Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
A new study reveals that adult stem cells can reshape organs in response to changes, with implications for diabetes and obesity. Intestinal stem cells respond to increased food intake by producing more cells, expanding the gut's size.
Researchers at A*STAR's Genome Institute of Singapore and Institute of Molecular Biology identify distal airway stem cells as the key to forming new alveoli, paving the way for novel therapies for respiratory diseases. The discovery provides insight into genes and secreted factors that can be used to enhance lung regeneration.
Researchers have cloned human airway stem cells, which can form alveoli tissue and rapidly deploy in lung regeneration. The findings suggest new strategies for enhancing lung regeneration following damage from infection or chronic disease.
Treatment with high-dose melphalan and autologous stem cell transplantation achieved a high organ response rate and increased overall survival, even in patients without hematologic complete response. The study found that careful patient selection and experienced management can lead to low treatment-related mortality rates.
Rutgers University has established a stem cell repository to study mental health disorders such as autism and schizophrenia. The repository will provide researchers with induced pluripotent stem cells derived from individuals with these conditions, enabling them to better understand the causes of mental disorders.
Researchers believe that timing has finally come to support the conduct of human clinical trials for stem cell therapy in spinal cord injuries. Currently, research is largely stuck at the animal model stage. Studies evaluate 11 different cell types/sources and provide evidence justifying their use.
Researchers have successfully joined epidermic stem cells to create healthy skin in the lab, preserving their regenerative potential. They can now use these cells to regenerate patients' skin, offering a new therapeutic strategy for those with limited treatment options.
Researchers have developed a method to grow cardiac muscle cells from human cord blood stem cells, which could lead to new treatment options for patients with damaged hearts. The study found that these cells can be expanded and differentiated into cardiomyocyte-like cells, overcoming the technical hurdle of deriving cardiac muscle-type...
Scientists have cleanly corrected a human gene mutation in a patient's stem cells, using cutting-edge methods to target and correct the sequence of the genome. The corrected gene worked normally, demonstrating the potential for patient-specific therapies.
A young scientist has won a $10,000 award for her research on regenerating eyes using stem cells from hair follicles. Her study showed an 80% rate of differentiation in mouse eyes following a cell transplant, highlighting the promising therapeutic potential of these cells.
Professor Peter J. Coffey's pioneering stem cell research aims to replace damaged retinal pigment epithelium cells in Age-Related Macular Degeneration. Clinical trials using his therapy are expected to begin in 2012, offering hope for preventing blindness and restoring sight.
Researchers developed a new method for reprogramming human cells into stem cells, increasing efficiency by 100-fold and producing high-quality cells faster. This breakthrough has potential applications in medicine, such as organ replacement, bone replacement, and treatment of neurodegenerative diseases.
Researchers have discovered a method to harness patient-derived neural stem cells as an alternative source of insulin-producing beta cells for regenerative treatments. This breakthrough could potentially overcome the shortage of donor pancreatic beta cells and provide a safer, more accessible way to treat diabetes.
Lack of compensation for human egg donors could stall recent breakthroughs in stem cell research due to difficulty in recruiting altruistic donors. A recent study on somatic cell nuclear transfer (SCNT) has created the first human stem cell line, but more donor eggs are needed to advance research.
Dr. Malgorzata Borowiak has been awarded a grant from the Helmholtz Association to return to the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Germany, as head of a Young Investigators Group. She aims to contribute to diabetes research by studying beta cell development.
Scientists at Johns Hopkins Medicine have corrected the genetic alteration causing sickle cell disease by using a patient's own stem cells. The team found four working iPS cell lines containing correct copies of the hemoglobin gene and successfully converted them into immature red blood cells.
Researchers identified a new pathway of stem cell activity in the subventricular zone of the human brain, which targets the prefrontal cortex in newborns. This discovery challenges previous reports that suggested neural stem cells remain active into adulthood.
Researchers successfully grafted deciduous canine teeth and dental pulp stem cells into parent canines, demonstrating bone regeneration after four weeks. The study found increased immunosuppressive activity of these stem cells, paving the way for potential clinical applications in allogenic in vivo stem cell transplantation.
A study from UNC Chapel Hill School of Medicine has illuminated a critical step in demethylation, giving stem cell researchers information to reprogram adult cells. The disappearance of chemical tags is a passive process, not catalyzed by an enzyme.
Researchers at Tel Aviv University have developed a patented technology that uses bone marrow stem cells to produce neuroprotectors, proteins that shield the brain from neurodegenerative disorders. The treatment has shown efficacy in animal models and is now being tested in human clinical trials.
