Articles tagged with Stem Cell Research
Human skeletal stem cells have been isolated from fetal and adult bones, providing a breakthrough in understanding the molecular diagnosis and treatment of skeletal diseases. The discovery enables researchers to create a detailed lineage map of stem-cell-mediated formation of skeletal tissues in humans.
Scientists at Virginia Tech Carilion Research Institute have identified a potential strategy in fighting brain cancer by targeting a gene associated with circadian rhythms. Inhibiting this gene may inhibit cancer stem cells from renewing themselves and differentiating into glioblastoma cells.
Researchers identified unique cell populations in human joint cartilage, crucial for cushioning and often lost in arthritis. Stem cell-derived cartilage can be transplanted into arthritic rats to regenerate the superficial zone, potentially leading to better treatments.
A new study approach reveals that healthy adults have between 50,000 and 200,000 blood-creating stem cells in their bone marrow. This finding opens up new opportunities for studying how stem cells change during ageing and disease, and may lead to insights into cancer development and effective stem cell therapies.
A new study reveals that c-MYC induces the production of a transcription factor, increasing the numbers of stem cells in the intestinal epithelium and contributing to adenoma formation. The loss of Ap4 protein leads to reduced tumors and longer survival, indicating its role in controlling intestinal homeostasis.
Studies with rodent models show reduced anxiety and improved brain function with early treatment using the histone deacetylase inhibitor LBH589. This approach may offer a new therapeutic strategy for Huntington disease.
Researchers at Duke-NUS Medical School discovered that gut stem cells have a unique population of cells with intrinsic toxin resistance, enabling them to withstand drugs and spicy foods. These 'drug efflux pumps' protect the gut from toxic compounds, promoting intestinal regeneration and overall health.
A new method allows for rapid generation of functional brain cells, known as astrocytes, from embryonic stem cells in just two weeks. This breakthrough enables researchers to study the role of astrocytes in various diseases, including neurodegenerative conditions such as dementia and ALS.
Researchers demonstrate that a single transplantation of iPSC-derived macrophages into the lungs of mice with herPAP can effectively treat this life-threatening disease. The transplanted macrophages adapt and differentiate to function efficiently, providing long-term therapeutic benefits.
Researchers have identified Tbx6 as a key transcription factor in the formation of mesoderm from stem cells. The study found that Tbx6 induces mesoderm formation and controls cardiac versus somite lineage diversification, with potential applications in regenerative medicine.
Experts believe extending the current 14-day limit would allow scientists to study embryonic development and improve IVF procedures. This could also enable research into 'organoids' - miniature human organs created in labs.
Researchers have identified a way to expand blood-forming adult stem cells from human umbilical cord blood, increasing their availability for transplant patients. This breakthrough could lead to more people being able to receive life-saving treatments without a suitable bone marrow match.
A new stem cell model developed by City of Hope researchers provides insight into the disease pathway of Alexander disease, a rare nervous system disorder. The study found that therapies targeting CHI3L1 protein may be able to treat Alexander's disease or leukodystrophic diseases.
Researchers at the University of Adelaide successfully applied cell transplantation therapy to replace damaged cells in CF patients, providing a potential cure. The innovative method involves harvesting adult stem cells from the lungs, correcting them with gene therapy, and reintroducing them back into the patient.
Researchers have found a possible active substance against the hepatitis E virus in naturally occurring silvestrol, which inhibits pathogen replication in cell cultures and mice. Silvestrol is formed by mahogany plants and has been shown to be effective against the virus in both lab tests and animal models.
Researchers at the University of Guelph have discovered that leopard geckos can create new brain cells using a specific type of stem cell. This finding has implications for treating brain injuries and diseases, as it suggests that geckos may be able to regenerate parts of their brains.
UNIGE researchers found that bioelectrical potential is a driving force for stem cells to generate different types of neurons during embryogenesis. This discovery reveals an unexpected role for electrical charge in generating neuronal diversity, which could help explain how neurological disorders affect brain development.
Researchers have developed a new procedure to generate human brain 'organoids' capable of myelination, modeling the brain's structure and function more closely than ever. This breakthrough could lead to better understanding and treatment of neurological diseases such as multiple sclerosis and Pelizaeus-Merzbacher disease.
A recent study found that Programmed Cell Death-1 (PD-1) is crucial for the self-renewal and differentiation of dental pulp stem cells. Removal of PD-1 from these cells led to reduced proliferation rates, highlighting its importance in maintaining stem cell function.
