Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Enteroviruses cause millions of infections worldwide, with infant fatality rates approaching 20 percent. A new study uses a miniature gut model to reveal how these viruses enter the intestine, targeting specific cells and facilitating bloodstream entry.
Researchers at Rice University have developed a new compound of bismuth and carbon nanotubes that improves upon existing cell-tracking agents. The improved Bi4C@US-tubes show up strongly on X-rays taken with computed tomography (CT) scanners, allowing for more efficient tracking of stem cells in the body.
Johns Hopkins researchers successfully created mature heart muscle cells from human or animal stem cells by implanting them into newborn rat hearts. The host animal's biological signals and chemistry enabled the immature cells to mature, overcoming a developmental blockade.
Researchers at UCL and Heinrich Heine University have discovered the OCT4 gene essential for chemically reprogramming human amniotic stem cells. The process allows these cells to be rejuvenated and function like embryonic stem cells, providing a promising alternative for therapies and research.
Researchers at Stanford University and the University of Tokyo successfully transplanted functional mouse islets into diabetic mice, reversing their condition with minimal immunosuppression. The study suggests a potential approach to generate genetically matched human organs in large animals.
Scientists at the University of North Carolina have discovered a promising new avenue for fighting gastrointestinal cancers by unmasking the previously misunderstood gene Gpr182. The study reveals that Gpr182 could be a key regulator of intestinal stem cell proliferation, and its protein code for a potential drug target.
Researchers at Boston University School of Medicine are creating an induced pluripotent stem cell-based library for sickle cell disease, offering a valuable resource for disease modeling and treatment development. The library comprises diverse patient samples, enabling the study of genetic backgrounds and potential therapies.
Stem cell therapies aim to restore function in degenerative conditions, but ensuring cell survival is a major hurdle. Researchers successfully restored long-term vision in blind mice by transplanting photoreceptors derived from human stem cells and suppressing the immune response that rejects transplanted cells.
Researchers successfully used CRISPR-Cas9 technology to repair genetic mutations in blood stem cells of patients with chronic granulomatous disease, a rare and life-threatening disorder. The engineered cells maintained their gene edits long-term without side effects when implanted into mice.
Researchers at Stanford University School of Medicine have discovered that diabetes impairs the activity of bone stem cells, leading to impaired fracture healing. A newly identified protein stimulates the activity of skeletal stem cells, counteracting this decrease and promoting efficient fracture repair.
Researchers have successfully generated epicardium cells using human stem cells and Wnt signaling pathway activation. The new method could potentially repair damaged heart tissue in patients who suffer from heart attacks, according to the study published in Nature Biomedical Engineering.
A team of researchers at King's College London has discovered a method to stimulate the renewal of living stem cells in tooth pulp using an Alzheimer's drug. This novel approach aims to promote natural tooth repair and potentially reduce the need for fillings or cements.
Researchers have developed synthetic stem cells that mimic natural cardiac stem cells, promoting tissue repair and reducing risks of tumor growth and immune rejection. These cells are more durable, can be used off-the-shelf, and can tolerate harsh freezing and thawing.
Researchers developed a method for generating Leydig cells by directly converting adult skin cells into functional testosterone-producing cells. The approach successfully restored normal testosterone levels in male rodents with hypogonadism, offering a promising alternative to existing therapies.
The Keck School of Medicine of USC has received a $2.5 million grant to develop an off-the-shelf stem cell therapy for osteoarthritis. The therapy aims to reduce the need for joint replacement surgery, mitigating the burden on patients and physicians.
Johns Hopkins scientists successfully created more-flexible human embryonic stem cells by dosing conventional ESCs with a cocktail of three chemical inhibitors. The new cells exhibit features similar to those of classic mouse ESCs, enabling their potential use in therapies and genetic disease modeling.
A deficiency of prohormone covertase (PC1) in the brain is linked to most neuro-hormonal abnormalities in Prader-Willi syndrome. The discovery provides insight into molecular mechanisms underlying the syndrome, highlighting a novel target for drug therapy.
Researchers found genetic mutations increased with donor age, particularly in late 80s and early 90s donors, which could impact iPSC therapies. Screening is crucial to filter out defects and ensure safe treatment.
Researchers found a dynamic, multi-step process in which multiple independent changes converge to transform stem cells into motor neurons. The study outlines challenges facing current cell-replacement technology but also highlights potential pathways for enhanced gene-therapy methods.
A new 17-gene signature derived from leukemia stem cells can predict AML patients' response to standard treatment, enabling clinicians to tailor treatment and improve patient care. The LSC17 score has been shown to accurately identify high-risk patients who are less likely to be cured by standard therapy.