Scientists have found a control switch that regulates stem cell pluripotency by altering the DNA binding properties of FOXP1, facilitating maintenance of pluripotency and reprogramming adult cells. The discovery has significant implications for therapeutic applications in regenerative medicine and cancer research.
Researchers at Yale University have successfully converted uterine stem cells into insulin-producing cells, which could lead to the development of a new treatment for Type 1 diabetes. The study found that these stem cells can adopt the characteristics of beta cells in the pancreas and produce insulin in response to glucose.
A team of researchers evaluated the effect of low-power Terahertz radiation on mouse stem cells, finding temperature increases were minimal and heat shock protein expression was unaffected. However, certain genes showed clear effects from THz irradiation, suggesting further investigations are needed to generalize findings.
Researchers at University of Wisconsin-Madison report 99% protein similarity between two types of do-it-all stem cells, shedding light on their potential applications in cell replacement therapies. The study measured over 6,000 proteins using mass spectrometry and provides insights into their biological role.
Patients in another clinical trial have reached the two-year mark following infusion of processed adult stem cells, while a new $12.8 million NIH grant renewal aims to perfect cardiac stem cell therapy for heart regeneration after a heart attack.
A Scripps Research team has overcome a major purification problem for stem cells, enabling more reliable and safe treatments. The new method uses lectin arrays to separate stem cells from other cell types, promising significant cost savings and reliability improvements.
Researchers identified a protein that helps maintain mouse stem cell pluripotency by activating signal pathways via CC chemokine ligand 2 (CCL2). This finding offers insights into cultivating human iPS/ES cells without feeder cells, reducing the risk of contamination and health risks.
Researchers at Scripps Research Institute have successfully produced stem cells from two endangered species, a drill and the northern white rhinoceros. These cells could enable lifesaving medical therapies or offer the potential to preserve or expand genetic diversity by offering new reproduction possibilities.
Researchers at IRB Barcelona have identified human colon stem cells and developed a method to grow them in lab-plates. This breakthrough could lead to significant advances in regenerative medicine, potentially treating diseases such as colorectal cancer and Crohn's disease.
Yale scientists identify adipose precursor cells as key players in triggering hair growth. These cells produce PDGF molecules necessary for producing hair growth in mice. The study offers a promising avenue for developing new treatments for male pattern baldness by targeting these stem cells and signals.
Research led by McMaster University found that exercise triggers mesenchymal stem cells to become bone instead of fat, leading to improved blood production and overall health. This finding suggests a new potential for exercise as a non-medicinal treatment for blood-related disorders.
Researchers at UTHealth report using a patient's own bone marrow stem cells as a safe and feasible treatment for acute stroke. The study, published in Annals of Neurology, showed no severe adverse events among the 10 patients enrolled.
Scientists describe an advance in encouraging stem cells to make decisions about their fate using chemically defined surfaces. This technology holds promise for regenerative medicine, including growing organs for transplants and tissues for treating diseases.
Scientists discover large RNAs regulate embryonic development by physically interacting with proteins, suggesting a critical role in developmental decisions. The study reveals that lincRNAs may play similar roles in most cells and could be engineered to target key genes in disease.
Researchers have found that acute myeloid leukemia (AML) contains rare cancer stem cells (LSCs) with unique properties that can predict clinical outcome. The LSC signature can identify patients who may benefit from more aggressive therapy, enabling personalized treatment approaches.
Researchers have discovered that human amniotic fluid-derived stem cells (hAECs) can differentiate into various cell types, including those found in the lungs. Transplanted hAECs were shown to reduce pulmonary fibrosis and enhance lung regeneration in animal models of lung disease.
Researchers at Tel Aviv University have discovered that oral mucosa stem cells can be manipulated into fetal-like stem cells with high therapeutic potential for treating neurodegenerative, heart, and autoimmune diseases. The cells can be derived from a small biopsy of tissue and show minimal discomfort and healing time.
Researchers investigated potential effects of G-CSF on chromosomes in healthy PBSC donors and found no replication asynchrony or atypical abnormalities. The study concludes that G-CSF mobilization process is safe for healthy stem cell donors, supporting its use in transplants.
UT Southwestern researchers have found a way to regulate adult blood stem cells to overcome an immune response that leads to transplant rejection. The study successfully supports human and mouse blood stem cells through culture, enabling significant repopulation of healthy cells in rodent recipients.
