The American Thoracic Society has released new guidelines for CCHS, citing crucial discoveries linking the condition to mutations in the PHOX2B gene. Affected individuals require fastidious medical supervision to attain optimal quality of life, and early identification and intervention are critical.
SourceAmerican Thoracic Society·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateMar 12, 2010
Researchers at Northwestern University characterized a special type of stem cell, endothelial progenitor cells (EPCs), to see if they can behave as endothelial cells in the body when cultured on a bioengineered surface. The study shows promise for improving surgery success rates for peripheral arterial disease.
SourceNorthwestern University·JournalStem Cells·DateMar 11, 2010
A study published in the Journal of Cerebral Blood Flow & Metabolism found that repeated anesthesia can cause a significant decrease in stem cells in the hippocampus, leading to impaired memory and learning in young animals. The researchers believe this effect may be age-related, with younger animals being more susceptible.
SourceUniversity of Gothenburg·JournalJournal of Cerebral Blood Flow & Metabolism·DateMar 7, 2010
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Researchers discovered endothelial cells can grow copious amounts of adult stem cells and their progeny over weeks, revolutionizing organ regeneration and cancer cell growth inhibition. This vascular-cell model could manufacture unlimited blood-related stem cells for transplantation.
SourceNewYork-Presbyterian·JournalCell Stem Cell·DateMar 4, 2010
Researchers at M. D. Anderson Cancer Center developed a new assessment tool to measure the severity of chronic graft-versus-host disease (cGVHD) symptoms, which can complicate stem cell transplantation. The tool, MDASI-cGVHD, assesses symptoms on a scale of zero to 10 and correlates with patient reports of overall quality of life.
SourceUniversity of Texas M. D. Anderson Cancer Center·DateMar 1, 2010
Scientists at Rhode Island Hospital have discovered a novel mechanism of cell-to-cell communication using microvesicles, which can reprogram stem cells to behave like healthy cells. This finding offers hope for tissue regeneration and potential treatments for diseases such as cancer.
SourceLifespan·JournalExperimental Hematology·DateFeb 26, 2010
Researchers at Columbia University Irving Medical Center successfully used mouse embryonic stem cells to replace diseased retinal cells and restore sight in a mouse model of retinitis pigmentosa. The study showed promising results, with one-fourth of the mice regaining vision after receiving the stem cells.
SourceColumbia University Irving Medical Center·JournalTransplantation·DateFeb 24, 2010
US government's lifting of restrictions on federally-funded stem cell research has helped scientists focus on science, but limitations remain. George Daley will discuss the current climate and potential of induced pluripotent stem cells (iPS) in treating devastating diseases.
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A UCSF team recommends modifying NIH stem cell guidelines to protect the rights of individuals donating egg or sperm to patients undergoing in vitro fertilization. The guidelines currently give IVF patients unrestricted authority over embryos leftover after fertility treatments.
SourceUniversity of California - San Francisco·JournalScience·DateFeb 18, 2010
Clive Svendsen's team develops specifically-engineered stem cells that stall nerve cell degeneration in ALS patients. The award will fund novel ex vivo gene therapy approaches to treat the disease.
Researchers at The Ottawa Hospital Research Institute have discovered that stem cells intentionally break and repair their own DNA as a mechanism of activating genes that promote tissue development. This novel process, crucial for muscle tissue development, may also be important for the development of most other tissues.
SourceThe Ottawa Hospital·JournalProceedings of the National Academy of Sciences·DateFeb 15, 2010
Researchers at UC San Diego have identified the region in vertebrates where adult blood stem cells arise during embryonic development. This discovery is a critical step towards developing safer and more effective stem cell therapies for patients with leukemia, multiple myeloma, and other diseases.
SourceUniversity of California - San Diego·JournalNature·DateFeb 14, 2010
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A clinical trial is underway to determine if infusing stem cells from umbilical cord blood can improve the lives of children with cerebral palsy. The study will include 40 children aged 2-12, who will receive either a real or placebo infusion of cord blood.
SourceMedical College of Georgia at Augusta University·DateFeb 11, 2010
Researchers use minicircles to reprogram adult cells, achieving higher efficiency than viral vectors and introducing new hope for regenerative medicine applications. The discovery enables easier creation of induced pluripotent stem cells, which can be used to study human diseases and develop novel treatments.
SourceStanford Medicine·JournalNature Methods·DateFeb 7, 2010
The University of California, Riverside's new Stem Cell Core Facility will enable faster breakthroughs in stem cell research, targeting diseases such as osteoporosis and diabetes. The facility is equipped with the first-in-country Nikon BioStation CT technology, expected to provide valuable data for attacking degenerative diseases.
SourceUniversity of California - Riverside·DateFeb 2, 2010
Researchers have successfully developed a new stem cell treatment that can arrest acute lung injury in mice, paving the way for potential treatments of respiratory diseases. The experimental treatment uses transplantable lung cells derived from human embryonic stem cells and has shown promising results in tests on mice with damaged lungs.
SourceUniversity of Texas Health Science Center at Houston·JournalMolecular Therapy·DateFeb 2, 2010
Materials scientists at the University of Washington have developed a three-dimensional scaffold made from natural materials that mimic the binding sites for stem cells. Human embryonic stem cells grow and multiply readily on this structure, offering a clean and biodegradable alternative to traditional feeder layers.
