Articles tagged with Stem Cell Research
Scientists at the University of Zurich discovered a novel mechanism that helps neural stem cells resist aging-induced damage. A diffusion barrier in the endoplasmic reticulum regulates the sorting of damaged proteins, allowing for rejuvenation and longer lifespan.
Researchers at Kyoto University have created a lab-based human germ cell development model, revealing specific key elements and events that occur at the beginning of human life. This breakthrough provides insight into how epigenetic marks are erased during early germ cell development, shedding light on conditions such as infertility.
A new study by USF researchers suggests that transplanted human bone marrow stem cells preferentially migrate to the spleen, reducing systemic inflammation and secondary brain cell death in post-stroke rats. The anti-inflammatory effects of the stem cells promoted reduced lesions caused by acute stroke.
A new strategy using porous, transplantable hydrogels has experimentally improved bone repair by boosting the survival rate of transplanted stem cells and influencing their cell differentiation. This breakthrough could lead to enhanced regenerative therapies for various tissues and organs.
A new method of harvesting and growing lung stem cells has been developed by researchers at NC State University, which could provide an effective treatment for idiopathic pulmonary fibrosis (IPF). The study used a multicellular spheroid environment to enrich adult lung stem cells, which showed promise in mice trials with reduced inflam...
A team of scientists is using an optical interferometer to monitor the growth of stem cells on tiny polymer spheres, enabling large-scale production and quality control. The device takes images as the tank is stirred, allowing researchers to track cell confluence and morphology.
Researchers from Drexel University used image-tracking technology to study the development of neural stem cells in mice, finding intrinsic differences between anterior and posterior stem cells that could explain how areas of the cortex develop into specialized structures. The discovery was made possible by powerful biological tracking ...
Researchers at the Centre for Genomic Regulation have discovered a unique genetic switch that guides stem cells into developing specialized heart muscle. The discovery of the Mel18 protein is expected to reveal underlying causes of heart defects and potentially lead to new methods for controlling stem cells in the laboratory.
A CNIO team has identified the origin of damage to induced pluripotent stem cells and developed strategies to reduce it, resulting in cells with less damage to their genome. This breakthrough improves the safety of iPS cells for use in biomedicine, potentially treating cardiovascular diseases, diabetes, and neurodegenerative disorders.
Researchers at UCSF have developed a method to precisely control embryonic stem cell differentiation with beams of light, revealing an internal timer within stem cells that lets them tune out extraneous biological noise. The technique enables stem cells to transform into neurons in response to a precise external cue.
Researchers at UC Berkeley created an implant containing stem cells that form functional brown-fat-like tissue, reducing weight gain and lowering blood glucose levels in mice. The study's results suggest the technique could lead to new therapeutic approaches for metabolic disorders.
Janos Peti-Peterdi, a USC kidney researcher, has made significant advances in visualizing the function of the living kidney's filter and studying kidney stem cells. He aims to find new treatments and therapies for patients with chronic kidney disease.
Participants with late-stage retinitis pigmentosa are being enrolled in the clinical trial to test the safety of retinal progenitor cells. The open-label phase I/IIa trial aims to evaluate the treatment's efficacy in preserving vision by protecting and potentially reactivating degenerating photoreceptors.
A comprehensive study found that cold water immersion after strength training reduced long-term muscle mass and strength gains. Muscle biopsies revealed blunted activity of satellite cells and pathways needed to build bigger muscles up to two days after exercise in the ice bath group.
Harvard researchers have reconstructed an ancient virus effective at delivering gene therapies to liver, muscle, and retina. The discovery may lead to novel vectors for safer and more potent gene therapies.
Researchers developed a stem cell model to assess the neurotoxicity of Bisphenol A (BPA) efficiently and cost-effectively. The study showed that BPA may alter embryonic development in vivo, highlighting the potential health risks associated with environmental pollution.
A team of ETH Zurich researchers has identified seven genes central to X chromosome inactivation in females, including Spen, which prevents gene expression at the X chromosome. The discovery sheds light on how the human body maintains a delicate balance between genes, preventing disease.
Researchers in China have independently transformed skin cells from humans and mice into neurons using chemical cocktails. The studies show that the reprogrammed cells exhibit similar gene expression and neuronal activity as those generated through traditional methods.
Researchers designed a revolutionary high-throughput robotic platform to automate the process of generating patient-specific stem cells, reducing variability and increasing scale. This technology allows for 'clinical trials in a dish' and can identify potential drug metabolism and toxicity issues in human cells before clinical trials.
