Articles tagged with Stem Cell Research
Researchers at SNPRC have developed an operational technique for delivering neural stem cells to the brain with low invasiveness and high accuracy, targeting the basal ganglia to treat Parkinson's disease. The technique revealed a pulsatile dispersion of injected cells, which could enhance cell survival and efficacy.
Izpisua Belmonte's lab aims to generate functional primate organs and tissues in vivo using novel stem cell technologies. His work could lead to new methods for growing transplantable human tissues and overcoming organ rejection issues.
Researchers have successfully corrected the mutated gene responsible for sickle cell disease in stem cells using CRISPR-Cas9 gene editing. The study holds promise for a new treatment by re-infusing edited stem cells into patients, potentially alleviating symptoms and improving lifespan.
Researchers found that satellite cells differentiate into myofibres only when Prox1 is active. The study also revealed that Prox1 is expressed in adult slow muscle fibres, which have high metabolic activity and are linked to type 2 diabetes risk.
A new study reveals the cellular mechanisms that help human mesenchymal stem cells (hMSCs) retain their therapeutic properties when cultured in the lab. Mitochondria play a central role in this process.
Researchers at Columbia University Irving Medical Center have identified stem cells in the temporomandibular joint that can generate cartilage and bone. The discovery suggests a potential new approach to repairing damaged joints, particularly for patients with TMJ disorders.
Researchers at the University of Minnesota found that endoglin modulates key signaling pathways to favor early cell differentiation into blood cells over the heart. High levels of endoglin expression enhance blood cell development, while cardiac cells are in deficit. The study's findings provide new insights into mechanisms regulating ...
Researchers found that vitamin D influences inflammatory signals controlling blood stem cell formation and multiplication. Vitamin D exposure led to an increase in blood stem cells, while deficiency resulted in fewer cells being formed.
Researchers used human embryonic stem cells to treat spinal cord injuries in mice, finding that the cells produced GABA, reduced neuropathic pain and bladder dysfunction, and improved voiding ability. The study suggests a new approach for treating chronic pain and bladder issues in spinal cord injury patients.
Researchers have found a way to restore youthful DNA length in aging cardiac stem cells, improving their ability to form new blood vessels and regenerate heart tissue. The treatment uses a drug to temporarily wake up the cells, making them more responsive to low-oxygen conditions.
Researchers discover that inflammatory signaling in bone marrow tumor environment drives malignancy and predicts leukemia development. The study reveals that mesenchymal stem cells under stress release inflammatory molecules causing DNA damage in hematopoietic stem cells, increasing leukemia risk.
Scientists in Japan have successfully demonstrated the transplantation of stem cell-derived retinal cells generated from immunologically matched donor animals without the need for harmful immunosuppressants. MHC-mismatched grafts produced tissue damage and signs of immune rejection, while matched grafts survived without immunosuppression.
Researchers discovered a Polycomb mechanism governing intestinal homeostasis, which is disrupted in coeliac disease and possibly in colorectal cancer. This study sheds light on the pathogenesis of intestinal damage in coeliac disease and provides diagnostic markers.
Researchers at TUM have developed molecular sensors from deep-sea jellyfish proteins to measure electrical activity in heart cells. This allows for the identification of specific cell types and improves disease modeling and drug testing.
Researchers found that stem cell transplant can accelerate cellular aging in patients with blood cancer, increasing the molecular age by up to three times pre-transplant levels. The study's findings may help physicians predict patient risk and benefit associated with the treatment.
A Case Western Reserve University researcher proposes a framework to address ethical questions surrounding potentially revolutionary research on part-human, part-animal embryos. The researcher suggests prioritizing animal welfare while enabling scientific progress in areas of biomedical importance.
Researchers identified a critical role for stem cells in cancer formation and found that specific organs are more susceptible due to high wear and tear. The study suggests behaviors like smoking or UV exposure increase the risk of developing cancer.
A large systematic study confirms the crucial contribution of stem cells to cancer origins in different organs. The study reveals that only cells with stem cell activity make cancer, and damage to tissues can 'wake up' sleeping stem cells, increasing cancer risk.
Scientists at Lund University have developed a barcode system to track the development of immune cells, revealing that stem cells undergo different stages of maturation. This discovery has significant implications for understanding leukemia and autoimmune diseases.
A new study found that a combination of stem cell grafts and a compound called 3K3A-APC significantly improves motor and sensory functions in mice with stroke-induced brain damage. The therapy increases the production of nerve cells, forming functional connections with the host's nervous system.
