Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Researchers at Monash University successfully derived and purified lens epithelium, paving the way for testing new drugs on human tissue. The breakthrough could lead to cures for congenital sight impairment caused by lens damage, particularly in developing countries.
Researchers from Arunachal Pradesh and the Research Institute of World's Ancient Traditions Cultures and Heritage successfully isolated dormant TB bacteria from CD271+ stem cells in bone marrow. The study provides evidence that TB bacteria hide in these stem cells to escape drug treatment, making it difficult to eradicate the disease.
Researchers found that stem cell therapy stimulates the heart's natural repair mechanism, boosting production of adult heart cells and recruitment of existing stem cells. The treatment enhances heart structure and function, with new muscle formed being functional and durable.
A study published in BioMed Central's Stem Cell Research & Therapy journal found that stem cells from bone marrow or fat improved brain and nerve repair after stroke in rats. The treated animals showed significant functional recovery, even without the stem cells migrating to the damaged area.
Researchers found a subset of leukemia cells with slower metabolism, allowing them to survive better. An experimental drug tailored to this unique status is being tested for its ability to attack the disease.
Researchers at the University of Edinburgh discovered that bacteria can change the properties of supporting cells within the nerve system, called Schwann cells, to mimic stem cells. This process enables bacteria to spread throughout the body and potentially aid research into degenerative conditions.
Researchers at North Carolina State University found that the lack of Sp2 protein disrupts neural stem cell division and leads to a decline in neurons in the developing and postnatal brain. This discovery could have implications for understanding neurodevelopmental diseases and regenerative medicine.
Stem-cell therapy has been shown to prevent the decline in heart function associated with Duchenne muscular dystrophy. The treatment involves transplanting stem cells derived from normal mouse blood vessels into the hearts of mice with DMD, where it prevents dilated cardiomyopathy and promotes angiogenesis.
The Jordan Baruch Stem Cell Research Fund was dedicated at Ben-Gurion University to support scholarly collaboration and the Center for Regenerative Medicine, Cellular Therapy and Stem Cell Research. The fund aims to develop treatments for debilitating diseases such as diabetes, ALS, Parkinson's, and leukemia.
Researchers used iPSCs to study the physiological basis of arrhythmias in a patient with LQTS. The results identified a specific regimen for correcting aberrant ion channel activity, offering promise for individualized drug therapies.
Scientists at the University of Granada have found that only a specific group of cord blood stem cells (CB-SC) maintained in culture are useful for therapeutic purposes. The researchers identified Wharton's jelly stem cells (HWJSC) as the most suitable subgroup, which can develop into several types of tissue and modulate immune responses.
A new method of generating stem cells could significantly enhance drug screening and treatment for diseases such as Huntington's and Parkinson's. Researchers developed water-based gels that support the growth of human embryonic stem cells, reducing damage and increasing efficiency.
Researchers from RIKEN have successfully created cancer-specific, immune system cells called killer T lymphocytes from induced pluripotent stem cells. These cells can potentially serve as a cancer therapy in the future, overcoming limitations of lab-produced killer T cells with short lifespan.
Scientists successfully regenerate patients' immune cells using stem cell technology, creating long-lived and targeted cells to combat cancer and viral infections. The findings could lead to the development of strategies to rejuvenate exhausted immune responses.
Researchers from Scotland have demonstrated a way to sort embryonic stem cells based on their electrical properties. The method uses electric fields to differentiate between undifferentiated and differentiated stem cells, which can be useful for biomedical research and potential treatments of diseases like Parkinson's.
Researchers at UNC School of Medicine identified polycomb-like proteins as key regulators in stem cell development and cancer. The study found that these proteins interact with epigenetic signals to control gene expression, implications for both stem cell biology and cancer development.
Researchers found that transplanting neural stem cells into mice with familial ALS slowed disease onset and progression, improved motor function, and extended survival. The study suggests targeting detrimental roles played by non-neuronal cells to develop more effective therapeutics.
Researchers have successfully transferred the nucleus of a healthy egg cell into an egg cell with mutant mitochondrial DNA, effectively eliminating the disease-causing genetic material. The technique has significant implications for preventing mitochondrial disorders, which affect approximately 1 in 10,000 people worldwide.
Researchers from NYSCF and CUMC developed a technique to transfer human egg cells' nuclei, eliminating the inheritance of mitochondrial diseases. This method demonstrates permanent elimination of mitochondrial DNA, preventing future generations from developing these devastating diseases.
A new selective target in muscle regeneration has been identified by researchers at the Bellvitge Biomedical Research Institute. The association of alpha-enolase protein and plasmin plays a crucial role in regulating immune cell attraction and formation of new muscle tissue from stem cells.