Researchers discover a single molecule, C/EBPa, can transform a B cell into a macrophage by 'short-circuiting' gene expression. This process involves the convergence of two DNA enhancer pathways, allowing for unnatural transdifferentiation. The findings have significant implications for regenerative medicine and cancer treatment.
A new study using human embryonic stem cells suggests that early exposure to bisphenol A may lead to an increased risk of prostate cancer. The research found that BPA caused the development of prostate organoids to produce an overabundance of prostate stem cells, which could be a risk factor for cancer.
Scientists have developed a novel process to regenerate salivary cells using silk fibers as a framework, which could help millions in the US with dry mouth due to Sjögren's syndrome. The process has been shown to retain salivary gland cell properties and is a significant step towards developing new cell-based therapeutics.
Researchers at University of Birmingham discovered how mutated FLT3 genes reprogram blood stem cells, leading to abnormal cell production. The findings provide hope for developing new treatments for acute myeloid leukaemia.
Researchers at Cedars-Sinai Medical Center have developed a new gene-editing technique involving low-dose irradiation, which is 10 times more effective than existing methods. This breakthrough could enable scientists to model human diseases more accurately and accelerate the discovery process.
Researchers at the University of Nottingham have created a fully synthetic substrate to grow billions of human pluripotent stem cells. This breakthrough could lead to the creation of 'stem cell factories' for clinical use in treating heart, liver and brain conditions.
Researchers at Yale School of Medicine have developed a stem cell study that could help predict autism spectrum disorder and identify new drug targets. The study used skin cells to generate simulated brain organoids, revealing gene expression and developmental abnormalities in autism.
Scientists have developed a new method to generate healthy stem cells from patient cells with mitochondrial mutations, which can then be converted into various cell types. This breakthrough has the potential to treat debilitating mitochondrial diseases that affect the brain and muscles, offering new hope for patients worldwide.
Scientists at UC Berkeley and Gladstone Institutes develop a system to grow beating cardiac tissue from stem cells, allowing for the screening of drugs that may cause cardiac birth defects. The model uses patient-derived human pluripotent stem cells to mimic early heart development.
Researchers at USC's Stem Cell labs have discovered new genes affecting blood stem cell development and function. The study found that certain genetic regulators, such as Hopx, play a crucial role in the formation of red and white blood cells in adults.
A team of researchers has identified netrin-1 as a molecule that can favour the production of induced pluripotent stem cells, which have huge potential applications in regenerative medicine. The discovery may ultimately enable the creation of new organs from patient cells, eliminating rejection risks and ethical concerns.
Researchers found that dental pulp stem cells can regenerate myelinated axons in laboratory rats with sciatic nerve defects, outperforming autologous nerve grafts. The study suggests that MDPSCs contribute to peripheral nerve regeneration through the secretion of neurotrophic and angiogenic factors.
A new method has been discovered to culture stem cells, allowing them to grow twice as fast and be more efficient in regulating the immune response. This breakthrough could lead to more effective treatments for transplant patients by reducing side effects of current immunosuppressant drugs.
A study published in Cell Reports reveals how Sox9 regulates cartilage production and its essential role in skeletal development. Researchers discovered that Sox9 binding to DNA controls gene expression, leading to the formation of chondrocytes and cartilage production.
Researchers used new methods to compare two stem cell types and found one superior at producing retinal cells. The study demonstrates a standardized method for quantifying effectiveness, which could advance treatments for age-related macular degeneration and other vision loss disorders.
Scientists at University of Michigan and University of Texas Southwestern Medical Center discovered microscopic nanotubes facilitating cell-to-cell communication in stem cells. The findings suggest that these structures may play a crucial role in retaining stem cell identities during division.
Researchers identified microtubule-based nanotubes in stem cells that tap into the niche, enabling specific signaling for self-renewal. This discovery sheds light on how stem cells reproduce and miscommunication can lead to diseases like cancer.
Researchers have evaluated the best potential sources for adult stem cells to be used for treating diabetic retinopathy. They found that cells taken from donors without diabetes are more effective than those from patients' own bodies. This discovery provides a crucial framework for evaluating stem cells for future treatments.
A new study reveals that Mycobacterium tuberculosis hijack protective hypoxic zones in bone marrow stem cells to hide and survive. The research found that these stem cells exhibit strong binding to pimonidazole, indicating hypoxia localization, and express a key gene involved in regulating oxygen levels.
A team of Temple researchers led by Dr. Raj Kishore used stem cell exosomes to induce the repair of damaged mouse hearts, improving heart function and reducing scar tissue. The study's findings suggest a unique way to regenerate the heart without using stem cells.