UC Davis investigator provides roadmap to overcome obstacles for using induced pluripotent stem cells to treat various human diseases. The technology has the potential to bypass immunological problems inherent in traditional stem cell therapy.
Researchers found that growing blood stem cells for about a week can improve transplantation success rates by reducing immune rejection. The lab-grown HSCs produce an immune system inhibitor on their surface, making them less likely to be rejected and more likely to engraft into the recipient's blood.
Scientists have successfully turned mouse embryonic stem cells into healthy sperm by coaxing them into primordial germ cells. This breakthrough allows for the potential creation of fertile offspring using induced pluripotent stem cells from adult skin cells.
Researchers at UCLA have created the first genome-wide mapping of 5-hydroxymethylcytosine (5hmC) in human embryonic stem cells, discovering its role in activating genes. The study's findings may lead to better understanding of gene regulation and potential cancer control.
Researchers at UNC School of Medicine have discovered the seventh and eighth bases of DNA, called 5-formylcytosine and 5-carboxylcytosine. These modified bases are thought to play a role in DNA demethylation and stem cell reprogramming.
Researchers at the University of Minnesota have developed a new strategy to improve the development of induced pluripotent stem cells (iPS) by fusing two proteins. This approach increases efficiency and purity, decreases tumor formation risk, and simplifies the process, making it more feasible for human transplantation.
A double-blind clinical trial is underway at UTHealth, studying the safety and efficacy of an innovative stem cell therapy for patients up to 19 days after ischemic stroke. The therapy, developed by Aldagen, uses a patient's own bone marrow stem cells to enhance recovery.
Scientists at the Salk Institute developed a new technique to generate large numbers of blood cells from patient cells, improving efficiency by 84% compared to previous methods. However, further refinements are needed to produce transplantable HSCs.
Researchers at Duke University Medical Center discovered that neighboring ependymal cells maintain a structure that keeps neural stem cells
A phase II clinical trial found that injections of adult patients' own CD34+ stem cells reduced angina episodes and improved exercise tolerance time. The treatment showed significant improvements in chest pain and exercise duration at six months after treatment.
Human stem cells can be directed to specific cell types through molecular cues, enabling more efficient tissue regeneration. Researchers found that pluripotent stem cells have unique 'suitcases' for different destinations, increasing specialized cell production.
Researchers isolate a single human blood stem cell capable of regenerating the entire blood system, offering a breakthrough for treating cancer and other diseases. The discovery enables the harnessing of these life-producing cells to treat patients more effectively.
Researchers at Salk Institute use genetically embedded tools to study neural stem cell differentiation and protein activity in brain cells. The technique, described in a recent study, may aid in the development of regenerative medicine and help scientists understand the mysteries of stem cells.
A recent Nevada study found that over two-thirds of respondents approved using therapeutic cloning and stem cells to cure cancer or treat heart attacks. For treatment of less-serious conditions, approval rates were lower but still significant. The study suggests a strong public support for stem cell research in the US.
Researchers at UCLA have identified a new stem cell that plays a vital role in repairing the large airways of the lungs. The discovery has implications for understanding airway diseases and developing novel cell-based therapies.
Researchers have discovered a single communication system that decides the fate of stem cells, paving the way for new stem cell therapies with fewer side effects. The Nodal/Activin pathway can specify a wide range of eventual cell types, offering a major step forward for personalized medicine.
Scientists at the University of Texas Health Science Center have identified a marker on the surface of adipose stem cells that produce white adipose tissue, a key contributor to obesity. The researchers developed a peptide probe targeting this marker, which may help deliver drugs to slow fat expansion and aid in weight loss efforts.
Researchers at Cedars-Sinai Medical Center are developing gene therapy in corneal stem cells to alleviate damage to corneas caused by diabetes. The therapy aims to correct abnormal protein production and restore normal corneal cell turnover, preventing vision loss.
Researchers at NYU Langone Health discovered that Wnt signaling, a biological process controlling many processes, is essential for coordinated actions of hair follicle stem cells and melanocyte stem cells. This study suggests manipulating Wnt signaling may be a novel strategy to target graying hair.
Researchers found that neural stem cells can adapt to stressful environments by producing more neurons when conditions become favorable. The study suggests a novel form of brain plasticity and potential treatment for neurodegenerative diseases.
Researchers have found that adult stem cells from the human olfactory system can provide a new source of cells to treat brain disorders. These cells, known as OE-MSCs, have been shown to migrate to damaged areas and stimulate nerve cell growth, improving learning and memory in mice.