Articles tagged with Stem Cell Research
Researchers at St. Jude Children's Research Hospital have identified trunk neural crest cells as key players in the development of blood-forming stem cells, which can produce any type of blood cell. This discovery may lead to new avenues for investigating stem cell biology and improving access to bone marrow transplantation.
Researchers at Washington State University have made a breakthrough in preserving sperm stem cells, which could improve fertility for boys undergoing cancer treatment. The new technology has shown an eight-fold improvement in viable sperm stem cells, allowing for potential long-term preservation and return to fertility.
A collaborative effort analyzed iPS cells to understand how individual mutations contribute to polygenetic diseases, revealing that smaller collections of cells can produce results and identifying small changes in gene expression with dramatic effects on cells. The study also found that some effects manifest before cell differentiation.
Researchers grew stem cells from children with Pelizaeus-Merzbacher Disease to understand the genetic causes of common symptoms. The study identified defects in brain cell function linked to patient genetics, suggesting distinct subgroups requiring different clinical approaches.
Researchers at Boston University School of Medicine have developed a novel approach to generate airway cells from stem cells using the Wnt signaling pathway. These cells can be grown into three-dimensional spheres and used to study lung diseases such as cystic fibrosis.
Case Western Reserve University researchers have developed a breakthrough technique to create durable stem cells directly from urine, providing an ethically sound and clinically relevant model for studying Down syndrome. The new method represents a significant improvement in induced pluripotent stem cell technology.
Researchers developed Single Cell Consensus Clustering (SC3) to overcome challenges in analysing complex single-cell RNA-sequence data. The tool resolved datasets from patients with myeloproliferative neoplasm, revealing correlations between gene expression and mutations.
Researchers at the University of Bristol have developed a technique to manufacture immortalized red blood cells, which can be cultured indefinitely and differentiated into mature red blood cells. This breakthrough could potentially provide a safe source of transfusions for people with rare blood types and areas with inadequate blood su...
Human embryonic stem cells exist in two states: naïve and primed. Researchers have identified molecular flags on these cells, allowing them to track and investigate their transition. This approach has revealed new insights into the timing and coordination of gene activity changes during reprogramming.
Researchers at Karolinska Institutet have developed a new tool to distinguish between immature and mature embryonic stem cells. These cells hold great potential for replacing damaged tissue and understanding early embryonic development.
Researchers found that a single dose of millions of adult stem cells can aid stroke recovery if given early, reducing destructive inflammation and the risk for serious infections. Early treatment within 36 hours after stroke symptoms surface also showed benefits in physical recovery and reduced disability one year out.
Researchers have successfully rejuvenated old gut stem cells by restoring Wnt signaling, suggesting a potential pathway to target for clinicians. This breakthrough offers new insights into the role of Wnt proteins in controlling stem cell growth and pluripotency in the gut later in life.
A recent study conducted at The Mount Sinai Hospital found that certain genetic mutations are challenging to recreate in laboratory-produced stem cells. This limitation may hinder neuropsychiatric research, highlighting the need for researchers to carefully check for retained genetic elements in newly created stem cells.
Researchers at IRB Barcelona have discovered a new group of quiescent intestinal stem cells that are resistant to chemotherapy. These cells, estimated to be one in ten compared to active stem cells, play a crucial role in tissue regeneration and can produce any type of intestinal cell.
Researchers have identified adipose stem cells as a suitable alternative to bone marrow stem cells for treating orthopedic diseases and injuries in dogs. The study reveals that adipose stem cells exhibit similar functional properties to bone marrow stem cells, including tissue generation and immunomodulation, but grow at a faster rate.
Researchers at Lund University successfully reprogrammed old blood stem cells to function like those of younger individuals, revealing a potential new approach to treating age-related diseases. This breakthrough suggests that epigenetic changes, rather than DNA mutations, underlie the decline in blood cell function with age.
The Global Biological Standards Institute reports encouraging progress toward improved research reproducibility, with stakeholders recognizing the severity of the problem and taking active steps for improvement. The report highlights tangible examples of community-led actions, including new funding guidelines and industry-wide research...
Researchers at Penn State have received a $6.1 million NIH grant to develop tools for using genomic data to advance medical treatments and pharmaceuticals. The project will focus on blood cell development as a model system for gene regulation in mammals, aiming to improve precision medicine.
A new nanofiber-on-microfiber matrix enables the scalable expansion of human pluripotent stem cells, resulting in high-quality cells with robust growth. The innovative system allows for easy exchange of nutrients and reduces stress on the cells, making it suitable for large-scale production.
A team of researchers has identified a long-lived type of stem cell in the breast that grows mammary glands during pregnancy and may be linked to high-risk breast cancer. The discovery reveals new insights into how cancers arise from long-lived stem cells.
