Articles tagged with Stem Cell Research
Researchers discovered that TOR signaling becomes activated in stem cells during regenerative responses, leading to the loss of stem cell status. Inhibiting TOR with rapamycin prevented this loss and reversed age-related decline in mouse trachea and muscle tissues.
A series of studies by Monash University researcher Jose Polo have unveiled new evidence in the decade-long mystery of cell reprogramming. The researchers found that the route to pluripotency depended on the original cell type, with different cell types requiring different approaches. This breakthrough has important implications for re...
A new harvesting method has been developed by the Massachusetts General Hospital team, which rapidly produces superior stem cells for bone marrow transplantation. The procedure, which combines GRO-beta and AMD3100 injections, mobilizes stem cells in just 15 minutes, making it less painful and disruptive for donors.
A new digital platform provides lay summaries of hot-topic articles from leading international academics, bridging the gap between researchers and individuals outside academia. The ultimate aim is to stimulate conversations in all sectors on the impact of regenerative medicine on society.
UC San Diego researchers receive nearly $8 million to develop and test stem cell-based treatments for acute myeloid leukemia (AML). The funding will support testing of novel therapeutic approaches targeting cancer stem cells in AML, which is responsible for a high relapse rate in the disease.
Scientists in Canada converted adult mouse respiratory tract cells into large populations of induced progenitor-like cells using an interrupted reprogramming strategy. These cells retained a residual memory of their parental cell lineage and showed potential as a cell replacement therapy in mice with cystic fibrosis.
Researchers from USC discovered that the levels of Hedgehog protein determine whether cells form bone or cartilage in developing ribs. High Hh concentrations favor bone formation, while lower concentrations promote cartilage growth.
Researchers have successfully treated paraplegic rats using human stem cells, which have shown significantly improved mobility and sensory perception after spinal cord injury. The engineered tissue containing stem cells also demonstrated some degree of spinal cord healing.
Researchers at Stanford Medicine found that isolated stem cells have a different gene-expression profile than their counterparts in the body. The study suggests that conclusions about stem cell function may need to be reconsidered due to changes in cell biology during isolation.
Researchers used CRISPR-Cas9 to pinpoint epigenetic signals driving cocaine addiction and shed light on rare genetic disorders. They also developed a cellular disease model to probe the neurobiological causes of schizophrenia and identified changes in neural stem cells caused by Zika virus.
Researchers at OHSU have successfully performed stem transplants on monkeys, offering a critical tool to explore the Berlin patient's unexpected cure. The findings provide hope for improving stem cell transplant outcomes for human patients with blood-related conditions.
Researchers have developed a method to prolong the survival of stem cells, which could aid in tissue regeneration after blood flow obstruction. By attaching vascular endothelial growth factor to microscopic particles, they increased stem cell lifespan and improved their ability to form new blood vessels.
Cristina Lo Celso, a rising star in biomedical research, has been awarded the Foulkes Foundation Medal for her groundbreaking work on leukemia. Her research focuses on understanding how leukaemia cells develop and relapse, with the ultimate goal of improving treatments and preventing disease recurrence.
A recent study published in Cell Stem Cell has discovered a mechanism to prevent genetic chaos caused by transposons in early human development. The research found that endosiRNAs, a type of small interfering RNA, play a crucial role in regulating transposon activity during epigenetic reprogramming.
Researchers review the effectiveness of stem cells and emerging agents in preventing and treating neurodegenerative pathologies. They discuss potential advantages and obstacles of using different types of stem cells and present evidence for further study of certain compounds.
The New York Stem Cell Foundation (NYSCF) has selected six promising researchers and neuroscientists to join the NYSCF - Robertson Investigators program, providing critical seed funding of $1.5 million over five years. The program supports high-risk/high-reward research that aims to accelerate treatments and cures for various diseases.
Dr. Paul Tesar receives the 2017 NYSCF Robertson Stem Cell Prize for his pioneering work on pluripotent epiblast stem cells, which holds promise for treating neurological disorders like multiple sclerosis and pediatric leukodystrophies.
Researchers created synthetic hydrogels that allowed human intestinal cells to grow and differentiate in a 3D environment, forming normal tissue structures. The hydrogels can be easily modified to support various cell types, offering a promising approach for treating gut injuries and potentially other organ damage.
Researchers have found that interaction between mesenchymal and adult neural stem cells can strongly promote oligodendrogenesis, potentially leading to improved treatment options for Multiple Sclerosis. The study's results demonstrate conservation across species, offering hope for clinical translation.
German researchers have made significant advancements in human gene therapy, including virotherapy capable of destroying tumor cells and engineered hematopoietic stem cell delivery systems. These innovations hold promise for treating immunodeficiencies and genetic diseases.
