Articles tagged with Stem Cell Research
Scientists have identified a key gene receptor and signaling pathway essential to maintaining human embryonic stem cells (hESCs) in an undifferentiated state. By blocking the WNT signaling pathway and its encoded receptor FZD7, researchers were able to keep hESCs in their pluripotent state.
Researchers successfully transplanted skin-derived stem cells into collagen tubes to bridge gaps in injured nerves, resulting in functional recovery and saving the upper arms from amputation. The study provides a promising new avenue for treating peripheral nerve injuries.
Scientists have identified fourteen genes that may be implicated in Alzheimer's disease and one gene that shows inflammation plays a crucial role in the brain of Alzheimer's patients. The study provides new insight into the cause of the disease, offering potential targets for drug discovery.
Researchers at NYSCF and Columbia University Medical Center successfully generated iPS cells from frozen brain tissue, allowing for the study of Alzheimer's disease at a cellular level. The new stem cell lines will enable drug testing on cells from patients with confirmed diagnoses.
A research team at the University of California, San Diego has discovered how calcium phosphate-based materials encourage stem cells to differentiate into bone-forming cells. The findings could lead to the development of new biomaterials that can be used to treat bone defects and diseases.
A study by Johns Hopkins Medicine found that patients overwhelmingly support stem cell research with induced pluripotent stem cells (iPSCs), despite ethical concerns. Patients prioritize full disclosure of anticipated uses and informed consent to alleviate concerns about privacy and commercialization.
Researchers at UCLA discovered a mechanism by which certain adult stem cells suppress their ability to initiate skin cancer during dormancy. The study found that PTEN gene plays a crucial role in tumor suppression via quiescence in hair follicle stem cells.
Researchers at Queen Mary University of London found that growing adult stem cells on micro-grooved surfaces disrupts primary cilia length, controlling subsequent behavior and specialization. This discovery has potential applications in treating conditions like arthritis, Alzheimer's disease, and Parkinson's disease.
Mayo Clinic researcher Abba Zubair is sending human stem cells into space to see if they grow more rapidly than on Earth. The experiment aims to expand the population of stem cells that can induce regeneration of neurons and blood vessels in patients who have suffered a hemorrhagic stroke.
Researchers at the University of Manchester have developed a novel technique for reprogramming somatic cells into induced pluripotent stem (iPS) cells without using viruses, reducing the risk of tumor formation. This breakthrough could revolutionize regenerative medicine and provide new hope for treating various diseases.
Researchers at Karolinska Institutet have successfully treated two babies in utero with mesenchymal stem cells, a type of connective tissue cell that can form and improve bone tissue. The treatment was administered to babies born with osteogenesis imperfecta, a rare congenital bone disease causing stunted growth and repeated fractures.
Researchers are developing a humanized monoclonal antibody that specifically targets and inhibits the functioning of ROR1 in cancer stem cells. The goal is to deliver toxins selectively to cancer stem cells without harming normal cells.
Researchers at CNIO demonstrate that cells from various tissues can be converted into embryonic stem cells using Shinya Yamanaka's technique, exhibiting higher plasticity than existing iPSCs.
The EUCelLEX Project examines current legislation on somatic cells, assessing relevance and proposing sustainable solutions. It aims to provide a stabilised legal context for the use of stem cells in clinical purposes.
The World Stem Cell Report 2013 presents innovative solutions for accelerating stem cell treatments and eventual cures, addressing regulatory, legal, and ethical roadblocks. The report is a benchmark guide for moving the field forward, supporting the 2013 World Stem Cell Summit.
Scientists at Brigham and Women's Hospital have developed a method to grow extensive numbers of intestinal stem cells, which can then be directed to mature into different types of intestinal cells. This breakthrough could lead to the creation of a new gut for patients with gastrointestinal disorders.
Researchers have found that prostate cancer stem cells change from basal to luminal cells as the disease progresses, rendering existing treatments less effective. This discovery could lead to more targeted therapies by targeting the evolving cancer stem cells.
Researchers at MIT and Brigham and Women's Hospital have successfully grown unlimited quantities of intestinal stem cells that can differentiate into mature cells. These cells hold promise for treating diseases such as ulcerative colitis and could be used for drug development and testing.
Mary Ann Liebert, President and CEO of Mary Ann Liebert, Inc., will receive the 2013 Education Award from the Genetics Policy Institute. She is being honored for her work educating patients, researchers, and the broader stem cell community about the promise and applications of stem cells in medicine.
Researchers at Princess Margaret Cancer Centre have identified a promising new therapeutic path for colorectal cancer by disarming the BMI-1 gene, which drives self-renewal in stem cells. Inhibiting this gene resulted in long-term and irreversible impairment of tumour growth, providing strong evidence for its clinical relevance.
