Scientists at the University of Washington have successfully created a line of human embryonic stem cells that can develop into various tissues. The new 'naive' cells retain their natural ability to differentiate into all types of human cells without artificial genes, opening up possibilities for regenerative medicine and transplantation.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalProceedings of the National Academy of Sciences·DateMar 13, 2014
Scientists have successfully studied protein synthesis in adult stem cells, finding that precise protein production is essential to their function. The discovery opens up new avenues of cellular biology and may lead to a better understanding of diseases associated with protein synthesis mutations.
SourceUT Southwestern Medical Center·JournalNature·DateMar 9, 2014
A team of researchers at Brigham and Women's Hospital has generated stem cells from skin biopsies of living family members with a genetic predisposition to early-onset Alzheimer's. The study found that the APPV7171 mutation alters amyloid-beta protein generation, Tau protein expression, and phosphorylation, providing new insights into ...
SourceBrigham and Women's Hospital·JournalHuman Molecular Genetics·DateMar 6, 2014
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Researchers developed a set of 64 parameters to evaluate stem cell-derived cardiac myocytes, providing a standardized method to test cell function. This approach addresses critical quality control issues in the industry, enabling more reliable and reproducible tests for cell function.
SourceHarvard University·JournalStem Cell Reports·DateMar 6, 2014
Researchers found that human umbilical cord blood cells transplanted into rats with simulated myocardial infarction improved left ventricular heart function and preserved myocardial fiber structure. The study showed long-term benefits for the treated rats, suggesting a potential therapy for MIs.
SourceCell Transplantation Center of Excellence for Aging and Brain Repair·JournalCell Transplantation·DateMar 6, 2014
Researchers at the University of Edinburgh's Roslin Institute have created working nerve cells from horse stem cells, paving the way for cell therapies targeting neurological conditions. The breakthrough could also benefit horses affected by grass sickness, a previously untreatable condition.
SourceUniversity of Edinburgh·JournalStem Cells and Development·DateMar 4, 2014
Researchers at Caltech have shown that bone marrow cells are sensitive to infection-related molecules and respond rapidly. They detect invasion and mount an inflammatory response, producing cytokines that stimulate the differentiation of immune cells.
SourceCalifornia Institute of Technology·JournalCell Stem Cell·DateFeb 20, 2014
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers have discovered a method for restoring strength to damaged skeletal muscles in the elderly using stem cell therapy. The treatment involves treating cells outside the body with a drug that prevents protein modification and culturing them on soft biomaterials, allowing aged cells to grow and self-renew.
SourceUniversity of Toronto·JournalNature Medicine·DateFeb 20, 2014
A study by American University researchers found that understanding public opinion goes beyond partisanship to address differences in people's perceptions about the social implications of science. Four distinct groups, including 'Scientific Optimists' and 'Disengaged', were identified as influencing opinions on stem cell research.
Researchers have found that aging muscle stem cells become less able to regenerate new fibers and self-renew. However, they discovered a process to rejuvenate old muscle stem cells using a drug and soft hydrogel substrate, enabling them to repair muscle damage in mice.
SourceStanford Medicine·JournalNature Medicine·DateFeb 16, 2014
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Cancer researchers have discovered a pre-leukemic stem cell that may initiate disease and trigger relapse in patients with acute myeloid leukemia (AML). This finding offers a potential tool for earlier diagnosis and targeted therapy, as the pre-leukemic stem cell can survive chemotherapy and be found in the bone marrow at remission.
SourceUniversity Health Network·JournalNature·DateFeb 12, 2014
Scientists have discovered how the prostate gland develops for the first time, identifying 80 genes and a signalling pathway involved in its growth. The finding provides potential targets for new therapies to combat common prostate diseases, including prostate cancer.
