Articles tagged with Stem Cell Research
Researchers identify FGF2 as a protein that stimulates cells to divide and activates dormant stem cells, leading to muscle depletion. By administering an FGF2 inhibitor, they halted the decline in muscle stem cells in mice.
Researchers found that a developmental protein called fibroblast growth factor-2 drives aging muscle stem cells out of dormancy, reducing their ability to regenerate. Blocking FGF signaling improved muscle tissue repair in aged animals.
Researchers at Sanford-Burnham Medical Research Institute have developed a new method to generate induced pluripotent stem cells (iPSCs) by adding kinase inhibitors, which significantly increase cellular reprogramming efficiency. This breakthrough has the potential to accelerate disease research and drug development.
Researchers used magnetic particles to target transplanted stem cells to specific retinal locations, improving biochemical changes in the target tissue. Magnetic targeting also enhanced cell retention in a rat model of ischemia/reperfusion injury by over five-fold.
The Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research at Albert Einstein College of Medicine hosted its first stem cell institute symposium, showcasing the latest research on induced pluripotent stem cells and hematopoietic stem cells. The event featured four presentations by renowned speakers fr...
Researchers have successfully developed a stable population of neural crest cells from mice that can differentiate into multiple cell types. This breakthrough enables the study of stem cell biology and human development, as well as potential applications in understanding diseases.
Researchers at Hospital for Special Surgery are studying the use of platelet-rich plasma (PRP) and stem cells to treat tendon injury and degeneration. The goal is to develop an effective therapeutic strategy to improve healing and reduce complications in NFL players.
Researchers designed molecular beacons that bind to mRNA of three genes expressed only when stem cells transform into bone cells, allowing for real-time monitoring of gene expression. The technology provides a tool for discovering optimal conditions for stem cell differentiation and identifying desired tissue cells.
Researchers at the University of Maryland School of Medicine have found that cardiac stem cells from newborns have a three-fold ability to restore heart function compared to adult-derived cells. This discovery may lead to new treatment options for congenital heart syndrome and improve heart function in children by up to 15 percent.
The California Institute for Regenerative Medicine awards UC Irvine $5.6 million for Alzheimer's research, while Dr. Henry Klassen receives $17.3 million to develop stem cells for retinitis pigmentosa treatment. Researchers aim to advance human clinical trials using stem cells to improve memory in people with Alzheimer's disease.
The Gruber Foundation honored Mary Gehring and Valerie Horsley with the Rosalind Franklin Young Investigator Award for their groundbreaking research in Arabidopsis epigenetics and mouse genetic models. The awards recognize early career female scientists making significant contributions to genetics.
Six UC San Diego researchers received over $7 million in CIRM funding to study human embryonic stem cells, induced pluripotent stem cells, and hematopoietic stem cells. Their work aims to develop unlimited sources of transplantable beta-cells for diabetes patients and promote immunological tolerance to hESC-derived tissues.
Researchers discovered that tumor suppressor genes TSC and PTEN regulate stem cell-like blood precursor cells in fruit flies. The TOR pathway uses these genes to gauge nutrition levels and stress, expanding or increasing the number of blood progenitor cells. High levels of ROS were found to be valuable in this context.
A*STAR scientists have identified a potential drug target, miR-138, that can prevent the progression and relapse of glioblastoma multiforme, a deadly form of brain tumour. Depleting this biomarker with antimiR-138 led to complete destruction of cancer cells in vitro.
Researchers identified a unique cell type that bridges bone marrow stem cells and the entire human immune system, offering insights into healthy immune function and potential therapies for diseases. The study's findings have significant implications for understanding cancer development and treatment.
Weill Cornell Medical College has received $1.8 million in grants to support translational research for blood cancers, focusing on leukemia, AML, multiple myeloma, and long-term therapy effects. Researchers will investigate novel therapies and genomic diversity to develop targeted treatments.
New research reveals that fat-derived stem cells secrete VEGF and other factors that inhibit cartilage regeneration. Pre-treating the cells with antibodies against VEGF can neutralize these effects, promoting chondrocyte survival and cartilage repair.
Researchers at Michigan Medicine have discovered the crucial role of Mof in preserving stem cells' ability to become any type of cell. By regulating DNA access, Mof enables stem cells to maintain their 'stem-ness' and differentiate into specialized cells.
A new technique using amniotic fluid stem cells can regenerate damaged urethral sphincter muscles and prevent pressure incontinence in mice. Researchers found that the stem cells induced regeneration of the mouse's own urethral sphincter muscle with proper nerve connections.
Researchers have successfully derived human embryonic stem cells from frozen embryos after 18 years of storage. This breakthrough provides a valuable alternative source of ES cells for drug screening and medical research.
