Articles tagged with Stem Cell Research
A team of researchers used stem cell technology to generate motor neurons from ALS patients with FUS mutations, revealing axonal transport defects. Genetic correction and pharmacological inhibition of HDAC6 restored axonal transport, suggesting a potential therapeutic approach for ALS.
Researchers at McMaster University have discovered that bolstering fat cells in the bone marrow can suppress leukemia cells while also regenerating healthy red blood cells. This innovative approach presents a new potential therapeutic strategy for treating acute myeloid leukemia, which often leads to anemia and infection.
Researchers developed improved mini brain organoids from stem cells, closely mimicking human brain structure. They found critical similarities between the organoids and real brain tissue and identified effective drugs to block Zika's entry into the brain, offering new avenues for studying neurological disorders
The National Eye Institute (NEI) awarded $90,000 to a team led by Erin Lavik for their innovative approach to creating a living model of the human retina. The award aims to develop next-generation models to study blinding diseases and test therapies.
A new study published in Circulation Research found that umbilical cord-derived stem cells improved heart muscle function and quality of life for patients with stable heart failure. The treatment was safe and showed significant improvements over placebo, paving the way for a promising new therapy.
Researchers found that altering stem cell volume changes its internal dynamics and influences the cell's fate, with removing water making it stiff pre-bone cells and adding water forming soft pre-fat cells. This study adds a new tool to understanding stem cell biology for regenerative medicine.
Researchers have discovered that Prostaglandin E1 (PGE1) can inhibit leukemia stem cells, which are resistant to chemotherapy and targeted therapies. Combining PGE1 with standard chemotherapy may improve treatment outcomes for patients with chronic myeloid leukemia.
Researchers have developed a better understanding of how to improve the production of beta cells, the cells responsible for insulin regulation in diabetics. The study shows that genes NXK6.1 and MNX1 play a crucial role in the development of beta cells.
A recent study has overturned a common belief about how bone morphogenetic proteins regulate the formation of nervous system cells during embryonic development. The findings could inform the creation of stem cell-based therapies that restore sensation, particularly for paralyzed patients.
Researchers have found that ovarian stem cells in mammals play a crucial role in egg production, with potential applications for fertility treatments. The study's findings also suggest that these stem cells may be able to delay the onset of menopause by repairing their 'house' rather than increasing their numbers.
Researchers in Germany have demonstrated that temporarily preventing hematopoietic stem cells from dying can improve HSC transplantation outcomes. By inhibiting apoptosis, HSCs can establish themselves in the bone marrow and produce healthy blood cells more effectively.
Researchers have found that Zika virus preferentially infects and kills glioblastoma stem cells compared to other cell types. A mutant strain of the virus shows promise in slowing tumor growth and extending lifespan when combined with chemotherapy, offering a new potential treatment for brain cancer.
Researchers at USC found that TAZ can convey different signals to stem cells based on its location within the cell, affecting differentiation and self-renewal. This discovery provides a new tool for stimulating stem cells and has potential applications in regenerative medicine.
Scientists from Helmholtz Zentrum München have found that retrotransposons, particularly LINE1 elements, regulate global chromatin accessibility in the early mouse embryo. This study identifies a novel role for retrotransposons in shaping the chromatin landscape necessary for correct developmental programming.
A new study has identified Del-1, a bone marrow protein, as a potential regulator of hematopoiesis, the process by which blood cells are created. Targeting Del-1 may enhance immune cell production and improve stem cell transplants for both donors and recipients.
Researchers at UC San Diego will study the combination of cirmtuzumab and ibrutinib in a phase Ib/IIa clinical trial to boost remission rates and long-term cancer control for B-cell cancers. The approach targets cancer stem cells, potentially improving complete and lasting remissions.
Researchers discovered that prolonged exposure to ionizing radiation can delay cell cycle and increase DNA repair efficiency, with potential implications for cancer risk reduction. The study found that human stem cells can activate alternative DNA repair mechanisms, such as homologous recombination, in response to prolonged irradiation.
Recent research reveals that bacterial infections activate hematopoietic stem cells in the bone marrow, inducing proliferation but also causing stress and reduced ability to produce blood. This finding suggests a link between bacterial infections and dysregulated hematopoiesis, highlighting potential prevention methods for blood diseases.
Id genes have been linked to heart development for the first time, revealing a new tool to create large numbers of cardiac cells to regenerate damaged heart tissue. The study uses CRISPR-Cas9 gene editing and high-throughput microRNA screening to identify the role Id genes play in heart development.
