Articles tagged with Stem Cell Research
Researchers at the University of Minnesota have successfully treated children with recessive dystrophic epidermolysis bullosa, a fatal skin disease, using bone marrow stem cell therapy. The treatment has shown promising results, increasing collagen production and improving skin resistance to blister formation.
A team led by Drs. Michael A. Matthay and Jae W. Lee found that bone marrow stem cells secreted a protein that restored the lung barrier, preventing fluid and other elements from entering the lungs. The study suggests that this therapy may be a viable option for preventing respiratory failure in critically ill patients.
Researchers at UCSF have successfully purified one type of human embryonic stem cell using a novel, high-throughput strategy that avoids genetic engineering. The technique links two existing technologies and enables the separation of pure stem cells from teratoma-forming cells at a rate of about 25,000 cells per second.
Researchers found purified blood stem cells outperform those with T cells in forming new blood cells and regenerating lymphoid tissues. The study challenges decades-old assumptions about the need for T cells in bone marrow transplants.
Stem cell differentiation is a crucial process that can be accelerated using a novel type of matrix, adjusting its stiffness without altering its chemical composition. By analyzing traction forces and cellular behavior, researchers predict stem cell differentiation as early as Day 1.
The American Society of Hematology will honor six scientists with significant contributions to the understanding and treatment of hematologic diseases. Volker Diehl, Sanford Shattil, David T. Scadden, Leonard I. Zon, Barry S. Coller, and Joel S. Bennett will receive awards for their pioneering research in Hodgkin lymphoma, platelet cel...
Dr. Anthony-Samuel LaMantia's research identifies stem cells responsible for generating nerve cells involved in eating, reproduction, and social behavior. These cells are essential for understanding neurological and mental disabilities, such as autism, schizophrenia, and Alzheimer's disease.
Researchers at USF found that combining nutrients called NT-020 increased adult neural stem cell proliferation and boosted learning and memory performance in aged rats. The study suggests aging may be linked to reduced neurogenesis due to inflammation.
Researchers at Stanford University School of Medicine developed a technique to grow muscle stem cells on a synthetic matrix that mimics the elasticity of real muscle, allowing them to maintain their self-renewing properties. This breakthrough may revolutionize the production of adult stem cells for therapies.
Researchers are using induced pluripotent stem cells from skin tissue to grow dopamine neurons and study Parkinson's disease. The goal is to better understand the cause of the disease by comparing healthy cells with those affected by Parkinson's.
Researchers found that adding palmitate to mouse stem cells affected their response to sex hormones, influencing the development of visceral versus subcutaneous fat. This discovery sheds light on the fundamental biology underlying obesity-related diseases.
A new technique developed by Professor Fiona Watt's team allows for the examination of individual stem cells to learn about their biology and screen new drugs. This approach has demonstrated its potential to encourage stem cells to repair damaged tissues.
Researchers identify a protein released by neural stem cells that induces signaling in glioblastoma cells, causing them to differentiate. This discovery could lead to new therapy concepts targeting tumor stem cells and potentially destroying the aggressive brain tumors.
Researchers at the University of Montreal have identified three proteins that regulate blood cell production and one protein that inhibits it. Understanding these factors is crucial for developing novel therapies to treat diseases caused by abnormal blood-making stem cells.
Researchers have identified a key molecular guard that prevents brain stem cells from proliferating, protecting the brain against excessive cell division. This study highlights the importance of bone morphogenetic factor protein (BMP) signaling for maintaining neural stem cells throughout adulthood.
Leading stem cell researcher Irving Weissman warns of unproven treatments being marketed on the internet, putting patients at risk of harm. His organization has launched a website to educate patients and provide guidance on how to spot fraudulent clinics.
A Texas A&M researcher has found that early mammalian embryos possess three stem cell lineages with different viral silencing strategies, including XEN cells that exhibit rapid and aggressive silencing of retroviruses. The study provides new insights into fetal diseases and has profound implications for diagnosis and treatment.
The Wallenberg Institute for Regenerative Medicine (WIRM) at Karolinska Institutet will focus on pioneering research in the blood system and stem-cell therapy, aiming to treat diseases like diabetes, spinal injuries, and neurodegenerative conditions. The grant strengthens the institute's infrastructure with advanced technical equipment...
Researchers at Cedars-Sinai are studying the mechanisms of how human immune systems reject or accept transplanted brain stem cells. The team aims to develop new stem cell therapies for patients with ALS, Parkinson's disease and other neurological disorders.
A Florida State University researcher has identified the important role that CDK5RAP2 plays in maintaining centriole engagement and cohesion, thereby restricting centriole replication. This discovery could lead to a greater understanding of stem cells and their connection to human diseases such as small brain syndrome.