A team of researchers used stem cell technology to generate motor neurons from ALS patients with FUS mutations, revealing axonal transport defects. Genetic correction and pharmacological inhibition of HDAC6 restored axonal transport, suggesting a potential therapeutic approach for ALS.
Researchers at McMaster University have discovered that bolstering fat cells in the bone marrow can suppress leukemia cells while also regenerating healthy red blood cells. This innovative approach presents a new potential therapeutic strategy for treating acute myeloid leukemia, which often leads to anemia and infection.
Researchers developed improved mini brain organoids from stem cells, closely mimicking human brain structure. They found critical similarities between the organoids and real brain tissue and identified effective drugs to block Zika's entry into the brain, offering new avenues for studying neurological disorders
The National Eye Institute (NEI) awarded $90,000 to a team led by Erin Lavik for their innovative approach to creating a living model of the human retina. The award aims to develop next-generation models to study blinding diseases and test therapies.
Researchers found that altering stem cell volume changes its internal dynamics and influences the cell's fate, with removing water making it stiff pre-bone cells and adding water forming soft pre-fat cells. This study adds a new tool to understanding stem cell biology for regenerative medicine.
A new study published in Circulation Research found that umbilical cord-derived stem cells improved heart muscle function and quality of life for patients with stable heart failure. The treatment was safe and showed significant improvements over placebo, paving the way for a promising new therapy.
Researchers have discovered that Prostaglandin E1 (PGE1) can inhibit leukemia stem cells, which are resistant to chemotherapy and targeted therapies. Combining PGE1 with standard chemotherapy may improve treatment outcomes for patients with chronic myeloid leukemia.
Researchers have developed a better understanding of how to improve the production of beta cells, the cells responsible for insulin regulation in diabetics. The study shows that genes NXK6.1 and MNX1 play a crucial role in the development of beta cells.
A recent study has overturned a common belief about how bone morphogenetic proteins regulate the formation of nervous system cells during embryonic development. The findings could inform the creation of stem cell-based therapies that restore sensation, particularly for paralyzed patients.
Researchers have found that ovarian stem cells in mammals play a crucial role in egg production, with potential applications for fertility treatments. The study's findings also suggest that these stem cells may be able to delay the onset of menopause by repairing their 'house' rather than increasing their numbers.
Researchers in Germany have demonstrated that temporarily preventing hematopoietic stem cells from dying can improve HSC transplantation outcomes. By inhibiting apoptosis, HSCs can establish themselves in the bone marrow and produce healthy blood cells more effectively.
Researchers at USC found that TAZ can convey different signals to stem cells based on its location within the cell, affecting differentiation and self-renewal. This discovery provides a new tool for stimulating stem cells and has potential applications in regenerative medicine.
Researchers have found that Zika virus preferentially infects and kills glioblastoma stem cells compared to other cell types. A mutant strain of the virus shows promise in slowing tumor growth and extending lifespan when combined with chemotherapy, offering a new potential treatment for brain cancer.
A new study has identified Del-1, a bone marrow protein, as a potential regulator of hematopoiesis, the process by which blood cells are created. Targeting Del-1 may enhance immune cell production and improve stem cell transplants for both donors and recipients.
Scientists from Helmholtz Zentrum München have found that retrotransposons, particularly LINE1 elements, regulate global chromatin accessibility in the early mouse embryo. This study identifies a novel role for retrotransposons in shaping the chromatin landscape necessary for correct developmental programming.
Researchers at UC San Diego will study the combination of cirmtuzumab and ibrutinib in a phase Ib/IIa clinical trial to boost remission rates and long-term cancer control for B-cell cancers. The approach targets cancer stem cells, potentially improving complete and lasting remissions.
Researchers discovered that prolonged exposure to ionizing radiation can delay cell cycle and increase DNA repair efficiency, with potential implications for cancer risk reduction. The study found that human stem cells can activate alternative DNA repair mechanisms, such as homologous recombination, in response to prolonged irradiation.
Recent research reveals that bacterial infections activate hematopoietic stem cells in the bone marrow, inducing proliferation but also causing stress and reduced ability to produce blood. This finding suggests a link between bacterial infections and dysregulated hematopoiesis, highlighting potential prevention methods for blood diseases.
Id genes have been linked to heart development for the first time, revealing a new tool to create large numbers of cardiac cells to regenerate damaged heart tissue. The study uses CRISPR-Cas9 gene editing and high-throughput microRNA screening to identify the role Id genes play in heart development.
