Articles tagged with Stem Cell Research
Researchers at Morgridge Institute for Research discovered a method to impose an immortal-like state on mouse progenitor cells responsible for producing blood and vascular tissue. The breakthrough enables the creation of functional endothelial, blood, and smooth muscle cells, paving the way for cell-based therapies and drug screening.
Researchers at Indiana University identified two proteins, FAK and PAK1, as crucial for the development of acute myeloid leukemia. They also found that targeting these proteins can block the disease's progression.
A study by Stanford University School of Medicine researchers reveals that the protein retinoblastoma, a known tumor suppressor, also inhibits the vital property of pluripotency in stem cells. This finding provides a direct molecular link between cancer and stem cell science.
A new study from Harvard Medical School reveals that genetic variants control DNA replication timing, varying among people. This variation affects mutation rates and individual disease risk, including blood cancers.
Researchers have identified a type of adult lung stem cell that contributes to lung regeneration after damage. The study found that these cells, known as p63+/Krt5+, proliferate upon injury and form new alveoli near sites of inflammation, highlighting their potential for therapeutic strategies.
Lori O'Brien, a USC postdoctoral research associate, has received the first Broad Fellowship to investigate how epigenetic regulation affects kidney stem cells. The fellowship will support her research on Phf19, an epigenetic regulator that encourages embryonic stem cell self-renewal.
Researchers at Harvard University have used CRISPR technology to edit out the CCR5 receptor in human blood stem cells, which could provide a new approach to treating HIV/AIDS. The edited cells showed no unwanted mutations and retained their functionality.
Researchers at NYSCF found that SCNT-derived cells and IPS cells share similar genetic profiles, suggesting both methods are effective in generating stem cells. The study's findings imply that further investigation is needed to determine the suitability of each method for treating chronic diseases.
Researchers created a cellular model of Parkinson's disease using human stem cells from identical twins with the disease. The study found that dopamine-producing neurons had reduced activity and higher levels of α-synuclein protein, which can be targeted for therapy.
Using mouse embryonic stem cells, researchers have successfully reconstructed the early stage of mammalian development in a lab, showing that a critical mass of cells is needed for self-organisation into an embryo. This breakthrough allows for the creation of an axis and gastrulation-like movements, mimicking the process of embryonic d...
Researchers at Michigan State University have discovered that a specific gene, Sox2, plays a crucial role in determining the source of stem cells in mammals. By studying mouse embryos, the team found that Sox2 appears to be acting ahead of other genes traditionally identified as playing critical roles in stem cell formation.
The New York Stem Cell Foundation has launched the largest-ever stem cell repository, offering over 600 induced pluripotent stem (iPS) cell lines from diverse human subjects. The repository provides a vast resource for scientists to study various diseases, including type 1 diabetes, Parkinson's disease, and multiple sclerosis.
Scientists at the Stowers Institute discovered that megakaryocytes, a type of 'mega' cell in bone marrow, regulate stem cells to produce platelets and other blood cells. This finding could lead to new treatments for patients recovering from chemotherapy or organ transplantation.
Researchers from the University of Pittsburgh School of Medicine discovered a pool of stem cells in the esophagus, which could lead to new treatments for esophageal cancer and Barrett's esophagus. The study found that these stem cells divide slowly compared to other cells in the esophagus, suggesting they may play a role in tissue rene...
Researchers have challenged conventional thinking on bowel cancer development, proposing a new mechanism involving crypt-generating stem cells. The study found that these stem cells are responsible for maintaining and regenerating the 'crypts' in the bowel lining, and their dysfunction may lead to precancerous and cancerous growths.
The New York Stem Cell Foundation has awarded $9 million to six promising scientists, including three stem cell researchers and three neuroscience researchers. The awards will enable them to expand their laboratories and train other scientists.
Researchers found that autophagy, a cellular recycling mechanism, helps activate muscle stem cells by inducing metabolic shifts and coping with increased biosynthesis demands. Inhibited autophagy delayed stem cell activation, highlighting SIRT1's regulatory role in this process.
A team of scientists received funding to investigate how neural stem cells vary, which could lead to better treatments for neurological conditions. The study aims to identify molecular differences between types of neural stem cells, shedding light on their behavior and potential therapies.
Researchers at Drexel University developed a program called LEVER that enables biologists to track and study the movement and multiplication of cells using 3D microscopic images. With enhanced version LEVER 3-D, scientists can visualize and analyze cell behavior in real-time.
Researchers discovered a turmeric compound, ar-turmerone, promotes stem cell proliferation and differentiation in the brain, suggesting its potential as a future drug candidate for treating stroke and Alzheimer's disease. The study found that ar-turmerone increased neural stem cell proliferation by up to 80% without affecting cell death.
