Articles tagged with Stem Cell Research
Stem-cell researchers have identified two distinct populations of leukemia stem cells that can lead to relapse in AML. The study, published in Nature, provides new insights into the cell types fated to relapse and may help accelerate the development of targeted therapies.
Researchers at Lund University have developed a method to produce diseased, aging brain cells on a large scale in a cell culture dish. This enables experiments that were previously not possible, opening up research areas linked to new drug testing, accurate disease models, and earlier diagnostics.
Researchers have found that brain regions can target specific pools of stem cells in the subventricular zone, stimulating them to divide and produce particular types of olfactory bulb neurons. This allows for the on-demand generation of specific neuron subtypes in the adult brain.
Researchers at Tel Aviv University discovered a molecular pathway involved in the toxic interaction between host cells and the immune system when using cardiac stem cells from patients with heart disease. The study suggests that these cells can develop inflammatory properties and exacerbate damage to the already diseased heart muscle.
Researchers developed a stem cell-based therapy to generate skin grafts for myelomeningocele defects before birth. The treatment successfully covered large defects and protected the spinal cord, but had some drawbacks, including decreased birth weight and body length.
Aging stem cells lose their ability to make bone and muscle, leading to frailty and falls. Researchers are targeting the metabolite kynurenine and IDO inhibitors to reverse age-related damage and improve healthspan.
Researchers from Turku, Finland have discovered new information about the mechanisms regulating gene activity in human embryonic stem cells. The study sheds light on indirect genomic regulatory mechanisms that maintain gene expression and self-renewal of stem cells.
The Hastings Center Report explores the ethics of opioid treatment agreements, which critics say are ethically suspect. The authors conclude that the purpose of these agreements is to disclose their requirements to patients, promoting mutual decision-making on pain management programs. In contrast, some experts propose replacing agreem...
Microglia, the brain's front line of immune defense, have been characterized for the first time. Genes linked to neurological diseases are highly expressed in microglia, suggesting a link between the cells and neurodegenerative and psychiatric illnesses.
Researchers in China have made a breakthrough in developing a new approach to treat premature ovarian failure using female germline stem cells. The study found that mice with transplanted egg-making stem cells produced healthy pups without genetic malfunctions, opening up avenues for investigating human oogenesis in vitro.
Scientists have developed a high-throughput protocol to derive human microglia from stem cells, which can be used to investigate the role of microglia in neurological disorders. This new method enables researchers to generate microglia from individual patients' samples and advance complex disease modeling in a dish.
Researchers at Weill Cornell Medicine have developed a method to generate healthy blood-forming stem cells from readily available cells lining blood vessels. This breakthrough enables the creation of an unlimited supply of new, healthy blood cells for transplantation, which may help cure patients with genetic and acquired blood diseases.
Researchers at USF Health used bone marrow stem cells to repair damage to the blood-spinal cord barrier in mice with ALS, improving motor functions and nervous system conditions. The study demonstrates an early step towards pursuing stem cell therapy for potential ALS treatment.
UCSB researchers have developed a new method to control gene expression in embryonic stem cells using light, allowing for the precise engineering of tissues. This breakthrough could lead to novel therapeutic applications and insights into tissue development.
UC Berkeley scientists have developed a new technique to track individual stem cells in the nose, uncovering clues that could help restore smell to those who have lost it. The team used single-cell RNA sequencing and statistical analysis to identify the molecules that trigger stem cell differentiation into specific cell types.
The Howard Hughes Medical Institute, Bill & Melinda Gates Foundation, Wellcome Trust, and Calouste Gulbenkian Foundation have awarded $26.7 million to 41 international researchers, providing them with the freedom to pursue innovative projects in various biological and medical research areas.
A study led by Johns Hopkins researchers found that the gene HMGA1 maintains intestinal stem cells and encourages their growth, supporting 'niche' cells. The discovery advances prospects for regenerative medicine and cancer treatments.
Scientists rewired mouse stem cells using CRISPR to produce biologic anti-inflammatory drugs that protect joints and tissues from chronic inflammation. The engineered cells can sense TNF-alpha and release a protective drug to combat inflammation.
Researchers discovered that signals from surrounding tissue trigger dental stem cells to proliferate and differentiate into mature tooth tissue. The findings have implications for understanding tissue renewal and could lead to improved therapies for cancer treatment.
Researchers found that human pluripotent stem cells can acquire mutations in the TP53 gene, a tumor suppressor responsible for controlling cell growth and division, highlighting the need for genetic screening methods to exclude mutated cells from scientific experiments and clinical therapies.
Researchers used stem cells from patients with Angelman syndrome to identify the underlying cellular defects that cause the disorder. They found that brain cells fail to mature, disrupting synaptic connections critical for learning and cognitive development.