The UK government has awarded £6 million to the XMaS facility at the European Synchrotron Radiation in Grenoble, allowing it to continue delivering world-class science. This funding will enable researchers to study the atomic and magnetic structures of materials and their properties under different conditions.
A Cedars-Sinai physician-scientist is leading a research study on Charcot-Marie-Tooth disease, the most common inherited neurological disorder, using induced pluripotent stem cells. The goal of the study is to determine if personalized stem cell lines can be generated for individual patients and potentially cure the disease.
Researchers found that tyrosine kinase inhibitor-resistant leukemia stem cells accumulate DNA damage, potentially leading to disease relapse. Identifying this source of genomic instability may help develop new treatment strategies against CML and other resistant diseases.
Researchers have successfully transplanted stem cells from monkeys into testicular tissue, allowing sperm production to resume and restoring fertility. This breakthrough could provide a new option for male cancer patients who are rendered infertile by chemotherapy and radiation treatments.
Researchers have made significant breakthroughs in optimizing stem cells and transplant approaches to treat patients with blood disorders. A new study has shown that the addition of vorinostat to standard therapy can safely reduce the incidence and severity of graft-versus-host disease, a life-threatening complication associated with h...
Scientists have identified an 'immune system kill switch' that triggers the destruction of blood stem cells in response to severe stress, such as chemotherapy or systemic infections. Blocking this internal signal could prevent death after chemotherapy and boost recovery from infection.
University of Rochester Medical Center scientists have discovered a new approach to speed up blood stem cell recovery after a vulnerable period following a stem-cell transplant. Prostaglandin E2 boosts blood production and protects the surrounding microenvironment, offering new hope for patients with leukemia or other blood disorders.
Researchers at the Salk Institute developed a new technique called indirect lineage conversion (ILC), which allows for faster and safer production of stem cells. ILC reduces production time by over half, from two months to two weeks, and increases cell yields, making it a promising step towards regenerative medicine therapies.
A new study published in PLOS ONE reveals that human stem cells are resistant to human cytomegalovirus (HCMV), a leading cause of congenital intellectual disability and deafness. The research findings suggest that HCMV infection distorts cell differentiation, leading to impaired brain maturation and intellectual ability.
Researchers found that both skeletal muscle MSCs and adipose tissue MSCs improved left ventricle function and reduced infarct size after injection into the heart of laboratory rats. The study suggests that these cells may be a potential treatment modality for patients with acute myocardial infarction.
The new consensus statement from the Hinxton Group highlights the tension between intellectual property policies and scientific norms in East Asia. Japan and China are underrepresented in patents and licensing, but have strengths in national health care systems that could benefit stem cell-based therapies.
Scientists at Johns Hopkins Medicine have successfully used human stem cells to test how diseased cells respond to drugs, paving the way for faster and cheaper drug development. The study identified a promising compound for treating Riley-Day syndrome and demonstrated the potential for tailored treatments for individual patients.
Scientists from the Danish Stem Cell Center found that stem cells grow better in three-dimensional environments, leading to improved insulin-producing cell development. This discovery holds promise for improving diabetes treatment with cell therapy.
Scientists at Stanford Medicine have found a way to let the body direct differentiation of transplanted stem cells without forced manipulation. This breakthrough could speed FDA approval and enable new therapies using pluripotent stem cells.
Researchers at Yale University have discovered that genetic variations are common in the body's tissues, with 30% of skin cells harboring copy number variations. This finding has significant implications for genetic screening and our understanding of human development and disease.
Researchers have developed a safe co-culture system using human umbilical cord blood cells to support the expansion of human embryonic stem cells. This method eliminates the risk of tumor formation associated with traditional feeder cultures, making it a more feasible option for cell transplantation.
A recent study published in the British medical journal 'Clinical & Experimental Allergy' found that children with skin manifestations have increased levels of eosinophil progenitors in their blood. Exposure to environmental contaminants, such as cigarette smoke, was also linked to higher levels of allergy-relevant stem cells.
Researchers investigated the use of stem cells in treating equine tendon injuries. Bone marrow-derived mesenchymal stem cells and adipose-derived stem cells showed promise in strengthening tendons after injury, while umbilical cord blood-derived stem cells may offer even greater potential for tendon regeneration.
Researchers successfully grew and sorted induced pluripotent stem cells for use in cartilage repair and studying osteoarthritis. The breakthrough uses adult stem cells converted into embryonic-like stem cells to produce cartilage tissue.
