Articles tagged with Stem Cell Research
Researchers investigated potential effects of G-CSF on chromosomes in healthy PBSC donors and found no replication asynchrony or atypical abnormalities. The study concludes that G-CSF mobilization process is safe for healthy stem cell donors, supporting its use in transplants.
UC Davis investigator provides roadmap to overcome obstacles for using induced pluripotent stem cells to treat various human diseases. The technology has the potential to bypass immunological problems inherent in traditional stem cell therapy.
Scientists have successfully turned mouse embryonic stem cells into healthy sperm by coaxing them into primordial germ cells. This breakthrough allows for the potential creation of fertile offspring using induced pluripotent stem cells from adult skin cells.
Researchers found that growing blood stem cells for about a week can improve transplantation success rates by reducing immune rejection. The lab-grown HSCs produce an immune system inhibitor on their surface, making them less likely to be rejected and more likely to engraft into the recipient's blood.
UT Southwestern researchers have found a way to regulate adult blood stem cells to overcome an immune response that leads to transplant rejection. The study successfully supports human and mouse blood stem cells through culture, enabling significant repopulation of healthy cells in rodent recipients.
Researchers at UCLA have created the first genome-wide mapping of 5-hydroxymethylcytosine (5hmC) in human embryonic stem cells, discovering its role in activating genes. The study's findings may lead to better understanding of gene regulation and potential cancer control.
Researchers at UNC School of Medicine have discovered the seventh and eighth bases of DNA, called 5-formylcytosine and 5-carboxylcytosine. These modified bases are thought to play a role in DNA demethylation and stem cell reprogramming.
Researchers at the University of Minnesota have developed a new strategy to improve the development of induced pluripotent stem cells (iPS) by fusing two proteins. This approach increases efficiency and purity, decreases tumor formation risk, and simplifies the process, making it more feasible for human transplantation.
A double-blind clinical trial is underway at UTHealth, studying the safety and efficacy of an innovative stem cell therapy for patients up to 19 days after ischemic stroke. The therapy, developed by Aldagen, uses a patient's own bone marrow stem cells to enhance recovery.
Scientists at the Salk Institute developed a new technique to generate large numbers of blood cells from patient cells, improving efficiency by 84% compared to previous methods. However, further refinements are needed to produce transplantable HSCs.
Researchers at Duke University Medical Center discovered that neighboring ependymal cells maintain a structure that keeps neural stem cells
A phase II clinical trial found that injections of adult patients' own CD34+ stem cells reduced angina episodes and improved exercise tolerance time. The treatment showed significant improvements in chest pain and exercise duration at six months after treatment.
Human stem cells can be directed to specific cell types through molecular cues, enabling more efficient tissue regeneration. Researchers found that pluripotent stem cells have unique 'suitcases' for different destinations, increasing specialized cell production.
Researchers isolate a single human blood stem cell capable of regenerating the entire blood system, offering a breakthrough for treating cancer and other diseases. The discovery enables the harnessing of these life-producing cells to treat patients more effectively.
Researchers at Salk Institute use genetically embedded tools to study neural stem cell differentiation and protein activity in brain cells. The technique, described in a recent study, may aid in the development of regenerative medicine and help scientists understand the mysteries of stem cells.
A recent Nevada study found that over two-thirds of respondents approved using therapeutic cloning and stem cells to cure cancer or treat heart attacks. For treatment of less-serious conditions, approval rates were lower but still significant. The study suggests a strong public support for stem cell research in the US.
Researchers at UCLA have identified a new stem cell that plays a vital role in repairing the large airways of the lungs. The discovery has implications for understanding airway diseases and developing novel cell-based therapies.
Researchers have discovered a single communication system that decides the fate of stem cells, paving the way for new stem cell therapies with fewer side effects. The Nodal/Activin pathway can specify a wide range of eventual cell types, offering a major step forward for personalized medicine.
Scientists at the University of Texas Health Science Center have identified a marker on the surface of adipose stem cells that produce white adipose tissue, a key contributor to obesity. The researchers developed a peptide probe targeting this marker, which may help deliver drugs to slow fat expansion and aid in weight loss efforts.
Researchers at Cedars-Sinai Medical Center are developing gene therapy in corneal stem cells to alleviate damage to corneas caused by diabetes. The therapy aims to correct abnormal protein production and restore normal corneal cell turnover, preventing vision loss.
Researchers at NYU Langone Health discovered that Wnt signaling, a biological process controlling many processes, is essential for coordinated actions of hair follicle stem cells and melanocyte stem cells. This study suggests manipulating Wnt signaling may be a novel strategy to target graying hair.
