Articles tagged with Stem Cell Research
The Maryland Stem Cell Research Commission has awarded 36 new projects with funding from the state's $10.4 million budget for FY2011. The projects focus on advancing regenerative medicine and addressing various debilitating medical conditions, including cancer, diabetes, and traumatic brain injuries.
A new article discusses the current status of neural stem cell research and its translation into clinical therapeutics. The authors highlight the need for a comprehensive and collaborative team effort to overcome hurdles in the process, including funding levels and regulatory approval.
A team of scientists at A*STAR have discovered a way to convert proteins involved in controlling genes into other types of cells by changing a single amino acid. This breakthrough has implications for generating stem cells more efficiently and could help develop treatments for diseases such as diabetes and Parkinson's disease.
Researchers at Texas AgriLife Research have identified a key molecular mechanism regulating plant stem cell development, which could lead to increased fruit, seed, and leaf production. By understanding how microRNAs interact with RNA silencing proteins, scientists can engineer plants to produce more biomass.
Researchers at Monash University have successfully reprogrammed healthy adult kidney cells into embryonic-like stem cells, offering a new approach to modeling genetic kidney disorders and developing personalized medicine. The breakthrough enables the creation of limitless patient-specific stem cell lines for drug testing and disease mo...
A study by North Carolina State University found that perceived media bias on specific issues can increase political engagement, while general bias may lead to apathy. Researchers discovered a direct link between biased views on stem cell research and increased political action.
Researchers found that human stem cells from bone marrow significantly reduced pulmonary edema and protein in lungs after acute lung injury. hMSC treatment also increased anti-inflammatory proteins, including TSG6 and IL-1RN.
Researchers at Brigham and Women's Hospital have identified a human lung stem cell capable of regenerating damaged lung tissue. The discovery has the potential to offer a new treatment option for those suffering from chronic lung diseases.
Researchers deciphered how hair stem cells communicate with each other to encourage mutually coordinated regeneration, holding potential for finding a cure for alopecia. The study's findings provide insight into potential stem cell behavior in other organs, which holds ramifications for regenerative medicine research.
Researchers at UNC Chapel Hill School of Medicine isolated normal stem cells with aggressive breast cancer properties and identified a genetic intersection that contributes to metastasis. The study suggests a new target for treating triple negative breast cancer.
Scripps Research Institute investigators Joel Gottesfeld and Kristin Baldwin receive grants to explore stem cells' potential in biology and medicine. The funding supports studies on induced pluripotent stem cells, including methods to identify cancer-causing mutations and their impact on genetic diseases.
Stem cells extracted from human fat may revolutionize soft tissue reconstruction, cartilage and bone development, and cardiovascular disease treatment. The researchers have developed a technique to decellularize adipose tissue, creating a scaffold for stem cell growth.
Researchers from Boston University's Center for Regenerative Medicine have demonstrated that induced pluripotent stem cells (iPSCs) can differentiate into definitive endoderm cells in vitro, with similar functional potential to embryonic stem cells. This finding is significant given the controversy surrounding iPSCs and their potential...
A Brazilian research team successfully established the first line of human embryonic stem cells (hES), but struggled to find a genetically diverse match for the diverse ethnic and genetic Brazilian population. The researchers overcame legal and ethical guidelines to create hES cell line BR-1, which is mostly European in origin.
Dr. Paul Sanberg, a renowned researcher in stem cell therapy, received the Everfront Award for his groundbreaking work on regenerative medicine for neurodegenerative disorders. His research expertise and initiatives in innovation and translational medicine were recognized by the symposium organizers.
Researchers at University of California - San Diego School of Medicine and colleagues report a game-changing advance in stem cell science: the creation of long-term, self-renewing neural precursor cells from human embryonic stem cells that can be directed to become many types of neuron. The new process promises to have broad applicatio...
Researchers at the Broad Institute have developed a method to measure how much messenger RNA is produced and degraded, revealing dynamic changes in RNA levels over time. The technique allows for high-resolution and comprehensive views of the RNA lifecycle, enabling scientists to investigate what happens when something goes wrong in cells.
Researchers from University of Granada successfully created the first bioartificial organ in Spain by replacing pig corneal cells with human stem cells. The new organ maintains the basic structure of the cornea while replacing its cellular components.
Researchers have successfully isolated and transplanted pig stem cells, providing a closer anatomical match to human retinas. This breakthrough opens up new avenues for studying degenerative conditions and repairing damaged retina tissue.