Researchers have developed silver ion-coated scaffolds that can slow the spread of MRSA and even regenerate new bone. The biodegradable scaffolds were seeded with stem cells and found to inhibit MRSA while supporting bone tissue formation, offering a potential solution for treating osteomyelitis.
A new study by researchers at Boston Children's Hospital has successfully used stem-cell-derived cells to identify potential treatments for the rare blood disorder Diamond Blackfan anemia. The team found a promising compound called SMER28, which was able to get live mice and zebrafish to produce red blood cells.
Researchers at the University of Freiburg have discovered how shoot stem cells form in plants, a process similar to animals. The transcription factor WOX2 regulates the balance between plant hormones cytokinin and auxin, allowing stem cells to maintain their unlimited potential for development.
Researchers at Rice University have developed a new compound of bismuth and carbon nanotubes that improves upon existing cell-tracking agents. The improved Bi4C@US-tubes show up strongly on X-rays taken with computed tomography (CT) scanners, allowing for more efficient tracking of stem cells in the body.
Enteroviruses cause millions of infections worldwide, with infant fatality rates approaching 20 percent. A new study uses a miniature gut model to reveal how these viruses enter the intestine, targeting specific cells and facilitating bloodstream entry.
Johns Hopkins researchers successfully created mature heart muscle cells from human or animal stem cells by implanting them into newborn rat hearts. The host animal's biological signals and chemistry enabled the immature cells to mature, overcoming a developmental blockade.
Researchers at UCL and Heinrich Heine University have discovered the OCT4 gene essential for chemically reprogramming human amniotic stem cells. The process allows these cells to be rejuvenated and function like embryonic stem cells, providing a promising alternative for therapies and research.
Researchers at Stanford University and the University of Tokyo successfully transplanted functional mouse islets into diabetic mice, reversing their condition with minimal immunosuppression. The study suggests a potential approach to generate genetically matched human organs in large animals.
Scientists at the University of North Carolina have discovered a promising new avenue for fighting gastrointestinal cancers by unmasking the previously misunderstood gene Gpr182. The study reveals that Gpr182 could be a key regulator of intestinal stem cell proliferation, and its protein code for a potential drug target.
Researchers at Boston University School of Medicine are creating an induced pluripotent stem cell-based library for sickle cell disease, offering a valuable resource for disease modeling and treatment development. The library comprises diverse patient samples, enabling the study of genetic backgrounds and potential therapies.
Stem cell therapies aim to restore function in degenerative conditions, but ensuring cell survival is a major hurdle. Researchers successfully restored long-term vision in blind mice by transplanting photoreceptors derived from human stem cells and suppressing the immune response that rejects transplanted cells.
Researchers have successfully generated epicardium cells using human stem cells and Wnt signaling pathway activation. The new method could potentially repair damaged heart tissue in patients who suffer from heart attacks, according to the study published in Nature Biomedical Engineering.
Researchers successfully used CRISPR-Cas9 technology to repair genetic mutations in blood stem cells of patients with chronic granulomatous disease, a rare and life-threatening disorder. The engineered cells maintained their gene edits long-term without side effects when implanted into mice.
Researchers at Stanford University School of Medicine have discovered that diabetes impairs the activity of bone stem cells, leading to impaired fracture healing. A newly identified protein stimulates the activity of skeletal stem cells, counteracting this decrease and promoting efficient fracture repair.
A team of researchers at King's College London has discovered a method to stimulate the renewal of living stem cells in tooth pulp using an Alzheimer's drug. This novel approach aims to promote natural tooth repair and potentially reduce the need for fillings or cements.
Researchers have developed synthetic stem cells that mimic natural cardiac stem cells, promoting tissue repair and reducing risks of tumor growth and immune rejection. These cells are more durable, can be used off-the-shelf, and can tolerate harsh freezing and thawing.
Researchers developed a method for generating Leydig cells by directly converting adult skin cells into functional testosterone-producing cells. The approach successfully restored normal testosterone levels in male rodents with hypogonadism, offering a promising alternative to existing therapies.
The Keck School of Medicine of USC has received a $2.5 million grant to develop an off-the-shelf stem cell therapy for osteoarthritis. The therapy aims to reduce the need for joint replacement surgery, mitigating the burden on patients and physicians.
Johns Hopkins scientists successfully created more-flexible human embryonic stem cells by dosing conventional ESCs with a cocktail of three chemical inhibitors. The new cells exhibit features similar to those of classic mouse ESCs, enabling their potential use in therapies and genetic disease modeling.
