Articles tagged with Stem Cell Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
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Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists have identified key DNA sequences and regulatory proteins controlling blood stem cell fate, revealing a more dynamic process than previously thought. The discovery has implications for developing diagnostic tools, personalized medicine, and regenerative therapies.
Research by bioengineers at UC San Diego reveals that the stiffness of the extracellular matrix is a key factor in guiding stem cells towards specific cell types. The study found that varying the stiffness of the hydrogel had no effect on the differentiation process, ruling out protein binding as a crucial factor.
Researchers have developed a method to grow human GI cells from patient tissue in as little as two weeks, creating over 65 cell lines. This breakthrough enables the study of individual patients' underlying problems and can be used to test new treatments.
Researchers at Queen Mary University of London have uncovered the behavior of stem cells in the human bowel for the first time. They found that within a healthy bowel, only a certain number of stem cells can exist within one area at a time, and increased competition for survival is seen in early tumours.
Researchers at Harvard University's H SCI have identified a promising new potential treatment for ALS, using compounds already in clinical trials. The study found that inhibiting a specific receptor in glial cells increased survival time in an animal model of the disease.
Researchers at the University of Luxembourg have made a breakthrough in implanting neurons into mouse brains, demonstrating long-term stability and functional integration. The successful technique, which uses reprogrammed skin cells to produce healthy neurons, holds promise for treating neurodegenerative diseases like Parkinson's disease.
A team of researchers has identified 5-lipoxygenase as a target for therapeutic management of stem cell-like cells in acute myeloid leukemia. Inhibiting this enzyme selectively attacks and eliminates leukemic stem cells in both cell culture models and mouse models, suggesting a promising approach for treating the disease.
Recent advances in stem cell biology offer immense hope for treating various diseases and conditions. Key findings include the potential for stem cells to replicate any other cells in the body and their possible applications in regenerative medicine.
Researchers at Inserm found that artificial light with blue wavelengths can synchronize the body clock and activate non-visual functions in extreme lighting conditions. This breakthrough has practical applications for dimly lit workplaces, enabling design of lighting strategies to maintain staff health, productivity, and safety.
Researchers found that blood-forming stem cells falter with age due to DNA replication problems, leading to a decline in immune function. However, even old stem cells can repair induced DNA damage efficiently and retain molecular tags associated with DNA damage.
Researchers investigated the impact of cellular senescence on adipose-derived stem cell morphology and function. The study found that senescence compromises the clinical application of these cells for peripheral nerve regenerative cell therapy. Senescence modulating factors influence adipose-derived stem cell behavior.
Researchers at The New York Stem Cell Foundation have developed a new protocol to induce pluripotent stem cells into oligodendrocytes, the myelin-forming cells implicated in multiple sclerosis. This accelerated approach cuts production time almost in half, enabling researchers to study disease progression and develop potential treatments.
The three institutions are working together to develop less painful treatments for babies with fused skulls, reducing the need for annual surgeries. Researchers have established a Craniofacial Anomalies Registry and plan to expand their collaboration to include postdoctoral fellows and graduate students.
Researchers have identified a key gene, ASF1A, that enables cellular reprogramming and the development of stem cells. This finding could lead to the creation of induced pluripotent stem cells derived from adult tissue, offering potential for safer cell-therapy strategies.
Researchers found that stress can disrupt the process of fat tissue development, leading to issues with fat storage within cells and in the bloodstream. The study identified a key signaling pathway involving adenosine receptors and stem cell factors that regulates this process.
Wisconsin scientists have identified two genetic programs that can turn blank-slate stem cells into red and white blood cells. The discovery gives scientists the tools to make blood products, investigate cell development and production of clinically relevant blood products.
USC Stem Cell scientists have created a transgenic mouse line called TRAP, which enables the detection of early signals of acute kidney injury. This breakthrough has the potential to improve patient outcomes by detecting kidney failure earlier, allowing for more effective treatment.
Researchers have found that using gene-editing techniques on stem cells does not increase the overall occurrence of mutations, easing previous safety concerns. The study's results were published in the journal Cell Stem Cell and provide new hope for the development of therapies for genetic diseases.
Researchers discovered that dental pulp stem cells can protect retinal ganglion cells from death and promote regeneration of their axons. The study found that these stem cells naturally express neurotrophic factors, providing a potentially limitless source of growth factors for injured neurons.
Researchers have discovered the gene zic-1, which enables planarians to regenerate their heads after decapitation. The study suggests that this ancient mechanism could be used to create tissue organizers for enhancing injury repair in humans.
A Johns Hopkins study finds that a gene deletion linked to schizophrenia alters brain cell skeletons, disrupting layer formation. Researchers also identify a crucial protein involved in building cellular skeletons, which may contribute to the condition.
