Articles tagged with Stem Cell Research
Researchers are developing new technologies to analyze pancreatic tumor super-enhancers and testing therapies targeting these signals in clinical trials. The goal is to reprogram cancer cells or create vulnerabilities that can be exploited with combination drug therapies.
Lung researcher Dr. Marie-Liesse Asselin-Labat has received a competitive $1.225 million Viertel Fellowship to investigate lung development and cancer. The funding will support her work on developing better treatments for premature babies with underdeveloped lungs and those with lung disease, including cancer.
Schizophrenia impacts brain protein synthesis rates, affecting cellular machinery and function in adult stem cells. The study's findings enhance understanding of the disorder and provide new approaches for future drug therapies.
Researchers at USC and Sangamo BioSciences have developed a more efficient method for editing genes in blood-forming stem cells (HSPCs), which could potentially treat diseases such as HIV and other blood disorders. By combining two delivery methods, the team achieved unprecedented efficiency rates ranging from 15 to 40 percent.
Researchers at Northwestern University have developed a microfluidic device to sort neural stem cell populations, making them easier to study. The device uses inertial forces to isolate single stem cells, reducing stress on the cells and preserving their multipotency.
Researchers have discovered a new view of how human blood is made, resolving how different kinds of blood cells form quickly from stem cells. This finding has significant implications for understanding and treating blood disorders and diseases.
The study has tremendous potential to improve our understanding of early development, enhance disease modeling, and promote therapeutic discovery. Researchers believe that work on chimeric embryos is vital to advance this field despite ethical concerns.
Researchers from the University of Gothenburg and Karolinska Institutet have cast doubt on the effectiveness of stem cell therapy for treating female infertility. The study, published in Nature Medicine, suggests that stem cells cannot generate new egg cells, rendering the treatment unreliable.
Researchers have developed a groundbreaking method to identify and separate human tonsil cancer stem cells, providing new insights into the disease. The study shows that these stem cells are key players in the development of tonsil cancer, with HPV infection being a major risk factor.
The Prkci gene plays a crucial role in maintaining the balance between stem cell self-renewal and differentiation into specialized cell types. Without Prkci, mouse embryonic stem cells overproduce stem cells, leading to an abundance of secondary structures.
A study led by Mount Sinai researchers identifies zinc finger protein 217 (ZFP217) as a factor that regulates stem cell self-renewal and differentiation, potentially balancing medically useful qualities for therapeutic applications. The discovery builds on understanding epigenetic mechanisms controlling gene expression.
The New York Stem Cell Foundation has awarded $7.5 million to five researchers through the NYSCF -- Robertson Investigator Program, supporting innovative work in stem cell biology and neuroscience. The recipients aim to advance our understanding of cellular processes and develop new treatments for diseases.
Franziska Michor is awarded the NYSCF -- Robertson Stem Cell Prize for her interdisciplinary research on cancer genesis, using mathematical models to understand cancer evolution. Her work simulates drug treatment regimens and has been tested in clinical trials for non-small-cell lung cancer and brain tumors.
Researchers have grown mini-kidney organoids in a laboratory by combining stem cell biology with leading-edge gene-editing techniques. These engineered mini-kidneys contain tubules, filtering cells and blood vessel cells, and can mimic both healthy and diseased kidneys.
A gene editing technique has been developed to increase the yield of laboratory-produced red blood cells, which could significantly reduce their cost. The technique targets a specific gene, SH2B3, and uses CRISPR gene editing to permanently shut it off in human embryonic stem cell lines.
Human embryonic stem-cell-derived cardiomyocytes surpass bone marrow-derived cells in repairing damaged heart tissue, suggesting a better option for future therapies. The study's findings also indicate that more mature and stable heart muscle cells may be more effective than progenitor cells in clinical studies.
Rutgers Genetics Research Center has been awarded a five-year grant to provide comprehensive stem-cell related services, including iPSC derivation and quality control. The new grant will enhance access to high-quality stem cells for researchers investigating Parkinson's, ALS, and Huntington's diseases.
Low SCF levels are linked to increased risk of cardiovascular disease and more severe atherosclerosis in patients with atherosclerosis. Smoking and diabetes can negatively impact the reparative capacity of cells responsible for blood vessel repair.
Scientists at Brigham and Women's Hospital have developed a method to create kidney structures from adult stem cells, which could be used to study diseases such as chronic kidney disease and test new therapies. These kidney structures can model the development of kidney abnormalities and susceptibility to drug toxicity.
Researchers at Scripps Research Institute in California and German institutes have partnered to develop rigorous genomics-based methods for analyzing human stem cells. The goal is to ensure high-quality induced pluripotent stem cells (iPSCs) are available for research and clinical use.
