Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Researchers found that R-spondin1 reduces GVHD by protecting intestinal stem cells, which help regenerate damaged tissues and reduce inflammation. The study's results suggest a potential therapeutic approach for human bone marrow transplant patients.
A team of UCLA researchers has developed a chemically defined culture medium that supports the long-term quality and maintenance of human embryonic stem cells. The new medium, using a feedback system control scheme, eliminates the need for animal products and enables routine single-cell passaging.
Researchers have developed a mathematical model to assess the growth of stem cells and their malignant counterparts. The method, published in PLOS ONE, may aid in developing stem cell therapies for diseases like Alzheimer's and Parkinson's.
Researchers at UCSF have discovered that a mother's immune response prevents fetal acceptance of transplanted blood stem cells, but their own stem cells can be used to overcome this issue. The study suggests that using maternal stem cells could lead to successful treatment of genetic diseases before birth.
Researchers have documented genetic abnormalities in human embryonic stem cells and induced pluripotent stem cells, including duplications near pluripotency-associated genes and deletions involving tumor suppressor genes. Frequent genomic monitoring of these cell lines is necessary to ensure their stability and clinical safety.
Researchers found that male pattern balding may arise from a problem with stem-cell activation rather than the numbers of stem cells in follicles. The team discovered that bald areas had the same number of stem cells as normal scalp, but were depleted in progenitor cells.
Researchers have isolated and characterized adult fat cell-derived stem cells, which maintain their stem cell characteristics and could aid in tissue regeneration. The study's findings suggest that these cells may be useful for cell-based therapies and represent a promising area of research for plastic surgery applications.
Researchers found that higher activity of certain LSC genes was associated with worse overall, event-free and relapse-free survival in acute myeloid leukemia patients. The study defined a signature of enriched AML-initiating cells linked to clinical outcomes.
Researchers found a strong correlation between high levels of gene expression associated with leukemia stem cells and poor outcomes in patients. The study suggests that targeting these self-renewing cells could lead to more effective treatments and improved patient survival.
Researchers at University of Illinois found that soft gel substrates promote homogeneous pluripotent stem cell cultures without expensive growth chemicals. This discovery has huge applications in regenerative medicine, offering a step toward understanding the basic biology of stem cells.
Scientists at King's College London have made a critical discovery about the role of beta-catenin in leukemia stem cells. By suppressing this protein, they were able to reverse leukaemic stem cells to a pre-leukaemic stage and 're-sensitize' resistant cells to treatment.
Researchers at Georgetown University Medical Center have successfully turned human testes cells into insulin-producing islet cells, offering a potential new treatment for type 1 diabetes. The study used spermatogonial stem cells extracted from testicular tissue to produce insulin-secreting beta islet cells without the use of extra genes.
Researchers at Georgetown University successfully generated human-derived islet cells from spermatogonial stem cells, demonstrating their potential to counter diabetic hyperglycemia. The bioengineered cells secreted insulin and exhibited markers characteristic of normal islet cells.
A team of scientists has discovered that microRNA profiles can predict the type of cell, including whether it's cancerous or not. This finding has significant implications for the use of stem cells in repairing damaged body parts, as it highlights the potential risks of creating cancer.
According to a recent study in Nature Biotechnology, states in the US are now funding more human embryonic stem cell research than the federal government. The extent of this funding varies significantly between states, with some prioritizing this research over others.
Researchers found that Duchenne muscular dystrophy symptoms emerge when skeletal muscle stem cells can no longer keep up with repairs, leading to progressive muscle weakening and respiratory failure. Successful treatments targeting muscle stem cells may alleviate symptoms and offer new hope for managing the disease.
Studies reveal that stem cell transplantation is safe and effective in treating various hematologic malignancies, with no significant increase in overall cancer risk. Researchers found a promising new treatment to prevent chronic graft-versus-host disease, a serious complication of stem cell transplantation.
Researchers at UCLA found that the protein Bmi-1 plays a crucial role in regulating self-renewal of normal prostate stem cells and transforming healthy cells into prostate cancer cells. Inhibiting Bmi-1 slowed the growth of aggressive prostate cancer in animal models.
Scientists at Scripps Research Institute have made a significant leap forward in finding chemicals needed to reprogram mature human cells and turn them into stem cells. The discovery represents a fundamentally different approach from previous methods and offers a new method for generating induced pluripotent stem cells with defined sma...
Researchers discovered a protein necessary for normal cell division in blood-forming stem cells, which resulted in abnormal numbers of chromosomes and high rates of cell death. This finding highlights the metabolic differences between stem cells and other blood-forming cells.