Using a molecule called ABCB5, researchers identified limbal stem cells in deceased donors' tissue and grew fully functional human corneas in mice. This breakthrough could restore vision for individuals with damaged eyes due to injury or disease, revolutionizing the field of regenerative medicine.
A new study finds that stem cells created by moving genetic material from a skin cell into an empty egg cell more closely resemble human embryonic stem cells than traditionally induced pluripotent stem (iPS) cells. The method, known as nuclear transfer, results in cells with fewer reprogramming issues and better gene expression patterns.
Researchers at Harvard University have developed a method to collect the best cell type for regenerating damaged corneas, with purified human stem cells showing promise in improving long-term vision in mice. The discovery is expected to quickly translate into improved human therapies and could potentially restore the corneal surface.
A new review article suggests that embryonic and induced pluripotent stem cells are not the only source of all three germ layers in the human body. Adult pluripotent stem cells are located throughout the body and can become every tissue, provided they receive the right instructions.
Researchers at Scripps Research Institute found that the drug rapamycin can improve the delivery of genes to blood stem cells, increasing efficiency from 30-40% to up to 80%. This breakthrough could lead to more effective and affordable treatments for leukemia and sickle cell anemia.
A study published in Scientific Reports reveals that CCL2 can activate the JAK/STAT pathway and increase stem cell colony attachment, differentiation efficiency, and X chromosome reactivation. The researchers also found higher expression of genes related to hypoxic response, suggesting a potential link between cellular stress and pluri...
Researchers at UCLA have discovered how factors regulating adult stem cells in lungs can lead to precancerous lesions. The study found that disrupting normal ROS regulation drives repair process, causing precancerous lesions to form.
Researchers found that peripheral blood stem cells stimulated by granulocyte colony-stimulating factor (G-CSF) can inhibit osteoarthritis progression in rats. The therapy has potential as a treatment for OA, but further studies are needed to determine its effectiveness in humans.
The New York Stem Cell Foundation (NYSCF) and the eagle-i Network will make NYSCF iPS cell lines and related information available on a user-friendly, web-based, searchable database. This database will help scientists find valuable resources, enabling collaboration and accelerating research.
Human embryonic stem cell therapy has been shown to significantly reduce MS disease severity in animal models, offering a promising new treatment for the debilitating disease. The therapy also provides an unlimited source of high-quality mesenchymal stem cells, which can be propagated indefinitely in lab cultures.
Scientists at Johns Hopkins Medicine have successfully created a three-dimensional complement of human retinal tissue in the laboratory, including functioning photoreceptor cells that can respond to light. The achievement offers new opportunities for vision-saving research and may ultimately lead to technologies that restore vision in ...
Researchers at Mount Sinai Hospital discovered that a protein called Sirtuin1 (SIRT1) is essential for maintaining healthy aging of blood stem cells. The study found that loss of SIRT1 leads to impaired regeneration and resembles aged, defective stem cells in mouse models.
Researchers at Case Western Reserve University have identified a new class of genetic switches, called seed enhancers, that guide the development of pluripotent stem cells. These enhancers play roles from before birth to adulthood and hold promise for regenerative medicine and disease prevention.
A study published in Cell Stem Cell shows that prolonged fasting cycles can induce immune system regeneration by shifting stem cells into a state of self-renewal. This process involves the depletion of white blood cells, which are then replaced by new ones, leading to improved immune function.
Researchers found that fasting can replenish stem cells in the blood, combating chemotherapy-induced and aging-related changes in immune cell function. Fasting has also been shown to rejuvenate the immune system of old mice and protect against white blood cell loss in human patients.
Researchers at the University of Missouri have successfully transplanted and grown human stem cells in genetically modified pigs. The breakthrough paves the way for future research on stem cell therapies and could lead to new treatments for debilitating human diseases.
Duke researchers discovered a novel neuron population in the adult brain that instructs stem cells to produce new neurons. The finding opens up possibilities for brain repair and regeneration through neural circuits.
University of Illinois researchers develop new technique to induce mouse embryonic stem cells to form three distinct germ layers, a crucial step towards regenerative medicine. The study provides insights into the biological process controlling tissue development and opens doors for efficient organ generation.
Researchers at Stanford University School of Medicine have identified a new cell-cycle phase in resting stem cells, dubbed an 'alert' state, which enables them to rapidly respond to tissue damage. This systemic response is distinct from fully resting or activated stem cells and has been observed in various types of injuries.