Researchers found genetic mutations increased with donor age, particularly in late 80s and early 90s donors, which could impact iPSC therapies. Screening is crucial to filter out defects and ensure safe treatment.
A deficiency of prohormone covertase (PC1) in the brain is linked to most neuro-hormonal abnormalities in Prader-Willi syndrome. The discovery provides insight into molecular mechanisms underlying the syndrome, highlighting a novel target for drug therapy.
Researchers found a dynamic, multi-step process in which multiple independent changes converge to transform stem cells into motor neurons. The study outlines challenges facing current cell-replacement technology but also highlights potential pathways for enhanced gene-therapy methods.
Researchers have developed a novel live-cell imaging method that allows for dynamic, high-resolution visualization of cell interactions. The Photonic Crystal Enhanced Microscope (PCEM) can quantify and measure cell adhesion, a critical process involved in cell migration, differentiation, division, and death.
A new 17-gene signature derived from leukemia stem cells can predict AML patients' response to standard treatment, enabling clinicians to tailor treatment and improve patient care. The LSC17 score has been shown to accurately identify high-risk patients who are less likely to be cured by standard therapy.
Researchers at Helmholtz Zentrum München found a mechanism controlling cell division after fertilization, allowing for diverse cellular development. The study reveals that the molecule Suv4-20h2 attaches methyl groups to histones, arresting cell progression and enabling totipotency.
Researchers at the Babraham Institute used CRISPR to delete PRC2 from human embryonic stem cells, revealing its role in keeping genes switched off until needed. Loss of PRC2 caused compromised cell quality and specialisation into mature cell types.
Researchers define how genetic factors affect blood-forming stem cells' regenerative properties, accelerating or hindering their ability to restore the immune system. The findings highlight two molecular mechanisms that could be manipulated to increase hematopoietic stem cell regeneration.
Researchers at Harvard University and Novartis have discovered that Zika virus can infect neural progenitor cells by grabbing onto a specific protein called AXL on the cell surface. This finding contradicts previous studies suggesting that targeting the AXL protein alone could defend against the virus.
Researchers compared three types of adult stem cells from 14 patients to determine their cardiac repair potential. Right atrial stem cells had the greatest protective effect on heart muscle cells, while ventricular stem cells promoted new blood vessel formation.
Researchers at McGill University's Montreal Neurological Institute will study motor neurons and astrocytes created from people with different forms of ALS via stem cell technology. The project aims to develop a potential screening mechanism for therapeutics and create new zebrafish models of the disease.
UCSF researchers found a way to pause the development of early mouse embryos for up to a month in the lab by inhibiting a master regulator of cell growth. The treatment could improve outcomes in assisted reproduction and regenerative medicine, while also potentially slowing cancer growth.
A new color-based labeling technique allows researchers to track the development and behavior of individual blood stem cells. The study reveals that these cells have a scripted set of responses and cannot make just any blood cell type.
Researchers at UCLA discovered that cardiac fibroblasts, which give rise to scar tissue after injury, can also produce bone-like cells. By blocking an enzyme involved in bone mineralization, they prevented calcification in mice, offering a potential new approach for treating abnormal calcium deposits in the heart.
EPFL scientists have developed a patent-pending hydrogel that can grow organoids in a standardized and controlled way, overcoming current limitations. The breakthrough provides a fully controllable and tunable environment for growing miniature organs, shedding light on the influence of physical factors on stem cell behavior.
New UCL research reveals that blood vessels play a vital role in telling neural stem cells when and how to reproduce. The study found that preventing blood vessel growth interferes with normal neuron production, causing stem cells to disappear from the brainstem.
A recent study published in the journal Stem Cells found that autologous stem cell therapy after traumatic brain injury appears to reduce inflammation and preserve critical brain regions. Researchers used this approach on 25 patients, including those with severe TBI, showing promising results.
Researchers identify Adamts1 as a key regulator of fat cell differentiation, triggered by high-fat diets and stress hormones. The hormone's production affects fat storage in different parts of the body, with implications for obesity treatment.
Researchers at Gladstone Institutes identify a gene mutation that enhances the efficiency of stem cell reprogramming, improving the number of induced pluripotent stem cells (iPSCs) generated from skin cells. This breakthrough could have significant implications for regenerative medicine and drug discovery.
Researchers at Stanford University School of Medicine discovered that a diet deficient in the amino acid valine can effectively deplete blood stem cells in mice, allowing for successful transplantation. This finding may lead to new ways to treat certain cancers and bone marrow disorders without chemotherapy or radiation therapy.
Researchers delivered human stem cells to damaged heart muscles in rats and found regional functional changes, while non-cell seeded sutures showed no effect. The study demonstrates potential for cell therapeutics to deliver cells to specific targets.