Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Scientists have developed a novel approach to track neural stem cells using microscopic iron beads and magnetic resonance imaging, allowing for non-invasive tracking without harming the cell. The findings focus mainly on neural stem cells but also show potential for use with mesenchymal stem cells.
Studies presented at the Eighth Annual PPSSC Conference showcased advancements in targeting stem cells, adipose-derived stem cell plasticity, and melanoma immunotherapy using genetically engineered iPSCs. These breakthroughs hold promise for developing effective treatments for regenerative medicine and cancer
A $6.3 million CIRM grant will fund stem cell trials to rescue and restore neurons devastated by ALS. The goal is to extend motor neuron survival, adding years to fulfilling life for patients.
Researchers at The Hebrew University of Jerusalem have successfully generated a new type of embryonic stem cell carrying a single copy of the human genome. These haploid stem cells are pluripotent and retain a single set of chromosomes, offering a powerful tool for genetic analysis and potential therapies for diseases.
Researchers at Columbia University Irving Medical Center have successfully generated a new type of human embryonic stem cell carrying a single copy of the human genome. These 'haploid' stem cells show potential as a powerful tool for genetic analysis in biomedical fields such as cancer research and precision medicine.
Researchers Qi-Long Ying and Austin Smith won the 2016 McEwen Award for Innovation for their discovery of inhibitory molecules that can mimic embryonic stem cells' ability to generate different cell types. Their work has opened new avenues of exploration towards understanding or treating human disease.
Australian scientists have developed a new method for harvesting stem cells that eliminates the need for growth factor injections, reducing side effects for donors. The new method combines two molecules to mobilize stem cells into the bloodstream within an hour of administration.
Researchers found that IGF2BP3 regulates various RNA messages contributing to the development of MLL-rearranged leukemia. The protein binds to and stabilizes hundreds of leukemia-promoting messages, leading to cancer cell growth.
Scientists at IRB Barcelona have identified two molecular signals and a pathway that allows differentiated cells to regain their stem cell properties. This discovery has implications for cell reprogramming, regenerative medicine, and understanding cancer.
Scientists have developed a modified form of CRISPR that can silence genes in stem cells more efficiently and precisely than the original CRISPR-Cas9 system. This new technology allows for flexible gene suppression and reversal, enabling versatile investigations into genetic diseases.
Scientists have discovered how three key molecules interact to generate blood stem cells, a crucial step in developing new treatments for leukaemia and other blood disorders. The breakthrough could lead to personalised blood therapies and reduce the need for bone marrow transplants.
A new treatment approach has been developed to remove congenital cataracts in infants and allow remaining stem cells to regrow functional lenses. The method produced fewer surgical complications and resulted in superior visual function compared to the current standard-of-care.
Researchers at Mount Sinai identified precursor cells in mice embryos that can be matured into hematopoietic stem/progenitor cells (HSPCs) using reprogramming technology. This breakthrough could lead to the development of patient-specific HSPCs for cell-replacement therapy and alleviate the need for transplantable stem cells.
Researchers at the University of Warwick have discovered a lack of stem cells in the womb lining is causing thousands of women to suffer from recurrent miscarriages. The team believes a new treatment could bring hope to those who have suffered failed pregnancies, correcting defects before pregnancy and potentially preventing miscarriages.
Researchers have found that Zika virus infects a type of neural stem cell responsible for brain development, leading to cell death and disruption of growth. The study provides new insights into the potential effects of Zika on neural tissue and may lead to the development of therapeutics.
A Johns Hopkins Medicine research team found that Zika virus selectively infects and kills cells in the brain's cortex, leading to disruptions in cell division and growth. This discovery using lab-grown stem cells may lead to identifying potential therapies for protecting these susceptible cells.
A high-fat diet drives a population boom of intestinal stem cells and generates a pool of 'stem-like' cells that can give rise to tumors. The study suggests a link between high-fat diets and increased colon cancer risk by altering the function of intestinal stem cells.
A high-fat diet drives a population boom of intestinal stem cells and generates a pool of other cells that behave like stem cells, leading to an increase in tumor formation. The researchers found that the high-fat diet changes the biology of both stem cells and non-stem-cell populations, ultimately resulting in more tumors.
Scientists have identified a crucial gene that regulates the activation of hair follicle stem cells, leading to increased hair growth but also wear and tear. In mice lacking this gene, hair follicles enter an overactive state, resulting in premature greying and balding.
Researchers found that a high-fat diet drives an increase in intestinal stem cells and stem-like cells, which can give rise to tumors. The diet also activates a nutrient-sensing pathway that promotes cell growth and mutations leading to cancer.
