Articles tagged with Stem Cell Research
A new process developed by Stanford researchers allows people to make IVF embryo donation decisions in private, reducing conflicts of interest. The study found that donors were equally likely to give consent for embryonic stem cell research or human development studies.
Researchers have determined that correcting a genetic defect does not substantially increase the number of potentially cancer-causing mutations in induced pluripotent stem cells. This breakthrough suggests that human-induced pluripotent stem cells altered to correct a genetic defect may be cultured into subsequent generations of cells ...
Researchers have discovered that a gene called Sox10 coordinates the balance of cell types in healthy development. This means that it's difficult to get 100% of cells to become one type, even in lab conditions. The study suggests that understanding these balancing mechanisms is crucial for harnessing stem cells in medical applications.
Researchers used human embryonic stem cells to study myotonic dystrophy type 1, revealing reduced expression of SLITRK genes in affected brains. The findings highlight the potential of embryonic stem cells for understanding complex diseases like muscular dystrophy.
Researchers grew mesenchymal stem cells as tiny spheres to form a variety of cell types, expanding their potential for regenerative medicine. The 3D technique recreates the microscopic environment found in human bodies, allowing MSCs to specialize more rapidly and completely.
Studies reveal Tet protein maintains pluripotency in stem cells by silencing differentiation genes while activating pluripotency genes. The protein's product, 5-hydroxymethylcytosine, plays a crucial role in regulating transcription and is the first genome-wide location of its role in development and disease.
Researchers have shown that stem cell injections can reduce heart size, scar tissue, and improve function to injured heart areas. The therapy has been found to be beneficial for patients with chronically enlarged hearts due to damage from heart attacks.
Researchers at the University of Bristol are developing biologically-engineered synthetic liquid polymers to create a permanent solution for cartilage defects. The injectable gel can form three-dimensional scaffolds that encourage healthy cell growth and tissue repair.
Researchers create induced pluripotent stem cells from adult siblings with schizophrenia and DISC1 gene mutation, providing a potential tool for screening treatments and understanding the disease. The stem cells can be coaxed to become brain cells like neurons, offering new insights into the causes of major mental illnesses.
Scientists found that a protein called Igf2 in the cerebrospinal fluid signals brain cells to multiply during embryonic development. This discovery could lead to new treatments for neurological diseases and cancer by targeting specific areas of the brain, eliminating the need for localized drug delivery.
A study published in Brain Research found that nutritionally deprived newborns are programmed to eat more due to reduced neurons in the brain's food intake region. This suggests maternal nutrition plays a critical role in preventing obesity and related diseases.
Deanna Thompson is utilizing NYSTEM funding to study adult neural stem cells for developing new stem cell therapies and research tools. Her research aims to understand how these stem cells proliferate and differentiate into new nerve cells, with potential applications in treating brain injuries, illnesses, and cancers.
A new study by Rice University's Baker Institute found that US researchers who collaborate with international scientists receive more citations and greater recognition than their peers. This is particularly true when the US scientist is a corresponding author, with an average of 20.3 citations compared to 15.0 for independent publicati...
Dr. Paul Tesar's research enhances understanding of pluriportent stem cells used to study debilitating diseases. His findings have potential to prevent or repair damage caused by disease, aging, and injury.
Researchers at Stanford University School of Medicine successfully derived neurons with symptoms of Parkinson's disease from a patient's skin cells. These neurons exhibit key features of the condition, including oxidative stress and Lewy body formation, in a short timeframe.
A new 'molecular switch' regulates epidermal stem cells, controlling skin growth and development. The study provides clues to new treatments for squamous cell carcinoma and burn patients.
Researchers found genetic rearrangements and 'copy number variations' associated with reprogramming adult cells to induced pluripotent stem cells. The study highlights the need for rigorous characterization of generated iPS lines to ensure genomic integrity.
Scientists have successfully fused human stem cells derived from fat tissue with muscle cells from rat hearts, forming new muscle cells that beat. This achievement demonstrates the potential for regenerative medicine to heal damaged hearts without transplantation.
Researchers at the University of Montreal have made a breakthrough in generating pluripotent stem cells from horses, paving the way for potential new treatments for human degenerative conditions. The discovery will aid the development of preclinical models leading to human applications.
Researchers from the Walter and Eliza Hall Institute have identified the Erg gene as crucial for blood stem cells' ability to self-renew. This discovery holds promise for developing new therapies using blood stem cells for tissue repair, transplantation, and other applications.