A study by Stanford researchers found that a widely used mouse model of the human immune system is inadequate for studying stem cell transplants. The humanized mice, engineered to have a human-like immune system, failed to robustly reject genetically mismatched human stem cells, making them unsuitable for studying immunosuppressive drugs.
Researchers at UT Southwestern Medical Center found that vitamin C regulates stem cell function and suppresses leukemia development. The study used mice with limited ascorbate production to mimic human levels and discovered a link between ascorbate, DNA modifications, and Tet2 enzyme activity.
Respondents showed stronger correlations between scientific beliefs and political/religious identity for topics like human evolution and stem cell research. However, this correlation weakened for non-polarized topics such as nanotechnology.
A UTSA professor has received a $1.5 million grant to study spermatogonial stem cells in a cutting-edge way. The goal is to understand how these cells form and support sperm production, leading to earlier diagnoses and more effective treatments for male infertility.
A novel lineage-restricted stem cell was identified in the mammary gland, maintaining ER+ lineage expansion during pubertal development and long-term renewing capacities in adult mice. This finding challenges the current model of cellular hierarchy governing tissue development and maintenance.
Researchers at UCLA have identified a novel method to activate dormant stem cells in the hair follicle, which could lead to breakthroughs in treating hair loss. By manipulating cellular metabolism, they found that increasing lactate production accelerates hair growth in mice.
Researchers found that aged stem cells reprogram their circadian functions to focus on tissue repair and stress response, rather than maintenance. A low-calorie diet also preserves the rhythmic functions of stem cells.
Scientists have successfully grown a structure similar to an early stage of human development using pluripotent stem cells. The lab-grown amniotic sac embryoid, or PASE, exhibits key features such as two distinct halves and a hollow center, making it a potential tool for exploring infertility research.
Engineered skin grafts from stem cells can regulate blood glucose levels and reverse insulin resistance in diabetic mice. The approach, using CRISPR gene editing, has shown promise for potential long-term treatment of human patients with diabetes.
A new study by the Reik lab finds that genetic noise is essential for cells to make decisions about their fate, enabling symmetry breaking and unique cell types.
Scientists coaxed early stage stem cells to create two types of organoids from different brain regions to show how the developing brain maintains proper balance of excitatory and inhibitory neurons. This imbalance has been implicated in neurodevelopmental disorders such as autism and schizophrenia.
Researchers at Albert Einstein College of Medicine found that adult neural stem cells in the hypothalamus govern how fast aging occurs in the body. By replenishing these stem cells or the molecules they produce, it's possible to slow and even reverse various aspects of aging throughout the body.
Researchers found that celecoxib, an anti-inflammatory drug, protects stem cells from harsh inflammation during wound repair. The study showed that celecoxib promoted stem cell survival and differentiation into skin cells, leading to better wound healing outcomes.
Researchers used a pig model to study chronic diseases, finding that pigs have similar gut bacterial profiles and immune systems as humans. The study suggests that a pig model could lead to better treatments and food-based prevention strategies for conditions like colon cancer and type 2 diabetes.
Lorenz Studer, a renowned stem cell biologist, has been awarded the prestigious Ogawa-Yamanaka Stem Cell Prize for his groundbreaking research on cellular reprogramming and human induced pluripotent stem cells. His work has advanced the therapeutic potential of stem cell-based therapies in Parkinson's disease.
US stem cell clinics are successfully registering for-profit, pay-to-participate studies on ClinicalTrials.gov, often with serious ethical and scientific flaws. These studies fail to disclose that patients are charged to participate in clinical research, using inappropriate inclusion and exclusion criteria.
Researchers discovered that plant parasitic nematodes activate plant stem cells to form galls on the roots of agricultural crops. This finding holds promise for developing resistant crop varieties and improving crop yields.
Research identified PTPRZ as a crucial enzyme for glioblastoma's maintenance and tumorigenicity. Pharmacological inhibition of PTPRZ shows promise in treating malignant gliomas.
Researchers have made key discoveries to improve the treatment of myelodysplastic syndrome (MDS), a blood disorder that can transform into acute leukemia. The study found that certain molecular mechanisms underlying resistance to treatment can be identified, allowing for early intervention and potentially more effective therapies.
Scientists at the University of California - Davis have discovered a way to steer neural stem cells transplanted into the rat brain towards specific locations using electric fields. This breakthrough opens up new possibilities for effectively guiding stem cells to repair brain damage and treat diseases such as stroke and injuries.
Researchers have successfully produced functional arterial cells using new techniques, exhibiting key functions required by the body. Mice treated with these cells showed an 83% survival rate, compared to 33% for controls, and demonstrated improved artery formation and survival.
