Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Researchers have discovered that zebrafish chemicals can differentiate human stem cells into muscle cells in the laboratory, making muscle cell therapy a more realistic clinical possibility. The discovery has the potential to revolutionize treatments for muscular dystrophy and diabetes.
Researchers at University of Copenhagen and University of Edinburgh identified 53 genes that regulate cell adhesion in embryonic stem cells. This new insight will enable scientists to maintain stem cells more effectively and efficiently manipulate adult cells to revert to a stem cell-like stage.
San Diego State University has received a $8.5 million grant to study how the heart heals and ways stem cells can help repair it. Researchers aim to clear away limitations that limit cardiac function and restore quality of life for patients suffering from heart failure.
A preclinical study led by UTHealth researchers found that stem cell therapy promotes lasting cognitive improvement after brain injury. The treatment, known as MAPC therapy, was shown to reduce inflammation and improve brain function in mice.
The center will integrate operations at four locations, including the UC San Diego Jacobs Medical Center and the Sanford Consortium for Regenerative Medicine. It aims to translate discoveries into therapies that can improve and save lives, with a focus on treating cancer, Lou Gehrig's disease, and spinal cord injury.
Researchers found that scar tissue formed by stem cells after spinal cord injury helps to prevent further damage and facilitates the survival of damaged nerve cells. The study suggests that more rather than less stem cell scarring could limit the consequences of a spinal cord injury.
A team of doctors and scientists at Cedars-Sinai Medical Center used stem cell technology to create neurons from patients' skin cells and block the damaging effects of a defective gene. The study provides proof of concept for a new therapeutic strategy, suggesting a potential future therapy for Lou Gehrig's disease.
A recent study published in PLOS ONE reveals that sweat gland stem cells have the ability to differentiate into multiple cell types, including hair follicles and skin layers. This discovery offers exciting possibilities for developing stem cell-based treatments for conditions like hyperhidrosis and hypohidrosis.
Researchers at USC have identified a novel way of culturing human ESCs by focusing on the Wnt/beta-catenin signaling pathway. This discovery reveals the important role of Tfcp2l1 in communicating to ESCs that they should self-renew, offering promise for developing stem cell-based therapies for diseases such as Parkinson's and spinal co...
The World Stem Cell Report 2013 outlines critical challenges and key action items to overcome them, including regulatory compliance and education for physicians and patients. Key opinion leaders like Paul Knoepfler bring a fresh perspective to the stem cell universe, highlighting areas of progress and need for advancement.
Researchers at Clemson University found that increasing mTOR pathway activity in neural stem cells leads to neuron generation and may offer a new treatment for neurodevelopmental disorders. The study, published in Cell Reports, points to the potential benefits of targeting 4E-BP2, a specific mTOR target.
University of Toronto researchers have developed a method to rapidly screen human stem cells, allowing for better control over their fate. The technology uses robotics and automation to test compounds or drugs at once, with controllable environments to study cell characteristics as they differentiate.
Researchers have identified a source of gut stem cells that can repair damaged gut tissue in mice with inflammatory bowel disease. These stem cells were found to be actively dividing and could form mature intestinal tissue under the right conditions.
Researchers at St. Michael's Hospital have found that enriched bone marrow stem cells secrete hormones that replicate the positive impact of stem cells on treating animals with chronic kidney disease and heart failure. The discovery opens up a potential new treatment approach by eliminating the need to inject stem cells.
The New York Stem Cell Foundation has awarded $10.5 million to seven researchers to advance their studies in stem cell biology and neuroscience. The new NYSCF – Robertson Investigators will receive funding over five years to expand their laboratories and train other scientists.
NYSCF and PPMI collaborate to develop stem cell lines from patients, enabling researchers to study Parkinson's disease progression. The partnership aims to identify biomarkers and accelerate treatment development.
Researchers at the University of Illinois Chicago identified a protein expressed by human bone marrow stem cells that guides blood vessel formation. The study found that mesenchymal stem cells support functional blood vessel growth, and their genetic signature may be used to individualize stem cell treatments for heart patients.
Research reveals that stomach chief cells can revert to stem cells even without noticeable injury, suggesting a potential new approach for repairing stomach damage. The findings also hint at the possibility of using this process to prevent stomach cancers.
Researchers at Harvard University have found that genes produce extracoding RNA to prevent silencing by DNA methylase 1. This discovery has therapeutic potential as an 'on-off switch' for gene expression.