Cardiac stem cell treatment is being explored as an option for treating heart failure. Dr. Bolli's study, SCIPIO, aims to perfect a technique using a patient's own cardiac stem cells to regenerate dead heart muscle after a heart attack. Results show promising improvements in patients' physical capabilities and ejection fraction.
A new process developed by Stanford researchers allows people to make IVF embryo donation decisions in private, reducing conflicts of interest. The study found that donors were equally likely to give consent for embryonic stem cell research or human development studies.
Researchers have determined that correcting a genetic defect does not substantially increase the number of potentially cancer-causing mutations in induced pluripotent stem cells. This breakthrough suggests that human-induced pluripotent stem cells altered to correct a genetic defect may be cultured into subsequent generations of cells ...
Researchers have discovered that a gene called Sox10 coordinates the balance of cell types in healthy development. This means that it's difficult to get 100% of cells to become one type, even in lab conditions. The study suggests that understanding these balancing mechanisms is crucial for harnessing stem cells in medical applications.
Researchers used human embryonic stem cells to study myotonic dystrophy type 1, revealing reduced expression of SLITRK genes in affected brains. The findings highlight the potential of embryonic stem cells for understanding complex diseases like muscular dystrophy.
Researchers grew mesenchymal stem cells as tiny spheres to form a variety of cell types, expanding their potential for regenerative medicine. The 3D technique recreates the microscopic environment found in human bodies, allowing MSCs to specialize more rapidly and completely.
Studies reveal Tet protein maintains pluripotency in stem cells by silencing differentiation genes while activating pluripotency genes. The protein's product, 5-hydroxymethylcytosine, plays a crucial role in regulating transcription and is the first genome-wide location of its role in development and disease.
Researchers have shown that stem cell injections can reduce heart size, scar tissue, and improve function to injured heart areas. The therapy has been found to be beneficial for patients with chronically enlarged hearts due to damage from heart attacks.
Researchers at the University of Bristol are developing biologically-engineered synthetic liquid polymers to create a permanent solution for cartilage defects. The injectable gel can form three-dimensional scaffolds that encourage healthy cell growth and tissue repair.
Researchers create induced pluripotent stem cells from adult siblings with schizophrenia and DISC1 gene mutation, providing a potential tool for screening treatments and understanding the disease. The stem cells can be coaxed to become brain cells like neurons, offering new insights into the causes of major mental illnesses.
Scientists found that a protein called Igf2 in the cerebrospinal fluid signals brain cells to multiply during embryonic development. This discovery could lead to new treatments for neurological diseases and cancer by targeting specific areas of the brain, eliminating the need for localized drug delivery.
A study published in Brain Research found that nutritionally deprived newborns are programmed to eat more due to reduced neurons in the brain's food intake region. This suggests maternal nutrition plays a critical role in preventing obesity and related diseases.
Deanna Thompson is utilizing NYSTEM funding to study adult neural stem cells for developing new stem cell therapies and research tools. Her research aims to understand how these stem cells proliferate and differentiate into new nerve cells, with potential applications in treating brain injuries, illnesses, and cancers.
A new study by Rice University's Baker Institute found that US researchers who collaborate with international scientists receive more citations and greater recognition than their peers. This is particularly true when the US scientist is a corresponding author, with an average of 20.3 citations compared to 15.0 for independent publicati...
Dr. Paul Tesar's research enhances understanding of pluriportent stem cells used to study debilitating diseases. His findings have potential to prevent or repair damage caused by disease, aging, and injury.
Researchers at Stanford University School of Medicine successfully derived neurons with symptoms of Parkinson's disease from a patient's skin cells. These neurons exhibit key features of the condition, including oxidative stress and Lewy body formation, in a short timeframe.
A new 'molecular switch' regulates epidermal stem cells, controlling skin growth and development. The study provides clues to new treatments for squamous cell carcinoma and burn patients.
Researchers found genetic rearrangements and 'copy number variations' associated with reprogramming adult cells to induced pluripotent stem cells. The study highlights the need for rigorous characterization of generated iPS lines to ensure genomic integrity.
Scientists have successfully fused human stem cells derived from fat tissue with muscle cells from rat hearts, forming new muscle cells that beat. This achievement demonstrates the potential for regenerative medicine to heal damaged hearts without transplantation.
Researchers at the University of Montreal have made a breakthrough in generating pluripotent stem cells from horses, paving the way for potential new treatments for human degenerative conditions. The discovery will aid the development of preclinical models leading to human applications.
Researchers from the Walter and Eliza Hall Institute have identified the Erg gene as crucial for blood stem cells' ability to self-renew. This discovery holds promise for developing new therapies using blood stem cells for tissue repair, transplantation, and other applications.
