Articles tagged with Stem Cell Research
A study by UT Southwestern Medical Center researchers has identified a protein receptor on cancer cells that induces differentiation, helping blood cancer cells grow. The receptor, called LILRB2, maintains stem cell readiness by inhibiting differentiation and preserving self-renewal.
The Maryland Stem Cell Research Fund has awarded grants to 29 Johns Hopkins researchers working on stem cell metabolism, disease modeling, and therapy development. New therapies aim to replace damaged cells in patients with conditions like schizophrenia and Rett syndrome.
Researchers from South Korea, Sweden, and the US have successfully transplanted HD-induced pluripotent stem cells into animal models, exhibiting significant behavioral recovery. The study provides new insights into the underlying disease process and potential treatments for Huntington's disease.
Researchers at UC San Diego have received over $12 million in new grants from the California Institute for Regenerative Medicine to develop stem cell-based treatments for various diseases. The awards will support projects that aim to repair gene mutations, find new drugs and regeneratin spinal cord injuries.
A UC Irvine immunologist has received a $4.8 million grant to create new neural stem cells for treating multiple sclerosis. The cells aim to halt ongoing myelin loss and encourage the growth of new myelin to mend damaged nerves.
Researchers at Lund University developed a new technique that converts stem cells into brain cells with improved safety and efficiency. The method mimics the brain's natural development process, reducing the risk of tumour formation and improving cell integration.
Stem cells, essential building blocks of life, gradually lose their ability to maintain tissues and organs as they age. Researchers at the Salk Institute found that the stem cell niche's biological events contribute to this decline, but also discovered a mechanism to reverse it by increasing expression of Imp.
Researchers at Hebrew University of Jerusalem have successfully generated neuronal cells from stem cells of Fragile X patients, paving the way for restoration of normal gene expression. The study identified a chemical compound, 5-azaC, that can clear methyl groups and reactivate FMR1 gene expression in both stem and neuronal brain cells.
Researchers at NYSCF have successfully grown compact bone tissue using human embryonic stem cells, which can be used to repair and replace damaged bone in patients. The breakthrough could lead to personalized bone grafts that avoid immune rejection.
Researchers from Brazil and Korea used human immature dental pulp stem cells to create induced pluripotent stem cells, showing promising characteristics for therapeutic applications. The studies suggest that dental stem cells may be a valuable alternative source for regenerative medicine, including tooth regeneration and repair.
Researchers at Northwestern University have identified the molecular trigger of uterine fibroids, a single stem cell mutation that activates other cells to grow uncontrollably. The study suggests a new direction for developing therapies to treat these tumors, which affect an estimated 15 million women in the US.
Researchers discovered dynamic changes in gene regulation in human stem cells, affecting their ability to serve as models for human disease and development. The study found that these cells can change their epigenomes, leading to unexpected outcomes in cell-based models of diseases like Lesch-Nyhan disease.
Embryonic stem cells have a rapid suicidal response to DNA damage, eliminating them from the developing embryo. This adaptation prevents mutations from harming the organism and allows scientists to harness their potential for therapeutic use.
Researchers from the University of Minnesota have effectively treated muscular dystrophy in mice using human stem cells derived from a new process that makes the production of human muscle cells efficient and effective. The study outlines a strategy for developing a rapidly dividing population of skeletal myogenic progenitor cells, set...
Research at Dartmouth-Hitchcock investigates the use of stem cells to treat lower-limb peripheral artery disease (PAD), a condition affecting 9 million US patients. The study shows significant improvement in blood flow and reduced risk of amputation among patients who received stem cell therapy.
Researchers found relatively few genetic changes in induced pluripotent stem (iPS) cells derived from human bone marrow cells using an improved method. The study suggests that iPS cells do not pose a heightened cancer risk, but sequencing more cell lines is needed for a better understanding of mutation rates.
Scientists at DanStem and Hagedorn Research Institute map new knowledge about insulin production, including the Notch signaling mechanism's role in controlling stem cell development. This breakthrough enables researchers to design new experimental methods for cultivating stem cells into insulin-producing beta cells.
Researchers have created a method to sequence epigenetic marks 5hmC and 5mC in DNA at single base resolution, improving our understanding of gene regulation and cell development. This breakthrough has major implications for regenerative medicine and stem cell research.
A new study reveals that mesenchymal stem cell infusions can control autoimmune disorders by targeting and defeating overactive immune cells through the FAS/FAS-ligand pathway, showing promising results in both animal models and human patients.