A study by Stanford researchers found that a widely used mouse model of the human immune system is inadequate for studying stem cell transplants. The humanized mice, engineered to have a human-like immune system, failed to robustly reject genetically mismatched human stem cells, making them unsuitable for studying immunosuppressive drugs.
Researchers at UT Southwestern Medical Center found that vitamin C regulates stem cell function and suppresses leukemia development. The study used mice with limited ascorbate production to mimic human levels and discovered a link between ascorbate, DNA modifications, and Tet2 enzyme activity.
Respondents showed stronger correlations between scientific beliefs and political/religious identity for topics like human evolution and stem cell research. However, this correlation weakened for non-polarized topics such as nanotechnology.
A UTSA professor has received a $1.5 million grant to study spermatogonial stem cells in a cutting-edge way. The goal is to understand how these cells form and support sperm production, leading to earlier diagnoses and more effective treatments for male infertility.
A novel lineage-restricted stem cell was identified in the mammary gland, maintaining ER+ lineage expansion during pubertal development and long-term renewing capacities in adult mice. This finding challenges the current model of cellular hierarchy governing tissue development and maintenance.
Researchers at UCLA have identified a novel method to activate dormant stem cells in the hair follicle, which could lead to breakthroughs in treating hair loss. By manipulating cellular metabolism, they found that increasing lactate production accelerates hair growth in mice.
Researchers found that aged stem cells reprogram their circadian functions to focus on tissue repair and stress response, rather than maintenance. A low-calorie diet also preserves the rhythmic functions of stem cells.
Scientists have successfully grown a structure similar to an early stage of human development using pluripotent stem cells. The lab-grown amniotic sac embryoid, or PASE, exhibits key features such as two distinct halves and a hollow center, making it a potential tool for exploring infertility research.
Engineered skin grafts from stem cells can regulate blood glucose levels and reverse insulin resistance in diabetic mice. The approach, using CRISPR gene editing, has shown promise for potential long-term treatment of human patients with diabetes.
A new study by the Reik lab finds that genetic noise is essential for cells to make decisions about their fate, enabling symmetry breaking and unique cell types.
Scientists coaxed early stage stem cells to create two types of organoids from different brain regions to show how the developing brain maintains proper balance of excitatory and inhibitory neurons. This imbalance has been implicated in neurodevelopmental disorders such as autism and schizophrenia.
Researchers at Albert Einstein College of Medicine found that adult neural stem cells in the hypothalamus govern how fast aging occurs in the body. By replenishing these stem cells or the molecules they produce, it's possible to slow and even reverse various aspects of aging throughout the body.
Researchers used a pig model to study chronic diseases, finding that pigs have similar gut bacterial profiles and immune systems as humans. The study suggests that a pig model could lead to better treatments and food-based prevention strategies for conditions like colon cancer and type 2 diabetes.
Lorenz Studer, a renowned stem cell biologist, has been awarded the prestigious Ogawa-Yamanaka Stem Cell Prize for his groundbreaking research on cellular reprogramming and human induced pluripotent stem cells. His work has advanced the therapeutic potential of stem cell-based therapies in Parkinson's disease.
Researchers found that celecoxib, an anti-inflammatory drug, protects stem cells from harsh inflammation during wound repair. The study showed that celecoxib promoted stem cell survival and differentiation into skin cells, leading to better wound healing outcomes.
US stem cell clinics are successfully registering for-profit, pay-to-participate studies on ClinicalTrials.gov, often with serious ethical and scientific flaws. These studies fail to disclose that patients are charged to participate in clinical research, using inappropriate inclusion and exclusion criteria.
Research identified PTPRZ as a crucial enzyme for glioblastoma's maintenance and tumorigenicity. Pharmacological inhibition of PTPRZ shows promise in treating malignant gliomas.
Researchers have made key discoveries to improve the treatment of myelodysplastic syndrome (MDS), a blood disorder that can transform into acute leukemia. The study found that certain molecular mechanisms underlying resistance to treatment can be identified, allowing for early intervention and potentially more effective therapies.
Researchers discovered that plant parasitic nematodes activate plant stem cells to form galls on the roots of agricultural crops. This finding holds promise for developing resistant crop varieties and improving crop yields.
Scientists at the University of California - Davis have discovered a way to steer neural stem cells transplanted into the rat brain towards specific locations using electric fields. This breakthrough opens up new possibilities for effectively guiding stem cells to repair brain damage and treat diseases such as stroke and injuries.
Researchers have successfully produced functional arterial cells using new techniques, exhibiting key functions required by the body. Mice treated with these cells showed an 83% survival rate, compared to 33% for controls, and demonstrated improved artery formation and survival.