A new study found that a human protein combined with stem cell therapy can repair brain damage caused by stroke. The treatment, known as 3K3A-APC, was tested in mice and showed promising results, including the growth of functional neurons and improved motor function. Researchers believe this could pave the way for a potential breakthro...
Researchers discover Zika virus kills off neural stem cells in adult mice, raising concerns about its impact on the adult brain. The study found a 4- to 10-fold drop in adult stem cell proliferation, which could have implications for learning and memory.
Researchers from the University of Pennsylvania have discovered a link between telomeres and the Wnt signaling cascade, which may hold a treatment option for patients with dyskeratosis congenita. Stimulating the Wnt pathway reversed signs of DC-related dysfunction in human tissues.
Researchers at Stowers Institute have identified a key molecule, EGFR-3, that directs planarian stem cells to make copies of themselves. The discovery has important implications for advancing regenerative medicine and developing effective cancer therapies.
Researchers have devised a method to conduct blood stem cell transplantation without the use of chemotherapy or radiotherapy. This technique uses antibodies to deplete blood-forming stem cells, allowing transplanted blood stem cells from a donor to take up residence in the bone marrow and generate a new immune system.
Researchers identified new mechanisms controlling stem cell properties in flatworms, including alternative splicing processes that operate only in stem cells. The study also reveals a previously unknown interaction between proteins MBNL and CELF, which may have implications for human regenerative medicine.
Researchers have made patients' stem cells available for worldwide study to better understand bipolar disorder, a serious mental illness with extreme mood swings. The shared stem cells can be turned into brain cells in the lab, enabling scientists to study how the disease affects brain cells and potentially lead to new treatments.
Researchers have identified two proteins that safeguard skin stem cells, which are essential for skin renewal and regeneration. The study reveals that without these proteins, skin stem cells collapse and disappear from the tissue.
Researchers at Indiana University School of Medicine found that the body's immune response system malfunctions during severe bacterial infections, leading to permanent damage to blood-producing cells. This discovery provides a new target for protecting the immune system during major infections.
Researchers at ETH Zurich study how stem cells differentiate into blood cells, revealing complex mechanisms beyond previously thought protein GATA1 and PU.1 roles. This knowledge is vital for developing effective treatments for life-threatening diseases.
A study suggests that stem cell infusion could help restore the trabecular meshwork, which drains fluid from the eye and prevents glaucoma. Researchers are confident that this approach may hold promise for primary open angle glaucoma, but further studies are needed to confirm its effectiveness.
Researchers at the University of Basel discovered that the choroid plexus produces key signaling factors that regulate adult neural stem cells. As people age, these signals change, affecting stem cell behavior and leading to a decrease in new neuron formation.
A key gene called AUF1 determines whether adult stem cells can regenerate muscle after injury and with age. The study found that mice engineered to lack the AUF1 gene showed reduced stem-cell-driven repair, leading to muscle breakdown.
Researchers at Cedars-Sinai Medical Center have discovered that current engineered stem cells are too immature to accurately model ALS. To improve this, they suggest 'aging' the motor neurons in a laboratory dish to better represent the disease's progression.
Researchers at Johns Hopkins University have discovered a protein that boosts the growth of damaged muscle tissue, potentially contributing to treatments for age-related muscle degeneration and diseases like muscular dystrophy. The protein, β1-integrin, promotes stem cell growth and restoration after muscle injury, with results showing...
The National Stem Cell Foundation has funded a grant to study how astrocytes can be manipulated to halt or prevent neurodegeneration in diseases like MS and Parkinson's. The researchers aim to advance understanding of cell cross-talk in the central nervous system.
Harvard Stem Cell Institute researchers found that bone marrow transplantation extended the lifespan of mice with a common ALS-causing gene mutation by 43 days. The study suggests that the gene operates at a crossroads between disease and autoimmunity, and may hold key to developing therapies for specific subpopulations of ALS patients.
Scientists developed guidelines to evaluate laboratory-generated stem cells, finding that no current methods produce truly naïve embryonic cells. The new criteria may aid researchers in achieving this goal, which could benefit both basic research and medical applications of stem cells.
Researchers have discovered a genetic switch, microRNA mirR-125a, that can be used to increase the supply of stem cells from cord blood. This discovery could potentially increase the availability of stem cell transplants for cancer patients with no matching donors.
Researchers have discovered a breakthrough in scaling up life-changing stem cell production by using a protein derived from human blood, Inter-alpha inhibitor. This method enables faster and cheaper large-scale industrial production of human pluripotent stem cells without the need for costly biological substrates.