Researchers found that neural stem cells can adapt to stressful environments by producing more neurons when conditions become favorable. The study suggests a novel form of brain plasticity and potential treatment for neurodegenerative diseases.
Researchers have found that adult stem cells from the human olfactory system can provide a new source of cells to treat brain disorders. These cells, known as OE-MSCs, have been shown to migrate to damaged areas and stimulate nerve cell growth, improving learning and memory in mice.
Researchers found that studying both types of stem cells has become more common, with a growing proportion of papers combining adult and embryonic stem cells. This means that banning either type of research could harm the field overall. The study suggests that federal funding for one area could negatively impact the other.
A new study by University of Michigan researchers suggests that banning federal funding for human embryonic stem cell research would have disastrous consequences on the use of induced pluripotent stem cells (iPS cells). The two cell types are complementary and interdependent research tools, and their use has become intertwined. As a re...
A new study by researchers at Stanford University School of Medicine and others found that curtailing human embryonic stem cell research would negatively impact induced pluripotent stem cell research. The study refutes the idea that iPS cells can replace embryonic stem cells in research.
Aging stem cells struggle to produce strong bones due to malnutrition and inadequate signals. Researchers explore the role of amino acids and satiety hormone leptin in rejuvenating these cells.
A new genetic technique reprograms mature skin cells directly into brain cells without passing through the stem cell stage, opening a field for cell transplants. The discovery represents a fundamental change in the view of mature cell function, offering potential to treat neurodegenerative diseases like Parkinson's.
Researchers at UCSD have discovered a novel signaling pathway and gene, Wnt16, essential for the formation of hematopoietic stem cells in vertebrate embryos. This breakthrough has significant implications for developing stem cell-based therapies for diseases such as leukemia.
Researchers at UNC School of Medicine have shown that transplantation of adult stem cells enriched with IGF-I can help mend bone fractures not healing properly. The treatment speeds up the healing process, restoring bone formation and strength.
Researchers at King's College London have identified a way to eliminate leukaemic stem cells, which could lead to new treatments enabling complete remission for leukemia patients. The study found that suppressing two proteins, Bmi1 and Hoxa9, can abolish the ability of MLL leukaemic stem cells to proliferate.
Researchers at the Max Delbrück Center (MDC) have identified E-cadherin as a key molecule enabling embryonic stem cells to differentiate into diverse cell types. The study found that E-cadherin plays a crucial role in maintaining pluripotent stem cells and reprogramming somatic cells into induced pluripotent stem cells.
Researchers created functional neurons from human skin cells using four proteins, bypassing the creation of induced pluripotent stem cells. This advancement enables the study of neural diseases and development of more effective treatments and cures.
The Maryland Stem Cell Research Commission has awarded 36 new projects with funding from the state's $10.4 million budget for FY2011. The projects focus on advancing regenerative medicine and addressing various debilitating medical conditions, including cancer, diabetes, and traumatic brain injuries.
A new article discusses the current status of neural stem cell research and its translation into clinical therapeutics. The authors highlight the need for a comprehensive and collaborative team effort to overcome hurdles in the process, including funding levels and regulatory approval.
A team of scientists at A*STAR have discovered a way to convert proteins involved in controlling genes into other types of cells by changing a single amino acid. This breakthrough has implications for generating stem cells more efficiently and could help develop treatments for diseases such as diabetes and Parkinson's disease.
Researchers at Texas AgriLife Research have identified a key molecular mechanism regulating plant stem cell development, which could lead to increased fruit, seed, and leaf production. By understanding how microRNAs interact with RNA silencing proteins, scientists can engineer plants to produce more biomass.
Researchers at Monash University have successfully reprogrammed healthy adult kidney cells into embryonic-like stem cells, offering a new approach to modeling genetic kidney disorders and developing personalized medicine. The breakthrough enables the creation of limitless patient-specific stem cell lines for drug testing and disease mo...
A study by North Carolina State University found that perceived media bias on specific issues can increase political engagement, while general bias may lead to apathy. Researchers discovered a direct link between biased views on stem cell research and increased political action.
Researchers found that human stem cells from bone marrow significantly reduced pulmonary edema and protein in lungs after acute lung injury. hMSC treatment also increased anti-inflammatory proteins, including TSG6 and IL-1RN.
Researchers at Brigham and Women's Hospital have identified a human lung stem cell capable of regenerating damaged lung tissue. The discovery has the potential to offer a new treatment option for those suffering from chronic lung diseases.
