Articles tagged with Stem Cell Research
Researchers at Stanford University School of Medicine have discovered that diabetes impairs the activity of bone stem cells, leading to impaired fracture healing. A newly identified protein stimulates the activity of skeletal stem cells, counteracting this decrease and promoting efficient fracture repair.
A team of researchers at King's College London has discovered a method to stimulate the renewal of living stem cells in tooth pulp using an Alzheimer's drug. This novel approach aims to promote natural tooth repair and potentially reduce the need for fillings or cements.
Researchers have developed synthetic stem cells that mimic natural cardiac stem cells, promoting tissue repair and reducing risks of tumor growth and immune rejection. These cells are more durable, can be used off-the-shelf, and can tolerate harsh freezing and thawing.
Researchers developed a method for generating Leydig cells by directly converting adult skin cells into functional testosterone-producing cells. The approach successfully restored normal testosterone levels in male rodents with hypogonadism, offering a promising alternative to existing therapies.
The Keck School of Medicine of USC has received a $2.5 million grant to develop an off-the-shelf stem cell therapy for osteoarthritis. The therapy aims to reduce the need for joint replacement surgery, mitigating the burden on patients and physicians.
Johns Hopkins scientists successfully created more-flexible human embryonic stem cells by dosing conventional ESCs with a cocktail of three chemical inhibitors. The new cells exhibit features similar to those of classic mouse ESCs, enabling their potential use in therapies and genetic disease modeling.
Researchers found genetic mutations increased with donor age, particularly in late 80s and early 90s donors, which could impact iPSC therapies. Screening is crucial to filter out defects and ensure safe treatment.
A deficiency of prohormone covertase (PC1) in the brain is linked to most neuro-hormonal abnormalities in Prader-Willi syndrome. The discovery provides insight into molecular mechanisms underlying the syndrome, highlighting a novel target for drug therapy.
Researchers found a dynamic, multi-step process in which multiple independent changes converge to transform stem cells into motor neurons. The study outlines challenges facing current cell-replacement technology but also highlights potential pathways for enhanced gene-therapy methods.
Researchers have developed a novel live-cell imaging method that allows for dynamic, high-resolution visualization of cell interactions. The Photonic Crystal Enhanced Microscope (PCEM) can quantify and measure cell adhesion, a critical process involved in cell migration, differentiation, division, and death.
A new 17-gene signature derived from leukemia stem cells can predict AML patients' response to standard treatment, enabling clinicians to tailor treatment and improve patient care. The LSC17 score has been shown to accurately identify high-risk patients who are less likely to be cured by standard therapy.
Researchers at Helmholtz Zentrum München found a mechanism controlling cell division after fertilization, allowing for diverse cellular development. The study reveals that the molecule Suv4-20h2 attaches methyl groups to histones, arresting cell progression and enabling totipotency.
Researchers at the Babraham Institute used CRISPR to delete PRC2 from human embryonic stem cells, revealing its role in keeping genes switched off until needed. Loss of PRC2 caused compromised cell quality and specialisation into mature cell types.
Researchers define how genetic factors affect blood-forming stem cells' regenerative properties, accelerating or hindering their ability to restore the immune system. The findings highlight two molecular mechanisms that could be manipulated to increase hematopoietic stem cell regeneration.
Researchers at Harvard University and Novartis have discovered that Zika virus can infect neural progenitor cells by grabbing onto a specific protein called AXL on the cell surface. This finding contradicts previous studies suggesting that targeting the AXL protein alone could defend against the virus.
Researchers compared three types of adult stem cells from 14 patients to determine their cardiac repair potential. Right atrial stem cells had the greatest protective effect on heart muscle cells, while ventricular stem cells promoted new blood vessel formation.
Researchers at McGill University's Montreal Neurological Institute will study motor neurons and astrocytes created from people with different forms of ALS via stem cell technology. The project aims to develop a potential screening mechanism for therapeutics and create new zebrafish models of the disease.
UCSF researchers found a way to pause the development of early mouse embryos for up to a month in the lab by inhibiting a master regulator of cell growth. The treatment could improve outcomes in assisted reproduction and regenerative medicine, while also potentially slowing cancer growth.
A new color-based labeling technique allows researchers to track the development and behavior of individual blood stem cells. The study reveals that these cells have a scripted set of responses and cannot make just any blood cell type.
Researchers at UCLA discovered that cardiac fibroblasts, which give rise to scar tissue after injury, can also produce bone-like cells. By blocking an enzyme involved in bone mineralization, they prevented calcification in mice, offering a potential new approach for treating abnormal calcium deposits in the heart.