Researchers at Duke University Health System have found that mesenchymal stem cells can prevent post-traumatic arthritis in mice with fractures. The study suggests that these stem cells alter the balance of inflammation and regeneration in knee joints, thereby preventing the development of osteoarthritis.
Scientists have identified a new stem cell population that gives rise to neurons in the upper layers of the cerebral cortex, which are responsible for higher thinking. This finding paves the way for developing better treatments for cognitive disorders such as schizophrenia and autism by producing these neurons in culture.
A team of researchers at Mount Sinai School of Medicine found that Aurora A (Aurka) activates p53 by phosphorylation, promoting ESC self-renewal. The study provides insight into the role of Aurka in embryonic stem cell regulation and cancer development.
Researchers have discovered that embryonic endothelial precursors can differentiate into beating cardiomyocytes in the absence of Scl, a master regulator of blood development. This finding may provide new avenues for creating cardiac stem cells and treating heart conditions through regenerative medicine.
Researchers at Sanford-Burnham Medical Research Institute have discovered a molecule that converts stem cells into heart cells, potentially replacing diseased or damaged tissue in heart disease patients. The molecule, ITD-1, blocks TGFϐ signaling, allowing stem cells to differentiate into cardiomyocytes.
The California Institute for Regenerative Medicine has awarded $20 million to UCI and StemCells Inc. to advance joint project treating cervical spinal cord injury using human neural stem cells. The funding will support the collection of data necessary to establish human clinical trials in the US.
Researchers have successfully grown healthy small-diameter blood vessels using adult stem cells extracted during liposuction. These lab-grown vessels may replace the need for grafts from elsewhere in the body or artificial blood vessels, reducing risks of clotting and rejection.
Researchers from IMIM have deciphered the role of β-catenin in generating haematopoietic stem cells, which can be used to treat leukaemia patients without compatible donors. The study lays the foundation for laboratory-generated stem cells that can improve transplant quality and quantity.
Modified human stem cells helped enhance the activity of an enzyme called telomerase, which elongates telomere length. This technique increased telomere length and activity, as well as increasing cardiac stem cell proliferation, vital steps in combating heart failure.
A new study published in the journal Stem Cell reveals an antibody developed by researchers can detect stem cells in organs like the liver and pancreas. This breakthrough helps understand tissue regeneration and cancer diagnosis and treatment.
Researchers have discovered that cells from burn eschar can differentiate into multipotent mesenchymal stromal cells, which could be used to treat burn injuries. The study found that these cells had a resemblance to adipose-derived stem cells and may play a crucial role in wound healing.
Researchers at Albert Einstein College of Medicine found that abnormal bone marrow stem cells drive the development of myelodysplastic syndromes (MDS), serious blood diseases. The study reveals genetic and epigenetic alterations in stem and progenitor cells, offering new hope for targeted therapies and improved cure rates.
A team of scientists has generated a human model of Huntington's disease directly from the skin cells of affected patients, providing a new tool for researchers to study the disease and test potential therapies. The re-created neurons will help understand what disables and kills brain cells in people with HD.
Scientists successfully converted skin cells from a patient with severe Huntington's disease into neurons that degenerate like those affected by the fatal disorder. This breakthrough enables researchers to test potential drug therapies on human brain cells in a dish.
Cedars-Sinai researchers created a laboratory model for Huntington's disease using induced pluripotent stem cells from patients' skin cells. The 'disease in a dish' model allows scientists to test therapies directly on human Huntington's neurons, offering a new pathway to identifying treatments.
Researchers at UBC successfully reversed diabetes in mice using stem cells, restoring insulin production and reversing the disease. The study re-created the 'feedback loop' that enables insulin levels to automatically rise or fall based on blood glucose levels.
Notre Dame has established professorships in adult stem cell research thanks to a $5 million gift from the Gallagher family. The new positions aim to accelerate the discovery of treatments for degenerative diseases, such as Type 1 diabetes and Parkinson's disease, using non-embryonic stem cells.
Scientists at the University of Liverpool have developed methods to track stem cells in the body, improving understanding of their behavior after transplantation. They use superparamagnetic iron oxide nanoparticles and advanced imaging systems to monitor stem cell movement and behavior.
A Johns Hopkins University team found a protein molecule, p190RhoGAP, that regulates cardiac stem cells to form healthy heart tissue or blood vessels. By altering its levels, the researchers were able to improve the effectiveness of stem cell therapy in treating heart attack patients.
Researchers at Michigan Medicine developed a new method to generate cardiac muscle patches from stem cells, which can mimic the heart's crucial squeezing action. The engineered cells displayed activity similar to most people's resting heart rate and could potentially be used to help 2.5 million people with arrhythmia.
