Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Researchers at the University of Pittsburgh School of Medicine have found that wisdom teeth stem cells can transform into corneal cells to repair scarring. The discovery could lead to new treatments for corneal blindness, a condition affecting millions worldwide.
State-funded programs in California and Connecticut have contributed to an increase in stem-cell-related publications, with California benefiting most. The study suggests that state funding has established California as a leader in this emerging field, while Maryland and New York saw minimal impact on publication trends.
Researchers at Queen Mary University of London found that regulating primary cilia length in stem cells can prevent the production of new fat cells. This study provides new insight into the regulation of fat cell formation and obesity, potentially leading to a new type of treatment called 'cilia-therapy'.
Researchers at the University of Cambridge discovered that the order of genetic mutations acquired determines how cancer behaves. The study found that patients who acquire mutations in JAK2 prior to those in TET2 are more likely to develop a severe red blood cell disease subtype and suffer from blood clots.
Researchers at the University of Minnesota Academic Health Center have developed a new reporter system to study bone regeneration potential in human embryonic stem cells. The system allows for better monitoring of cell properties and may lead to the creation of new therapies for diseases such as leukemia or genetic blood disorders.
A new study by Sanford-Burnham Medical Research Institute has identified a specific stem cell signaling process that regulates intestinal tumors. The findings suggest that protein kinase C-zeta inhibits stem cell activity through downregulation of two signaling pathways: beta-catenin and Yap.
Scientists at Gladstone Institutes have discovered a way to enhance CRISPR's precision while boosting its efficiency using small molecules. This breakthrough has important implications for correcting disease-causing genetic mutations and creating personalized therapeutics.
MIT researchers have engineered a way to use human liver cells to screen potential antimalarial drugs and vaccines for their ability to treat the liver stage of malaria infection. The approach may offer new opportunities for personalized antimalarial drug testing.
Human stem cells have been shown to repair damage caused by radiation therapy for brain cancer in rats, regaining cognitive and motor functions lost after treatment. The study uses human embryonic stem cells or induced pluripotent stem cells to replace damaged oligodendrocyte progenitor cells.
Researchers at the University of Gothenburg and Karolinska Institute have failed to successfully treat infertility with stem cells, contradicting previous claims. The study shows that female mice can only produce eggs from birth, rendering stem cell-based treatment unrealistic.
Researchers at Keck Medicine of USC have received grants to develop a temporary liver support system for transplant patients and improve gene editing for blood diseases. They also plan to create transgenic rats for researching heart failure, diabetes, and neurodegenerative diseases.
A San Diego team has won a $1.7 million grant to develop quality control methods for stem cells, enabling researchers to detect abnormal cells and ensure the safety and efficacy of potential therapies.
Researchers at Cedars-Sinai Medical Center have developed a novel method to generate transplantable corneal stem cells, which may benefit patients with life-altering forms of blindness. The study shows that these cells can differentiate into corneal cells in the laboratory, offering a promising treatment option.
Scientists have developed a breakthrough culturing system for human liver stem cells and pancreatic cancer stem cells, allowing for the growth of mini-organisms in the lab. This technology has the potential to revolutionize liver transplantation and aid in the fight against pancreatic cancer, with applications in personalized medicine.
Blood stem cells bud off from aorta, circulate until finding niche, then attach to vessel wall and interact with endothelial cells. The process involves chemical signals, cell attachment, and division to form blood system in zebrafish and possibly humans.
Researchers at Stanford University School of Medicine have discovered a stem cell in mice that gives rise to bone, cartilage and stroma. The discovery sets the stage for therapies for skeletal disorders such as bone fractures, brittle bones, and damaged cartilage.
Researchers have successfully improved muscle repair in mice with muscular dystrophy by increasing the BMI1 gene, leading to increased strength and longer treadmill runs. The study provides a proof of concept for harnessing this gene to enhance muscle regeneration and may lead to new treatments for patients.
Researchers at Northwestern University have developed a novel microfluidic device that allows for electroporation of adherent stem cells during differentiation, enabling the delivery of molecules in a non-destructive manner. This breakthrough has the potential to advance fundamental knowledge and state-of-the-art in stem cell research.
Professor Warburton's book, Stem Cells, Tissue Engineering and Regenerative Medicine, surveys current issues in stem cell biology and regenerative medicine. The book provides overviews of recent progress in stem cell research, including progenitor cell therapies for organ systems.
Belgian researchers used patient-derived stem cells to model frontotemporal dementia, a condition that affects about half of dementia cases before age 60. The study found a targetable defect in the Wnt signaling pathway, which can be corrected with genetic therapy or compounds inhibiting this pathway.