Researchers have successfully generated brain tissue with all major cell types using organoid technology, providing a more accurate representation of human brain development. This breakthrough enables the study of neurological diseases such as multiple sclerosis and Pelizaeus-Merzbacher disease in laboratory-dish models.
Scientists at the University of Cambridge have successfully generated key life event in artificial mouse embryo created from stem cells. The team used three types of stem cells to reconstruct the process of gastrulation, a crucial step in embryonic development.
The SLAS Technology special issue showcases advancements in cell separation methods, bioreactor systems and automation to improve the manufacturing process of cell-based therapies. These technologies aim to decrease costs and enhance safety while expanding applications beyond oncology.
Harvard researchers create a scale model of a beating heart ventricle using human heart cells and nanofiber scaffolds. The model can be used to study heart function and test new treatments for arrhythmia and other conditions.
The NYSCF Research Institute has developed a novel bioengineering technique called Segmental Additive Tissue Engineering (SATE), allowing for the creation of large-scale, personalized bone grafts. This technology overcomes limitations of current treatments, such as immune rejection and limited size and shape options.
Researchers at NUS have successfully reprogrammed mature cells into pluripotent stem cells by confining them in a defined geometric space for an extended period. By the 10th day, the cells expressed genes associated with embryonic stem cells and iPSCs, indicating complete transition into re-deployable stem cells.
Researchers found that adult stem cells in the intestines are replaced by fetal growth genes after parasite injury, enabling rapid wound repair. This discovery could lead to new treatments for internal wounds and improve understanding of mammalian body repair mechanisms.
Researchers identified adventitial CD90+ and mesenchymal stem cells in human arteries for the first time, providing a clear link to vascular diseases like coronary artery disease. These cells appear to play a key role in mediating vascular diseases.
A team of scientists from McGill University discovered a key role for the GRIN2B gene in early neural stem cell development and autism. They used genetic engineering to reprogram skin cells into brain cells with the patient's mutation, showing how improper protein production leads to impaired brain development.
Lund University researchers have developed a fluorescent variant of salinomycin to understand its mechanism against cancer stem cells. The molecule rapidly passes through the outer cell membrane and acts as an ion transporter in the endoplasmic reticulum, leading to a reduction in cancer stem cells
Researchers at Harvard University have discovered that the 'blood stem cell niche' evolved to protect blood stem cells from ultraviolet (UV) rays in sunlight. This finding has significant implications for improving the safety of blood stem cell transplants, a procedure used to treat patients with blood diseases and cancers.
Researchers from Newcastle University discovered that human embryonic stem cells travel back and forth in a line, revealing subtle patterns to their movement. This finding has important implications for the development of computer models to predict and control stem cell evolution.
A first-in-human phase I clinical trial using neural stem cells to treat chronic spinal cord injuries showed measurable improvement in three of four participants. No serious adverse effects were observed, suggesting the approach can be performed safely.
Scientists have developed a method to track biological samples using RFID chips, which can withstand extreme conditions and identify organoids grown from stem cells. This technology has the potential to advance drug testing and transplantation by providing real-time data on organoid health.
Researchers discovered that blood stem cells with a genetic mutation can be compensated by normal stem cells producing specific types of immune cells. Key findings suggest these highly productive stem cells proliferate dramatically and maintain a balanced immune system when transplanted into mice.
Researchers at Duke-NUS Medical School have identified CK1 as the priming kinase that 'switches on' the biological clock's phosphorylation process, shedding light on circadian rhythm regulation. This discovery may lead to treatments for circadian clock disorders and improve sleep-wake cycles.
Researchers at Helmholtz Zentrum München discovered that cerebrospinal fluid flow stimulates neural stem cell division through ENaC channel protein. The study highlights a new mechanism controlling neural stem cell proliferation and has implications for brain function and treatment.
Researchers at the University of Washington School of Medicine developed a robotic system to rapidly produce human mini-organs derived from stem cells, expanding basic research and drug discovery capabilities. The new technology enables mass production of organoids, which resemble rudimentary organs and behave similarly.
Researchers successfully convert mature skin cells into immature muscle cells using a simple approach, promoting muscle regeneration in injured mice. The induced myogenic progenitor cells (iMPCs) engrafted in damaged tissue and contributed to sustained muscle regeneration.
Researchers at University of Illinois Chicago have created atrial cells from pluripotent stem cells using vitamin A. This breakthrough enables better study of atrial fibrillation and potential personalized treatments.
A 24-hour fast can reverse age-related decline in intestinal stem cells' regenerative capacity. Fasting induces a metabolic switch that enhances stem cell function, which can be reproduced by activating PPARs with a molecule.