Scientists at UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have discovered a new role for netrin1 in organizing axon growth during embryonic development. The study reveals that netrin1 acts locally, guiding axons to form a normal functioning nervous system.
A new study reveals that a signal in blood, called Hepatocyte Growth Factor Activator (HGFA), can alert stem cells to heal faster and more efficiently after an injury. By injecting HGFA into mice before an injury, researchers showed improved tissue repair, quicker recovery, and better regeneration of damaged tissues.
Researchers have identified a way to prevent graft-versus-host disease after stem cell transplants while preserving anti-cancer effects on fighting leukemia and lymphoma. By depleting specific donor T cells, the regimen may stop GVHD without subduing cancer-killing immune cells.
Researchers have developed a 3D-bioprinted patch that can heal scarred heart tissue after a heart attack. The patch was made from cells and structural proteins native to the heart and showed significant improvement in functional capacity in mice after just four weeks.
Iowa State researchers have developed a nanotechnology that uses inkjet printers to print multi-layer graphene circuits, which can be used to differentiate stem cells into Schwann-like cells. The electrical stimulation is effective, differentiating 85% of the stem cells compared to 75% by the standard chemical process.
The Salk Institute has received a $3 million gift from the Glenn Foundation, enabling continued investigation into aging and age-related diseases. The center aims to advance understanding of biological aging and its effects on various diseases, with a focus on developing interventions to delay or cure age-related conditions.
Researchers at St. Jude Children's Research Hospital have identified trunk neural crest cells as key players in the development of blood-forming stem cells, which can produce any type of blood cell. This discovery may lead to new avenues for investigating stem cell biology and improving access to bone marrow transplantation.
Researchers at Washington State University have made a breakthrough in preserving sperm stem cells, which could improve fertility for boys undergoing cancer treatment. The new technology has shown an eight-fold improvement in viable sperm stem cells, allowing for potential long-term preservation and return to fertility.
A collaborative effort analyzed iPS cells to understand how individual mutations contribute to polygenetic diseases, revealing that smaller collections of cells can produce results and identifying small changes in gene expression with dramatic effects on cells. The study also found that some effects manifest before cell differentiation.
Researchers grew stem cells from children with Pelizaeus-Merzbacher Disease to understand the genetic causes of common symptoms. The study identified defects in brain cell function linked to patient genetics, suggesting distinct subgroups requiring different clinical approaches.
Researchers at Boston University School of Medicine have developed a novel approach to generate airway cells from stem cells using the Wnt signaling pathway. These cells can be grown into three-dimensional spheres and used to study lung diseases such as cystic fibrosis.
Case Western Reserve University researchers have developed a breakthrough technique to create durable stem cells directly from urine, providing an ethically sound and clinically relevant model for studying Down syndrome. The new method represents a significant improvement in induced pluripotent stem cell technology.
Researchers developed Single Cell Consensus Clustering (SC3) to overcome challenges in analysing complex single-cell RNA-sequence data. The tool resolved datasets from patients with myeloproliferative neoplasm, revealing correlations between gene expression and mutations.
Researchers at the University of Bristol have developed a technique to manufacture immortalized red blood cells, which can be cultured indefinitely and differentiated into mature red blood cells. This breakthrough could potentially provide a safe source of transfusions for people with rare blood types and areas with inadequate blood su...
Human embryonic stem cells exist in two states: naïve and primed. Researchers have identified molecular flags on these cells, allowing them to track and investigate their transition. This approach has revealed new insights into the timing and coordination of gene activity changes during reprogramming.
Researchers at Karolinska Institutet have developed a new tool to distinguish between immature and mature embryonic stem cells. These cells hold great potential for replacing damaged tissue and understanding early embryonic development.
Researchers found that a single dose of millions of adult stem cells can aid stroke recovery if given early, reducing destructive inflammation and the risk for serious infections. Early treatment within 36 hours after stroke symptoms surface also showed benefits in physical recovery and reduced disability one year out.
Researchers have successfully rejuvenated old gut stem cells by restoring Wnt signaling, suggesting a potential pathway to target for clinicians. This breakthrough offers new insights into the role of Wnt proteins in controlling stem cell growth and pluripotency in the gut later in life.
A recent study conducted at The Mount Sinai Hospital found that certain genetic mutations are challenging to recreate in laboratory-produced stem cells. This limitation may hinder neuropsychiatric research, highlighting the need for researchers to carefully check for retained genetic elements in newly created stem cells.
Researchers at IRB Barcelona have discovered a new group of quiescent intestinal stem cells that are resistant to chemotherapy. These cells, estimated to be one in ten compared to active stem cells, play a crucial role in tissue regeneration and can produce any type of intestinal cell.