Researchers have found that combining gene therapy with an extra boost of stem cells leads to faster healing of burns and greater blood flow to the site of the wound. The study uses elderly mice as a model to understand why older people with burns fail to heal well and how to potentially harness the body's own bone marrow stem cells to...
The study, published in the journal Blood, shows that 12 adult patients underwent successful umbilical cord blood transplantation for leukemia or lymphoma. The treatment, 16,16 dimethyl prostaglandin E2, improved blood formation and reduced complications.
Stem cells can be engineered as targeted drug factories to deliver anti-inflammatory molecules to sites of inflammation, reducing swelling. The approach uses modified messenger RNA to stimulate cell production and secretion, overcoming previous limitations such as rapid clearance.
A new approach turns iPSCs into hematopoietic stem and progenitor cells, enabling blood disease-specific animal models. The technique overcomes technical barriers to generate engraftable cells needed for human patient models.
Research shows that DNA methylation plays a key role in generating non-genetic differences between sister cells, which could lead to cancer treatment breakthroughs. The study highlights the importance of controlling DNA methylation to reduce variation in cancer cells and increase treatment efficacy.
Researchers discovered the critical role of retinoic acid signaling pathway in forming blood-forming stem cells. The study used mouse models to demonstrate that disrupting this pathway eliminates blood-forming stem cells, while activating it increases their numbers.
Researchers have developed a method to isolate and grow pancreatic stem cells from mice, which can differentiate into hormone-producing beta cells or pancreatic duct cells. This breakthrough could lead to the development of new therapeutic interventions for pancreatic diseases like diabetes.
Researchers from CNIO successfully produce embryonic stem cells directly from living adult mice, exhibiting primitive totipotent characteristics and broader differentiation capacity than in vitro-derived cells.
Exposure to ionizing radiation during puberty increases the risk of developing aggressive ER negative breast cancers later in life. Researchers discovered that self-renewal of stem cells is the primary mechanism behind this increased risk.
Defective stem cell regulation throughout the body may contribute to learning and physical disabilities in people with Down syndrome. Reducing the expression of the Usp16 gene on chromosome 21 alleviates these defects and raises the possibility of an eventual therapy.
Cardiac muscle cells can be purified using molecular beacons, enabling their use in treating heart diseases. The technique has broad applications across regenerative medicine.
Researchers found that cortical bone-derived stem cells (CBSCs) triggered the growth of new blood vessels and matured into heart muscle cells, improving survival and heart function in mice. The study challenges the general assumption that cardiac stem cells are the most capable of repairing damaged heart tissue.
Four UCLA researchers received significant funding to advance promising stem cell therapies for HIV/AIDS, prostate cancer, and sickle cell disease. Drs. Jerome Zack, Robert Reiter, Donald Kohn, and Gerald Lipshutz will use the grants to develop innovative treatments with potential to revolutionize disease care.
A Cedars-Sinai researcher has been awarded $5.18 million to advance stem cell technologies in segmental bone defects. The team aims to develop a novel approach to treat the condition without grafting bone, using stem cells and ultrasound to deliver a bone-forming gene.
Researchers engineered 'helper cells' to provide growth factors to transplanted stem cells, increasing their endurance and survival rate. The study aims to overcome a major barrier to successful stem cell therapy.
Researchers have developed a novel treatment for stroke using exosomes containing genetic material from bone marrow stem cells, which significantly improved neurological function in lab rats. The treatment, tested on lab rats with induced stroke, showed gradual and eventually significant improvement over four weeks.
Researchers have identified a crucial role for the gene GATA3 in regulating blood stem cell self-renewal. This discovery has significant implications for expanding blood stem cells in the lab for clinical use in bone marrow transplantation.
Researchers transplanted fetal stem cells into lab animals with radiation-induced cognitive impairments, showing improved hippocampal spatial memory and fear-conditioning performance. The study suggests fetal stem cell transplantation may provide a potential treatment for cranially irradiated patients.
Manuela E. Gomes, a Portuguese researcher, has received the 2013 TERMIS-EU Young Scientist Award for her contributions to tissue engineering and regenerative medicine. Her research focuses on bone and cartilage tissue engineering strategies, including scaffold materials, stem cells, and dynamic cell culturing systems.
A recent study published in the journal Cell highlights the natural regenerative capacity of cardiac stem cells that reside in the heart. These cells are responsible for repairing and regenerating muscle tissue damaged by a heart attack, which leads to heart failure.
The skin uses a unique method to renew itself, with differentiated levels of stem cells and their micro-environment determining cell types. This challenges current stem cell models and provides new knowledge on skin cancer and wound healing.
