Articles tagged with Stem Cell Research
Researchers have shown that electrical stimulation of human heart muscle cells can aid their development and function. The team used electrical signals designed to mimic those in a developing heart to regulate and synchronize the beating properties of nascent cardiomyocytes, which support the beating function of the heart.
Researchers at Rockefeller University discover a new signaling mechanism that instructs cells to become stem cells during embryonic development. The finding suggests that stem cells may exist before the niche is formed and has implications for understanding skin cancer treatments.
A study by IRCM researchers has discovered a mechanism that controls the production of neurons from stem cells. This discovery could lead to more effective cell therapies and targeted treatments against cancer, particularly in diseases causing blindness where specific retinal cells degenerate.
Human pluripotent stem cells have been shown to develop normally when transplanted into an embryo, offering new hope for regenerative medicine treatments. The study provides strong evidence that stem cells are likely to be safe and effective for treating serious conditions like heart disease and Parkinson's disease.
Researchers discovered that sepsis causes severe muscle damage, impairing muscle function and leading to debilitating long-term effects. Mesenchymal stem cell transplantation has shown promising results in restoring muscle capacity and repairing mitochondrial dysfunction.
University of Louisville scientists enhance understanding of muscle repair process by revealing the vital role of protein TAK1 in regulating satellite stem cells. The protein is required for satellite cell proliferation and survival to regenerate adult skeletal muscles after injury or disease.
University of Oregon scientists have identified a molecular change in aging stem cells that stops them from making tumors. The discovery, detailed in the journal Current Biology, focuses on the larval stage of fruit fly development and reveals that a protein called Eyeless plays a crucial role in regulating Notch signaling.
Adult stem cells adjust proliferative activity in response to various signals through intracellular calcium signaling, revealing a master regulator of stem cell activity. Elevated Ca2+ levels regulate stem cell division and growth in response to L-glutamate, infection, and tissue damage.
Johns Hopkins researchers have developed a method to efficiently turn human stem cells into retinal ganglion cells, a type of nerve cell that transmits visual signals. The breakthrough could lead to the development of cell transplant therapies for glaucoma and multiple sclerosis patients.
Researchers at UofL discovered a mechanism involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult stem cell therapies. TRAF6 ensures the vitality of stem cells, which regenerate muscle tissue, and its removal depletes Pax7, resulting in reduced muscle regeneration.
Researchers have found that bone marrow stem cells can produce fat cells that contribute to chronic illnesses like diabetes and cardiovascular disease. The discovery highlights the possibility of genetically modifying fat-storing cells to prevent or reverse fat-related diseases.
Researchers found that prenatal exposure to valproic acid inhibited new neuron birth and impaired learning, but running prevented these effects. The findings suggest that voluntary exercise could improve cognitive functioning in children of epileptic mothers.
Researchers from TUM developed a robust intestinal model for molecular research into incretin release, growing mini-intestines in a test tube that exhibit functions of the human intestine. The mini-intestines can absorb nutrients and release hormones, transmitting signals to control these processes.
Researchers at the Babraham Institute have discovered a delicate balance between three key transcription factors that determine the fate of trophoblast stem cells. This balance, rather than the presence or absence of individual factors, dictates whether stem cells self-renew or differentiate into specialized cell types.
Researchers have developed a new method to genetically correct stem cells in just two weeks, compared to conventional approaches that take over three months. This breakthrough could make personalized stem cell therapies possible for patients with genetic disorders, such as severe combined immunodeficiency and retinal degeneration.
A new study has revealed reasons why lab-grown stem cells fail to mature in the laboratory and provided a possible solution to overcome these 'developmental arrest'. The researchers analyzed over 200 heart cell samples from mice embryos and animals, identifying biochemical pathways that are out of sync with adult cells.
A recent study found that chronic arsenic exposure can lead to stem cell dysfunction, impairing muscle healing and regeneration. Inhibiting a certain protein in an inflammatory pathway can reverse the harmful effects of arsenic exposure.
Lung researcher Dr. Marie-Liesse Asselin-Labat has received a competitive $1.225 million Viertel Fellowship to investigate lung development and cancer. The funding will support her work on developing better treatments for premature babies with underdeveloped lungs and those with lung disease, including cancer.
Schizophrenia impacts brain protein synthesis rates, affecting cellular machinery and function in adult stem cells. The study's findings enhance understanding of the disorder and provide new approaches for future drug therapies.
Researchers at USC and Sangamo BioSciences have developed a more efficient method for editing genes in blood-forming stem cells (HSPCs), which could potentially treat diseases such as HIV and other blood disorders. By combining two delivery methods, the team achieved unprecedented efficiency rates ranging from 15 to 40 percent.