Researchers have developed a novel live-cell imaging method that allows for dynamic, high-resolution visualization of cell interactions. The Photonic Crystal Enhanced Microscope (PCEM) can quantify and measure cell adhesion, a critical process involved in cell migration, differentiation, division, and death.
Researchers at the Babraham Institute used CRISPR to delete PRC2 from human embryonic stem cells, revealing its role in keeping genes switched off until needed. Loss of PRC2 caused compromised cell quality and specialisation into mature cell types.
Researchers at Helmholtz Zentrum München found a mechanism controlling cell division after fertilization, allowing for diverse cellular development. The study reveals that the molecule Suv4-20h2 attaches methyl groups to histones, arresting cell progression and enabling totipotency.
Researchers define how genetic factors affect blood-forming stem cells' regenerative properties, accelerating or hindering their ability to restore the immune system. The findings highlight two molecular mechanisms that could be manipulated to increase hematopoietic stem cell regeneration.
Researchers at Harvard University and Novartis have discovered that Zika virus can infect neural progenitor cells by grabbing onto a specific protein called AXL on the cell surface. This finding contradicts previous studies suggesting that targeting the AXL protein alone could defend against the virus.
Researchers at McGill University's Montreal Neurological Institute will study motor neurons and astrocytes created from people with different forms of ALS via stem cell technology. The project aims to develop a potential screening mechanism for therapeutics and create new zebrafish models of the disease.
Researchers compared three types of adult stem cells from 14 patients to determine their cardiac repair potential. Right atrial stem cells had the greatest protective effect on heart muscle cells, while ventricular stem cells promoted new blood vessel formation.
A new color-based labeling technique allows researchers to track the development and behavior of individual blood stem cells. The study reveals that these cells have a scripted set of responses and cannot make just any blood cell type.
UCSF researchers found a way to pause the development of early mouse embryos for up to a month in the lab by inhibiting a master regulator of cell growth. The treatment could improve outcomes in assisted reproduction and regenerative medicine, while also potentially slowing cancer growth.
Researchers at UCLA discovered that cardiac fibroblasts, which give rise to scar tissue after injury, can also produce bone-like cells. By blocking an enzyme involved in bone mineralization, they prevented calcification in mice, offering a potential new approach for treating abnormal calcium deposits in the heart.
EPFL scientists have developed a patent-pending hydrogel that can grow organoids in a standardized and controlled way, overcoming current limitations. The breakthrough provides a fully controllable and tunable environment for growing miniature organs, shedding light on the influence of physical factors on stem cell behavior.
New UCL research reveals that blood vessels play a vital role in telling neural stem cells when and how to reproduce. The study found that preventing blood vessel growth interferes with normal neuron production, causing stem cells to disappear from the brainstem.
A recent study published in the journal Stem Cells found that autologous stem cell therapy after traumatic brain injury appears to reduce inflammation and preserve critical brain regions. Researchers used this approach on 25 patients, including those with severe TBI, showing promising results.
Researchers identify Adamts1 as a key regulator of fat cell differentiation, triggered by high-fat diets and stress hormones. The hormone's production affects fat storage in different parts of the body, with implications for obesity treatment.
Researchers at Gladstone Institutes identify a gene mutation that enhances the efficiency of stem cell reprogramming, improving the number of induced pluripotent stem cells (iPSCs) generated from skin cells. This breakthrough could have significant implications for regenerative medicine and drug discovery.
Researchers at Stanford University School of Medicine discovered that a diet deficient in the amino acid valine can effectively deplete blood stem cells in mice, allowing for successful transplantation. This finding may lead to new ways to treat certain cancers and bone marrow disorders without chemotherapy or radiation therapy.
Researchers delivered human stem cells to damaged heart muscles in rats and found regional functional changes, while non-cell seeded sutures showed no effect. The study demonstrates potential for cell therapeutics to deliver cells to specific targets.
Izpisua Belmonte's lab aims to generate functional primate organs and tissues in vivo using novel stem cell technologies. His work could lead to new methods for growing transplantable human tissues and overcoming organ rejection issues.
Researchers at SNPRC have developed an operational technique for delivering neural stem cells to the brain with low invasiveness and high accuracy, targeting the basal ganglia to treat Parkinson's disease. The technique revealed a pulsatile dispersion of injected cells, which could enhance cell survival and efficacy.
Researchers found that satellite cells differentiate into myofibres only when Prox1 is active. The study also revealed that Prox1 is expressed in adult slow muscle fibres, which have high metabolic activity and are linked to type 2 diabetes risk.