A team of scholars calls for collective action to address the negative effects of patenting and privatizing stem cell lines, data, and technologies. The experts warn that the lack of transparency and ambiguity in ownership and control can hinder progress toward breakthroughs.
Researchers have discovered that mucosa-derived stem cells can preserve hearing function in children with sensorineural hearing loss. The study shows promising results for nasal stem cell transplants as a potential treatment for this condition and potentially other diseases such as Parkinson's disease and cardiac infarction.
A groundbreaking study found that mesenchymal stem cells delivered through the nose improved motor function and increased dopamine levels in rats with Parkinson's disease. This non-invasive approach offers a safer alternative to surgical transplantation.
Researchers found that hematopoietic stem cells can shift between rapidly dividing and dormant states, suggesting a more equal sharing of blood cell production burden. This adaptability allows cells to respond quickly to life-threatening situations, such as bacterial infections.
Professor Alan Stitt has received a Royal Society Wolfson Research Merit Award to support his ground-breaking research on vascular stem cells and eye disease treatment at Queen's University. The award aims to retain top researchers in the UK and reflects the excellence of the School of Medicine, Dentistry and Biomedical Science.
A recent survey of US stem cell scientists reveals substantial negative impacts of ongoing policy uncertainty on their work, including changes to science type and quality, delays in new projects, and hindered collaborations.
Researchers at University of Rochester identify Nrf2 and Keap1 genes as key regulators of stem cell activity. Nrf2 prevents stem cell division, while Keap1 enables it when ROS levels increase.
A team at Sanford-Burnham identified specific microRNAs that enhance the reprogramming process from skin cells to induced pluripotent stem (iPS) cells. Adding these miRNAs increases cell survival and improves iPS cell generation.
A Cedars-Sinai research team has received a $1.9 million grant to develop a new pharmaceutical discovery process using pluripotent stem cells, aiming to find a treatment for Spinal Muscular Atrophy. Another team will create a new imaging system to monitor stem cell treatments in real-time, providing insights into tissue regeneration.
Human amniotic epithelial cells, derived from discarded human placenta, demonstrate therapeutic response when transplanted into lab test tubes and animal models of stroke. The interaction with melatonin receptor MT1 promotes functional recovery.
Researchers found that R-spondin1 reduces GVHD by protecting intestinal stem cells, which help regenerate damaged tissues and reduce inflammation. The study's results suggest a potential therapeutic approach for human bone marrow transplant patients.
A team of UCLA researchers has developed a chemically defined culture medium that supports the long-term quality and maintenance of human embryonic stem cells. The new medium, using a feedback system control scheme, eliminates the need for animal products and enables routine single-cell passaging.
Researchers have developed a mathematical model to assess the growth of stem cells and their malignant counterparts. The method, published in PLOS ONE, may aid in developing stem cell therapies for diseases like Alzheimer's and Parkinson's.
Researchers at UCSF have discovered that a mother's immune response prevents fetal acceptance of transplanted blood stem cells, but their own stem cells can be used to overcome this issue. The study suggests that using maternal stem cells could lead to successful treatment of genetic diseases before birth.
Researchers have documented genetic abnormalities in human embryonic stem cells and induced pluripotent stem cells, including duplications near pluripotency-associated genes and deletions involving tumor suppressor genes. Frequent genomic monitoring of these cell lines is necessary to ensure their stability and clinical safety.
Researchers found that male pattern balding may arise from a problem with stem-cell activation rather than the numbers of stem cells in follicles. The team discovered that bald areas had the same number of stem cells as normal scalp, but were depleted in progenitor cells.
Researchers have isolated and characterized adult fat cell-derived stem cells, which maintain their stem cell characteristics and could aid in tissue regeneration. The study's findings suggest that these cells may be useful for cell-based therapies and represent a promising area of research for plastic surgery applications.
Researchers found that higher activity of certain LSC genes was associated with worse overall, event-free and relapse-free survival in acute myeloid leukemia patients. The study defined a signature of enriched AML-initiating cells linked to clinical outcomes.
Researchers found a strong correlation between high levels of gene expression associated with leukemia stem cells and poor outcomes in patients. The study suggests that targeting these self-renewing cells could lead to more effective treatments and improved patient survival.
Researchers at University of Illinois found that soft gel substrates promote homogeneous pluripotent stem cell cultures without expensive growth chemicals. This discovery has huge applications in regenerative medicine, offering a step toward understanding the basic biology of stem cells.