EPFL scientists have developed a patent-pending hydrogel that can grow organoids in a standardized and controlled way, overcoming current limitations. The breakthrough provides a fully controllable and tunable environment for growing miniature organs, shedding light on the influence of physical factors on stem cell behavior.
New UCL research reveals that blood vessels play a vital role in telling neural stem cells when and how to reproduce. The study found that preventing blood vessel growth interferes with normal neuron production, causing stem cells to disappear from the brainstem.
A recent study published in the journal Stem Cells found that autologous stem cell therapy after traumatic brain injury appears to reduce inflammation and preserve critical brain regions. Researchers used this approach on 25 patients, including those with severe TBI, showing promising results.
Researchers identify Adamts1 as a key regulator of fat cell differentiation, triggered by high-fat diets and stress hormones. The hormone's production affects fat storage in different parts of the body, with implications for obesity treatment.
Researchers at Gladstone Institutes identify a gene mutation that enhances the efficiency of stem cell reprogramming, improving the number of induced pluripotent stem cells (iPSCs) generated from skin cells. This breakthrough could have significant implications for regenerative medicine and drug discovery.
Researchers at Stanford University School of Medicine discovered that a diet deficient in the amino acid valine can effectively deplete blood stem cells in mice, allowing for successful transplantation. This finding may lead to new ways to treat certain cancers and bone marrow disorders without chemotherapy or radiation therapy.
Researchers delivered human stem cells to damaged heart muscles in rats and found regional functional changes, while non-cell seeded sutures showed no effect. The study demonstrates potential for cell therapeutics to deliver cells to specific targets.
Izpisua Belmonte's lab aims to generate functional primate organs and tissues in vivo using novel stem cell technologies. His work could lead to new methods for growing transplantable human tissues and overcoming organ rejection issues.
Researchers at SNPRC have developed an operational technique for delivering neural stem cells to the brain with low invasiveness and high accuracy, targeting the basal ganglia to treat Parkinson's disease. The technique revealed a pulsatile dispersion of injected cells, which could enhance cell survival and efficacy.
Researchers have successfully corrected the mutated gene responsible for sickle cell disease in stem cells using CRISPR-Cas9 gene editing. The study holds promise for a new treatment by re-infusing edited stem cells into patients, potentially alleviating symptoms and improving lifespan.
Researchers found that satellite cells differentiate into myofibres only when Prox1 is active. The study also revealed that Prox1 is expressed in adult slow muscle fibres, which have high metabolic activity and are linked to type 2 diabetes risk.
A new study reveals the cellular mechanisms that help human mesenchymal stem cells (hMSCs) retain their therapeutic properties when cultured in the lab. Mitochondria play a central role in this process.
Researchers at Columbia University Irving Medical Center have identified stem cells in the temporomandibular joint that can generate cartilage and bone. The discovery suggests a potential new approach to repairing damaged joints, particularly for patients with TMJ disorders.
Researchers at the University of Minnesota found that endoglin modulates key signaling pathways to favor early cell differentiation into blood cells over the heart. High levels of endoglin expression enhance blood cell development, while cardiac cells are in deficit. The study's findings provide new insights into mechanisms regulating ...
Researchers found that vitamin D influences inflammatory signals controlling blood stem cell formation and multiplication. Vitamin D exposure led to an increase in blood stem cells, while deficiency resulted in fewer cells being formed.
Researchers have found a way to restore youthful DNA length in aging cardiac stem cells, improving their ability to form new blood vessels and regenerate heart tissue. The treatment uses a drug to temporarily wake up the cells, making them more responsive to low-oxygen conditions.
Researchers discover that inflammatory signaling in bone marrow tumor environment drives malignancy and predicts leukemia development. The study reveals that mesenchymal stem cells under stress release inflammatory molecules causing DNA damage in hematopoietic stem cells, increasing leukemia risk.
Researchers used human embryonic stem cells to treat spinal cord injuries in mice, finding that the cells produced GABA, reduced neuropathic pain and bladder dysfunction, and improved voiding ability. The study suggests a new approach for treating chronic pain and bladder issues in spinal cord injury patients.
Scientists in Japan have successfully demonstrated the transplantation of stem cell-derived retinal cells generated from immunologically matched donor animals without the need for harmful immunosuppressants. MHC-mismatched grafts produced tissue damage and signs of immune rejection, while matched grafts survived without immunosuppression.