A Scripps Research Institute team will study how cellular damage drives the aging process, with a focus on stress caused by DNA damage and potential therapeutic targets for slowing aging. The grant aims to identify ways to minimize degenerative changes associated with aging, potentially leading to improved healthspan.
HSCI researchers mapped nearly all cytosine-guanine pairs in human DNA and found that only a small fraction are dynamic, playing a key role in regulating gene expression. The study improves current approaches to mapping epigenetic marks and sheds light on how genes are controlled in different cell types.
A new study by the Ostrow School of Dentistry of USC found that stem cells in gum tissue can relieve inflammatory diseases, including colitis. The cells, called gingival mesenchymal stem cells (GMSC), have the ability to become other cell types and affect the immune system.
Researchers have developed a new laboratory model to study hepatitis C by infecting monkey stem cells with the virus. The model may lead to new treatments and vaccines for the disease, which affects over three million people in the US.
The new approach has broad applicability for the successful production of iPSCs for use in human stem cell studies and eventual cell therapies. The method is highly reproducible, efficient, non-integrative, and works on both young and old human cells.
Researchers discover human blood stem cells residing in the end of bones have highest regenerative ability, potentially improving bone marrow transplants. The discovery aims to lower donated bone marrow needs while increasing regeneration and reducing rejection rates.
Researchers have generated functional human liver cells from stem cells and transplanted them into mice with acute liver injury. The stem-cell derived human liver cells were able to function normally and increase the survival of treated animals. This breakthrough demonstrates a scalable method for producing these cells, which could lea...
Despite claims of their existence, Stanford researchers failed to identify pluripotent 'embryonic-like' cells in the bone marrow of adult mice. The study's findings contradict previous research and highlight the need for rigorous validation of scientific results.
A new study published in Stem Cell Reports found no evidence of the existence of very small embryonic-like stem cells (VSELs), which could have been used for regenerative medicine. The researchers refuted claims of VSELs' potential, calling into question current plans for a clinical trial.
A new study by UCSF researchers has identified a key protein called BMI1 that plays a vital role in ensuring normal tissue development. The findings suggest that manipulating BMI1 could be a strategy for creating cell-based treatments to replace damaged tissues and potentially slow tumor growth.
Gingival stem cells derived from cranial neural crest cells and mesoderm show distinct capacities for differentiation and immune modulation. These cells demonstrate superior effects in ameliorating inflammatory-related disease phenotypes when transplanted into mice.
Researchers at Johns Hopkins Medicine have successfully grown new blood vessels from pluripotent stem cells and transplanted them into mice, a crucial step towards developing personalized treatments. The new technique could enable genetically matched blood vessels that are less likely to be rejected by patients' immune systems.
Researchers discover cell competition in early embryo, where cells with higher Myc protein levels eliminate those with lower levels. This mechanism optimizes the development of long-lived organisms like humans by selecting suitable cells.
Scientists engineer stem cells using gelatin-based microparticles to deliver growth factors, providing localized control of cell differentiation. This technique reduces the need for growth factor, a crucial cost consideration for manufacturing stem cells.
Researchers from the University of Toronto have identified key proteins that control pluripotency, a crucial step in producing induced pluripotent stem cells (iPSCs) for research and therapy. The discovery could lead to a more efficient production method for these cells, which can develop into many different cell types.
Researchers at UCLA's Eli and Edythe Broad Center have successfully established a foundation for using hematopoietic stem cells to treat sickle cell disease. The breakthrough technique uses anti-sickling genes to create healthy red blood cells that do not sickle, offering a revolutionary alternative to current treatments.
Researchers at UCSF discovered that vitamin C helps release brakes on genes in mouse stem cells, potentially playing a key role in normal development. This finding may lead to the use of vitamin C in IVF and cancer treatments, as it can stimulate gene activity similar to early embryonic development.
A recent study by University of South Florida researchers found that a cardiac hormone signaling receptor plays a key role in the link between inflammation and cancer-causing tumors. By blocking this receptor, scientists hope to develop new treatments that cut off tumor growth by cutting off blood supply. The research aims to create in...
A study found that autologous bone marrow-derived stem cell transplantation in patients with type 2 diabetes resulted in a significant reduction in insulin requirement. The treatment was associated with improved glycemic control, and the researchers suggest it may be a promising therapeutic option for managing the disease.
Researchers at the Buck Institute manipulated a signaling pathway implicated in Barrett's esophagus, suggesting a change in stem cell function as the cause of this transformation. This discovery may lead to new targets for therapies and inform the development of more effective treatments for Barrett's esophagus.