A study by Thomas Jefferson University found that bone marrow stromal stem cells can significantly recover motor behavior in laboratory rats after a simulated stroke. Early administration of the stem cells was more effective than late administration, with profound changes in brain structure and long-lasting motor function improvement.
Two studies published in Cell Transplantation found that administering bone marrow stem cells promoted functional recovery and reduced damage after stroke, while VEGF administration provided near complete neurological protection. These findings suggest two potential treatments for stroke and could offer new recourse against its ravages.
A study has revealed a relationship between blood cells and their stem cell 'parents', influencing gene expression and behavior. The discovery opens up new research avenues into diseases caused by stem cell disorders.
Researchers have developed a medical model for regenerating bladders using stem cells harvested from a patient's own bone marrow. The study demonstrates the feasibility of MSCs in partial bladder regeneration and provides valuable insight into the processes governing bladder regeneration.
Researchers at Hebrew University found that induced pluripotent stem (iPS) cells undergo abnormal chromosomal changes, including trisomy and up-regulation of specific genes, which can lead to tumorigenic risk. This discovery hinders progress on using iPS cells in future therapy.
Researchers have developed a medical model for regenerating bladders using stem cells, which could lead to new organ replacement therapies. The study used bone marrow mesenchymal stem cells, which have been shown to retain their ability to populate and function in a grafted area.
Researchers at Duke University Medical Center discovered a stem cell secreted protein that improves heart muscle repair after a heart attack. The protein, sfrp2, reduces collagen layering and prevents heart failure in study rats.
UC San Diego undergraduate bioengineers develop a new microenvironment that provides all three types of cues necessary for stem cell growth and differentiation. The system uses a gelatin-like hydrogel bathed in an electrolyte solution, mimicking the natural environment to steer stem cells towards specific cell types.
A team of researchers has developed a human cell-based model of Rett syndrome, overcoming the main limitation of accessing live neurons from patients. The study provides evidence of functional rescue using human cells and opens up new avenues for drug development and high-throughput screening.
Researchers at Rice University have developed gadonanotubes that can effectively track mesenchymal stem cells through magnetic resonance imaging, potentially improving disease diagnosis and treatment. The study found that GNTs are 40 times better than standard contrast agents in helping doctors spot signs of disease or damage.
A recent study published in Stem Cells journal has awarded human cord-blood research with a $10,000 prize for its potential to cure acute kidney injury. The research revealed the regenerative potentials of human cord-blood stem cells as a future cell therapy.
Scientists at McMaster University have discovered how to make human blood directly from adult skin cells, bypassing the need for a pluripotent stem cell conversion. This breakthrough could lead to new treatments for patients in need of blood transfusions, reducing reliance on donor matches and increasing access to life-saving therapies.
The Scripps Research Institute scientists have found strong evidence that a DNA repair enzyme is involved in the expansion of triplet repeats in the FXN gene, leading to the silencing of the gene and the disease. The study suggests that the enzyme mistakenly identifies the repeat expansions as DNA damage and attempts to repair them.
Stem cells can sense a decrease in available nutrients and respond by retaining only a small pool of active stem cells for tissue maintenance. Upon re-feeding, insulin-like peptide expression and stem cell numbers recover quickly.
Researchers found that nerve cell activity regulates balance between stem cells and mature nerve cells in the developing brain. The study suggests that abnormal brain activity may have long-lasting effects on brain development and could lead to new therapies for neurodegenerative diseases.
Researchers tested three MRI contrast agents on different stem cell populations and found changes in stem cell proliferation depending on the agent used. The study revealed varying labeling efficiencies with each agent, but no significant alterations in cell phenotypes or differentiation.
Researchers found that NSAIDs like aspirin trigger programmed cell death in abnormal stem cells, preventing colon cancer. This discovery could lead to new strategies for protecting people at high risk of the disease.
University of Pittsburgh researchers have developed a 3D system to mimic colon cancer stem cell growth patterns. They found that some cancer stem cells produce differentiated cells, while others produce self-renewing cells, paving the way for testing new therapies.
A team of researchers has generated 100 new lines of human induced pluripotent stem cells (iPSCs) from individuals with lung diseases, including cystic fibrosis and emphysema. The new stem cell lines could lead to new treatments for these debilitating diseases.
A study suggests that plant stem cells derived from trees could be used to produce the anticancer compound paclitaxel at a low cost. This method avoids the use of mature trees and environmentally damaging by-products associated with current industrial manufacturing processes.