Researchers found that viruses invading the human genome millions of years ago have changed gene regulation in human embryonic stem cells. The discovery provides definitive proof of a theory proposed by Barbara McClintock and has significant implications for regenerative medicine.
Researchers at the University of Michigan have developed a new synthetic stem cell growth matrix that overcomes major challenges in human embryonic stem cell research. The new coating, made from a water-soluble gel, has been shown to support long-term growth and maintenance of pluripotency in human embryonic stem cells.
A UCLA team of scientists discovered a relationship between DNA methylation and nucleosome positioning, which compact and regulate access to DNA. This finding could lead to techniques to control DNA methylation patterns and prevent cancer.
A UCI study identifies the body's immune system as a key player in navigating transplanted stem cells to injured areas in the central nervous system. Adult neural stem cells were shown to be guided by CXCR-4 receptors and chemokine proteins to specific sites, where they differentiated into oligodendrocytes to repair damaged tissue.
Researchers at Karolinska Institutet have successfully cultured human embryonic stem cells under chemically controlled conditions without the use of animal substances. This breakthrough enables large quantities of human embryonic stem cells to be produced in a completely defined environment, paving the way for future clinical uses.
Researchers have discovered a new source of stem cells that can form heart muscle cells, which can help repair damaged hearts. The stem cells, called human amniotic membrane-derived mesenchymal cells (hAMCs), were obtained from the amniotic membrane and showed promising results in laboratory studies.
The DFG approved twelve new Collaborative Research Centres to explore various research topics including the molecular interactions of immune response in pneumonia, innovative programming techniques, and materials for bone regeneration. The new centres aim to advance our understanding of complex phenomena and develop new therapies.
Scientists at UCI created an eight-layer, early-stage retina from human embryonic stem cells, a complex tissue structure that could lead to transplant-ready retinas for treating eye disorders. The breakthrough uses differentiation technique to create multiple cell types necessary for the retina, mimicking early-stage retinal development.
Rensselaer Polytechnic Institute has been awarded a four-year $2.45 million grant from the New York Stem Cell Science Program to create an upstate center of excellence for basic stem cell research. The grant will be used to build sophisticated laboratories with high-throughput culture and imaging equipment, enhancing stem cell research...
Researchers used clinical-grade human mesenchymal stem cells (hMSCs) to treat ALI, restoring normal function of alveolar epithelial cells and reducing inflammatory cytokines. The study found that intravenous delivery of hMSCs was as effective as intrabronchial administration in repairing damaged lung tissue.
Researchers have identified a previously undiagnosed condition and treated it with a stem cell transplant, saving the patient's life. The key to unlocking the reason for the patient's symptoms was contracting a rare version of glandular fever.
Researchers discover a combination of drugs that effectively target stubborn leukemia stem cells, which often escape standard treatment and lead to disease relapse. The study supports clinical trials of HDACi in combination with tyrosine kinase inhibitors to eliminate leukemia stem cells in patients with CML.
Researchers at the University of Texas M. D. Anderson Cancer Center have successfully transplanted adult stem cells into injured hearts, improving pumping efficiency for a year in a mouse model. The study used innovative imaging techniques to track the stem cells' location and performance over time.
Researchers at Yale University have discovered that endometrial stem cells can repair brain cells damaged by Parkinson's disease, potentially treating women with the condition. The study, published in Journal of Cellular and Molecular Medicine, found that these stem cells can differentiate into dopamine-producing nerve cells.
A new study compares induced pluripotent stem (iPS) cells and embryonic stem cells in modeling fragile X syndrome, a genetic disorder. The research reveals that the two cell types behave differently in the disease model, with iPS cells not fully replicating the gene silencing process.
Researchers successfully transplanted endometrial stem cells into the brains of mice with a Parkinson-like condition, restoring partially dopamine levels. This finding raises the possibility of women serving as their own stem cell donors and banks being established for men and women with Parkinson's disease.
Researchers at PMH discovered that progesterone alters breast stem cells, a finding with significant implications for breast cancer risk. The study shows how hormones affect breast stem cells during the reproductive cycle, providing a new pathway to understanding cell growth leading to breast cancer.
The study found that embryonic stem cell metabolites have highly unsaturated structures compared to mature cells, and levels decrease as they mature. The researchers also discovered a pattern in the chemistry that mirrors the cells' increasing biological maturity.
UCI scientists Marian Waterman and Aileen Anderson receive grants totaling $2.6 million to study human stem cells for therapeutic use and biomedical innovation. The research will further understanding of how stem cells survive and remain pluripotent, potentially leading to breakthroughs in induced pluripotent stem cell therapies.
Weill Cornell researchers discovered a single gene, Slitrk5, responsible for OCD-like behaviors in mice. The genetically altered mice exhibited repetitive self-grooming and extreme anxiety, with altered brain functioning mirroring those seen in human OCD patients.