Researchers at USC Health Sciences have discovered how a gene mutation affects facial development, revealing the underlying mechanisms of DiGeorge syndrome. The study's findings provide new insights into the complex cellular rearrangements that shape the face during early development.
Researchers at NYU Langone Health have discovered a highly efficient method for generating pluripotent stem cells, increasing yields by over 20-fold compared to standard protocols. The new technique uses vitamin C and two other compounds to modulate enzymes involved in cell reprogramming.
Researchers at the University of Cambridge discovered that stem cells 'communicate' with damaged cells by transferring molecules via fluid-filled bags called vesicles, helping other cells modify the damaging immune response. This novel mechanism enables stem-cell-based therapies to work more efficiently.
A new protocol converts stem cells into reliable, insulin-producing cells in about six weeks, a significant improvement over previous methods. The breakthrough could lead to an unlimited supply of insulin-producing cells to treat patients with Type 1 diabetes.
In a breakthrough study published in Nature Communications, Cedars-Sinai researchers successfully targeted stem cells to injured heart muscle using antibody-studded iron nanoparticles. This innovative approach enables precise localization of the body's own stem cells to the site of injury, promoting regeneration and repair.
A single nucleotide change in the FMR1 gene near its replication origin may cause fragile X syndrome by inactivating DNA replication. This substitution leads to increased risk of repeat expansions, resulting in intellectual disability.
Researchers from CU School of Medicine and Taiga Biotechnologies have discovered a way to expand production of stem cells used to treat cancer patients. This breakthrough technology could also be used to treat inborn immunodeficiency conditions, metabolic diseases, and autoimmune disorders.
Researchers have created an online analytic platform called CellNet to aid stem cell engineering. The tool uses network biology methods to analyze and predict cell fate and corresponding engineering strategies, offering a reliable shortcut for drug development and individualized cancer therapies.
Researchers explore adipose-derived stem cells as a tool for improving nerve regeneration through bioengineered nerve grafts, aiming to revolutionize peripheral nerve repair. Adipose-derived stem cells have shown potential to stimulate improved nerve regeneration and could replace current clinical approaches.
Researchers have identified key mechanisms that trigger hematopoietic stem cell production, which could lead to new treatments for blood disorders. The discovery brings the potential for more widespread use of blood stem cells in therapy closer.
Scientists have identified key DNA sequences and regulatory proteins controlling blood stem cell fate, revealing a more dynamic process than previously thought. The discovery has implications for developing diagnostic tools, personalized medicine, and regenerative therapies.
Research by bioengineers at UC San Diego reveals that the stiffness of the extracellular matrix is a key factor in guiding stem cells towards specific cell types. The study found that varying the stiffness of the hydrogel had no effect on the differentiation process, ruling out protein binding as a crucial factor.
Researchers have developed a method to grow human GI cells from patient tissue in as little as two weeks, creating over 65 cell lines. This breakthrough enables the study of individual patients' underlying problems and can be used to test new treatments.
Researchers at Queen Mary University of London have uncovered the behavior of stem cells in the human bowel for the first time. They found that within a healthy bowel, only a certain number of stem cells can exist within one area at a time, and increased competition for survival is seen in early tumours.
Researchers at Harvard University's H SCI have identified a promising new potential treatment for ALS, using compounds already in clinical trials. The study found that inhibiting a specific receptor in glial cells increased survival time in an animal model of the disease.
Researchers at the University of Luxembourg have made a breakthrough in implanting neurons into mouse brains, demonstrating long-term stability and functional integration. The successful technique, which uses reprogrammed skin cells to produce healthy neurons, holds promise for treating neurodegenerative diseases like Parkinson's disease.
A team of researchers has identified 5-lipoxygenase as a target for therapeutic management of stem cell-like cells in acute myeloid leukemia. Inhibiting this enzyme selectively attacks and eliminates leukemic stem cells in both cell culture models and mouse models, suggesting a promising approach for treating the disease.
Recent advances in stem cell biology offer immense hope for treating various diseases and conditions. Key findings include the potential for stem cells to replicate any other cells in the body and their possible applications in regenerative medicine.
Researchers at Inserm found that artificial light with blue wavelengths can synchronize the body clock and activate non-visual functions in extreme lighting conditions. This breakthrough has practical applications for dimly lit workplaces, enabling design of lighting strategies to maintain staff health, productivity, and safety.
Researchers found that blood-forming stem cells falter with age due to DNA replication problems, leading to a decline in immune function. However, even old stem cells can repair induced DNA damage efficiently and retain molecular tags associated with DNA damage.