The updated Strategic Research Plan identifies seven high-priority initiatives, including automated technologies for stem cell research and clinical research enterprise enhancements. These initiatives aim to strengthen existing research areas while exploring new ones.
The grants will advance research on retinitis pigmentosa, Huntington's disease and traumatic brain injury. The selected projects are expected to result in candidate drugs or cell therapies, which can be developed for clinical trials.
A team of researchers aims to develop a biological treatment for compression fractures, the most common type of bone fracture in osteoporosis patients. The goal is to promote healing and stimulate normal bone production.
A team of Singaporean scientists has made a major breakthrough by discovering the most important genes in human embryonic stem cells, which are crucial for treating debilitating conditions. The researchers identified a particular gene called PRDM14 that makes it easier to turn adult cells into pluripotent stem cells.
Researchers at Karolinska Institutet have discovered how stem cells and other cells repair damaged spinal cord tissue in mice. The study identified ependymal cells as a key player in this process, which is crucial for developing therapies for spinal cord injury.
Research in the Journal of Tissue Engineering reveals that stem cells detect surface features with mechanosensors, which modulate gene expression through biochemical signaling cascades. This understanding opens doors to develop improved clinical prostheses with topographies that directly modulate stem cell fate.
The NIH has awarded $14.6M to Georgia Tech and Emory University to develop nanotechnology tools for detecting and treating atherosclerosis. The research aims to translate these technologies into clinical utility, including diagnosing cardiovascular disease from a blood sample and delivering targeted drug delivery.
A team of researchers has found a way to increase the number of blood-forming stem cells by using a unique stretchy surface. This breakthrough could revolutionize stem cell transplants by generating up to three times more stem cells than current methods.
Menstrual blood-derived stem cells may aid in brain repair following stroke, with no risk of creating tumors. The study aims to advance the clinical application of self-donor cell therapy for stroke patients.
Researchers at UIC's Brodie Laboratory have successfully developed a technique to reattach teeth using stem cells, which could lead to a major advance in the battle against gum disease. The new strategy involves using periodontal ligament stem cells to form new fibrous attachments between the tooth and bone.
Researchers at McLean Hospital have been awarded a $1.9 million grant to continue their research into creating human induced pluripotent (iPS) stem cells using a method that eliminates cancer risks. The goal is to develop universal red blood cells and platelets for transfusion, eliminating immune rejection problems.
Engineered 'firefly' stem cells can help repair damaged hearts without cutting into patients' chests. Researchers can now track the cells' progress using a special camera lens that picks up the glow under a microscope.
The annual Stem Cells Young Investigator Award is presented to a young scientist who published an important paper in the journal. The award recognizes innovative young investigators making significant contributions to stem cell biology and applications.
Researchers at Cincinnati Children's Hospital Medical Center identified a molecular communications pathway influencing hematopoietic stem cell mobilization. Pharmacological inhibition of the Egfr signaling pathway increased stem cell mobilization in mice, suggesting a new rationale for targeted therapies.
The University of Minnesota Masonic Cancer Center will lead national hematopoietic stem cell transplantation and cell therapies research, benefiting thousands of patients worldwide. The center's leading physician-scientists will conduct clinical trials to test new treatments, including umbilical cord blood 'T regulatory cells' and NK c...
A multi-center team of scientists from OHSU is part of the prestigious Beta Cell Biology Consortium, aiming to develop a cell-based therapy for insulin delivery in type 1 diabetes patients. The researchers hope to produce abundant quantities of functional human insulin-producing beta cells that can be used for transplantation.
A study published in Cell Stem Cell reveals that NURF, an enzyme that regulates DNA packaging, allows specific genes to be turned on and off in stem cells. This dynamic structure enables stem cells to maintain their potency and prevent differentiation into other cell types.
The special issue of Translational Research presents an in-depth view of stem cell research, considering its potential for therapy in various human diseases. Despite scientific and technical advancements, serious ethical concerns remain, including issues of privacy and consent.
Researchers at UC Riverside have identified a chemical compound, blebbistatin, that inhibits the molecular motor NMII and prevents cell death in human pluripotent stem cells. This breakthrough discovery brings stem cell research closer to finding therapies for various diseases.
Researchers at Hebrew University develop theoretical model and conduct experiments to understand how stem cells differentiate based on their surroundings' rigidity. The study reveals elongated, muscle-like fibers in cells on rigid supports, differing from brain and bone cell structures on softer or harder substrates.