Stem-cell researchers have identified two distinct populations of leukemia stem cells that can lead to relapse in AML. The study, published in Nature, provides new insights into the cell types fated to relapse and may help accelerate the development of targeted therapies.
Researchers at Lund University have developed a method to produce diseased, aging brain cells on a large scale in a cell culture dish. This enables experiments that were previously not possible, opening up research areas linked to new drug testing, accurate disease models, and earlier diagnostics.
Researchers have found that brain regions can target specific pools of stem cells in the subventricular zone, stimulating them to divide and produce particular types of olfactory bulb neurons. This allows for the on-demand generation of specific neuron subtypes in the adult brain.
Researchers at Tel Aviv University discovered a molecular pathway involved in the toxic interaction between host cells and the immune system when using cardiac stem cells from patients with heart disease. The study suggests that these cells can develop inflammatory properties and exacerbate damage to the already diseased heart muscle.
Aging stem cells lose their ability to make bone and muscle, leading to frailty and falls. Researchers are targeting the metabolite kynurenine and IDO inhibitors to reverse age-related damage and improve healthspan.
Researchers developed a stem cell-based therapy to generate skin grafts for myelomeningocele defects before birth. The treatment successfully covered large defects and protected the spinal cord, but had some drawbacks, including decreased birth weight and body length.
The Hastings Center Report explores the ethics of opioid treatment agreements, which critics say are ethically suspect. The authors conclude that the purpose of these agreements is to disclose their requirements to patients, promoting mutual decision-making on pain management programs. In contrast, some experts propose replacing agreem...
Microglia, the brain's front line of immune defense, have been characterized for the first time. Genes linked to neurological diseases are highly expressed in microglia, suggesting a link between the cells and neurodegenerative and psychiatric illnesses.
Researchers from Turku, Finland have discovered new information about the mechanisms regulating gene activity in human embryonic stem cells. The study sheds light on indirect genomic regulatory mechanisms that maintain gene expression and self-renewal of stem cells.
Scientists have developed a high-throughput protocol to derive human microglia from stem cells, which can be used to investigate the role of microglia in neurological disorders. This new method enables researchers to generate microglia from individual patients' samples and advance complex disease modeling in a dish.
Researchers in China have made a breakthrough in developing a new approach to treat premature ovarian failure using female germline stem cells. The study found that mice with transplanted egg-making stem cells produced healthy pups without genetic malfunctions, opening up avenues for investigating human oogenesis in vitro.
Researchers at Weill Cornell Medicine have developed a method to generate healthy blood-forming stem cells from readily available cells lining blood vessels. This breakthrough enables the creation of an unlimited supply of new, healthy blood cells for transplantation, which may help cure patients with genetic and acquired blood diseases.
UCSB researchers have developed a new method to control gene expression in embryonic stem cells using light, allowing for the precise engineering of tissues. This breakthrough could lead to novel therapeutic applications and insights into tissue development.
Researchers at USF Health used bone marrow stem cells to repair damage to the blood-spinal cord barrier in mice with ALS, improving motor functions and nervous system conditions. The study demonstrates an early step towards pursuing stem cell therapy for potential ALS treatment.
UC Berkeley scientists have developed a new technique to track individual stem cells in the nose, uncovering clues that could help restore smell to those who have lost it. The team used single-cell RNA sequencing and statistical analysis to identify the molecules that trigger stem cell differentiation into specific cell types.
The Howard Hughes Medical Institute, Bill & Melinda Gates Foundation, Wellcome Trust, and Calouste Gulbenkian Foundation have awarded $26.7 million to 41 international researchers, providing them with the freedom to pursue innovative projects in various biological and medical research areas.
A study led by Johns Hopkins researchers found that the gene HMGA1 maintains intestinal stem cells and encourages their growth, supporting 'niche' cells. The discovery advances prospects for regenerative medicine and cancer treatments.
Researchers discovered that signals from surrounding tissue trigger dental stem cells to proliferate and differentiate into mature tooth tissue. The findings have implications for understanding tissue renewal and could lead to improved therapies for cancer treatment.
Scientists rewired mouse stem cells using CRISPR to produce biologic anti-inflammatory drugs that protect joints and tissues from chronic inflammation. The engineered cells can sense TNF-alpha and release a protective drug to combat inflammation.
Researchers found that human pluripotent stem cells can acquire mutations in the TP53 gene, a tumor suppressor responsible for controlling cell growth and division, highlighting the need for genetic screening methods to exclude mutated cells from scientific experiments and clinical therapies.