SourceUniversity of York·JournalStem Cell Reports·DateFeb 6, 2014
A Cedars-Sinai research team led by Paul W. Noble is developing a novel approach to treat idiopathic pulmonary fibrosis, a disease that destroys the lungs and damages vital organs. The two-year study aims to build upon preliminary research and uncover the precise way normal lung stem cell repair occurs.
Researchers from RIKEN in Japan have identified a duo of histone proteins, TH2A and TH2B, that dramatically enhance the generation of induced pluripotent stem cells (iPSCs). The study demonstrates that these proteins function as substitutes for two Yamanaka factors and increase iPSC cell generation by twentyfold and speed up the process.
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Researchers at Boston Children's Hospital have developed a new pathway to reverse lung diseases in mice by coaxing the production of healthy cells. By enhancing the natural signaling pathway, they successfully increased the production of alveolar epithelial cells, which line the small sacs where gas exchange takes place.
SourceBoston Children's Hospital·JournalCell·DateJan 30, 2014
Two UC Irvine research teams will use the grants to investigate the fundamental structure and function of stem cells, with potential applications for treating cancer, neurological diseases, and injuries. The funded projects aim to uncover specific properties of human stem cells used in transplants.
Researchers at Johns Hopkins Medicine have developed human induced-pluripotent stem cells that can repair damaged retinal vascular tissue in mice without using viruses. These non-viral, human retinal iPSCs were grown using a safer method and showed comparable ability to human embryonic-derived iPSCs.
SourceJohns Hopkins Medicine·JournalCirculation·DateJan 23, 2014
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Researchers at UT Southwestern Medical Center found that estrogen increases proliferation of blood-forming stem cells in females, leading to increased red blood cell production. This discovery raises possibilities for treating blood cancers and reducing chemotherapy toxicity by considering estrogen levels.
SourceUT Southwestern Medical Center·JournalNature·DateJan 22, 2014
Researchers have discovered two types of breast cancer stem cells, each playing a crucial role in metastasis. The findings highlight the need for targeted therapies that can tackle both forms of stem cells, offering new hope for patients with metastatic breast cancer.
SourceMichigan Medicine - University of Michigan·JournalStem Cell Reports·DateJan 14, 2014
Azim Surani receives the McEwen Award for Innovation for pioneering epigenetics research; Valentina Greco wins the ISSCR-BD Biosciences Outstanding Young Investigator Award for her noninvasive method to visualize skin stem cell division. Paolo Bianco, Elena Cattaneo, and Michele De Luca receive the ISSCR Public Service Award for their ...
SourceInternational Society for Stem Cell Research·DateJan 14, 2014
Scientists have identified a key gene receptor and signaling pathway essential to maintaining human embryonic stem cells (hESCs) in an undifferentiated state. By blocking the WNT signaling pathway and its encoded receptor FZD7, researchers were able to keep hESCs in their pluripotent state.
SourceUniversity of California - San Diego·JournalProceedings of the National Academy of Sciences·DateJan 13, 2014
Researchers successfully transplanted skin-derived stem cells into collagen tubes to bridge gaps in injured nerves, resulting in functional recovery and saving the upper arms from amputation. The study provides a promising new avenue for treating peripheral nerve injuries.
SourceCell Transplantation Center of Excellence for Aging and Brain Repair·JournalCell Transplantation·DateJan 9, 2014
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Scientists have identified fourteen genes that may be implicated in Alzheimer's disease and one gene that shows inflammation plays a crucial role in the brain of Alzheimer's patients. The study provides new insight into the cause of the disease, offering potential targets for drug discovery.
SourceNew York Stem Cell Foundation·JournalPLOS ONE·DateJan 8, 2014
Researchers at NYSCF and Columbia University Medical Center successfully generated iPS cells from frozen brain tissue, allowing for the study of Alzheimer's disease at a cellular level. The new stem cell lines will enable drug testing on cells from patients with confirmed diagnoses.