Researchers at UCLA identified new genetic components controlling neural stem cell adhesion and proliferation, crucial for normal nervous system development. The study's findings could lead to a better understanding of birth defects and disorders like autism, as well as the formation of brain tumors.
Scientists at Lund University have identified a new stem cell type in the adult brain that can form various cell types, including neuronal cells. The discovery holds promise for treating neurodegenerative diseases and stroke by harnessing the stem cell's repair mechanisms.
A molecular pathway that controls the retention and release of brain stem cells has been identified. The discovery reveals that this pathway is critical for the adhesion of stem cells to their niche and for stem cell maintenance, suggesting a new idea in understanding stem cell regulation.
Researchers at Lund University have identified a new stem cell in the adult brain that can proliferate and form several different cell types, including new brain cells. The discovery has great potential for developing methods to heal and repair brain injury and disease.
The Merkin Family Foundation will fund promising Broad Institute scientists as Merkin Institute Fellows, supporting bold research in areas like stem cell biology and regenerative medicine. The program aims to create a pipeline of talented researchers advancing science and medicine at the Broad Institute.
A team of UCLA researchers demonstrates that genetically engineered human blood stem cells can form mature, multi-functional T cells that specifically target HIV-infected cells. This approach shows promise for suppressing the virus in living tissues in animal models.
A team of researchers at Caltech has traced the developmental process that ensures certain stem cells become T cells. They identified key genes and regulatory proteins involved in this process, shedding light on how stem cells are committed to a specific cell fate.
Researchers suggest that stem cells have intrinsic capacities for self-maintenance and evasion of differentiation. By analyzing current properties and characteristics of stem cells, the 'by default' hypothesis proposes that stem cells exist due to factors that repress cellular signals for specialization.
Researchers have developed a new type of human stem cell called endodermal progenitor cells, which can differentiate into multiple cell types, including functioning pancreatic beta cells. The cells show promise for modeling human diseases and may offer a potential source for future diabetes treatments.
A combination approach therapy targeting β-catenin pathway may stamp out CML for good. Leukemia stem cells are vulnerable to treatments aiming at this pathway, unlike normal blood stem cells.
Human embryonic stem cells are regulated by three genes: Nanog, Oct 4, and Sox 2. These genes control self-renewal and differentiation, essential for treating diseases like Parkinson's and Alzheimer's. The study highlights the importance of human research over mouse models.
Researchers have developed a unique suspension technique for growing stem cells, eliminating the need for surface growth and increasing efficiency. This breakthrough has the potential to make cost-effective large-scale stem cell manufacturing possible, which could lead to new treatments for heart disease.
Researchers at NIH have discovered how arsenic exposure can turn normal stem cells into cancer stem cells, spur tumor growth. This finding suggests that cancer may be a stem-cell-based disease and has implications for understanding carcinogenesis.
A new study reveals a population of intestinal stem cells that respond to damage and prevent cancer, increasing understanding of normal and cancer cell progression in the intestines. The discovery highlights the potential for Lrig1 as a target for treating intestinal and colon cancer.
Researchers have identified a new population of intestinal stem cells marked by the protein Lrig1, which appears to be relatively quiescent and acts as a tumor suppressor. This finding may hold clues to the origin of colorectal cancer and could lead to better understanding of its development and therapeutic targets.
A recent study has created motor neurons using skin cells from a patient with inherited MND, discovering abnormalities in protein TDP-43 that lead to motor neuron cell death. This breakthrough model could speed up the discovery of new treatments for the devastating disease.
A study led by Mayo Clinic researchers found that bone marrow-derived stem cells improved ejection fraction, a measure of the left ventricle's pumping ability, by 2.7% in patients with chronic heart failure. The most significant improvements were seen in younger patients and those with enriched CD34+ and CD133+ type of stem cells.
Researchers discovered that embryonic stem cells undergo a metabolic shift, using glucose as their primary energy source like cancer cells. This shift occurs under low oxygen conditions and is driven by a transcription factor called hypoxia-inducible factor 1alpha.
The Scripps Research Institute has received a $206,250 grant from the California Institute for Regenerative Medicine (CIRM) to expand its high school summer internship program. The program aims to inspire talented students from diverse backgrounds to pursue careers in stem cell research.
A symposium on TMJ stem cell biology and engineering presents novel clinical therapy approaches for TMJ disorders. Researchers discuss the origin, homeostasis, differentiation, hormonal regulation, and bioengineering of temporomandibular joint tissues.
Researchers at Kansas State University are developing genetic models to study diseases like Parkinson's and spinal cord injury. They aim to create cell lines that can help solve medical mysteries.
