Articles tagged with Stem Cell Research
A recent study published in Stem Cells journal has awarded human cord-blood research with a $10,000 prize for its potential to cure acute kidney injury. The research revealed the regenerative potentials of human cord-blood stem cells as a future cell therapy.
Scientists at McMaster University have discovered how to make human blood directly from adult skin cells, bypassing the need for a pluripotent stem cell conversion. This breakthrough could lead to new treatments for patients in need of blood transfusions, reducing reliance on donor matches and increasing access to life-saving therapies.
The Scripps Research Institute scientists have found strong evidence that a DNA repair enzyme is involved in the expansion of triplet repeats in the FXN gene, leading to the silencing of the gene and the disease. The study suggests that the enzyme mistakenly identifies the repeat expansions as DNA damage and attempts to repair them.
Stem cells can sense a decrease in available nutrients and respond by retaining only a small pool of active stem cells for tissue maintenance. Upon re-feeding, insulin-like peptide expression and stem cell numbers recover quickly.
Researchers found that nerve cell activity regulates balance between stem cells and mature nerve cells in the developing brain. The study suggests that abnormal brain activity may have long-lasting effects on brain development and could lead to new therapies for neurodegenerative diseases.
Researchers tested three MRI contrast agents on different stem cell populations and found changes in stem cell proliferation depending on the agent used. The study revealed varying labeling efficiencies with each agent, but no significant alterations in cell phenotypes or differentiation.
Researchers found that NSAIDs like aspirin trigger programmed cell death in abnormal stem cells, preventing colon cancer. This discovery could lead to new strategies for protecting people at high risk of the disease.
University of Pittsburgh researchers have developed a 3D system to mimic colon cancer stem cell growth patterns. They found that some cancer stem cells produce differentiated cells, while others produce self-renewing cells, paving the way for testing new therapies.
A team of researchers has generated 100 new lines of human induced pluripotent stem cells (iPSCs) from individuals with lung diseases, including cystic fibrosis and emphysema. The new stem cell lines could lead to new treatments for these debilitating diseases.
A study suggests that plant stem cells derived from trees could be used to produce the anticancer compound paclitaxel at a low cost. This method avoids the use of mature trees and environmentally damaging by-products associated with current industrial manufacturing processes.
The updated Strategic Research Plan identifies seven high-priority initiatives, including automated technologies for stem cell research and clinical research enterprise enhancements. These initiatives aim to strengthen existing research areas while exploring new ones.
The grants will advance research on retinitis pigmentosa, Huntington's disease and traumatic brain injury. The selected projects are expected to result in candidate drugs or cell therapies, which can be developed for clinical trials.
A team of researchers aims to develop a biological treatment for compression fractures, the most common type of bone fracture in osteoporosis patients. The goal is to promote healing and stimulate normal bone production.
A team of Singaporean scientists has made a major breakthrough by discovering the most important genes in human embryonic stem cells, which are crucial for treating debilitating conditions. The researchers identified a particular gene called PRDM14 that makes it easier to turn adult cells into pluripotent stem cells.
Researchers at Karolinska Institutet have discovered how stem cells and other cells repair damaged spinal cord tissue in mice. The study identified ependymal cells as a key player in this process, which is crucial for developing therapies for spinal cord injury.
Research in the Journal of Tissue Engineering reveals that stem cells detect surface features with mechanosensors, which modulate gene expression through biochemical signaling cascades. This understanding opens doors to develop improved clinical prostheses with topographies that directly modulate stem cell fate.
The NIH has awarded $14.6M to Georgia Tech and Emory University to develop nanotechnology tools for detecting and treating atherosclerosis. The research aims to translate these technologies into clinical utility, including diagnosing cardiovascular disease from a blood sample and delivering targeted drug delivery.
A team of researchers has found a way to increase the number of blood-forming stem cells by using a unique stretchy surface. This breakthrough could revolutionize stem cell transplants by generating up to three times more stem cells than current methods.
Menstrual blood-derived stem cells may aid in brain repair following stroke, with no risk of creating tumors. The study aims to advance the clinical application of self-donor cell therapy for stroke patients.
Researchers at McLean Hospital have been awarded a $1.9 million grant to continue their research into creating human induced pluripotent (iPS) stem cells using a method that eliminates cancer risks. The goal is to develop universal red blood cells and platelets for transfusion, eliminating immune rejection problems.
Researchers at UIC's Brodie Laboratory have successfully developed a technique to reattach teeth using stem cells, which could lead to a major advance in the battle against gum disease. The new strategy involves using periodontal ligament stem cells to form new fibrous attachments between the tooth and bone.