Scientists at King's College London have made a critical discovery about the role of beta-catenin in leukemia stem cells. By suppressing this protein, they were able to reverse leukaemic stem cells to a pre-leukaemic stage and 're-sensitize' resistant cells to treatment.
Researchers at Georgetown University Medical Center have successfully turned human testes cells into insulin-producing islet cells, offering a potential new treatment for type 1 diabetes. The study used spermatogonial stem cells extracted from testicular tissue to produce insulin-secreting beta islet cells without the use of extra genes.
Researchers at Georgetown University successfully generated human-derived islet cells from spermatogonial stem cells, demonstrating their potential to counter diabetic hyperglycemia. The bioengineered cells secreted insulin and exhibited markers characteristic of normal islet cells.
A team of scientists has discovered that microRNA profiles can predict the type of cell, including whether it's cancerous or not. This finding has significant implications for the use of stem cells in repairing damaged body parts, as it highlights the potential risks of creating cancer.
According to a recent study in Nature Biotechnology, states in the US are now funding more human embryonic stem cell research than the federal government. The extent of this funding varies significantly between states, with some prioritizing this research over others.
Researchers found that Duchenne muscular dystrophy symptoms emerge when skeletal muscle stem cells can no longer keep up with repairs, leading to progressive muscle weakening and respiratory failure. Successful treatments targeting muscle stem cells may alleviate symptoms and offer new hope for managing the disease.
Studies reveal that stem cell transplantation is safe and effective in treating various hematologic malignancies, with no significant increase in overall cancer risk. Researchers found a promising new treatment to prevent chronic graft-versus-host disease, a serious complication of stem cell transplantation.
Researchers at UCLA found that the protein Bmi-1 plays a crucial role in regulating self-renewal of normal prostate stem cells and transforming healthy cells into prostate cancer cells. Inhibiting Bmi-1 slowed the growth of aggressive prostate cancer in animal models.
Scientists at Scripps Research Institute have made a significant leap forward in finding chemicals needed to reprogram mature human cells and turn them into stem cells. The discovery represents a fundamentally different approach from previous methods and offers a new method for generating induced pluripotent stem cells with defined sma...
Researchers discovered a protein necessary for normal cell division in blood-forming stem cells, which resulted in abnormal numbers of chromosomes and high rates of cell death. This finding highlights the metabolic differences between stem cells and other blood-forming cells.
A study by Thomas Jefferson University found that bone marrow stromal stem cells can significantly recover motor behavior in laboratory rats after a simulated stroke. Early administration of the stem cells was more effective than late administration, with profound changes in brain structure and long-lasting motor function improvement.
Two studies published in Cell Transplantation found that administering bone marrow stem cells promoted functional recovery and reduced damage after stroke, while VEGF administration provided near complete neurological protection. These findings suggest two potential treatments for stroke and could offer new recourse against its ravages.
A study has revealed a relationship between blood cells and their stem cell 'parents', influencing gene expression and behavior. The discovery opens up new research avenues into diseases caused by stem cell disorders.
Researchers have developed a medical model for regenerating bladders using stem cells harvested from a patient's own bone marrow. The study demonstrates the feasibility of MSCs in partial bladder regeneration and provides valuable insight into the processes governing bladder regeneration.
Researchers at Hebrew University found that induced pluripotent stem (iPS) cells undergo abnormal chromosomal changes, including trisomy and up-regulation of specific genes, which can lead to tumorigenic risk. This discovery hinders progress on using iPS cells in future therapy.
Researchers have developed a medical model for regenerating bladders using stem cells, which could lead to new organ replacement therapies. The study used bone marrow mesenchymal stem cells, which have been shown to retain their ability to populate and function in a grafted area.
Researchers at Duke University Medical Center discovered a stem cell secreted protein that improves heart muscle repair after a heart attack. The protein, sfrp2, reduces collagen layering and prevents heart failure in study rats.
UC San Diego undergraduate bioengineers develop a new microenvironment that provides all three types of cues necessary for stem cell growth and differentiation. The system uses a gelatin-like hydrogel bathed in an electrolyte solution, mimicking the natural environment to steer stem cells towards specific cell types.
A team of researchers has developed a human cell-based model of Rett syndrome, overcoming the main limitation of accessing live neurons from patients. The study provides evidence of functional rescue using human cells and opens up new avenues for drug development and high-throughput screening.
Researchers at Rice University have developed gadonanotubes that can effectively track mesenchymal stem cells through magnetic resonance imaging, potentially improving disease diagnosis and treatment. The study found that GNTs are 40 times better than standard contrast agents in helping doctors spot signs of disease or damage.