Researchers at UCLA have identified a method to correct human mitochondrial mutations by targeting corrective RNAs, which could lead to treating a range of mitochondrial diseases. The study builds on previous work that uncovered a role for an essential protein in regulating RNA import into mitochondria.
A study by Columbia researchers suggests that intestinal progenitor cells can be coaxed into producing insulin, offering a potential new treatment for type I diabetes. The technique involves knocking out the Foxo1 gene in these cells, which then produce functional insulin-producing cells.
Researchers found that insulin and nutritional factors help maintain the 'stemness' of blood stem cells in fruit flies. The study's implications include a potential connection between metabolic disruptions and chronic inflammation in humans.
Studies on Drosophila melanogaster have provided insights into human stem cell development, particularly in the formation of specialized cells. The research also explores the role of membrane lipids in establishing polarity in sperm cells, which may contribute to cancer progression.
Scientists at Northwestern University developed a powerful analytical method called nanocombinatorics to rapidly identify the chemical and physical structures that cue stem cells to become osteocytes. The researchers successfully directed stem cell differentiation without additional chemical cues, demonstrating better control than curr...
Researchers from the University of Victoria have developed a new 3D stem cell culture method, enabling scientists to study cell behavior in conditions similar to those in the body. This breakthrough has significant implications for regenerative medicine and other fields.
Researchers identified PDGF-B signaling in trophoblasts as a vital component of the placental niche, supporting blood stem cell generation and expansion without promoting differentiation. This discovery provides new insights into regulating EPO expression and governing the fates of blood stem cells during development.
Researchers at UGA created the first blueprint of how stem cells respond to external signaling molecules. The finding reconciles years of conflicting results and enables precise control over stem cell differentiation into specific cell types.
Research identifies SIRT1 as a key enzyme protecting leukemia stem cells from stress and driving cancer recurrence. Inhibiting SIRT1 selectively reduces CML stem cell survival and growth, offering a potential therapeutic target for treatment resistance.
Researchers at Rice University and Texas Children's Hospital have successfully derived vessel-forming stem cells from amniotic fluid, offering hope for repairing infant hearts. The breakthrough could lead to growing tissue patches using the infant's own cells, potentially replacing defective tissue with beating heart tissue.
A novel technique enhances bone growth by guiding stem cells to the bone surface, increasing bone density and preventing age-related bone loss. The study successfully tested this approach in mice with osteoporosis, paving the way for human trials.
Researchers at University of Oxford and Harvard Stem Cell Institute have developed a common standard to describe and integrate large datasets from various fields, enabling better coordination of findings. The ISA Commons platform allows small research groups to store laboratory data without dedicated bioinformatics support.
Researchers have discovered that stem cells from patients with schizophrenia proliferate faster than healthy individuals, indicating dysregulation of the natural cell cycle. This finding provides a potential path to understanding schizophrenia and developing new treatments.
Scientists have identified endothelial and perivascular cells as the key creators of the niche that nurtures haematopoietic stem cells. This discovery could lead to increased safety and effectiveness of bone marrow transplantation by replicating signals that promote blood-forming stem cell expansion.
Scientists at UC San Diego School of Medicine have created in vitro models of sporadic and hereditary Alzheimer's disease using induced pluripotent stem cells. The living cells provide an unprecedented tool for developing and testing drugs to treat the disorder, offering a new method for understanding the cause of the disease.
Researchers at UC Davis have developed a new approach using stem cells to deliver gene therapy specifically targeting the genetic abnormality found in Huntington's disease. By transferring inhibitory RNA sequences from donor cells into target neurons, they significantly decreased the synthesis of the abnormal huntingtin protein.
Researchers have created new microtweezers capable of manipulating objects to build tiny structures, print coatings for advanced sensors, and grab live stem cell spheres. The tool enables the precision printing of chemical or protein dots onto microcantilevers, which can detect chemicals in air and water.
Bioengineers at Rensselaer Polytechnic Institute receive $2 million NIH grant to study how chemicals in drugs and environment impact stem cells. The team aims to develop a new predictive safety screening tool that eliminates animal testing.
Scientists at OHSU successfully produced the world's first primate chimeric offspring, three baby rhesus macaques, shedding light on stem cell functions and abilities in primates compared to rodents. The research has significant implications for regenerative medicine, particularly in treating diseases like Parkinson's.
Scientists at the University of Pittsburgh School of Medicine have discovered that injecting stem cells from young, healthy animals into rapidly aging mice can improve their health and increase their lifespan. The study found that stem cell dysfunction is a major contributor to the aging process.