Articles tagged with Stem Cell Research
Manuela E. Gomes, a Portuguese researcher, has received the 2013 TERMIS-EU Young Scientist Award for her contributions to tissue engineering and regenerative medicine. Her research focuses on bone and cartilage tissue engineering strategies, including scaffold materials, stem cells, and dynamic cell culturing systems.
A recent study published in the journal Cell highlights the natural regenerative capacity of cardiac stem cells that reside in the heart. These cells are responsible for repairing and regenerating muscle tissue damaged by a heart attack, which leads to heart failure.
The skin uses a unique method to renew itself, with differentiated levels of stem cells and their micro-environment determining cell types. This challenges current stem cell models and provides new knowledge on skin cancer and wound healing.
A Scripps Research Institute team will study how cellular damage drives the aging process, with a focus on stress caused by DNA damage and potential therapeutic targets for slowing aging. The grant aims to identify ways to minimize degenerative changes associated with aging, potentially leading to improved healthspan.
HSCI researchers mapped nearly all cytosine-guanine pairs in human DNA and found that only a small fraction are dynamic, playing a key role in regulating gene expression. The study improves current approaches to mapping epigenetic marks and sheds light on how genes are controlled in different cell types.
A new study by the Ostrow School of Dentistry of USC found that stem cells in gum tissue can relieve inflammatory diseases, including colitis. The cells, called gingival mesenchymal stem cells (GMSC), have the ability to become other cell types and affect the immune system.
Researchers have developed a new laboratory model to study hepatitis C by infecting monkey stem cells with the virus. The model may lead to new treatments and vaccines for the disease, which affects over three million people in the US.
The new approach has broad applicability for the successful production of iPSCs for use in human stem cell studies and eventual cell therapies. The method is highly reproducible, efficient, non-integrative, and works on both young and old human cells.
Researchers discover human blood stem cells residing in the end of bones have highest regenerative ability, potentially improving bone marrow transplants. The discovery aims to lower donated bone marrow needs while increasing regeneration and reducing rejection rates.
Researchers have generated functional human liver cells from stem cells and transplanted them into mice with acute liver injury. The stem-cell derived human liver cells were able to function normally and increase the survival of treated animals. This breakthrough demonstrates a scalable method for producing these cells, which could lea...
Despite claims of their existence, Stanford researchers failed to identify pluripotent 'embryonic-like' cells in the bone marrow of adult mice. The study's findings contradict previous research and highlight the need for rigorous validation of scientific results.
A new study published in Stem Cell Reports found no evidence of the existence of very small embryonic-like stem cells (VSELs), which could have been used for regenerative medicine. The researchers refuted claims of VSELs' potential, calling into question current plans for a clinical trial.
A new study by UCSF researchers has identified a key protein called BMI1 that plays a vital role in ensuring normal tissue development. The findings suggest that manipulating BMI1 could be a strategy for creating cell-based treatments to replace damaged tissues and potentially slow tumor growth.
Gingival stem cells derived from cranial neural crest cells and mesoderm show distinct capacities for differentiation and immune modulation. These cells demonstrate superior effects in ameliorating inflammatory-related disease phenotypes when transplanted into mice.
Researchers at Johns Hopkins Medicine have successfully grown new blood vessels from pluripotent stem cells and transplanted them into mice, a crucial step towards developing personalized treatments. The new technique could enable genetically matched blood vessels that are less likely to be rejected by patients' immune systems.
Researchers discover cell competition in early embryo, where cells with higher Myc protein levels eliminate those with lower levels. This mechanism optimizes the development of long-lived organisms like humans by selecting suitable cells.
Scientists engineer stem cells using gelatin-based microparticles to deliver growth factors, providing localized control of cell differentiation. This technique reduces the need for growth factor, a crucial cost consideration for manufacturing stem cells.
Researchers from the University of Toronto have identified key proteins that control pluripotency, a crucial step in producing induced pluripotent stem cells (iPSCs) for research and therapy. The discovery could lead to a more efficient production method for these cells, which can develop into many different cell types.
Researchers at UCLA's Eli and Edythe Broad Center have successfully established a foundation for using hematopoietic stem cells to treat sickle cell disease. The breakthrough technique uses anti-sickling genes to create healthy red blood cells that do not sickle, offering a revolutionary alternative to current treatments.
Researchers at UCSF discovered that vitamin C helps release brakes on genes in mouse stem cells, potentially playing a key role in normal development. This finding may lead to the use of vitamin C in IVF and cancer treatments, as it can stimulate gene activity similar to early embryonic development.