A team of scientists has discovered a critical protein, Utf1, that balances activation and deactivation of genes for cell differentiation. This finding sheds light on the complex process of embryonic stem cell self-renewal and differentiation.
The partnership enables the publication of high-quality stem cell research in an open-access venue, promoting outreach and quality in the field. Stem Cell Reports will feature various article types and allow authors to retain full copyright over their work.
Researchers at OHSU have successfully demonstrated a new gene therapy method that can replace mutated mitochondrial DNA with healthy copies in human cells. This breakthrough has the potential to prevent devastating diseases passed from mother to infant.
A recent study by Duke University researchers has identified pleiotrophin as a protein that can promote the growth of blood stem cells. The finding may lead to new treatments for patients undergoing chemotherapy or bone marrow transplants, enabling them to quickly regenerate healthy blood levels.
Salk scientists pinpointed damage to neural stem cells, specifically deformed nuclear envelopes, leading to neuronal loss and dysfunction in Parkinson's patients. The discovery may lead to new diagnostic and therapeutic approaches, including targeted gene-editing technologies.
Scientists at UC Santa Barbara aim to create a synthetic patch of fresh cells to replace malfunctioning ones in the eyes, treating age-related macular degeneration. The Garland Initiative, funded by philanthropist Bill Bowes, will advance regenerative bioengineering and cellular therapies for diabetic retinopathy.
Scientists have identified a new type of stem cell that can generate new blood vessels, offering new possibilities for treating cardiovascular disease and cancer. The discovery could lead to the development of new therapeutics to prevent or stimulate neoangiogenesis.
Researchers at UCLA's Broad Center of Regenerative Medicine have discovered that the Trop2 protein promotes the self-renewal of cancer cells through a mechanism involving cleavage. This finding may lead to the development of new therapies that block Trop2 molecular signaling, stopping tumor growth in various epithelial malignancies.
Scientists at the University of Maryland School of Medicine created a stem cell model for Gaucher disease, allowing them to test potential therapies in a dish. The study uses genetically similar stem cells that react to drugs like patient cells, accelerating drug discovery and bringing hope to patients.
Researchers at Wake Forest Baptist Medical Center have isolated neural precursor cells from skeletal muscle tissue, which can survive in the brain and migrate to areas where neural stem cells originate. The cells also showed no signs of tumor formation, offering a potential alternative source for treating brain tumors and other central...
A Phase II intra-arterial stem cell trial has demonstrated the safety of a regenerative therapy in patients with ischemic stroke. The ALD-401 therapy uses patient-derived bone marrow stem cells to promote brain repair after stroke.
A Phase I clinical trial demonstrates signs of engraftment and safety at 1 year, with modest gains in neurological function. The study provides encouraging results for the use of transplanted neural stem cells as a potential treatment for severe myelination diseases.
The New York Stem Cell Foundation has announced funding of $9 million to six new investigators conducting innovative stem cell and neuroscience research. The award will support these researchers as they establish their own laboratories and expand their work.
Researchers identified epigenetic changes that occur in adult stem cells to generate different body tissues. The study shows that laboratory-created muscle and bone cells resemble those found in nature and are biologically secure for implantation.
A new regulator for heart formation has been discovered by studying DNA packaging in embryonic stem cells. The researchers found that specific genetic regulators are activated at distinct times during the process of transforming stem cells into heart muscle cells, revealing potential insights into human development and organ repair.
Researchers identify FGF2 as a protein that stimulates cells to divide and activates dormant stem cells, leading to muscle depletion. By administering an FGF2 inhibitor, they halted the decline in muscle stem cells in mice.
Researchers found that a developmental protein called fibroblast growth factor-2 drives aging muscle stem cells out of dormancy, reducing their ability to regenerate. Blocking FGF signaling improved muscle tissue repair in aged animals.
Researchers at Sanford-Burnham Medical Research Institute have developed a new method to generate induced pluripotent stem cells (iPSCs) by adding kinase inhibitors, which significantly increase cellular reprogramming efficiency. This breakthrough has the potential to accelerate disease research and drug development.
Researchers used magnetic particles to target transplanted stem cells to specific retinal locations, improving biochemical changes in the target tissue. Magnetic targeting also enhanced cell retention in a rat model of ischemia/reperfusion injury by over five-fold.
The Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at Albert Einstein College of Medicine hosted its first stem cell institute symposium, showcasing the latest research on induced pluripotent stem cells and hematopoietic stem cells. The event featured four presentations by renowned speakers fr...
Researchers have successfully developed a stable population of neural crest cells from mice that can differentiate into multiple cell types. This breakthrough enables the study of stem cell biology and human development, as well as potential applications in understanding diseases.