Researchers found that human periodontal ligament stem cells exhibit similar therapeutic effects to autologous Schwann cells in repairing peripheral nerve injuries. The study suggests a potential value for the use of human periodontal ligament stem cells in the repair of mental nerve injury.
Researchers used patient-derived stem cells to show that a genetic mutation in the alpha-synuclein gene increases vulnerability to pesticides, leading to Parkinson's disease. The study identified a molecule that protects neurons from pesticide damage and may have potential clinical implications for treating the disease.
Researchers at UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have identified a specific type of cell and related cell communication pathway crucial for healthy placenta growth. The findings may help clarify the causes of fetal growth restriction and other pregnancy complications.
A study from the University of Pennsylvania has uncovered a mechanism that allows blood stem cells to divide in perpetuity, using the motor protein myosin II. The researchers found that asymmetric division is enabled by myosin IIB, which helps to partition key factors and keep one side as a stem cell.
Researchers at the University of Granada have successfully grown artificial skin using Wharton jelly mesenchymal stem cells from the umbilical cord. This breakthrough could provide instant use for burn victims, reducing the need for weeks-long growth periods.
A recent study by the Cardiovascular Cell Therapy Research Network found that bone marrow mononuclear stem cells did not improve heart function significantly at one year compared to six months. The treatment also showed a measurable decrease in scar tissue, but its effectiveness was no different from a placebo.
Scientists at A*STAR's Singapore Immunology Network discovered the exact mode of action of plerixafor, a drug that stimulates immune responses in patients with neutropenia. The study found that the inhibition of CXCR4 by the drug plays a dual role, increasing neutrophil count in the blood and promoting retention in the bloodstream.
Researchers used genetic engineering to precisely study a key protein's role in familial Alzheimer's disease, discovering that simple loss-of-function doesn't contribute to the inherited form. The findings could help elucidate Alzheimer's mechanisms and inform drug development.
Researchers used induced pluripotent stem cells from patients with Wolfram syndrome to model beta-cell failure. They found that protein-folding stress caused cells to fail and discovered a chemical, 4-phenyl butyric acid, that relieves this stress, potentially leading to new treatments.
Scientists have found a critical mechanism to keep newborn neurons alive, which may help understand underlying causes of diseases like Alzheimer's and mental illness. The discovery suggests that parvalbumin-expressing interneurons release GABA, a chemical signal that promotes the survival of new brain cells.
Researchers have discovered that zebrafish chemicals can differentiate human stem cells into muscle cells in the laboratory, making muscle cell therapy a more realistic clinical possibility. The discovery has the potential to revolutionize treatments for muscular dystrophy and diabetes.
Researchers at University of Copenhagen and University of Edinburgh identified 53 genes that regulate cell adhesion in embryonic stem cells. This new insight will enable scientists to maintain stem cells more effectively and efficiently manipulate adult cells to revert to a stem cell-like stage.
San Diego State University has received a $8.5 million grant to study how the heart heals and ways stem cells can help repair it. Researchers aim to clear away limitations that limit cardiac function and restore quality of life for patients suffering from heart failure.
A preclinical study led by UTHealth researchers found that stem cell therapy promotes lasting cognitive improvement after brain injury. The treatment, known as MAPC therapy, was shown to reduce inflammation and improve brain function in mice.
The center will integrate operations at four locations, including the UC San Diego Jacobs Medical Center and the Sanford Consortium for Regenerative Medicine. It aims to translate discoveries into therapies that can improve and save lives, with a focus on treating cancer, Lou Gehrig's disease, and spinal cord injury.
Researchers found that scar tissue formed by stem cells after spinal cord injury helps to prevent further damage and facilitates the survival of damaged nerve cells. The study suggests that more rather than less stem cell scarring could limit the consequences of a spinal cord injury.
A team of doctors and scientists at Cedars-Sinai Medical Center used stem cell technology to create neurons from patients' skin cells and block the damaging effects of a defective gene. The study provides proof of concept for a new therapeutic strategy, suggesting a potential future therapy for Lou Gehrig's disease.
A recent study published in PLOS ONE reveals that sweat gland stem cells have the ability to differentiate into multiple cell types, including hair follicles and skin layers. This discovery offers exciting possibilities for developing stem cell-based treatments for conditions like hyperhidrosis and hypohidrosis.
Researchers at USC have identified a novel way of culturing human ESCs by focusing on the Wnt/beta-catenin signaling pathway. This discovery reveals the important role of Tfcp2l1 in communicating to ESCs that they should self-renew, offering promise for developing stem cell-based therapies for diseases such as Parkinson's and spinal co...