Researchers deciphered how hair stem cells communicate with each other to encourage mutually coordinated regeneration, holding potential for finding a cure for alopecia. The study's findings provide insight into potential stem cell behavior in other organs, which holds ramifications for regenerative medicine research.
Scripps Research Institute investigators Joel Gottesfeld and Kristin Baldwin receive grants to explore stem cells' potential in biology and medicine. The funding supports studies on induced pluripotent stem cells, including methods to identify cancer-causing mutations and their impact on genetic diseases.
Researchers at UNC Chapel Hill School of Medicine isolated normal stem cells with aggressive breast cancer properties and identified a genetic intersection that contributes to metastasis. The study suggests a new target for treating triple negative breast cancer.
Stem cells extracted from human fat may revolutionize soft tissue reconstruction, cartilage and bone development, and cardiovascular disease treatment. The researchers have developed a technique to decellularize adipose tissue, creating a scaffold for stem cell growth.
Researchers from Boston University's Center for Regenerative Medicine have demonstrated that induced pluripotent stem cells (iPSCs) can differentiate into definitive endoderm cells in vitro, with similar functional potential to embryonic stem cells. This finding is significant given the controversy surrounding iPSCs and their potential...
A Brazilian research team successfully established the first line of human embryonic stem cells (hES), but struggled to find a genetically diverse match for the diverse ethnic and genetic Brazilian population. The researchers overcame legal and ethical guidelines to create hES cell line BR-1, which is mostly European in origin.
Dr. Paul Sanberg, a renowned researcher in stem cell therapy, received the Everfront Award for his groundbreaking work on regenerative medicine for neurodegenerative disorders. His research expertise and initiatives in innovation and translational medicine were recognized by the symposium organizers.
Researchers at University of California - San Diego School of Medicine and colleagues report a game-changing advance in stem cell science: the creation of long-term, self-renewing neural precursor cells from human embryonic stem cells that can be directed to become many types of neuron. The new process promises to have broad applicatio...
Researchers at the Broad Institute have developed a method to measure how much messenger RNA is produced and degraded, revealing dynamic changes in RNA levels over time. The technique allows for high-resolution and comprehensive views of the RNA lifecycle, enabling scientists to investigate what happens when something goes wrong in cells.
Researchers from University of Granada successfully created the first bioartificial organ in Spain by replacing pig corneal cells with human stem cells. The new organ maintains the basic structure of the cornea while replacing its cellular components.
Researchers have successfully isolated and transplanted pig stem cells, providing a closer anatomical match to human retinas. This breakthrough opens up new avenues for studying degenerative conditions and repairing damaged retina tissue.
Cardiac stem cell treatment is being explored as an option for treating heart failure. Dr. Bolli's study, SCIPIO, aims to perfect a technique using a patient's own cardiac stem cells to regenerate dead heart muscle after a heart attack. Results show promising improvements in patients' physical capabilities and ejection fraction.
A new process developed by Stanford researchers allows people to make IVF embryo donation decisions in private, reducing conflicts of interest. The study found that donors were equally likely to give consent for embryonic stem cell research or human development studies.
Researchers have determined that correcting a genetic defect does not substantially increase the number of potentially cancer-causing mutations in induced pluripotent stem cells. This breakthrough suggests that human-induced pluripotent stem cells altered to correct a genetic defect may be cultured into subsequent generations of cells ...
Researchers have discovered that a gene called Sox10 coordinates the balance of cell types in healthy development. This means that it's difficult to get 100% of cells to become one type, even in lab conditions. The study suggests that understanding these balancing mechanisms is crucial for harnessing stem cells in medical applications.
Researchers used human embryonic stem cells to study myotonic dystrophy type 1, revealing reduced expression of SLITRK genes in affected brains. The findings highlight the potential of embryonic stem cells for understanding complex diseases like muscular dystrophy.
Researchers grew mesenchymal stem cells as tiny spheres to form a variety of cell types, expanding their potential for regenerative medicine. The 3D technique recreates the microscopic environment found in human bodies, allowing MSCs to specialize more rapidly and completely.
Studies reveal Tet protein maintains pluripotency in stem cells by silencing differentiation genes while activating pluripotency genes. The protein's product, 5-hydroxymethylcytosine, plays a crucial role in regulating transcription and is the first genome-wide location of its role in development and disease.
Researchers have shown that stem cell injections can reduce heart size, scar tissue, and improve function to injured heart areas. The therapy has been found to be beneficial for patients with chronically enlarged hearts due to damage from heart attacks.