SourceNew York Stem Cell Foundation·JournalActa Neuropathologica·DateJan 7, 2014
A research team at the University of California, San Diego has discovered how calcium phosphate-based materials encourage stem cells to differentiate into bone-forming cells. The findings could lead to the development of new biomaterials that can be used to treat bone defects and diseases.
SourceUniversity of California - San Diego·JournalProceedings of the National Academy of Sciences·DateJan 6, 2014
A study by Johns Hopkins Medicine found that patients overwhelmingly support stem cell research with induced pluripotent stem cells (iPSCs), despite ethical concerns. Patients prioritize full disclosure of anticipated uses and informed consent to alleviate concerns about privacy and commercialization.
SourceJohns Hopkins Medicine·JournalCell Stem Cell·DateJan 2, 2014
Researchers at UCLA discovered a mechanism by which certain adult stem cells suppress their ability to initiate skin cancer during dormancy. The study found that PTEN gene plays a crucial role in tumor suppression via quiescence in hair follicle stem cells.
SourceUniversity of California - Los Angeles·JournalNature Cell Biology·DateDec 20, 2013
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Mayo Clinic researcher Abba Zubair is sending human stem cells into space to see if they grow more rapidly than on Earth. The experiment aims to expand the population of stem cells that can induce regeneration of neurons and blood vessels in patients who have suffered a hemorrhagic stroke.
Researchers at Queen Mary University of London found that growing adult stem cells on micro-grooved surfaces disrupts primary cilia length, controlling subsequent behavior and specialization. This discovery has potential applications in treating conditions like arthritis, Alzheimer's disease, and Parkinson's disease.
SourceQueen Mary University of London·JournalScientific Reports·DateDec 18, 2013
Researchers at the University of Manchester have developed a novel technique for reprogramming somatic cells into induced pluripotent stem (iPS) cells without using viruses, reducing the risk of tumor formation. This breakthrough could revolutionize regenerative medicine and provide new hope for treating various diseases.
SourceThe Journal of Visualized Experiments·JournalJournal of Visualized Experiments·DateDec 17, 2013
Researchers at Karolinska Institutet have successfully treated two babies in utero with mesenchymal stem cells, a type of connective tissue cell that can form and improve bone tissue. The treatment was administered to babies born with osteogenesis imperfecta, a rare congenital bone disease causing stunted growth and repeated fractures.
SourceKarolinska Institutet·JournalStem Cells Translational Medicine·DateDec 16, 2013
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Researchers are developing a humanized monoclonal antibody that specifically targets and inhibits the functioning of ROR1 in cancer stem cells. The goal is to deliver toxins selectively to cancer stem cells without harming normal cells.
Researchers at CNIO demonstrate that cells from various tissues can be converted into embryonic stem cells using Shinya Yamanaka's technique, exhibiting higher plasticity than existing iPSCs.
SourceCentro Nacional de Investigaciones Oncológicas (CNIO)·JournalNature Medicine·DateDec 11, 2013
The EUCelLEX Project examines current legislation on somatic cells, assessing relevance and proposing sustainable solutions. It aims to provide a stabilised legal context for the use of stem cells in clinical purposes.
SourceINSERM (Institut national de la santé et de la recherche médicale)·DateDec 9, 2013
The World Stem Cell Report 2013 presents innovative solutions for accelerating stem cell treatments and eventual cures, addressing regulatory, legal, and ethical roadblocks. The report is a benchmark guide for moving the field forward, supporting the 2013 World Stem Cell Summit.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalStem Cells and Development·DateDec 4, 2013
Scientists at Brigham and Women's Hospital have developed a method to grow extensive numbers of intestinal stem cells, which can then be directed to mature into different types of intestinal cells. This breakthrough could lead to the creation of a new gut for patients with gastrointestinal disorders.
SourceBrigham and Women's Hospital·JournalNature Methods·DateDec 3, 2013
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Researchers have found that prostate cancer stem cells change from basal to luminal cells as the disease progresses, rendering existing treatments less effective. This discovery could lead to more targeted therapies by targeting the evolving cancer stem cells.