A recent study by University of South Florida researchers found that a cardiac hormone signaling receptor plays a key role in the link between inflammation and cancer-causing tumors. By blocking this receptor, scientists hope to develop new treatments that cut off tumor growth by cutting off blood supply. The research aims to create in...
A study found that autologous bone marrow-derived stem cell transplantation in patients with type 2 diabetes resulted in a significant reduction in insulin requirement. The treatment was associated with improved glycemic control, and the researchers suggest it may be a promising therapeutic option for managing the disease.
Researchers at the Buck Institute manipulated a signaling pathway implicated in Barrett's esophagus, suggesting a change in stem cell function as the cause of this transformation. This discovery may lead to new targets for therapies and inform the development of more effective treatments for Barrett's esophagus.
A study by researchers at the University of Oregon reveals a novel stem cell mechanism in fruit flies that may help explain how neurons form in humans. The research shows how a select group of stem cells can create progenitors that generate numerous subtypes of cells, increasing neural diversity.
Researchers from NYSCF and Columbia University have generated patient-specific beta cells using skin cells from MODY patients. These cells accurately reflect the features of maturity-onset diabetes of the young (MODY) and can be used to develop new therapies for the disease. The study's findings demonstrate a critical proof-of-principl...
Researchers at Mount Sinai have made a breakthrough in programming blood-forming stem cells, which could lead to the development of patient-specific blood products. The study uses mouse fibroblast cells and identifies a combination of four genetic factors that can generate blood vessel precursor cells with hematopoietic cells.
Researchers at the University of Edinburgh have successfully generated human liver cells in a lab setting that are equally effective as those used to assess drug safety, offering a renewable and uniform alternative.
The 2013 World Stem Cell Report will be published as a special supplement to the peer-reviewed journal Stem Cells and Development. The report delivers an orbital and unique viewpoint on regenerative medicine, featuring content from leading policy-makers, regulators, and experts.
Researchers at Mount Sinai have discovered a novel liver progenitor cell that can be differentiated from human embryonic stem cells and produce mature liver cells. This breakthrough discovery has the potential to revolutionize the treatment of liver disease, potentially overcoming the organ shortage issue.
A study published in PLOS Biology reveals that a single mutation in the JAK2 gene reduces the ability of blood stem cells to self-renew without affecting their progeny daughter cells. This finding has implications for understanding how single stem cells contribute to tumor growth in cancers suspected to have a stem cell origin.
Scientists discovered that a subset of normal breast precursor cells have dangerously short telomeres and display high DNA damage response localized at their chromosome ends. This suggests new indicators for identifying women at higher risk for breast cancer.
A $150,000 grant from Coalition Duchenne will fund a clinical trial investigating the use of cardiac stem cells to treat Duchenne muscular dystrophy patients with heart disease. The experimental therapy has shown promising results in regenerating healthy heart muscle and reducing damage caused by heart attacks.
A study published in Stem Cell Research and Therapy found that grafting fetal human stem cells into the spine improves both motor and sensory functions, as well as structural integrity, in rats with acute lumbar compression injuries. The researchers also observed long-term improvements in spinal cord segments.
FAPESP has invested $680 million in 17 Research, Innovation and Dissemination Centers (RIDCs) in São Paulo, Brazil, with a focus on various research areas. The centers aim to contribute to commercially relevant high-impact applications while disseminating knowledge through education.
A team of Caltech biologists found that microRNA-146a acts as a critical regulator and protector of blood-forming stem cells during chronic inflammation. Mice lacking miR-146a showed a decline in HSCs, while normal mice maintained their levels despite long-term inflammation.
Synthetic silicate nanoplatelets induce stem cell differentiation into bone cells, providing a potential therapeutic tool for tissue repair and regeneration. The study's findings offer new insights into the use of bioactive materials in medicine and biotechnology.
Researchers from USC Keck School of Medicine have uncovered unique cellular and molecular mechanisms behind tooth renewal in American alligators. The study found that alligator teeth are complex units of three components, including a functional tooth, replacement tooth, and dental lamina, which contain stem cells for regeneration.
Researchers used induced pluripotent stem cells to create a disease-in-a-dish model of ataxia telangiectasia, a rare genetic disorder causing neurodegeneration and immune system failure. The study identified potential new therapeutic drugs that can increase ATM protein activity and improve DNA repair.
Researchers at NYSCF's Research Institute created patient-specific bone substitutes from skin cells to repair large bone defects. The new method uses induced pluripotent stem (iPS) cells, which can become any body cell type, and overcomes previous limitations of bone formation.
Stem cells use a process called nonrandom chromosome segregation to divide into different cell types, suggesting that distinct genetic information on the chromosome copies may underlie this diversification. The study used fruit fly stem cells to demonstrate this ability and sheds light on how cells develop into complex organisms.