A team of scholars calls for collective action to address the negative effects of patenting and privatizing stem cell lines, data, and technologies. The experts warn that the lack of transparency and ambiguity in ownership and control can hinder progress toward breakthroughs.
Researchers have discovered that mucosa-derived stem cells can preserve hearing function in children with sensorineural hearing loss. The study shows promising results for nasal stem cell transplants as a potential treatment for this condition and potentially other diseases such as Parkinson's disease and cardiac infarction.
A groundbreaking study found that mesenchymal stem cells delivered through the nose improved motor function and increased dopamine levels in rats with Parkinson's disease. This non-invasive approach offers a safer alternative to surgical transplantation.
Researchers found that hematopoietic stem cells can shift between rapidly dividing and dormant states, suggesting a more equal sharing of blood cell production burden. This adaptability allows cells to respond quickly to life-threatening situations, such as bacterial infections.
Professor Alan Stitt has received a Royal Society Wolfson Research Merit Award to support his ground-breaking research on vascular stem cells and eye disease treatment at Queen's University. The award aims to retain top researchers in the UK and reflects the excellence of the School of Medicine, Dentistry and Biomedical Science.
A recent survey of US stem cell scientists reveals substantial negative impacts of ongoing policy uncertainty on their work, including changes to science type and quality, delays in new projects, and hindered collaborations.
Researchers at University of Rochester identify Nrf2 and Keap1 genes as key regulators of stem cell activity. Nrf2 prevents stem cell division, while Keap1 enables it when ROS levels increase.
A Cedars-Sinai research team has received a $1.9 million grant to develop a new pharmaceutical discovery process using pluripotent stem cells, aiming to find a treatment for Spinal Muscular Atrophy. Another team will create a new imaging system to monitor stem cell treatments in real-time, providing insights into tissue regeneration.
A team at Sanford-Burnham identified specific microRNAs that enhance the reprogramming process from skin cells to induced pluripotent stem (iPS) cells. Adding these miRNAs increases cell survival and improves iPS cell generation.
Human amniotic epithelial cells, derived from discarded human placenta, demonstrate therapeutic response when transplanted into lab test tubes and animal models of stroke. The interaction with melatonin receptor MT1 promotes functional recovery.
Researchers found that R-spondin1 reduces GVHD by protecting intestinal stem cells, which help regenerate damaged tissues and reduce inflammation. The study's results suggest a potential therapeutic approach for human bone marrow transplant patients.
A team of UCLA researchers has developed a chemically defined culture medium that supports the long-term quality and maintenance of human embryonic stem cells. The new medium, using a feedback system control scheme, eliminates the need for animal products and enables routine single-cell passaging.
Researchers have developed a mathematical model to assess the growth of stem cells and their malignant counterparts. The method, published in PLOS ONE, may aid in developing stem cell therapies for diseases like Alzheimer's and Parkinson's.
Researchers at UCSF have discovered that a mother's immune response prevents fetal acceptance of transplanted blood stem cells, but their own stem cells can be used to overcome this issue. The study suggests that using maternal stem cells could lead to successful treatment of genetic diseases before birth.
Researchers have documented genetic abnormalities in human embryonic stem cells and induced pluripotent stem cells, including duplications near pluripotency-associated genes and deletions involving tumor suppressor genes. Frequent genomic monitoring of these cell lines is necessary to ensure their stability and clinical safety.
Researchers found that male pattern balding may arise from a problem with stem-cell activation rather than the numbers of stem cells in follicles. The team discovered that bald areas had the same number of stem cells as normal scalp, but were depleted in progenitor cells.
Researchers have isolated and characterized adult fat cell-derived stem cells, which maintain their stem cell characteristics and could aid in tissue regeneration. The study's findings suggest that these cells may be useful for cell-based therapies and represent a promising area of research for plastic surgery applications.
Researchers found that higher activity of certain LSC genes was associated with worse overall, event-free and relapse-free survival in acute myeloid leukemia patients. The study defined a signature of enriched AML-initiating cells linked to clinical outcomes.
Researchers found a strong correlation between high levels of gene expression associated with leukemia stem cells and poor outcomes in patients. The study suggests that targeting these self-renewing cells could lead to more effective treatments and improved patient survival.
Researchers at University of Illinois found that soft gel substrates promote homogeneous pluripotent stem cell cultures without expensive growth chemicals. This discovery has huge applications in regenerative medicine, offering a step toward understanding the basic biology of stem cells.