A study by Juan Méndez at CNIO sheds light on molecular mechanisms of ageing in blood stem cells, opening a new avenue for reducing their decline with age and potentially treating aplastic anaemia. Researchers managed to prevent embryonic lethality by increasing the levels of gene CHK1, showing less pronounced anaemia in mice.
A University of California, Irvine study found that neural stem cells can improve both motor and cognitive impairments associated with dementia with Lewy bodies. The treatment involves the production of brain-derived neurotrophic factor, which enhances dopamine- and glutamate-producing neurons.
Min Yu, USC scientist, wins $2.475 million NIH New Innovator Award to target breast cancer stem cells for personalized treatment. Her research aims to identify biomarkers and tailor drugs to individual patients, addressing the significant challenge of metastatic cancer stem cells.
Researchers at IMIM have found that Notch protein activation intensity determines cell fate, revealing a competition between two proteins for hematopoietic stem cell formation. This study could lead to more efficient and reproducible lab-grown blood stem cells for patients with no compatible donors.
A new study found that sleep deprivation can reduce the effectiveness of stem cell transplants by up to 50%. Researchers at Stanford University discovered that a four-hour sleep deficit can impair the ability of stem cells to migrate and function properly. However, recovery sleep can restore the cells' normal function.
Researchers have successfully generated aged neurons using stem cell technology, allowing for the study of age-related changes in the brain. The newly created neurons exhibit defects in protein transport and gene expression patterns similar to those found in older brains.
Researchers have developed a new technique to create brain cells directly from skin samples, retaining age-related signatures. This breakthrough enables scientists to study the effects of aging on the brain without relying on animal models or stem cell reprogramming.
A Johns Hopkins University biologist has made significant progress in understanding the mysterious shape-shifting ways of stem cells. The study found that an enzyme in the niche where stem cells are found can help sustain them and promote other cells to become like stem cells, which has medical implications for diseases such as cancer.
Researchers used single-cell RNA sequencing technology to study gene expression in mouse embryonic stem cells, identifying new genes involved in pluripotency and discovering new subpopulations of cells. The findings provide insights into the links between environment and inter-cell heterogeneity.
Researchers have created a new investigational drug that traps IGFBP3, preventing gastrointestinal symptoms and restoring the intestine's mucosal lining structure. The drug may hold promise as a potential treatment for diabetic enteropathy, a common complication of type 1 diabetes.
Albert D. Kim, a postdoctoral fellow at the Keck School of Medicine of USC, has received the first Hearst Fellowship for his work on turning stem cells into nephrons, the functional units of the kidney. He aims to isolate and generate kidney progenitor cells to repair damaged adult kidneys.
Researchers have identified a unique group of stem cells in the human brain that generate most neurons, expanding the cortex by 1,000-fold. These stem cells, called outer radial glia (oRGs), exhibit remarkable generative capacity and self-renewal properties.
Researchers have developed a sticky gel that helps stem cells adhere to and restore their metabolism in rat hearts, improving cardiac function after simulated heart attacks. The gel, which combines serum and hyaluronic acid, has been shown to retain up to 73% of transplanted cells in the heart.
Researchers have successfully isolated human muscle stem cells that can robustly replicate and repair damaged muscles when grafted onto an injured site. The findings hold promise for patients with severe muscle injury, paralysis, or genetic diseases like muscular dystrophy.
Researchers from IMCB identified 303 genes linked to proviral silencing, revealing coordinated mechanisms involving multiple cellular pathways. The study found that Chaf1a and Sumo2 are the key factors controlling this process, with potential implications for stem cell therapy and disease diagnosis.
Researchers developed a custom silicone guide implanted with biochemical cues to promote both motor and sensory nerve regeneration. The study showed improved walking ability in rats within 10-12 weeks, paving the way for human trials.
Scientists at the University of Zurich discovered a novel mechanism that helps neural stem cells resist aging-induced damage. A diffusion barrier in the endoplasmic reticulum regulates the sorting of damaged proteins, allowing for rejuvenation and longer lifespan.
Researchers at Kyoto University have created a lab-based human germ cell development model, revealing specific key elements and events that occur at the beginning of human life. This breakthrough provides insight into how epigenetic marks are erased during early germ cell development, shedding light on conditions such as infertility.
A new study by USF researchers suggests that transplanted human bone marrow stem cells preferentially migrate to the spleen, reducing systemic inflammation and secondary brain cell death in post-stroke rats. The anti-inflammatory effects of the stem cells promoted reduced lesions caused by acute stroke.
A new strategy using porous, transplantable hydrogels has experimentally improved bone repair by boosting the survival rate of transplanted stem cells and influencing their cell differentiation. This breakthrough could lead to enhanced regenerative therapies for various tissues and organs.
