonstrating improved commercialization and therapeutic safety for future stem cell-based therapies.
The discovery of the human skeletal stem cell could lead to treatments for regenerating bone and cartilage in people. The researchers created a family tree of stem cells important to the development and maintenance of the human skeleton.
Human skeletal stem cells have been isolated from fetal and adult bones, providing a breakthrough in understanding the molecular diagnosis and treatment of skeletal diseases. The discovery enables researchers to create a detailed lineage map of stem-cell-mediated formation of skeletal tissues in humans.
Researchers at Cincinnati Children's Hospital Medical Center successfully grew human esophageal organoids using pluripotent stem cells, enabling the study of diseases like esophageal cancer and gastroesophageal reflux disease. The bioengineered tissues were compared to patient biopsies and showed striking similarities in composition.
Scientists at Virginia Tech Carilion Research Institute have identified a potential strategy in fighting brain cancer by targeting a gene associated with circadian rhythms. Inhibiting this gene may inhibit cancer stem cells from renewing themselves and differentiating into glioblastoma cells.
Researchers identified unique cell populations in human joint cartilage, crucial for cushioning and often lost in arthritis. Stem cell-derived cartilage can be transplanted into arthritic rats to regenerate the superficial zone, potentially leading to better treatments.
A new study approach reveals that healthy adults have between 50,000 and 200,000 blood-creating stem cells in their bone marrow. This finding opens up new opportunities for studying how stem cells change during ageing and disease, and may lead to insights into cancer development and effective stem cell therapies.
A new study reveals that c-MYC induces the production of a transcription factor, increasing the numbers of stem cells in the intestinal epithelium and contributing to adenoma formation. The loss of Ap4 protein leads to reduced tumors and longer survival, indicating its role in controlling intestinal homeostasis.
Studies with rodent models show reduced anxiety and improved brain function with early treatment using the histone deacetylase inhibitor LBH589. This approach may offer a new therapeutic strategy for Huntington disease.
Researchers at Duke-NUS Medical School discovered that gut stem cells have a unique population of cells with intrinsic toxin resistance, enabling them to withstand drugs and spicy foods. These 'drug efflux pumps' protect the gut from toxic compounds, promoting intestinal regeneration and overall health.
A new method allows for rapid generation of functional brain cells, known as astrocytes, from embryonic stem cells in just two weeks. This breakthrough enables researchers to study the role of astrocytes in various diseases, including neurodegenerative conditions such as dementia and ALS.
Researchers have identified Tbx6 as a key transcription factor in the formation of mesoderm from stem cells. The study found that Tbx6 induces mesoderm formation and controls cardiac versus somite lineage diversification, with potential applications in regenerative medicine.
Researchers demonstrate that a single transplantation of iPSC-derived macrophages into the lungs of mice with herPAP can effectively treat this life-threatening disease. The transplanted macrophages adapt and differentiate to function efficiently, providing long-term therapeutic benefits.
Experts believe extending the current 14-day limit would allow scientists to study embryonic development and improve IVF procedures. This could also enable research into 'organoids' - miniature human organs created in labs.
Researchers have identified a way to expand blood-forming adult stem cells from human umbilical cord blood, increasing their availability for transplant patients. This breakthrough could lead to more people being able to receive life-saving treatments without a suitable bone marrow match.
Researchers at the University of Adelaide successfully applied cell transplantation therapy to replace damaged cells in CF patients, providing a potential cure. The innovative method involves harvesting adult stem cells from the lungs, correcting them with gene therapy, and reintroducing them back into the patient.
A new stem cell model developed by City of Hope researchers provides insight into the disease pathway of Alexander disease, a rare nervous system disorder. The study found that therapies targeting CHI3L1 protein may be able to treat Alexander's disease or leukodystrophic diseases.
Researchers have found a possible active substance against the hepatitis E virus in naturally occurring silvestrol, which inhibits pathogen replication in cell cultures and mice. Silvestrol is formed by mahogany plants and has been shown to be effective against the virus in both lab tests and animal models.
Researchers at the University of Guelph have discovered that leopard geckos can create new brain cells using a specific type of stem cell. This finding has implications for treating brain injuries and diseases, as it suggests that geckos may be able to regenerate parts of their brains.
UNIGE researchers found that bioelectrical potential is a driving force for stem cells to generate different types of neurons during embryogenesis. This discovery reveals an unexpected role for electrical charge in generating neuronal diversity, which could help explain how neurological disorders affect brain development.
A recent study found that Programmed Cell Death-1 (PD-1) is crucial for the self-renewal and differentiation of dental pulp stem cells. Removal of PD-1 from these cells led to reduced proliferation rates, highlighting its importance in maintaining stem cell function.
Researchers have successfully generated brain tissue with all major cell types using organoid technology, providing a more accurate representation of human brain development. This breakthrough enables the study of neurological diseases such as multiple sclerosis and Pelizaeus-Merzbacher disease in laboratory-dish models.
Researchers have developed a new procedure to generate human brain 'organoids' capable of myelination, modeling the brain's structure and function more closely than ever. This breakthrough could lead to better understanding and treatment of neurological diseases such as multiple sclerosis and Pelizaeus-Merzbacher disease.
Scientists at the University of Cambridge have successfully generated key life event in artificial mouse embryo created from stem cells. The team used three types of stem cells to reconstruct the process of gastrulation, a crucial step in embryonic development.
The SLAS Technology special issue showcases advancements in cell separation methods, bioreactor systems and automation to improve the manufacturing process of cell-based therapies. These technologies aim to decrease costs and enhance safety while expanding applications beyond oncology.