SourceUniversity of California - Los Angeles·JournalProceedings of the National Academy of Sciences·DateDec 3, 2013
Mary Ann Liebert, President and CEO of Mary Ann Liebert, Inc., will receive the 2013 Education Award from the Genetics Policy Institute. She is being honored for her work educating patients, researchers, and the broader stem cell community about the promise and applications of stem cells in medicine.
SourceMary Ann Liebert, Inc./Genetic Engineering News·DateDec 2, 2013
Researchers at MIT and Brigham and Women's Hospital have successfully grown unlimited quantities of intestinal stem cells that can differentiate into mature cells. These cells hold promise for treating diseases such as ulcerative colitis and could be used for drug development and testing.
SourceMassachusetts Institute of Technology·JournalNature Methods·DateDec 2, 2013
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Researchers at Princess Margaret Cancer Centre have identified a promising new therapeutic path for colorectal cancer by disarming the BMI-1 gene, which drives self-renewal in stem cells. Inhibiting this gene resulted in long-term and irreversible impairment of tumour growth, providing strong evidence for its clinical relevance.
SourceUniversity Health Network·JournalNature Medicine·DateDec 1, 2013
Researchers used patient-derived stem cells to show that a genetic mutation in the alpha-synuclein gene increases vulnerability to pesticides, leading to Parkinson's disease. The study identified a molecule that protects neurons from pesticide damage and may have potential clinical implications for treating the disease.
Researchers found that human periodontal ligament stem cells exhibit similar therapeutic effects to autologous Schwann cells in repairing peripheral nerve injuries. The study suggests a potential value for the use of human periodontal ligament stem cells in the repair of mental nerve injury.
SourceNeural Regeneration Research·JournalNeural Regeneration Research·DateNov 27, 2013
A study from the University of Pennsylvania has uncovered a mechanism that allows blood stem cells to divide in perpetuity, using the motor protein myosin II. The researchers found that asymmetric division is enabled by myosin IIB, which helps to partition key factors and keep one side as a stem cell.
SourceUniversity of Pennsylvania·JournalCell Stem Cell·DateNov 26, 2013
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Researchers at UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have identified a specific type of cell and related cell communication pathway crucial for healthy placenta growth. The findings may help clarify the causes of fetal growth restriction and other pregnancy complications.
SourceUniversity of California - Los Angeles·JournalDevelopmental Cell·DateNov 26, 2013
Researchers at the University of Granada have successfully grown artificial skin using Wharton jelly mesenchymal stem cells from the umbilical cord. This breakthrough could provide instant use for burn victims, reducing the need for weeks-long growth periods.
SourceUniversity of Granada·JournalStem Cells Translational Medicine·DateNov 22, 2013
A recent study by the Cardiovascular Cell Therapy Research Network found that bone marrow mononuclear stem cells did not improve heart function significantly at one year compared to six months. The treatment also showed a measurable decrease in scar tissue, but its effectiveness was no different from a placebo.
SourceMinneapolis Heart Institute Foundation·DateNov 18, 2013
Researchers used genetic engineering to precisely study a key protein's role in familial Alzheimer's disease, discovering that simple loss-of-function doesn't contribute to the inherited form. The findings could help elucidate Alzheimer's mechanisms and inform drug development.
SourceUniversity of California - San Diego·JournalCell Reports·DateNov 14, 2013
Scientists at A*STAR's Singapore Immunology Network discovered the exact mode of action of plerixafor, a drug that stimulates immune responses in patients with neutropenia. The study found that the inhibition of CXCR4 by the drug plays a dual role, increasing neutrophil count in the blood and promoting retention in the bloodstream.