Researchers investigated the impact of cellular senescence on adipose-derived stem cell morphology and function. The study found that senescence compromises the clinical application of these cells for peripheral nerve regenerative cell therapy. Senescence modulating factors influence adipose-derived stem cell behavior.
Researchers at The New York Stem Cell Foundation have developed a new protocol to induce pluripotent stem cells into oligodendrocytes, the myelin-forming cells implicated in multiple sclerosis. This accelerated approach cuts production time almost in half, enabling researchers to study disease progression and develop potential treatments.
The three institutions are working together to develop less painful treatments for babies with fused skulls, reducing the need for annual surgeries. Researchers have established a Craniofacial Anomalies Registry and plan to expand their collaboration to include postdoctoral fellows and graduate students.
Researchers have identified a key gene, ASF1A, that enables cellular reprogramming and the development of stem cells. This finding could lead to the creation of induced pluripotent stem cells derived from adult tissue, offering potential for safer cell-therapy strategies.
Researchers found that stress can disrupt the process of fat tissue development, leading to issues with fat storage within cells and in the bloodstream. The study identified a key signaling pathway involving adenosine receptors and stem cell factors that regulates this process.
Wisconsin scientists have identified two genetic programs that can turn blank-slate stem cells into red and white blood cells. The discovery gives scientists the tools to make blood products, investigate cell development and production of clinically relevant blood products.
USC Stem Cell scientists have created a transgenic mouse line called TRAP, which enables the detection of early signals of acute kidney injury. This breakthrough has the potential to improve patient outcomes by detecting kidney failure earlier, allowing for more effective treatment.
Researchers have found that using gene-editing techniques on stem cells does not increase the overall occurrence of mutations, easing previous safety concerns. The study's results were published in the journal Cell Stem Cell and provide new hope for the development of therapies for genetic diseases.
Researchers discovered that dental pulp stem cells can protect retinal ganglion cells from death and promote regeneration of their axons. The study found that these stem cells naturally express neurotrophic factors, providing a potentially limitless source of growth factors for injured neurons.
Researchers have discovered the gene zic-1, which enables planarians to regenerate their heads after decapitation. The study suggests that this ancient mechanism could be used to create tissue organizers for enhancing injury repair in humans.
A Johns Hopkins study finds that a gene deletion linked to schizophrenia alters brain cell skeletons, disrupting layer formation. Researchers also identify a crucial protein involved in building cellular skeletons, which may contribute to the condition.
Using a molecule called ABCB5, researchers identified limbal stem cells in deceased donors' tissue and grew fully functional human corneas in mice. This breakthrough could restore vision for individuals with damaged eyes due to injury or disease, revolutionizing the field of regenerative medicine.
A new study finds that stem cells created by moving genetic material from a skin cell into an empty egg cell more closely resemble human embryonic stem cells than traditionally induced pluripotent stem (iPS) cells. The method, known as nuclear transfer, results in cells with fewer reprogramming issues and better gene expression patterns.
Researchers at Harvard University have developed a method to collect the best cell type for regenerating damaged corneas, with purified human stem cells showing promise in improving long-term vision in mice. The discovery is expected to quickly translate into improved human therapies and could potentially restore the corneal surface.
A new review article suggests that embryonic and induced pluripotent stem cells are not the only source of all three germ layers in the human body. Adult pluripotent stem cells are located throughout the body and can become every tissue, provided they receive the right instructions.
Researchers at Scripps Research Institute found that the drug rapamycin can improve the delivery of genes to blood stem cells, increasing efficiency from 30-40% to up to 80%. This breakthrough could lead to more effective and affordable treatments for leukemia and sickle cell anemia.
A study published in Scientific Reports reveals that CCL2 can activate the JAK/STAT pathway and increase stem cell colony attachment, differentiation efficiency, and X chromosome reactivation. The researchers also found higher expression of genes related to hypoxic response, suggesting a potential link between cellular stress and pluri...
Researchers at UCLA have discovered how factors regulating adult stem cells in lungs can lead to precancerous lesions. The study found that disrupting normal ROS regulation drives repair process, causing precancerous lesions to form.
Researchers found that peripheral blood stem cells stimulated by granulocyte colony-stimulating factor (G-CSF) can inhibit osteoarthritis progression in rats. The therapy has potential as a treatment for OA, but further studies are needed to determine its effectiveness in humans.
The New York Stem Cell Foundation (NYSCF) and the eagle-i Network will make NYSCF iPS cell lines and related information available on a user-friendly, web-based, searchable database. This database will help scientists find valuable resources, enabling collaboration and accelerating research.