Researchers at Northwestern University have developed a microfluidic device to sort neural stem cell populations, making them easier to study. The device uses inertial forces to isolate single stem cells, reducing stress on the cells and preserving their multipotency.
Researchers are developing new technologies to analyze pancreatic tumor super-enhancers and testing therapies targeting these signals in clinical trials. The goal is to reprogram cancer cells or create vulnerabilities that can be exploited with combination drug therapies.
Researchers have discovered a new view of how human blood is made, resolving how different kinds of blood cells form quickly from stem cells. This finding has significant implications for understanding and treating blood disorders and diseases.
The study has tremendous potential to improve our understanding of early development, enhance disease modeling, and promote therapeutic discovery. Researchers believe that work on chimeric embryos is vital to advance this field despite ethical concerns.
Researchers from the University of Gothenburg and Karolinska Institutet have cast doubt on the effectiveness of stem cell therapy for treating female infertility. The study, published in Nature Medicine, suggests that stem cells cannot generate new egg cells, rendering the treatment unreliable.
Researchers have developed a groundbreaking method to identify and separate human tonsil cancer stem cells, providing new insights into the disease. The study shows that these stem cells are key players in the development of tonsil cancer, with HPV infection being a major risk factor.
The Prkci gene plays a crucial role in maintaining the balance between stem cell self-renewal and differentiation into specialized cell types. Without Prkci, mouse embryonic stem cells overproduce stem cells, leading to an abundance of secondary structures.
A study led by Mount Sinai researchers identifies zinc finger protein 217 (ZFP217) as a factor that regulates stem cell self-renewal and differentiation, potentially balancing medically useful qualities for therapeutic applications. The discovery builds on understanding epigenetic mechanisms controlling gene expression.
The New York Stem Cell Foundation has awarded $7.5 million to five researchers through the NYSCF -- Robertson Investigator Program, supporting innovative work in stem cell biology and neuroscience. The recipients aim to advance our understanding of cellular processes and develop new treatments for diseases.
Franziska Michor is awarded the NYSCF -- Robertson Stem Cell Prize for her interdisciplinary research on cancer genesis, using mathematical models to understand cancer evolution. Her work simulates drug treatment regimens and has been tested in clinical trials for non-small-cell lung cancer and brain tumors.
Researchers have grown mini-kidney organoids in a laboratory by combining stem cell biology with leading-edge gene-editing techniques. These engineered mini-kidneys contain tubules, filtering cells and blood vessel cells, and can mimic both healthy and diseased kidneys.
A gene editing technique has been developed to increase the yield of laboratory-produced red blood cells, which could significantly reduce their cost. The technique targets a specific gene, SH2B3, and uses CRISPR gene editing to permanently shut it off in human embryonic stem cell lines.
Human embryonic stem-cell-derived cardiomyocytes surpass bone marrow-derived cells in repairing damaged heart tissue, suggesting a better option for future therapies. The study's findings also indicate that more mature and stable heart muscle cells may be more effective than progenitor cells in clinical studies.
Rutgers Genetics Research Center has been awarded a five-year grant to provide comprehensive stem-cell related services, including iPSC derivation and quality control. The new grant will enhance access to high-quality stem cells for researchers investigating Parkinson's, ALS, and Huntington's diseases.
Low SCF levels are linked to increased risk of cardiovascular disease and more severe atherosclerosis in patients with atherosclerosis. Smoking and diabetes can negatively impact the reparative capacity of cells responsible for blood vessel repair.
Scientists at Brigham and Women's Hospital have developed a method to create kidney structures from adult stem cells, which could be used to study diseases such as chronic kidney disease and test new therapies. These kidney structures can model the development of kidney abnormalities and susceptibility to drug toxicity.
A study by Juan Méndez at CNIO sheds light on molecular mechanisms of ageing in blood stem cells, opening a new avenue for reducing their decline with age and potentially treating aplastic anaemia. Researchers managed to prevent embryonic lethality by increasing the levels of gene CHK1, showing less pronounced anaemia in mice.
A University of California, Irvine study found that neural stem cells can improve both motor and cognitive impairments associated with dementia with Lewy bodies. The treatment involves the production of brain-derived neurotrophic factor, which enhances dopamine- and glutamate-producing neurons.
Researchers at Scripps Research Institute in California and German institutes have partnered to develop rigorous genomics-based methods for analyzing human stem cells. The goal is to ensure high-quality induced pluripotent stem cells (iPSCs) are available for research and clinical use.
Researchers at IMIM have found that Notch protein activation intensity determines cell fate, revealing a competition between two proteins for hematopoietic stem cell formation. This study could lead to more efficient and reproducible lab-grown blood stem cells for patients with no compatible donors.