Researchers found that amniotic fluid stem cells can communicate with mature heart cells through channels in the membrane, forming functional gap junction connections. However, these cells do not differentiate into cardiac tissue under these conditions.
Scientists have created a model cell system that allows them to investigate normal brain development and identify specific disruptions in biological signals contributing to neurodevelopmental disorders. The new model uses human embryonic stem cells to produce cortical interneurons, which control electrical firing in brain circuits.
A team of researchers at the University of Minnesota has discovered that a single gene, Mesp1, can be used to create different cell types, including heart, blood, and muscle cells, from stem cells.
Scientists at the University of Edinburgh made a fundamental discovery about how embryonic stem cells renew and increase in number. Reducing the levels of protein Oct 4 enables pluripotent stem cells to self-renew more efficiently.
Researchers at Carnegie Institution find that adult mice ovaries lack germ-line stem cells for egg production, debunking previous claims of continuous follicle turnover and resupply by adult stem cells. The study uses lineage-tracing technique to show primordial follicles are highly stable, with no detectable stem cell activity.
Research published in BioMed Central's Stem Cell Research & Therapy found that injecting human stem cells into mice with tumors slowed down tumor growth. The study suggests that stem cells may restrict oxygen and nutrient delivery to the tumor, limiting cell division.
A UCSB researcher has identified a protein molecule that helps maintain adult stem cells in fruit flies, revealing insights into regenerative medicine. The study found that this protein, castor, plays a critical role in specifying brain cell types during embryonic development and maintaining follicle stem cells throughout life.
Researchers at Case Western Reserve University developed a new material system that permits 3D patterning to regulate stem cell behavior, offering promise for studying influences on cell fate decisions. The technique enables local control over cell proliferation and differentiation, potentially allowing the engineering of complex tissues.
Researchers have discovered that hematopoietic stem cells can perceive signals from the body during emergencies and produce specialized white blood cells, such as macrophages. This discovery could lead to new strategies for protecting patients undergoing bone marrow transplants from infections.
Researchers found that high levels of cytokine TGFβ cause neural stem cells to become dormant, leading to reduced neurogenesis in aging and irradiation. Targeted therapies targeting TGFβ may improve cognitive function in elderly individuals.
Researchers at the University of East Anglia have identified a population of stem cells capable of generating new appetite-regulating neurons in the brains of young and adult rodents. This discovery could lead to a permanent intervention for obesity, potentially offering a solution that lasts beyond dieting.
For the first time, researchers have isolated adult stem cells from human intestinal tissue, providing a much-needed resource for scientists to study human stem cell biology. The isolated stem cells can be used to explore new treatments for inflammatory bowel disease and chemotherapy side effects.
New York Stem Cell Foundation researchers have developed a quantitative protocol to consistently harvest early-reprogrammed cells, resulting in standardized iPS cell lines. This method enables the derivation of 228 individual iPS cell lines, which can be compared to one another for use in drug screens and cell therapies.
Researchers at the New York Stem Cell Foundation have developed a 3D stem cell culture technique to study Alzheimer's disease. This technique enables the creation of neuron aggregates that can be used to model and study diseases such as Alzheimer's and Parkinson's.
Researchers at the University of Pennsylvania have found that a stem cell's environment influences its differentiation into various cell types, with 'grip' playing a crucial role. The study suggests that three-dimensional matrices impact mechanotransduction, guiding stem cell fate and differentiation.
Researchers at Mount Sinai Hospital are collaborating with the New York Stem Cell Foundation to use stem cells to gain a better understanding of Alzheimer's disease. The project aims to identify causes and cures for the common form of AD, using reprogrammed skin cells into brain cells.
Researchers found that environmental enrichment, including running and exposure to novel objects, improved neurobehavioral function in mice after transplanting adipose-derived stem cells. Exercise-induced fibroblast growth factor 2 enhanced brain repair by promoting angiogenesis, neurogenesis, and astrocytic activation.
Researchers have successfully rejuvenated the blood of mice by reprogramming their stem cells, reversing epigenetic changes that occur with age. This breakthrough could potentially lead to new treatments for diseases such as leukemia, where cancer often originates in older, damaged bone marrow.
Stem cells from amniotic fluid have been shown to repair gut damage and improve survival rates in rodents with intestinal damage. The study found that these cells work by releasing growth factors that reduce inflammation and trigger the formation of new tissues.
Researchers at UCLA and Caltech have successfully monitored the change in genetically modified immune cells, showing a promising treatment for melanoma. A new group of non-engineered T cells arose with a similar tumor-killing effect that lasted even longer than the engineered cells.