The annual Stem Cells Young Investigator Award is presented to a young scientist who published an important paper in the journal. The award recognizes innovative young investigators making significant contributions to stem cell biology and applications.
Engineered 'firefly' stem cells can help repair damaged hearts without cutting into patients' chests. Researchers can now track the cells' progress using a special camera lens that picks up the glow under a microscope.
Researchers at Cincinnati Children's Hospital Medical Center identified a molecular communications pathway influencing hematopoietic stem cell mobilization. Pharmacological inhibition of the Egfr signaling pathway increased stem cell mobilization in mice, suggesting a new rationale for targeted therapies.
The University of Minnesota Masonic Cancer Center will lead national hematopoietic stem cell transplantation and cell therapies research, benefiting thousands of patients worldwide. The center's leading physician-scientists will conduct clinical trials to test new treatments, including umbilical cord blood 'T regulatory cells' and NK c...
A multi-center team of scientists from OHSU is part of the prestigious Beta Cell Biology Consortium, aiming to develop a cell-based therapy for insulin delivery in type 1 diabetes patients. The researchers hope to produce abundant quantities of functional human insulin-producing beta cells that can be used for transplantation.
A study published in Cell Stem Cell reveals that NURF, an enzyme that regulates DNA packaging, allows specific genes to be turned on and off in stem cells. This dynamic structure enables stem cells to maintain their potency and prevent differentiation into other cell types.
The special issue of Translational Research presents an in-depth view of stem cell research, considering its potential for therapy in various human diseases. Despite scientific and technical advancements, serious ethical concerns remain, including issues of privacy and consent.
Researchers at UC Riverside have identified a chemical compound, blebbistatin, that inhibits the molecular motor NMII and prevents cell death in human pluripotent stem cells. This breakthrough discovery brings stem cell research closer to finding therapies for various diseases.
Researchers at Hebrew University develop theoretical model and conduct experiments to understand how stem cells differentiate based on their surroundings' rigidity. The study reveals elongated, muscle-like fibers in cells on rigid supports, differing from brain and bone cell structures on softer or harder substrates.
Researchers have discovered unique metabolic properties of bone-marrow stem cells that allow them to survive and replicate in low-oxygen environments. This finding may lead to new strategies for enriching stem cells by selecting those with specific metabolic characteristics.
For the first time, researchers have identified and isolated adult mammary stem cells in mice using a genetically modified mouse model. The tagged stem cells exhibit bright green fluorescence under a microscope, representing a new alternative to induced pluripotent stem cells for various medical applications.
Scientists at MIT have developed a new synthetic surface that allows human pluripotent stem cells to stay alive and continue reproducing themselves for at least three months. This breakthrough enables the growth of large quantities of cells, necessary for treating diseases such as Parkinson's disease and spinal cord injuries.
A UC Irvine study shows that human neural stem cells can reverse long-term hind-limb paralysis in mice with chronic spinal cord injuries. The therapy demonstrates potential for treating a broader population of patients with spinal cord injuries.
Scientists have successfully converted stem cells from a key immune system organ into skin stem cells without genetic modification. This breakthrough allows for potential applications in regenerating tissues and has implications for the development of new therapies.
The University of South Florida researchers warn that the growing number of stem cell journals may compromise the quality of research in the field. They recommend authors to follow Good Publications Practices when choosing a publication outlet.
Researchers at the Buck Institute have used human induced pluripotent stem cells (iPSCs) to treat rodent models of Parkinson's Disease, paving the way for potential cell therapies. The study shows that iPSC-derived dopamine-producing neurons can engraft and ameliorate behavioral deficits in animals with PD.
A study by Dr. Paul Frenette reveals a unique 'partnership' between bone marrow stem cells, which could lead to advances in regenerative medicine. The partnership involves hematopoietic stem cells (HSCs) and mesenchymal stem cells, with the latter playing crucial roles in maintaining HSCs and facilitating regeneration.
The NSF-funded program aims to develop engineering methods for stem cell production, focusing on scalable and standardized approaches. The initiative will support 30 new Ph.D. students over five years, with plans for international collaborations.
Researchers found that MSCs create a supportive niche for HSCs, allowing them to self-renew and develop into blood cells. Altering MSC numbers affects HSC population, suggesting a regulatory interaction between the two cell types.
Researchers at the University of Minnesota have successfully treated children with recessive dystrophic epidermolysis bullosa, a fatal skin disease, using bone marrow stem cell therapy. The treatment has shown promising results, increasing collagen production and improving skin resistance to blister formation.