A new study found that sleep deprivation can reduce the effectiveness of stem cell transplants by up to 50%. Researchers at Stanford University discovered that a four-hour sleep deficit can impair the ability of stem cells to migrate and function properly. However, recovery sleep can restore the cells' normal function.
Min Yu, USC scientist, wins $2.475 million NIH New Innovator Award to target breast cancer stem cells for personalized treatment. Her research aims to identify biomarkers and tailor drugs to individual patients, addressing the significant challenge of metastatic cancer stem cells.
Researchers have developed a new technique to create brain cells directly from skin samples, retaining age-related signatures. This breakthrough enables scientists to study the effects of aging on the brain without relying on animal models or stem cell reprogramming.
Researchers have successfully generated aged neurons using stem cell technology, allowing for the study of age-related changes in the brain. The newly created neurons exhibit defects in protein transport and gene expression patterns similar to those found in older brains.
A Johns Hopkins University biologist has made significant progress in understanding the mysterious shape-shifting ways of stem cells. The study found that an enzyme in the niche where stem cells are found can help sustain them and promote other cells to become like stem cells, which has medical implications for diseases such as cancer.
Researchers have created a new investigational drug that traps IGFBP3, preventing gastrointestinal symptoms and restoring the intestine's mucosal lining structure. The drug may hold promise as a potential treatment for diabetic enteropathy, a common complication of type 1 diabetes.
Researchers used single-cell RNA sequencing technology to study gene expression in mouse embryonic stem cells, identifying new genes involved in pluripotency and discovering new subpopulations of cells. The findings provide insights into the links between environment and inter-cell heterogeneity.
Albert D. Kim, a postdoctoral fellow at the Keck School of Medicine of USC, has received the first Hearst Fellowship for his work on turning stem cells into nephrons, the functional units of the kidney. He aims to isolate and generate kidney progenitor cells to repair damaged adult kidneys.
Researchers have developed a sticky gel that helps stem cells adhere to and restore their metabolism in rat hearts, improving cardiac function after simulated heart attacks. The gel, which combines serum and hyaluronic acid, has been shown to retain up to 73% of transplanted cells in the heart.
Researchers have identified a unique group of stem cells in the human brain that generate most neurons, expanding the cortex by 1,000-fold. These stem cells, called outer radial glia (oRGs), exhibit remarkable generative capacity and self-renewal properties.
Researchers have successfully isolated human muscle stem cells that can robustly replicate and repair damaged muscles when grafted onto an injured site. The findings hold promise for patients with severe muscle injury, paralysis, or genetic diseases like muscular dystrophy.
Researchers from IMCB identified 303 genes linked to proviral silencing, revealing coordinated mechanisms involving multiple cellular pathways. The study found that Chaf1a and Sumo2 are the key factors controlling this process, with potential implications for stem cell therapy and disease diagnosis.
Researchers developed a custom silicone guide implanted with biochemical cues to promote both motor and sensory nerve regeneration. The study showed improved walking ability in rats within 10-12 weeks, paving the way for human trials.
Scientists at the University of Zurich discovered a novel mechanism that helps neural stem cells resist aging-induced damage. A diffusion barrier in the endoplasmic reticulum regulates the sorting of damaged proteins, allowing for rejuvenation and longer lifespan.
Researchers at Kyoto University have created a lab-based human germ cell development model, revealing specific key elements and events that occur at the beginning of human life. This breakthrough provides insight into how epigenetic marks are erased during early germ cell development, shedding light on conditions such as infertility.
A new study by USF researchers suggests that transplanted human bone marrow stem cells preferentially migrate to the spleen, reducing systemic inflammation and secondary brain cell death in post-stroke rats. The anti-inflammatory effects of the stem cells promoted reduced lesions caused by acute stroke.
A new strategy using porous, transplantable hydrogels has experimentally improved bone repair by boosting the survival rate of transplanted stem cells and influencing their cell differentiation. This breakthrough could lead to enhanced regenerative therapies for various tissues and organs.
A new method of harvesting and growing lung stem cells has been developed by researchers at NC State University, which could provide an effective treatment for idiopathic pulmonary fibrosis (IPF). The study used a multicellular spheroid environment to enrich adult lung stem cells, which showed promise in mice trials with reduced inflam...
A team of scientists is using an optical interferometer to monitor the growth of stem cells on tiny polymer spheres, enabling large-scale production and quality control. The device takes images as the tank is stirred, allowing researchers to track cell confluence and morphology.
Researchers from Drexel University used image-tracking technology to study the development of neural stem cells in mice, finding intrinsic differences between anterior and posterior stem cells that could explain how areas of the cortex develop into specialized structures. The discovery was made possible by powerful biological tracking ...