Researchers at the University of Copenhagen have discovered a way to promote stem cell growth by inhibiting their ability to make decisions. By blocking key choices, embryonic stem cells can be transformed into more efficient cell types, potentially leading to breakthroughs in cancer treatment and gut-related disorder therapies.
Researchers at Stanford University School of Medicine found that faulty stem cells surrounding muscle fibers are responsible for the progression of Duchenne muscular dystrophy. A drug called losartan has been shown to inhibit fibrosis and partially restore muscle function in laboratory mice, offering new hope for potential treatments.
Scientists at Indiana University and colleagues have demonstrated a technique for correcting genetic mutations in sperm-producing adult stem cells, a breakthrough that could prevent inherited defects in future generations. The method uses homologous recombination to repair flawed segments of DNA with correct ones.
Researchers find that embryonic stem cells can modify their metabolism to keep their entire genome accessible, allowing them to renew themselves. This discovery could lead to breakthroughs in regenerative medicine and a better understanding of cancer.
Scientists have developed a method to transmute living cells into more permanent materials that defy rot and can endure high-powered probes. This technique is widening research opportunities for biologists developing cancer treatments and materials scientists creating commercially useful shapes.
Researchers at Harvard University have developed a system using human stem cells to screen for compounds that can turn white, or 'bad', fat cells into brown, or 'good' fat cells. They have identified two compounds that can accomplish this in human cells, taking the first step towards a potential pill for obesity treatment.
Researchers have identified new ways to regulate and control the growth of various cell and tissue types by analyzing individual stem cells' genetic makeup. The findings reveal a complex
A team of scientists found that a specific chemical modification on RNA plays a key role in determining the ability of embryonic stem cells to adopt different cellular identities. Depleting or knocking out this component blocks stem cells from differentiating into specialized types of cells.
Scientists at McMaster University have discovered that human induced pluripotent stem cells retain a memory of their original tissue type, allowing for more targeted regeneration and therapy development. This breakthrough challenges the conventional thought that any pluripotent human stem cell can be used to generate mature tissue cells.
Fibrotic diseases cause up to 45 percent of deaths worldwide. Researchers identified Gli1 cells around blood vessels as responsible for fibrosis. Abating these cells improved organ function in mice with kidney and cardiac fibrosis.
Scientists at Cedars-Sinai Medical Center have developed a method to re-create stem cells from stored blood samples of deceased patients. This approach enables researchers to study the biological mechanisms behind diseases and potentially design new therapies for conditions such as Crohn's disease.
Researchers at USC Health Sciences identified a new population of nail stem cells that can self-renew or differentiate into multiple tissues, including nail and skin. These stem cells play a crucial role in nail repair, but their potential to generate additional types of tissue is still unknown.
Researchers at Mount Sinai aim to re-create patients' ocular stem cells to restore vision, eliminating the need for immunosuppressive drugs. The grant will support efforts to discover new stem cell therapies and develop biomaterials for engrafting patient-owned stem cells.
Researchers at Harvard University have identified a rare population of stem cells that give rise to fibrosis, a condition characterized by the buildup of scar tissue in organs. The study suggests that targeting these stem cells could lead to therapeutic breakthroughs for conditions such as diabetes, lung disease, and high blood pressure.
Researchers found that administering stem cell factor directly into damaged heart muscle after a heart attack can help repair and regenerate injured tissue. The study showed improved cardiac function, reduced cell death, and increased regeneration of heart tissue blood vessels.
Researchers at Cedars-Sinai Medical Center have found that injections of cardiac stem cells may help reverse heart damage caused by Duchenne muscular dystrophy, potentially leading to improved heart function and exercise capacity. The study involved laboratory mice infused with cardiac stem cells, which showed marked improvement in hea...
A study by Stanford University School of Medicine researchers reveals that the protein retinoblastoma, a known tumor suppressor, also inhibits the vital property of pluripotency in stem cells. This finding provides a direct molecular link between cancer and stem cell science.
A new study from Harvard Medical School reveals that genetic variants control DNA replication timing, varying among people. This variation affects mutation rates and individual disease risk, including blood cancers.
Scientists at Karolinska Institutet have discovered a key role for the signal molecule TGF-beta in regulating brain stem cells' development potential. By understanding this mechanism, researchers hope to develop new treatments for neurodegenerative diseases.
Researchers at Morgridge Institute for Research discovered a method to impose an immortal-like state on mouse progenitor cells responsible for producing blood and vascular tissue. The breakthrough enables the creation of functional endothelial, blood, and smooth muscle cells, paving the way for cell-based therapies and drug screening.
Researchers at Indiana University identified two proteins, FAK and PAK1, as crucial for the development of acute myeloid leukemia. They also found that targeting these proteins can block the disease's progression.