Researchers at Cedars-Sinai Medical Center have made a breakthrough in treating heart failure with preserved ejection fraction, a difficult-to-treat condition affecting millions. Cardiosphere-derived cells (CDCs) infused into laboratory rats reversed the condition, improving heart function and filling capacity.
Scientists have discovered that some human fat cells originate from stem cells in bone marrow, which could lead to new strategies for preventing and reversing fat-related chronic diseases. By manipulating the production of these cells, researchers hope to reduce the risk of conditions like cardiovascular disease and obesity.
Researchers at Scripps Florida Institute have developed a new method to predict the activity of stem cells in treating various diseases. The Clinical Indications Prediction scale uses TWIST1 levels to determine therapeutic potential, highlighting the importance of considering both angiogenesis and anti-inflammatory effects.
Researchers turned skin cells into cancer-hunting stem cells that destroy brain tumors known as glioblastoma, a breakthrough discovery in medical science. The technique increases survival time by 160-220% and has the potential to offer a new and more effective treatment for the disease.
Researchers assessed three methods of induced pluripotent stem cell production and found no significant risk of cancer-causing mutations. However, they warn that harmful mutations can accumulate later on as iPSCs multiply in lab cultures.
Researchers have discovered that tissue from the lower stomach has the greatest potential to be reprogrammed into beta-cell state. Engineered mini-organs produced insulin and refreshed themselves with stem cells, giving the tissue a sustainable regenerative boost.
A stem cell study published in Stem Cell Reports has discovered that the GBA1 mutation creates problems with protein processing and recycling in cells, leading to an accumulation of alpha-synuclein. This excess protein is released into the brain, contributing to Parkinson's spread and symptoms.
Scientists have discovered that deactivating the MYC oncogene can induce a dormant state in embryonic stem cells, similar to diapause, allowing them to survive without growth or metabolism. This finding has implications for controlling cancer stem cells and metastasis.
Researchers at St. Jude Children's Research Hospital have identified 17 new genes that regulate hematopoietic stem cell transplantation in mice. The study found that the Foxa3 gene plays a crucial role in repopulating blood-forming stem cells after transplantation, offering hope for improving transplant outcomes and reducing mortality.
Scientists at UCLA have developed a new approach using CRISPR/Cas9 to correct genetic mutations that cause Duchenne muscular dystrophy. The approach, which can be used in clinical trials within 10 years, has the potential to treat 60% of patients with the deadly disease.
Researchers at the University of Bath have developed a method to detect and preserve human pluripotent stem cells in the laboratory. This breakthrough allows for easier acquisition and cultivation of these rare cells, which can potentially be used to develop pioneering treatments for various diseases.
Researchers at the University of Rochester Medical Center have identified a population of stem cells capable of repairing skull formation and craniofacial bone repair in mice. This discovery contributes to an emerging field involving tissue engineering that uses stem cells to replace damaged bones in humans.
A team of scientists at UCL has discovered a way to fast-track the screening of induced pluripotent stem cells (iPSCs) using DNA methylation as a biomarker. This new approach can help identify 'good' and 'bad' cell lines, which is crucial for laboratory research and potential cell replacement therapies.
The study reveals that 5hmC mark acts as a key signal connecting complexes that regulate gene expression, influencing cellular differentiation and energy metabolism in embryonic stem cells. The findings suggest that 5hmC may play a central role in the coordinated evolution of chromatin-related proteins.
Researchers have successfully corrected a blindness-causing gene mutation in stem cells derived from a patient's skin cells, offering hope for personalized, precision medicine. The technology uses CRISPR/Cas9 gene editing to repair the damaged gene, and the corrected tissue can be transplanted without harm.
Scientists have developed a method to detect and preserve human pluripotent stem cells, which can become any cell type, for potential use in treating diseases. The technique allows researchers to isolate and maintain these cells, which are difficult to cultivate, using a reporter linked to fluorescent protein.
Researchers developed a potential therapy using adipose-derived stem cells to promote blood vessel growth and revascularization. The study successfully treated animals modeled with CLI, showing improved tissue reperfusion and reduced morbidity.
Researchers have shown that electrical stimulation of human heart muscle cells can aid their development and function. The team used electrical signals designed to mimic those in a developing heart to regulate and synchronize the beating properties of nascent cardiomyocytes, which support the beating function of the heart.
Researchers at Rockefeller University discover a new signaling mechanism that instructs cells to become stem cells during embryonic development. The finding suggests that stem cells may exist before the niche is formed and has implications for understanding skin cancer treatments.
A study by IRCM researchers has discovered a mechanism that controls the production of neurons from stem cells. This discovery could lead to more effective cell therapies and targeted treatments against cancer, particularly in diseases causing blindness where specific retinal cells degenerate.