A new method of harvesting and growing lung stem cells has been developed by researchers at NC State University, which could provide an effective treatment for idiopathic pulmonary fibrosis (IPF). The study used a multicellular spheroid environment to enrich adult lung stem cells, which showed promise in mice trials with reduced inflam...
A team of scientists is using an optical interferometer to monitor the growth of stem cells on tiny polymer spheres, enabling large-scale production and quality control. The device takes images as the tank is stirred, allowing researchers to track cell confluence and morphology.
Researchers at the Centre for Genomic Regulation have discovered a unique genetic switch that guides stem cells into developing specialized heart muscle. The discovery of the Mel18 protein is expected to reveal underlying causes of heart defects and potentially lead to new methods for controlling stem cells in the laboratory.
Researchers from Drexel University used image-tracking technology to study the development of neural stem cells in mice, finding intrinsic differences between anterior and posterior stem cells that could explain how areas of the cortex develop into specialized structures. The discovery was made possible by powerful biological tracking ...
A CNIO team has identified the origin of damage to induced pluripotent stem cells and developed strategies to reduce it, resulting in cells with less damage to their genome. This breakthrough improves the safety of iPS cells for use in biomedicine, potentially treating cardiovascular diseases, diabetes, and neurodegenerative disorders.
Researchers at UCSF have developed a method to precisely control embryonic stem cell differentiation with beams of light, revealing an internal timer within stem cells that lets them tune out extraneous biological noise. The technique enables stem cells to transform into neurons in response to a precise external cue.
Researchers at UC Berkeley created an implant containing stem cells that form functional brown-fat-like tissue, reducing weight gain and lowering blood glucose levels in mice. The study's results suggest the technique could lead to new therapeutic approaches for metabolic disorders.
Janos Peti-Peterdi, a USC kidney researcher, has made significant advances in visualizing the function of the living kidney's filter and studying kidney stem cells. He aims to find new treatments and therapies for patients with chronic kidney disease.
Participants with late-stage retinitis pigmentosa are being enrolled in the clinical trial to test the safety of retinal progenitor cells. The open-label phase I/IIa trial aims to evaluate the treatment's efficacy in preserving vision by protecting and potentially reactivating degenerating photoreceptors.
A comprehensive study found that cold water immersion after strength training reduced long-term muscle mass and strength gains. Muscle biopsies revealed blunted activity of satellite cells and pathways needed to build bigger muscles up to two days after exercise in the ice bath group.
Harvard researchers have reconstructed an ancient virus effective at delivering gene therapies to liver, muscle, and retina. The discovery may lead to novel vectors for safer and more potent gene therapies.
Researchers developed a stem cell model to assess the neurotoxicity of Bisphenol A (BPA) efficiently and cost-effectively. The study showed that BPA may alter embryonic development in vivo, highlighting the potential health risks associated with environmental pollution.
A team of ETH Zurich researchers has identified seven genes central to X chromosome inactivation in females, including Spen, which prevents gene expression at the X chromosome. The discovery sheds light on how the human body maintains a delicate balance between genes, preventing disease.
Researchers in China have independently transformed skin cells from humans and mice into neurons using chemical cocktails. The studies show that the reprogrammed cells exhibit similar gene expression and neuronal activity as those generated through traditional methods.
Researchers designed a revolutionary high-throughput robotic platform to automate the process of generating patient-specific stem cells, reducing variability and increasing scale. This technology allows for 'clinical trials in a dish' and can identify potential drug metabolism and toxicity issues in human cells before clinical trials.
Researchers discover a single molecule, C/EBPa, can transform a B cell into a macrophage by 'short-circuiting' gene expression. This process involves the convergence of two DNA enhancer pathways, allowing for unnatural transdifferentiation. The findings have significant implications for regenerative medicine and cancer treatment.
A new study using human embryonic stem cells suggests that early exposure to bisphenol A may lead to an increased risk of prostate cancer. The research found that BPA caused the development of prostate organoids to produce an overabundance of prostate stem cells, which could be a risk factor for cancer.
Scientists have developed a novel process to regenerate salivary cells using silk fibers as a framework, which could help millions in the US with dry mouth due to Sjögren's syndrome. The process has been shown to retain salivary gland cell properties and is a significant step towards developing new cell-based therapeutics.
Researchers at University of Birmingham discovered how mutated FLT3 genes reprogram blood stem cells, leading to abnormal cell production. The findings provide hope for developing new treatments for acute myeloid leukaemia.
Researchers at Cedars-Sinai Medical Center have developed a new gene-editing technique involving low-dose irradiation, which is 10 times more effective than existing methods. This breakthrough could enable scientists to model human diseases more accurately and accelerate the discovery process.