Researchers have identified a type of adult lung stem cell that contributes to lung regeneration after damage. The study found that these cells, known as p63+/Krt5+, proliferate upon injury and form new alveoli near sites of inflammation, highlighting their potential for therapeutic strategies.
Lori O'Brien, a USC postdoctoral research associate, has received the first Broad Fellowship to investigate how epigenetic regulation affects kidney stem cells. The fellowship will support her research on Phf19, an epigenetic regulator that encourages embryonic stem cell self-renewal.
Researchers created a cellular model of Parkinson's disease using human stem cells from identical twins with the disease. The study found that dopamine-producing neurons had reduced activity and higher levels of α-synuclein protein, which can be targeted for therapy.
Researchers at Harvard University have used CRISPR technology to edit out the CCR5 receptor in human blood stem cells, which could provide a new approach to treating HIV/AIDS. The edited cells showed no unwanted mutations and retained their functionality.
Researchers at NYSCF found that SCNT-derived cells and IPS cells share similar genetic profiles, suggesting both methods are effective in generating stem cells. The study's findings imply that further investigation is needed to determine the suitability of each method for treating chronic diseases.
Using mouse embryonic stem cells, researchers have successfully reconstructed the early stage of mammalian development in a lab, showing that a critical mass of cells is needed for self-organisation into an embryo. This breakthrough allows for the creation of an axis and gastrulation-like movements, mimicking the process of embryonic d...
Researchers at Michigan State University have discovered that a specific gene, Sox2, plays a crucial role in determining the source of stem cells in mammals. By studying mouse embryos, the team found that Sox2 appears to be acting ahead of other genes traditionally identified as playing critical roles in stem cell formation.
The New York Stem Cell Foundation has launched the largest-ever stem cell repository, offering over 600 induced pluripotent stem (iPS) cell lines from diverse human subjects. The repository provides a vast resource for scientists to study various diseases, including type 1 diabetes, Parkinson's disease, and multiple sclerosis.
Scientists at the Stowers Institute discovered that megakaryocytes, a type of 'mega' cell in bone marrow, regulate stem cells to produce platelets and other blood cells. This finding could lead to new treatments for patients recovering from chemotherapy or organ transplantation.
Researchers from the University of Pittsburgh School of Medicine discovered a pool of stem cells in the esophagus, which could lead to new treatments for esophageal cancer and Barrett's esophagus. The study found that these stem cells divide slowly compared to other cells in the esophagus, suggesting they may play a role in tissue rene...
Researchers have challenged conventional thinking on bowel cancer development, proposing a new mechanism involving crypt-generating stem cells. The study found that these stem cells are responsible for maintaining and regenerating the 'crypts' in the bowel lining, and their dysfunction may lead to precancerous and cancerous growths.
Researchers found that autophagy, a cellular recycling mechanism, helps activate muscle stem cells by inducing metabolic shifts and coping with increased biosynthesis demands. Inhibited autophagy delayed stem cell activation, highlighting SIRT1's regulatory role in this process.
The New York Stem Cell Foundation has awarded $9 million to six promising scientists, including three stem cell researchers and three neuroscience researchers. The awards will enable them to expand their laboratories and train other scientists.
A team of scientists received funding to investigate how neural stem cells vary, which could lead to better treatments for neurological conditions. The study aims to identify molecular differences between types of neural stem cells, shedding light on their behavior and potential therapies.
Researchers at Drexel University developed a program called LEVER that enables biologists to track and study the movement and multiplication of cells using 3D microscopic images. With enhanced version LEVER 3-D, scientists can visualize and analyze cell behavior in real-time.
Researchers discovered a turmeric compound, ar-turmerone, promotes stem cell proliferation and differentiation in the brain, suggesting its potential as a future drug candidate for treating stroke and Alzheimer's disease. The study found that ar-turmerone increased neural stem cell proliferation by up to 80% without affecting cell death.
Researchers at USC Health Sciences have discovered how a gene mutation affects facial development, revealing the underlying mechanisms of DiGeorge syndrome. The study's findings provide new insights into the complex cellular rearrangements that shape the face during early development.
Researchers at the University of Cambridge discovered that stem cells 'communicate' with damaged cells by transferring molecules via fluid-filled bags called vesicles, helping other cells modify the damaging immune response. This novel mechanism enables stem-cell-based therapies to work more efficiently.
Researchers at NYU Langone Health have discovered a highly efficient method for generating pluripotent stem cells, increasing yields by over 20-fold compared to standard protocols. The new technique uses vitamin C and two other compounds to modulate enzymes involved in cell reprogramming.