Researchers discovered a Polycomb mechanism governing intestinal homeostasis, which is disrupted in coeliac disease and possibly in colorectal cancer. This study sheds light on the pathogenesis of intestinal damage in coeliac disease and provides diagnostic markers.
Researchers at TUM have developed molecular sensors from deep-sea jellyfish proteins to measure electrical activity in heart cells. This allows for the identification of specific cell types and improves disease modeling and drug testing.
Researchers found that stem cell transplant can accelerate cellular aging in patients with blood cancer, increasing the molecular age by up to three times pre-transplant levels. The study's findings may help physicians predict patient risk and benefit associated with the treatment.
A Case Western Reserve University researcher proposes a framework to address ethical questions surrounding potentially revolutionary research on part-human, part-animal embryos. The researcher suggests prioritizing animal welfare while enabling scientific progress in areas of biomedical importance.
A large systematic study confirms the crucial contribution of stem cells to cancer origins in different organs. The study reveals that only cells with stem cell activity make cancer, and damage to tissues can 'wake up' sleeping stem cells, increasing cancer risk.
Researchers identified a critical role for stem cells in cancer formation and found that specific organs are more susceptible due to high wear and tear. The study suggests behaviors like smoking or UV exposure increase the risk of developing cancer.
Scientists at Lund University have developed a barcode system to track the development of immune cells, revealing that stem cells undergo different stages of maturation. This discovery has significant implications for understanding leukemia and autoimmune diseases.
A new study found that a human protein combined with stem cell therapy can repair brain damage caused by stroke. The treatment, known as 3K3A-APC, was tested in mice and showed promising results, including the growth of functional neurons and improved motor function. Researchers believe this could pave the way for a potential breakthro...
A new study found that a combination of stem cell grafts and a compound called 3K3A-APC significantly improves motor and sensory functions in mice with stroke-induced brain damage. The therapy increases the production of nerve cells, forming functional connections with the host's nervous system.
Researchers from the University of Pennsylvania have discovered a link between telomeres and the Wnt signaling cascade, which may hold a treatment option for patients with dyskeratosis congenita. Stimulating the Wnt pathway reversed signs of DC-related dysfunction in human tissues.
Researchers discover Zika virus kills off neural stem cells in adult mice, raising concerns about its impact on the adult brain. The study found a 4- to 10-fold drop in adult stem cell proliferation, which could have implications for learning and memory.
Researchers at Stowers Institute have identified a key molecule, EGFR-3, that directs planarian stem cells to make copies of themselves. The discovery has important implications for advancing regenerative medicine and developing effective cancer therapies.
Researchers have devised a method to conduct blood stem cell transplantation without the use of chemotherapy or radiotherapy. This technique uses antibodies to deplete blood-forming stem cells, allowing transplanted blood stem cells from a donor to take up residence in the bone marrow and generate a new immune system.
Researchers identified new mechanisms controlling stem cell properties in flatworms, including alternative splicing processes that operate only in stem cells. The study also reveals a previously unknown interaction between proteins MBNL and CELF, which may have implications for human regenerative medicine.
Researchers have made patients' stem cells available for worldwide study to better understand bipolar disorder, a serious mental illness with extreme mood swings. The shared stem cells can be turned into brain cells in the lab, enabling scientists to study how the disease affects brain cells and potentially lead to new treatments.
Researchers at Indiana University School of Medicine found that the body's immune response system malfunctions during severe bacterial infections, leading to permanent damage to blood-producing cells. This discovery provides a new target for protecting the immune system during major infections.
Researchers have identified two proteins that safeguard skin stem cells, which are essential for skin renewal and regeneration. The study reveals that without these proteins, skin stem cells collapse and disappear from the tissue.
Researchers at ETH Zurich study how stem cells differentiate into blood cells, revealing complex mechanisms beyond previously thought protein GATA1 and PU.1 roles. This knowledge is vital for developing effective treatments for life-threatening diseases.
A study suggests that stem cell infusion could help restore the trabecular meshwork, which drains fluid from the eye and prevents glaucoma. Researchers are confident that this approach may hold promise for primary open angle glaucoma, but further studies are needed to confirm its effectiveness.
Researchers at the University of Basel discovered that the choroid plexus produces key signaling factors that regulate adult neural stem cells. As people age, these signals change, affecting stem cell behavior and leading to a decrease in new neuron formation.
A key gene called AUF1 determines whether adult stem cells can regenerate muscle after injury and with age. The study found that mice engineered to lack the AUF1 gene showed reduced stem-cell-driven repair, leading to muscle breakdown.