A team led by Drs. Michael A. Matthay and Jae W. Lee found that bone marrow stem cells secreted a protein that restored the lung barrier, preventing fluid and other elements from entering the lungs. The study suggests that this therapy may be a viable option for preventing respiratory failure in critically ill patients.
Researchers at UCSF have successfully purified one type of human embryonic stem cell using a novel, high-throughput strategy that avoids genetic engineering. The technique links two existing technologies and enables the separation of pure stem cells from teratoma-forming cells at a rate of about 25,000 cells per second.
Researchers found purified blood stem cells outperform those with T cells in forming new blood cells and regenerating lymphoid tissues. The study challenges decades-old assumptions about the need for T cells in bone marrow transplants.
Stem cell differentiation is a crucial process that can be accelerated using a novel type of matrix, adjusting its stiffness without altering its chemical composition. By analyzing traction forces and cellular behavior, researchers predict stem cell differentiation as early as Day 1.
The American Society of Hematology will honor six scientists with significant contributions to the understanding and treatment of hematologic diseases. Volker Diehl, Sanford Shattil, David T. Scadden, Leonard I. Zon, Barry S. Coller, and Joel S. Bennett will receive awards for their pioneering research in Hodgkin lymphoma, platelet cel...
Dr. Anthony-Samuel LaMantia's research identifies stem cells responsible for generating nerve cells involved in eating, reproduction, and social behavior. These cells are essential for understanding neurological and mental disabilities, such as autism, schizophrenia, and Alzheimer's disease.
Researchers at USF found that combining nutrients called NT-020 increased adult neural stem cell proliferation and boosted learning and memory performance in aged rats. The study suggests aging may be linked to reduced neurogenesis due to inflammation.
Researchers at Stanford University School of Medicine developed a technique to grow muscle stem cells on a synthetic matrix that mimics the elasticity of real muscle, allowing them to maintain their self-renewing properties. This breakthrough may revolutionize the production of adult stem cells for therapies.
Researchers are using induced pluripotent stem cells from skin tissue to grow dopamine neurons and study Parkinson's disease. The goal is to better understand the cause of the disease by comparing healthy cells with those affected by Parkinson's.
Researchers found that adding palmitate to mouse stem cells affected their response to sex hormones, influencing the development of visceral versus subcutaneous fat. This discovery sheds light on the fundamental biology underlying obesity-related diseases.
A new technique developed by Professor Fiona Watt's team allows for the examination of individual stem cells to learn about their biology and screen new drugs. This approach has demonstrated its potential to encourage stem cells to repair damaged tissues.
Researchers identify a protein released by neural stem cells that induces signaling in glioblastoma cells, causing them to differentiate. This discovery could lead to new therapy concepts targeting tumor stem cells and potentially destroying the aggressive brain tumors.
Researchers at the University of Montreal have identified three proteins that regulate blood cell production and one protein that inhibits it. Understanding these factors is crucial for developing novel therapies to treat diseases caused by abnormal blood-making stem cells.
Researchers have identified a key molecular guard that prevents brain stem cells from proliferating, protecting the brain against excessive cell division. This study highlights the importance of bone morphogenetic factor protein (BMP) signaling for maintaining neural stem cells throughout adulthood.
Leading stem cell researcher Irving Weissman warns of unproven treatments being marketed on the internet, putting patients at risk of harm. His organization has launched a website to educate patients and provide guidance on how to spot fraudulent clinics.
A Texas A&M researcher has found that early mammalian embryos possess three stem cell lineages with different viral silencing strategies, including XEN cells that exhibit rapid and aggressive silencing of retroviruses. The study provides new insights into fetal diseases and has profound implications for diagnosis and treatment.
The Wallenberg Institute for Regenerative Medicine (WIRM) at Karolinska Institutet will focus on pioneering research in the blood system and stem-cell therapy, aiming to treat diseases like diabetes, spinal injuries, and neurodegenerative conditions. The grant strengthens the institute's infrastructure with advanced technical equipment...
Researchers at Cedars-Sinai are studying the mechanisms of how human immune systems reject or accept transplanted brain stem cells. The team aims to develop new stem cell therapies for patients with ALS, Parkinson's disease and other neurological disorders.
A Florida State University researcher has identified the important role that CDK5RAP2 plays in maintaining centriole engagement and cohesion, thereby restricting centriole replication. This discovery could lead to a greater understanding of stem cells and their connection to human diseases such as small brain syndrome.