Researchers at UCLA discovered that purified human perivascular stem cells can form bone faster and with higher quality than traditional methods, potentially eliminating the need for invasive bone grafts. The study uses a fresh cell composition called stromal vascular fraction to isolate and purify the stem cells.
Stem cells in the developing embryo give rise to adult nephrons, but unlike skin and gut, kidneys can't build new ones. FGF9 and FGF20 proteins maintain the embryonic kidney's stem cell niche, which is crucial for future research on growing kidney stem cells in the lab.
Researchers at A*STAR's Singapore Immunology Network discovered that long-lived, skin-deep immune cells called Langerhans cells originate from two distinct embryonic sites - the early yolk sac and the foetal liver. These cells play a critical role in initiating protective responses against harmful foreign invaders.
A study by UT Southwestern Medical Center researchers has identified a protein receptor on cancer cells that induces differentiation, helping blood cancer cells grow. The receptor, called LILRB2, maintains stem cell readiness by inhibiting differentiation and preserving self-renewal.
The Maryland Stem Cell Research Fund has awarded grants to 29 Johns Hopkins researchers working on stem cell metabolism, disease modeling, and therapy development. New therapies aim to replace damaged cells in patients with conditions like schizophrenia and Rett syndrome.
Researchers from South Korea, Sweden, and the US have successfully transplanted HD-induced pluripotent stem cells into animal models, exhibiting significant behavioral recovery. The study provides new insights into the underlying disease process and potential treatments for Huntington's disease.
Researchers at UC San Diego have received over $12 million in new grants from the California Institute for Regenerative Medicine to develop stem cell-based treatments for various diseases. The awards will support projects that aim to repair gene mutations, find new drugs and regeneratin spinal cord injuries.
A UC Irvine immunologist has received a $4.8 million grant to create new neural stem cells for treating multiple sclerosis. The cells aim to halt ongoing myelin loss and encourage the growth of new myelin to mend damaged nerves.
Researchers at Lund University developed a new technique that converts stem cells into brain cells with improved safety and efficiency. The method mimics the brain's natural development process, reducing the risk of tumour formation and improving cell integration.
Stem cells, essential building blocks of life, gradually lose their ability to maintain tissues and organs as they age. Researchers at the Salk Institute found that the stem cell niche's biological events contribute to this decline, but also discovered a mechanism to reverse it by increasing expression of Imp.
Researchers at Hebrew University of Jerusalem have successfully generated neuronal cells from stem cells of Fragile X patients, paving the way for restoration of normal gene expression. The study identified a chemical compound, 5-azaC, that can clear methyl groups and reactivate FMR1 gene expression in both stem and neuronal brain cells.
Researchers at NYSCF have successfully grown compact bone tissue using human embryonic stem cells, which can be used to repair and replace damaged bone in patients. The breakthrough could lead to personalized bone grafts that avoid immune rejection.
Researchers from Brazil and Korea used human immature dental pulp stem cells to create induced pluripotent stem cells, showing promising characteristics for therapeutic applications. The studies suggest that dental stem cells may be a valuable alternative source for regenerative medicine, including tooth regeneration and repair.
Researchers at Northwestern University have identified the molecular trigger of uterine fibroids, a single stem cell mutation that activates other cells to grow uncontrollably. The study suggests a new direction for developing therapies to treat these tumors, which affect an estimated 15 million women in the US.
Researchers discovered dynamic changes in gene regulation in human stem cells, affecting their ability to serve as models for human disease and development. The study found that these cells can change their epigenomes, leading to unexpected outcomes in cell-based models of diseases like Lesch-Nyhan disease.
Embryonic stem cells have a rapid suicidal response to DNA damage, eliminating them from the developing embryo. This adaptation prevents mutations from harming the organism and allows scientists to harness their potential for therapeutic use.
Researchers from the University of Minnesota have effectively treated muscular dystrophy in mice using human stem cells derived from a new process that makes the production of human muscle cells efficient and effective. The study outlines a strategy for developing a rapidly dividing population of skeletal myogenic progenitor cells, set...
Research at Dartmouth-Hitchcock investigates the use of stem cells to treat lower-limb peripheral artery disease (PAD), a condition affecting 9 million US patients. The study shows significant improvement in blood flow and reduced risk of amputation among patients who received stem cell therapy.
Researchers found relatively few genetic changes in induced pluripotent stem (iPS) cells derived from human bone marrow cells using an improved method. The study suggests that iPS cells do not pose a heightened cancer risk, but sequencing more cell lines is needed for a better understanding of mutation rates.
Scientists at DanStem and Hagedorn Research Institute map new knowledge about insulin production, including the Notch signaling mechanism's role in controlling stem cell development. This breakthrough enables researchers to design new experimental methods for cultivating stem cells into insulin-producing beta cells.