SourceAgency for Science, Technology and Research (A*STAR), Singapore·JournalJournal of Experimental Medicine·DateNov 14, 2013
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Researchers used induced pluripotent stem cells from patients with Wolfram syndrome to model beta-cell failure. They found that protein-folding stress caused cells to fail and discovered a chemical, 4-phenyl butyric acid, that relieves this stress, potentially leading to new treatments.
SourceNew York Stem Cell Foundation·JournalDiabetes·DateNov 13, 2013
Scientists have found a critical mechanism to keep newborn neurons alive, which may help understand underlying causes of diseases like Alzheimer's and mental illness. The discovery suggests that parvalbumin-expressing interneurons release GABA, a chemical signal that promotes the survival of new brain cells.
SourceJohns Hopkins Medicine·JournalNature Neuroscience·DateNov 11, 2013
Researchers have discovered that zebrafish chemicals can differentiate human stem cells into muscle cells in the laboratory, making muscle cell therapy a more realistic clinical possibility. The discovery has the potential to revolutionize treatments for muscular dystrophy and diabetes.
Apple iPad Pro 11-inch (M4)
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Researchers at University of Copenhagen and University of Edinburgh identified 53 genes that regulate cell adhesion in embryonic stem cells. This new insight will enable scientists to maintain stem cells more effectively and efficiently manipulate adult cells to revert to a stem cell-like stage.
SourceUniversity of Copenhagen·JournalCurrent Biology·DateNov 7, 2013
San Diego State University has received a $8.5 million grant to study how the heart heals and ways stem cells can help repair it. Researchers aim to clear away limitations that limit cardiac function and restore quality of life for patients suffering from heart failure.
A preclinical study led by UTHealth researchers found that stem cell therapy promotes lasting cognitive improvement after brain injury. The treatment, known as MAPC therapy, was shown to reduce inflammation and improve brain function in mice.
SourceUniversity of Texas Health Science Center at Houston·JournalStem Cells Translational Medicine·DateNov 4, 2013
The center will integrate operations at four locations, including the UC San Diego Jacobs Medical Center and the Sanford Consortium for Regenerative Medicine. It aims to translate discoveries into therapies that can improve and save lives, with a focus on treating cancer, Lou Gehrig's disease, and spinal cord injury.
SourceUniversity of California - San Diego·DateNov 4, 2013
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Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers found that scar tissue formed by stem cells after spinal cord injury helps to prevent further damage and facilitates the survival of damaged nerve cells. The study suggests that more rather than less stem cell scarring could limit the consequences of a spinal cord injury.
A team of doctors and scientists at Cedars-Sinai Medical Center used stem cell technology to create neurons from patients' skin cells and block the damaging effects of a defective gene. The study provides proof of concept for a new therapeutic strategy, suggesting a potential future therapy for Lou Gehrig's disease.
SourceCedars-Sinai Medical Center·JournalScience Translational Medicine·DateOct 25, 2013
Researchers at USC have identified a novel way of culturing human ESCs by focusing on the Wnt/beta-catenin signaling pathway. This discovery reveals the important role of Tfcp2l1 in communicating to ESCs that they should self-renew, offering promise for developing stem cell-based therapies for diseases such as Parkinson's and spinal co...
SourceUniversity of Southern California - Health Sciences·JournalNature Communications·DateOct 23, 2013
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
The World Stem Cell Report 2013 outlines critical challenges and key action items to overcome them, including regulatory compliance and education for physicians and patients. Key opinion leaders like Paul Knoepfler bring a fresh perspective to the stem cell universe, highlighting areas of progress and need for advancement.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalStem Cells and Development·DateOct 23, 2013
A recent study published in PLOS ONE reveals that sweat gland stem cells have the ability to differentiate into multiple cell types, including hair follicles and skin layers. This discovery offers exciting possibilities for developing stem cell-based treatments for conditions like hyperhidrosis and hypohidrosis.
SourceUniversity of Southern California - Health Sciences·JournalPLOS ONE·DateOct 23, 2013