The World Stem Cell Report 2013 outlines critical challenges and key action items to overcome them, including regulatory compliance and education for physicians and patients. Key opinion leaders like Paul Knoepfler bring a fresh perspective to the stem cell universe, highlighting areas of progress and need for advancement.
Researchers at Clemson University found that increasing mTOR pathway activity in neural stem cells leads to neuron generation and may offer a new treatment for neurodevelopmental disorders. The study, published in Cell Reports, points to the potential benefits of targeting 4E-BP2, a specific mTOR target.
University of Toronto researchers have developed a method to rapidly screen human stem cells, allowing for better control over their fate. The technology uses robotics and automation to test compounds or drugs at once, with controllable environments to study cell characteristics as they differentiate.
Researchers have identified a source of gut stem cells that can repair damaged gut tissue in mice with inflammatory bowel disease. These stem cells were found to be actively dividing and could form mature intestinal tissue under the right conditions.
Researchers at St. Michael's Hospital have found that enriched bone marrow stem cells secrete hormones that replicate the positive impact of stem cells on treating animals with chronic kidney disease and heart failure. The discovery opens up a potential new treatment approach by eliminating the need to inject stem cells.
The New York Stem Cell Foundation has awarded $10.5 million to seven researchers to advance their studies in stem cell biology and neuroscience. The new NYSCF – Robertson Investigators will receive funding over five years to expand their laboratories and train other scientists.
NYSCF and PPMI collaborate to develop stem cell lines from patients, enabling researchers to study Parkinson's disease progression. The partnership aims to identify biomarkers and accelerate treatment development.
Researchers at the University of Illinois Chicago identified a protein expressed by human bone marrow stem cells that guides blood vessel formation. The study found that mesenchymal stem cells support functional blood vessel growth, and their genetic signature may be used to individualize stem cell treatments for heart patients.
Research reveals that stomach chief cells can revert to stem cells even without noticeable injury, suggesting a potential new approach for repairing stomach damage. The findings also hint at the possibility of using this process to prevent stomach cancers.
Researchers at Harvard University have found that genes produce extracoding RNA to prevent silencing by DNA methylase 1. This discovery has therapeutic potential as an 'on-off switch' for gene expression.
Researchers have found that combining gene therapy with an extra boost of stem cells leads to faster healing of burns and greater blood flow to the site of the wound. The study uses elderly mice as a model to understand why older people with burns fail to heal well and how to potentially harness the body's own bone marrow stem cells to...
The study, published in the journal Blood, shows that 12 adult patients underwent successful umbilical cord blood transplantation for leukemia or lymphoma. The treatment, 16,16 dimethyl prostaglandin E2, improved blood formation and reduced complications.
Stem cells can be engineered as targeted drug factories to deliver anti-inflammatory molecules to sites of inflammation, reducing swelling. The approach uses modified messenger RNA to stimulate cell production and secretion, overcoming previous limitations such as rapid clearance.
A new approach turns iPSCs into hematopoietic stem and progenitor cells, enabling blood disease-specific animal models. The technique overcomes technical barriers to generate engraftable cells needed for human patient models.
Research shows that DNA methylation plays a key role in generating non-genetic differences between sister cells, which could lead to cancer treatment breakthroughs. The study highlights the importance of controlling DNA methylation to reduce variation in cancer cells and increase treatment efficacy.
Researchers discovered the critical role of retinoic acid signaling pathway in forming blood-forming stem cells. The study used mouse models to demonstrate that disrupting this pathway eliminates blood-forming stem cells, while activating it increases their numbers.
Researchers have developed a method to isolate and grow pancreatic stem cells from mice, which can differentiate into hormone-producing beta cells or pancreatic duct cells. This breakthrough could lead to the development of new therapeutic interventions for pancreatic diseases like diabetes.
Researchers from CNIO successfully produce embryonic stem cells directly from living adult mice, exhibiting primitive totipotent characteristics and broader differentiation capacity than in vitro-derived cells.
Exposure to ionizing radiation during puberty increases the risk of developing aggressive ER negative breast cancers later in life. Researchers discovered that self-renewal of stem cells is the primary mechanism behind this increased risk.
Defective stem cell regulation throughout the body may contribute to learning and physical disabilities in people with Down syndrome. Reducing the expression of the Usp16 gene on chromosome 21 alleviates these defects and raises the possibility of an eventual therapy.
Cardiac muscle cells can be purified using molecular beacons, enabling their use in treating heart diseases. The technique has broad applications across regenerative medicine.