Human pluripotent stem cells have been shown to develop normally when transplanted into an embryo, offering new hope for regenerative medicine treatments. The study provides strong evidence that stem cells are likely to be safe and effective for treating serious conditions like heart disease and Parkinson's disease.
Researchers discovered that sepsis causes severe muscle damage, impairing muscle function and leading to debilitating long-term effects. Mesenchymal stem cell transplantation has shown promising results in restoring muscle capacity and repairing mitochondrial dysfunction.
University of Louisville scientists enhance understanding of muscle repair process by revealing the vital role of protein TAK1 in regulating satellite stem cells. The protein is required for satellite cell proliferation and survival to regenerate adult skeletal muscles after injury or disease.
University of Oregon scientists have identified a molecular change in aging stem cells that stops them from making tumors. The discovery, detailed in the journal Current Biology, focuses on the larval stage of fruit fly development and reveals that a protein called Eyeless plays a crucial role in regulating Notch signaling.
Adult stem cells adjust proliferative activity in response to various signals through intracellular calcium signaling, revealing a master regulator of stem cell activity. Elevated Ca2+ levels regulate stem cell division and growth in response to L-glutamate, infection, and tissue damage.
Johns Hopkins researchers have developed a method to efficiently turn human stem cells into retinal ganglion cells, a type of nerve cell that transmits visual signals. The breakthrough could lead to the development of cell transplant therapies for glaucoma and multiple sclerosis patients.
Researchers at UofL discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies. TRAF6 ensures the vitality of stem cells, which regenerate muscle tissue, and its removal depletes Pax7, resulting in reduced muscle regeneration.
Researchers have found that bone marrow stem cells can produce fat cells that contribute to chronic illnesses like diabetes and cardiovascular disease. The discovery highlights the possibility of genetically modifying fat-storing cells to prevent or reverse fat-related diseases.
Researchers at the Babraham Institute have discovered a delicate balance between three key transcription factors that determine the fate of trophoblast stem cells. This balance, rather than the presence or absence of individual factors, dictates whether stem cells self-renew or differentiate into specialized cell types.
Researchers found that prenatal exposure to valproic acid inhibited new neuron birth and impaired learning, but running prevented these effects. The findings suggest that voluntary exercise could improve cognitive functioning in children of epileptic mothers.
Researchers from TUM developed a robust intestinal model for molecular research into incretin release, growing mini-intestines in a test tube that exhibit functions of the human intestine. The mini-intestines can absorb nutrients and release hormones, transmitting signals to control these processes.
Researchers have developed a new method to genetically correct stem cells in just two weeks, compared to conventional approaches that take over three months. This breakthrough could make personalized stem cell therapies possible for patients with genetic disorders, such as severe combined immunodeficiency and retinal degeneration.
A new study has revealed reasons why lab-grown stem cells fail to mature in the laboratory and provided a possible solution to overcome these 'developmental arrest'. The researchers analyzed over 200 heart cell samples from mice embryos and animals, identifying biochemical pathways that are out of sync with adult cells.
A recent study found that chronic arsenic exposure can lead to stem cell dysfunction, impairing muscle healing and regeneration. Inhibiting a certain protein in an inflammatory pathway can reverse the harmful effects of arsenic exposure.
Researchers are developing new technologies to analyze pancreatic tumor super-enhancers and testing therapies targeting these signals in clinical trials. The goal is to reprogram cancer cells or create vulnerabilities that can be exploited with combination drug therapies.
Lung researcher Dr. Marie-Liesse Asselin-Labat has received a competitive $1.225 million Viertel Fellowship to investigate lung development and cancer. The funding will support her work on developing better treatments for premature babies with underdeveloped lungs and those with lung disease, including cancer.
Schizophrenia impacts brain protein synthesis rates, affecting cellular machinery and function in adult stem cells. The study's findings enhance understanding of the disorder and provide new approaches for future drug therapies.
Researchers at USC and Sangamo BioSciences have developed a more efficient method for editing genes in blood-forming stem cells (HSPCs), which could potentially treat diseases such as HIV and other blood disorders. By combining two delivery methods, the team achieved unprecedented efficiency rates ranging from 15 to 40 percent.
Researchers at Northwestern University have developed a microfluidic device to sort neural stem cell populations, making them easier to study. The device uses inertial forces to isolate single stem cells, reducing stress on the cells and preserving their multipotency.
Researchers have discovered a new view of how human blood is made, resolving how different kinds of blood cells form quickly from stem cells. This finding has significant implications for understanding and treating blood disorders and diseases.