Researchers have successfully corrected the mutated gene responsible for sickle cell disease in stem cells using CRISPR-Cas9 gene editing. The study holds promise for a new treatment by re-infusing edited stem cells into patients, potentially alleviating symptoms and improving lifespan.
A new study reveals the cellular mechanisms that help human mesenchymal stem cells (hMSCs) retain their therapeutic properties when cultured in the lab. Mitochondria play a central role in this process.
Researchers at Columbia University Irving Medical Center have identified stem cells in the temporomandibular joint that can generate cartilage and bone. The discovery suggests a potential new approach to repairing damaged joints, particularly for patients with TMJ disorders.
Researchers at the University of Minnesota found that endoglin modulates key signaling pathways to favor early cell differentiation into blood cells over the heart. High levels of endoglin expression enhance blood cell development, while cardiac cells are in deficit. The study's findings provide new insights into mechanisms regulating ...
Researchers found that vitamin D influences inflammatory signals controlling blood stem cell formation and multiplication. Vitamin D exposure led to an increase in blood stem cells, while deficiency resulted in fewer cells being formed.
Researchers discover that inflammatory signaling in bone marrow tumor environment drives malignancy and predicts leukemia development. The study reveals that mesenchymal stem cells under stress release inflammatory molecules causing DNA damage in hematopoietic stem cells, increasing leukemia risk.
Researchers used human embryonic stem cells to treat spinal cord injuries in mice, finding that the cells produced GABA, reduced neuropathic pain and bladder dysfunction, and improved voiding ability. The study suggests a new approach for treating chronic pain and bladder issues in spinal cord injury patients.
Researchers have found a way to restore youthful DNA length in aging cardiac stem cells, improving their ability to form new blood vessels and regenerate heart tissue. The treatment uses a drug to temporarily wake up the cells, making them more responsive to low-oxygen conditions.
Scientists in Japan have successfully demonstrated the transplantation of stem cell-derived retinal cells generated from immunologically matched donor animals without the need for harmful immunosuppressants. MHC-mismatched grafts produced tissue damage and signs of immune rejection, while matched grafts survived without immunosuppression.
Researchers discovered a Polycomb mechanism governing intestinal homeostasis, which is disrupted in coeliac disease and possibly in colorectal cancer. This study sheds light on the pathogenesis of intestinal damage in coeliac disease and provides diagnostic markers.
Researchers at TUM have developed molecular sensors from deep-sea jellyfish proteins to measure electrical activity in heart cells. This allows for the identification of specific cell types and improves disease modeling and drug testing.
Researchers found that stem cell transplant can accelerate cellular aging in patients with blood cancer, increasing the molecular age by up to three times pre-transplant levels. The study's findings may help physicians predict patient risk and benefit associated with the treatment.
A Case Western Reserve University researcher proposes a framework to address ethical questions surrounding potentially revolutionary research on part-human, part-animal embryos. The researcher suggests prioritizing animal welfare while enabling scientific progress in areas of biomedical importance.
Researchers identified a critical role for stem cells in cancer formation and found that specific organs are more susceptible due to high wear and tear. The study suggests behaviors like smoking or UV exposure increase the risk of developing cancer.
A large systematic study confirms the crucial contribution of stem cells to cancer origins in different organs. The study reveals that only cells with stem cell activity make cancer, and damage to tissues can 'wake up' sleeping stem cells, increasing cancer risk.
Scientists at Lund University have developed a barcode system to track the development of immune cells, revealing that stem cells undergo different stages of maturation. This discovery has significant implications for understanding leukemia and autoimmune diseases.
A new study found that a combination of stem cell grafts and a compound called 3K3A-APC significantly improves motor and sensory functions in mice with stroke-induced brain damage. The therapy increases the production of nerve cells, forming functional connections with the host's nervous system.
A new study found that a human protein combined with stem cell therapy can repair brain damage caused by stroke. The treatment, known as 3K3A-APC, was tested in mice and showed promising results, including the growth of functional neurons and improved motor function. Researchers believe this could pave the way for a potential breakthro...
Researchers from the University of Pennsylvania have discovered a link between telomeres and the Wnt signaling cascade, which may hold a treatment option for patients with dyskeratosis congenita. Stimulating the Wnt pathway reversed signs of DC-related dysfunction in human tissues.
Researchers discover Zika virus kills off neural stem cells in adult mice, raising concerns about its impact on the adult brain. The study found a 4- to 10-fold drop in adult stem cell proliferation, which could have implications for learning and memory.