Researchers have identified adipose stem cells as a suitable alternative to bone marrow stem cells for treating orthopedic diseases and injuries in dogs. The study reveals that adipose stem cells exhibit similar functional properties to bone marrow stem cells, including tissue generation and immunomodulation, but grow at a faster rate.
Researchers at Lund University successfully reprogrammed old blood stem cells to function like those of younger individuals, revealing a potential new approach to treating age-related diseases. This breakthrough suggests that epigenetic changes, rather than DNA mutations, underlie the decline in blood cell function with age.
The Global Biological Standards Institute reports encouraging progress toward improved research reproducibility, with stakeholders recognizing the severity of the problem and taking active steps for improvement. The report highlights tangible examples of community-led actions, including new funding guidelines and industry-wide research...
A new nanofiber-on-microfiber matrix enables the scalable expansion of human pluripotent stem cells, resulting in high-quality cells with robust growth. The innovative system allows for easy exchange of nutrients and reduces stress on the cells, making it suitable for large-scale production.
Researchers at Penn State have received a $6.1 million NIH grant to develop tools for using genomic data to advance medical treatments and pharmaceuticals. The project will focus on blood cell development as a model system for gene regulation in mammals, aiming to improve precision medicine.
A team of researchers has identified a long-lived type of stem cell in the breast that grows mammary glands during pregnancy and may be linked to high-risk breast cancer. The discovery reveals new insights into how cancers arise from long-lived stem cells.
Researchers have developed silver ion-coated scaffolds that can slow the spread of MRSA and even regenerate new bone. The biodegradable scaffolds were seeded with stem cells and found to inhibit MRSA while supporting bone tissue formation, offering a potential solution for treating osteomyelitis.
A new study by researchers at Boston Children's Hospital has successfully used stem-cell-derived cells to identify potential treatments for the rare blood disorder Diamond Blackfan anemia. The team found a promising compound called SMER28, which was able to get live mice and zebrafish to produce red blood cells.
Researchers at the University of Freiburg have discovered how shoot stem cells form in plants, a process similar to animals. The transcription factor WOX2 regulates the balance between plant hormones cytokinin and auxin, allowing stem cells to maintain their unlimited potential for development.
Researchers at Rice University have developed a new compound of bismuth and carbon nanotubes that improves upon existing cell-tracking agents. The improved Bi4C@US-tubes show up strongly on X-rays taken with computed tomography (CT) scanners, allowing for more efficient tracking of stem cells in the body.
Enteroviruses cause millions of infections worldwide, with infant fatality rates approaching 20 percent. A new study uses a miniature gut model to reveal how these viruses enter the intestine, targeting specific cells and facilitating bloodstream entry.
Johns Hopkins researchers successfully created mature heart muscle cells from human or animal stem cells by implanting them into newborn rat hearts. The host animal's biological signals and chemistry enabled the immature cells to mature, overcoming a developmental blockade.
Researchers at UCL and Heinrich Heine University have discovered the OCT4 gene essential for chemically reprogramming human amniotic stem cells. The process allows these cells to be rejuvenated and function like embryonic stem cells, providing a promising alternative for therapies and research.
Researchers at Stanford University and the University of Tokyo successfully transplanted functional mouse islets into diabetic mice, reversing their condition with minimal immunosuppression. The study suggests a potential approach to generate genetically matched human organs in large animals.
Scientists at the University of North Carolina have discovered a promising new avenue for fighting gastrointestinal cancers by unmasking the previously misunderstood gene Gpr182. The study reveals that Gpr182 could be a key regulator of intestinal stem cell proliferation, and its protein code for a potential drug target.
Researchers at Boston University School of Medicine are creating an induced pluripotent stem cell-based library for sickle cell disease, offering a valuable resource for disease modeling and treatment development. The library comprises diverse patient samples, enabling the study of genetic backgrounds and potential therapies.
Stem cell therapies aim to restore function in degenerative conditions, but ensuring cell survival is a major hurdle. Researchers successfully restored long-term vision in blind mice by transplanting photoreceptors derived from human stem cells and suppressing the immune response that rejects transplanted cells.
Researchers have successfully generated epicardium cells using human stem cells and Wnt signaling pathway activation. The new method could potentially repair damaged heart tissue in patients who suffer from heart attacks, according to the study published in Nature Biomedical Engineering.
Researchers successfully used CRISPR-Cas9 technology to repair genetic mutations in blood stem cells of patients with chronic granulomatous disease, a rare and life-threatening disorder. The engineered cells maintained their gene edits long-term without side effects when implanted into mice.