Leading scientists from the U.S., Canada, and Belgium discussed cancer stem cells, highlighting their challenges in targeted cancer treatments. The symposium aimed to spark productive dialogues among researchers attending, according to Paul Frenette, director and chair of Einstein's Stem Cell Institute.
A new study challenges the use of stem cells in heart attack patients, finding that they do not regenerate damaged heart tissue at high enough rates. The study suggests that any potential benefit from injecting c-kit-positive cells into the hearts of patients may come from improving circulation rather than generating new cardiomyocytes.
Researchers at Mount Sinai identified a new technique to expand hematopoietic stem cells in cord blood, making them more useful for adult patients. This study has important implications for patients battling blood cancers and the success of life-saving stem cell transplants.
Exosomes secreted by cardiac stem cells carry messages that reduce cell death, promote growth of new heart muscle cells and encourage development of healthy blood vessels. The researchers pinpointed one microRNA as responsible for some of the benefits, suggesting it may be an attractive alternative to living-cell transplantation.
GDF11 protein improves the exercise capability of aging mice by making their brains and skeletal muscles more like those of young health mice. The protein also restores DNA damage associated with aging in muscle stem cells, leading to improved function in unmanipulated muscle.
Researchers successfully coaxed induced pluripotent stem cells from infertile men into producing sperm cell precursors after transplantation into mice testes. This breakthrough helps explain genetic causes of male infertility and holds potential for clinical applications.
Researchers at Stanford University and Montana State University have successfully transplanted stem cells from infertile men into mice, resulting in the formation of primordial germ cells. The study provides a valuable model for understanding the earliest stages of human reproduction, which varies significantly from that of common labo...
Johns Hopkins researchers have successfully used stem cells derived from human body fat to deliver biological treatments directly to the brains of mice with glioblastoma, a deadly form of brain tumor. The treatment extended the mice's lives by an average of 24 days, offering new hope for treating aggressive brain cancer in humans.
Researchers at the University of Adelaide have discovered that stem cells taken from teeth can grow to resemble brain cells, suggesting they could be used as a therapy for stroke. These cells have the potential to form complex networks and communicate like normal neurons, offering hope for new treatments.
Researchers at NYSCF and Columbia University Medical Center have successfully created the first disease-specific human embryonic stem cell line using somatic cell nuclear transfer (SCNT). The achievement marks a major step towards developing personalized cell therapies for life-threatening diseases like type 1 diabetes. By reprogrammin...
A study by Johns Hopkins researchers found that when a certain kind of stem cell is killed off experimentally, another group of non-stem cells can replace them naturally. The discovery may help explain how stem cells in tumors replenish themselves and could offer new targets for controlling cancer growth.
Scientists studying fetal stem cells that facilitate scarless wound healing aim to develop cell-based approaches to minimize scarring in adult wounds. Researchers have identified a new stem cell capable of participating in this process.
Researchers have developed a new method to generate bone tissue using the body's own stem cells, which could replace traditional bone grafting techniques. The process, known as biodegradable polymer scaffolding material and BMP, has been successful in lab experiments and shows promise for future clinical trials.
Researchers at UC Irvine's Sue & Bill Gross Stem Cell Research Center found that bone marrow stem cells significantly improved multiple outcome measures in animal studies of stroke. The effects were robust regardless of dosage, timing, or method of administration.
A recent study published in Stem Cell Reports has found no evidence of complete heart regeneration in newborn mice after apex resection. The researchers, led by Ditte Andersen, were unable to replicate the findings of a previous 2011 study that suggested complete regeneration was possible.
A new human trial demonstrates the effectiveness of injecting bone marrow-derived stem cells into the heart muscle to improve heart function in patients with severe ischemic heart disease. The treatment improved heart pump function by 8.2 milliliters, compared to an increase of 6 milliliters in the placebo group.
Researchers discovered that the p53 gene is hyperactive in stem cells when cellular damage is present, but not in other cells. This finding suggests that p53's tumor suppression ability may have evolved from its original role in regulating stem cell growth.
Researchers have developed a new technique to generate large concentrations of skeletal muscle cells and muscle progenitors directly from human pluripotent stem cells. This method, described in Stem Cells Translational Medicine, uses growth factors to guide the stem cells towards a muscle fate, avoiding genetic modification.
Researchers at UC Davis successfully coax laboratory cultures of human stem cells into the specialized, unique cells needed to repair a patient's defective or diseased bladder. The breakthrough provides a pathway to regenerate replacement bladder tissue for patients whose bladders are too small or do not function properly.
Scientists at A*STAR's IMCB develop a method to generate human induced pluripotent stem cells from a single drop of finger-pricked blood. This technique enables donors to collect their own blood samples, potentially boosting recruitment and diversities of donors for large-scale hiPSC banks.