Researchers at the University of Nottingham have developed a novel method for culturing human stem cells using a protein derived from human blood, which could lead to faster and more cost-effective large-scale production. This breakthrough has the potential to revolutionize the field of regenerative medicine and disease research.
USC researchers studied epigenetic signals regulating Atoh1, a critical factor in hair cell development and sensory structure formation. The studies aim to develop new therapies to stimulate hair cell regeneration in individuals with hearing loss or deafness.
A new government study suggests that the graying of the biomedical workforce is driving younger scientists away from academia, but found no evidence of a preference for older applicants in NIH grant funding. The study's authors conclude that other factors, such as changes in academic training and payment, are more likely to be contribu...
A study found that at least 351 US businesses are marketing unapproved stem cell procedures, targeting various medical conditions. The businesses are mainly concentrated in California, Florida, and Texas.
Therapeutic stem cells exit the bloodstream via a distinct process called angiopellosis, where endothelial cells actively push them out of blood vessels. This alternative mechanism allows for longer exit times and multiple cell exits at once, with implications for cancer research and intravenous therapies.
Researchers developed a new method to maintain the transplantation efficiency of satellite cells, which are found in skeletal muscles. The study used leukemia inhibitory factor (LIF) to enhance muscle fiber formation after transplantation, resulting in two to three times more fibers formed compared to control cells.
Scientists at Massachusetts General Hospital developed a new procedure to generate and expand airway stem cells from lung tissue samples, allowing for multiple generations of cultures. This breakthrough may lead to improved treatments for airway diseases like asthma and COPD.
Columbia University researchers develop groundbreaking technique to repair large bone defects in the head and face with lab-grown living bone. The innovative approach, which uses autologous stem cells derived from a patient's fat, enables precise anatomical replication and active bone remodeling.
Researchers from the University of Pennsylvania have identified distinct characteristics that differentiate reserve stem cells from label-retaining cells, resolving a decades-long debate. The study uses single-cell gene expression analyses to demonstrate that reserve stem cells are a separate population in the intestines.
A team of researchers has successfully grown functional pituitary tissue from human stem cells that can release hormones important for growth, reproductive functions, and stress response. The study's findings hold promise for a more permanent therapeutic option for patients with hypopituitarism.
Researchers found that Prkci gene plays a crucial role in organizing cells into balls and tubes during early embryo and organ formation. By mixing functional Prkci with cells lacking it, they restored normal polarity, suggesting an unknown molecular signal was transmitted to disoriented cells.
Researchers found that 30% of induced pluripotent stem cells were genetically unstable and not safe for clinical use. Despite this, a large set of iPSCs met quality standards, and the study established an online database to support further research.
Researchers at ULB developed new methods to determine stem cell multipotency and unipotency with high confidence. The findings show that prostate cells are multipotent while mammary gland cells are unipotent, resolving a long-standing debate in the field.
Researchers have unraveled how pre-leukemic white blood cell precursors become leukemia stem cells by targeting the RNA editing enzyme ADAR1. Inhibiting ADAR1 can counteract its effect on leukemia stem cell self-renewal, potentially reducing cancer progression.
Research at Washington University School of Medicine found that a metabolite produced by beneficial gut microbes restricts the proliferation of intestinal stem cells. This limits the intestine's ability to repair itself after injury or damage, potentially hampering treatment for inflammatory bowel disease (IBD).
Noninvasive cell-tracking methods enable assessment of stem-cell based therapy safety and efficacy. Current tracking methods for transplanted stem cells include reporter-gene based, exogenous contrast label-based, and multimodel imaging techniques.
Scientists at NYSCF Research Institute discovered strategies to prevent mitochondrial mixtures, leading to effective mitochondrial replacement. Egg freezing enables doctors to avoid synchronized ovulation between patient and donor, allowing for safer treatment of mitochondrial diseases.
Researchers at Carnegie Mellon University have developed a new method for preparing and labeling mesenchymal stem cells (MSCs) that allows them to be tracked using magnetic resonance imaging (MRI). This breakthrough technology uses a bio-mimicry approach to create an environment similar to the body, enabling MSCs to internalize iron-ox...
Assoc Prof Lim Soon Thye has received a S$2.5 million Tanoto Foundation Professorship to advance research on Non-Hodgkin's Lymphoma, a cancer prevalent in Asia with limited treatment options. The funding will focus on improving diagnostic and clinical outcomes for patients.
Researchers in China report that fetal mice infected with the Asian Zika virus strain display characteristic features of microcephaly. The study found that neural progenitor cells were initially infected, followed by neurons, and that almost all cell death occurred in neurons, not progenitor cells.