Researchers find nucleoporins, proteins that guard the nucleus, also regulate gene expression and control stem cell differentiation into neurons. The discovery sheds new light on genetic diseases caused by mutations in these proteins.
Researchers discovered that high doses of antioxidants can disrupt intracellular signaling in neural stem cells, leading to a decrease in their stemness properties. However, treatment with antioxidants improved stem cell function, but only up to a point.
Researchers at the University of York have identified individual stem cells that can regenerate tissue, cartilage and bone, opening the way for improved treatment options for osteoarthritis. The discovery has the potential to develop targeted therapies for arthritis patients, making cell-based treatments less of a lottery.
Massey researchers have identified three patterns of lymphocyte recovery following stem cell transplantation that are significantly associated with clinical outcomes. The study found Group B patients experienced the best clinical outcomes, while Groups A and C had poorer survival rates. The discovery builds on previous research into th...
Researchers at Uppsala University have made significant progress in using stem cells to treat spinal cord injuries. Human stem cells transplanted into injured mice restored damaged sensory nerve connections, enabling long-term recovery of sensory functions.
Depletion of naïve T cells from stem cell grafts limits chronic graft-versus host disease by reducing its occurrence and severity. This approach also results in generally responsive acute GVHD to corticosteroid therapy, supporting it as a potential treatment option.
Researchers found that autologous bone marrow stem cells significantly reduced cranial pressure and therapeutic intensity in TBI patients, decreasing neurointensive care time by nearly 60%.
A special issue of Cell Stem Cell highlights the biology of aging and sex differences in stem cell behavior. Research suggests that estrogen may play a role in increasing lifespan in females, while testosterone may have different effects on males. Scientists are also exploring ways to model late-onset conditions using stem cells.
The Azrieli Foundation donated $10 million to fund groundbreaking stem cell and genetic research at the Hebrew University of Jerusalem's newly inaugurated center. Researchers will focus on developing therapies for Down syndrome, Prader-Willi syndrome, and Fragile X syndrome, among other conditions.
The study provides a starting point to understand the role of methyl groups in influencing gene expression and development. Researchers detected unusual methylation patterns in various tissues, suggesting potential stem cell populations and new avenues for exploration.
Researchers developed an algorithm called KeyGenes that uses gene expression to predict the future identity of human fetal stem cells. The platform integrates data from both human fetal and adult tissue, allowing for more accurate differentiation protocols.
Researchers at the Buck Institute discovered that macrophage-like hemocytes play a crucial role in regulating stem cell activity in the fly gut. This complex signaling interaction helps control intestinal regeneration after damage, but goes awry with age, potentially contributing to human diseases like IBS and colorectal cancer.
Researchers have found that epilepsy reduces the generation of new neurons in the hippocampus, a brain region crucial for learning and stress response. The study's findings suggest that preserving neural stem cells could prevent or mitigate epilepsy symptoms.
Scientists at University of Toronto have made breakthroughs in cell transplantation using hydrogel biomaterials, showing potential for partially restoring vision and aiding brain recovery from stroke. The new gel-like material boosts cell survival and integration in the eye and brain, paving the way for stem-cell-based therapies.
The journal Regenerative Medicine has published a special focus issue on methods to avoid immune rejection in regenerative medicine. The field is immature, but research continues to address the importance of immunity in progress and development.
Researchers find single protein, nuclear Fibroblast Growth Factor Receptor 1 (nFGFR1), orchestrates gene expression in embryo development. This discovery has potential to enhance understanding and treatment of cancers and congenital diseases.
Researchers at the Salk Institute have discovered a novel type of pluripotent stem cell capable of developing into any type of tissue. The new cells, dubbed region-selective pluripotent stem cells (rsPSCs), were easier to grow in the laboratory and offered advantages for large-scale production and gene editing.
Researchers from Mount Sinai presented a first successful 3D printed trachea, as well as studies on increased mortality in black patients after esophageal cancer surgery and the potential benefits of surgical resection for myasthenia gravis. These findings highlight the importance of personalized medicine and access to specialized care.
The study, which followed four individuals for a year after they were treated with embryonic stem cell-derived retinal pigment epithelial cells, observed no serious side effects related to the therapy. The researchers reported positive results in visual acuity improvements among patients.
Researchers at the University of Cambridge have identified a pathway linking proteins amyloid precursor protein and tau, which may be targeted for treatment. This discovery using human stem cells suggests that manipulating this pathway could halt disease progression.
Researchers analyzed 3,550 North American rodent fossils to show how fundamental evolutionary mechanisms drive the emergence of novel mammalian stem cells. The study found that most extinct species can acquire continuously growing molars through evolution, and the final developmental step is surprisingly simple.