Researchers have successfully extracted stem cells from sections of vein removed for heart bypass surgery, which can stimulate new blood vessels to grow and potentially help repair damaged heart muscle after a heart attack. The discovery brings the possibility of 'cell therapy' for damaged hearts one step closer.
Researchers have identified the location of bone generating stem cells in mice and found factors that control their growth. The discovery opens up avenues for studying bone tumor formation and regenerating damaged or injured bone.
A physics strategy called resonant activation is being tested as a solution for antibiotic resistance, targeting dormant persister cells. The approach involves repetitive antibiotic treatment to accelerate sterilization of bacterial colonies.
Einstein will increase research space and recruit new stem cell scientists with the new facility expansion, focusing on four broad themes: stem cell biology, genetics, cancer stem cells, and translational stem cell research. The renovation is expected to create 150 new jobs and drive scientific innovation for multiple diseases.
The Rutgers Stem Cell Research Center has derived new human embryonic stem cell lines, addressing concerns of contamination in previously approved lines. The center also offers a training course for stem cell scientists, with over 100 trained researchers to date.
Researchers at UTHealth are developing new strategies to derive hematopoietic stem cells from pluripotent stem cells, which could potentially treat blood diseases. Additionally, they are exploring gene-corrected induced pluripotent stem cells for treating two pediatric lung diseases, Surfactant Protein B Deficiency and Cystic Fibrosis.
Researchers solve the decade-old mystery of fragile human embryonic stem cells by discovering two novel synthetic small molecule drugs that promote cell survival. The team also unravels the mechanisms behind e-cadherin's role in cell signaling, providing a new understanding of stem cell biology and paving the way for potential therapies.
A new clinical trial, IMPACT-CABG, evaluates the safety and efficacy of injecting stem cells into the hearts of patients undergoing coronary bypass surgery. The study aims to promote healing and regeneration of damaged heart muscle, offering a less invasive alternative to heart transplant.
Scientists have developed tissue-engineered grafts composed of adult stem cells that can replace synthetic vascular bypass grafts. The study found that these grafts prevented clotting and thickening of the graft wall, improving their effectiveness in treating peripheral artery disease and dialysis access grafting.
Researchers discover a commercially available supplement stimulates production of hematopoietic stem cells, repairing the body. The supplement increases levels of these cells in the blood over a two-week period, showing potential for treating conditions associated with low cell counts.
A study published in Cell Transplantation has found that using ICG to label human embryonic stem cell-derived cardiomyocytes substantially improves efforts to optically track stem cells after transplanting them into heart tissues. The labeling procedure did not impair the viability or functional integrity of the cells.
Researchers find random gene expression changes during early differentiation, but stability increases by a factor of 100 after nine generations. This discovery sheds light on the mechanisms behind epigenetic inheritance and its impact on stem cell research.
A team of researchers led by Dr. Christopher Fasano successfully derived floor plate tissue from human embryonic stem cells, a crucial signaling center in brain development. This achievement paves the way for better understanding of neurodegenerative diseases like Parkinson's.
Researchers have pinpointed a key molecular player to control mesenchymal stem cell development, which could lead to new therapies for bone and cartilage diseases. The study found that activating the Notch pathway can delay the development of these cells, potentially making them more useful for treating conditions like osteoporosis.
Researchers at Boston Children's Hospital discovered a possible way to kill off leukemia stem cells and prevent relapse. The study found that targeting the Wnt/beta-catenin pathway can suppress leukemia recurrence by inhibiting beta-catenin, a crucial player in leukemia stem cell development.
Scientists at Duke University Medical Center have discovered a new growth factor that stimulates the expansion and regeneration of hematopoietic stem cells. The growth factor, pleiotrophin, has been shown to increase the numbers of human cord blood stem cells in culture capable of engraftment in immune-deficient mice.
Researchers have discovered that infantile hemangiomas originate from stem cells. Steroids target these stem cells specifically, inhibiting their ability to stimulate blood vessel growth. This finding opens the way for more specific and safer therapies for hemangioma.
Researchers at Johns Hopkins School of Medicine have discovered a potential new treatment using bone marrow stem cells to build new blood vessels in the upper leg. The treatment, which uses X-ray-visible microbubbles to deliver stem cells, was shown to dramatically improve the body's ability to form new blood vessels and provide a more...
Researchers at USC identified retinoic acid, a derivative of vitamin A, as a critical regulator of the Second Heart Field's tissue formation and septation process. Disruptions in this pathway can result in serious congenital malformations of the heart.
UC Irvine researchers have sequenced the Hydra genome, discovering genes linked to Huntington's disease and beta-amyloid plaque formation in Alzheimer's. The genome sequencing advances research on regeneration, stem cells, and patterning, offering potential new treatments for various injuries and diseases.