A UMD researcher has discovered mechanisms dictating germline stem cell development and epigenetic markers associated with diseases such as cancers, viral infections, and male infertility. These findings provide insight into treatments for these conditions and unlock future animal and human health research.
A new study has identified a critical stage in human embryonic development that may contribute to infertility and miscarriage. The research, led by UCLA biologist Amander Clark, reveals that epigenomic changes in early embryonic stem cells play a crucial role in determining embryo viability.
A new review concludes that stem cells derived from adult body tissues can differentiate into mature body cells with similar efficiency to those from younger donors. This validates induced pluripotent stem cells (iPSCs) as a viable alternative to embryonic stem cells in regenerative medicine.
Mammary stem cells from dairy cows may help heal damaged tissue and combat bacterial infections, potentially reducing antibiotic use and improving milk quality. The secreted factors of these cells have been shown to promote tissue regeneration, form new blood vessels, and protect epithelial cells from damage.
Researchers at Stockholm University discovered a new mechanism regulating stem cells in the fruit fly's intestine and found that a specific protein can slow tumour growth. The study sheds light on how intestinal diseases occur and may contribute to the development of new medicine to prevent and cure them.
Scientists from Brigham and Women's Hospital have developed 3D mini-brains from human stem cells to investigate the effects of a specific gene mutation tied to major mental illnesses. The results show that the mutated mini-brains exhibit structural disruptions, suggesting a potential new target pathway for therapies.
Researchers at Washington University in St. Louis have developed a new process to generate NP-like cells from human induced pluripotent stem cells (hiPSCs). The team mimicked the embryonic development process to produce nucleus pulposus cells, which could potentially be used to treat degenerative disc disease.
CReM researchers engineered two new categories of lung epithelial cells in vitro using pluripotent stem cells. The study used single-cell RNA sequencing to generate comprehensive profiles of air sack-like and airway-like cells, which can be used to create lung tissue in vitro.
Researchers at CU Anschutz are working on stem cell-created skin grafts to treat Epidermolysis Bullosa, a debilitating inherited skin disease. The $3.8M grant from the DoD will help move technology into clinical trials, bringing hope for potential cures.
Researchers at the University of Iowa have discovered glandular myoepithelial cells that can regenerate airways after severe injury. These reserve stem cells can develop into new replacement cells in both submucosal glands and the lining of the airway, offering a potential therapeutic target for lung diseases.
A research team at Lund University has discovered a crucial mechanism regulating protein production in hematopoietic stem cells. The enzyme PUS7 and pseudouridine modification play a vital role in controlling protein synthesis machinery. This control ensures the correct amount of proteins is made, preventing unbalanced stem cell growth.
Researchers at Duke-NUS Medical School have identified key regulators of the intestinal stem cell niche, including hormones R-spondins and Wnts. The team's study shows that subepithelial myofibroblasts are essential sources of these hormones, highlighting the close interaction between epithelial stem cells and their niche.
Scientists at the University of Cambridge have discovered a new type of 'sleeping' stem cell in the brain that has a high potential for repair following brain injury or disease. The G2 quiescent stem cell can awaken and produce key brain cells, such as neurons and glia, faster than previously identified quiescent stem cells.
Researchers have found that older adults can produce thousands of new hippocampal neurons, similar to younger individuals, which may suggest that senior citizens remain more cognitively intact than believed. However, they also had less vascularization and reduced connections between new neurons.
Evan Y. Snyder, a leading researcher on stem cells and neural development, has been elected to the Association of American Physicians for his groundbreaking contributions to human health. He will be inducted at the AAP annual meeting on April 21, 2018.
A new study by the University of Nottingham found that lower temperatures can activate the formation of 'good' brown adipose tissue (BAT) in adults. This discovery could lead to new ways of controlling diseases such as diabetes and obesity.
Researchers at UCSB developed a specially engineered retinal patch using stem cells to treat people with sudden severe sight loss from wet AMD. The study showed improvements in vision, enabling patients to read and perform daily tasks.
Researchers have successfully treated two participants with stem cells, increasing estrogen levels and alleviating menopausal symptoms. The treatment has also led to the resumption of menses and potentially restored fertility in these patients.
Researchers have developed remote-controlled nanospears that can pierce membrane walls and deliver DNA into selected cells with precision. The technique shows promise for the production of new gene therapies and may lead to more effective and less harmful methods for delivering genetic material.
Researchers are testing a new combination of cirmtuzumab and ibrutinib to eradicate leukemias and other blood cancers. The trial aims to determine the safety and effectiveness of the duo's treatment, which could potentially lead to complete remissions without continuous therapy.