SourceUniversity of Washington·JournalBiomaterials·DateFeb 2, 2010
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Researchers propose a model of adult stem cell regulation that explains how coexistence of quiescent and active stem cell populations supports tissue renewal and regeneration. The new model suggests separate functional roles for both sub-populations, which may also contribute to cancer drug resistance.
SourceStowers Institute for Medical Research·JournalScience·DateJan 29, 2010
Shinya Yamanaka has developed a method to reprogram adult skin cells into pluripotent stem cells, eliminating the need for embryos. This breakthrough will aid research into preventing birth defects and improving baby health.
A study led by NYSCF Fellow Daylon James has generated a human embryonic stem cell line to measure and boost endothelial cell production, establishing a standard methodology for producing functional endothelial cells from hESCs. The cells can now be used for pre-clinical assessment of vascular disease in large animal models.
SourceNew York Stem Cell Foundation·JournalNature Biotechnology·DateJan 21, 2010
Scientists from University of Wisconsin-Madison present a new model of stem cell regulation in Caenorhabditis elegans, balancing stem cell maintenance and differentiation. The regulatory network defines two states - stem cell state and differentiated state - and regulates their balance.
SourceUniversity of Wisconsin-Madison·JournalProceedings of the National Academy of Sciences·DateJan 11, 2010
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A study published in PNAS found that delivering stem cells on a polymer scaffold to treat large areas of missing bone leads to improved bone formation. However, the therapeutic effect is limited by the migration of stem cells away from the injury site, highlighting the need for improved delivery methods.
SourceGeorgia Institute of Technology·JournalProceedings of the National Academy of Sciences·DateJan 11, 2010
Scientists at Queen Mary University of London have discovered that medulloblastomas, the most common type of children's brain cancer, can arise from a specific type of stem cell. This breakthrough finding may lead to new ways to tackle the disease and improve treatment outcomes for patients.
SourceQueen Mary University of London·JournalOncogene·DateJan 10, 2010
Chinese researchers have become a leading contributor to peer-reviewed scientific literature on clock-reversing regenerative medicine, with over 1,100 publications in 2008. New regulations aim to improve patient safety and restore China's global reputation.
SourceSandra Rotman Centre for Global Health·JournalRegenerative Medicine·DateJan 8, 2010
Researchers found that MyoD activates CDC6 expression to promote rapid proliferation of muscle stem cells. The study suggests a new mechanism for muscle regeneration and highlights the importance of transcription factors in controlling cell cycle progression.
SourceRockefeller University Press·JournalJournal of Cell Biology·DateJan 4, 2010
A recent study developed a straightforward technique to determine the ethnic origin of stem cells, finding that Caucasian and East Asian populations are overrepresented in current cell lines. The team created a new stem cell line with a West African Yoruba genetic profile, which could lead to more diverse research and safer therapies.
SourceScripps Research Institute·JournalNature Methods·DateDec 29, 2009
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Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Researchers have identified a critical component, Jarid2, of the delicate balancing act between stem cell specialization and cellular chaos. The study reveals how Jarid2 recruits PRC2 to genes important in differentiation and modulates its activity to keep it poised for action.
Researchers found that vitamin C accelerates gene expression changes and promotes efficient iPSC generation. The study suggests a simple way to improve iPSC production, which can be considered a reversal of the aging process at the cellular level.
Researchers at the University of Pittsburgh School of Medicine have found that umbilical cord tissue contains a plentiful supply of stem cells that could be used to treat various muscle and bone disorders. The study reveals that these cells can be easily harvested from the tissue, expanded in number, and are remarkably stable.
SourceUniversity of Pittsburgh Schools of the Health Sciences·JournalJournal of Biomedicine and Biotechnology·DateDec 17, 2009
A University of Michigan research team analyzed 47 embryonic stem cell lines and found they lacked genetic diversity, with most derived from northern and western European ancestry. The lack of diversity raises concerns about unequal access to therapies for certain groups.
SourceUniversity of Michigan·JournalNew England Journal of Medicine·DateDec 16, 2009
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Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
The University of Maryland School of Medicine will coordinate a consortium of national experts in stem cell research, with a focus on regenerative therapy and new clinical therapies. The seven-year grant aims to advance the field at a faster pace and realize potential for new treatments sooner.
SourceUniversity of Maryland Medical Center·DateDec 16, 2009
Researchers at the Broad Stem Cell Research Center found that tissue-specific genes are indeed marked by transcription factors, potentially crucial for stem cell function. The study suggests that faithful marking of these genes may be essential for pluripotency and efficient differentiation of stem cells.
SourceUniversity of California - Los Angeles·JournalGenes & Development·DateDec 15, 2009
Researchers discuss consent, privacy and clinical translation issues in iPS cell study. The emergence of iPS cells adds new challenges to the legal and social debates in stem-cell science.
Researchers at the North East England Stem Cell Institute have developed a successful stem cell therapy to treat Limbal Stem Cell Deficiency (LSCD), a painful and blinding disease. The treatment, which uses patients' own stem cells without immunosuppression, shows promise for restoring sight in hundreds of people.
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Researchers have created human stem cell-derived neurons to model Alzheimer's disease and Niemann-Pick Type C, revealing early transport defects as a key factor in severe neuronal dysfunction. The study aims to understand how genetic differences affect cellular transport and behavior in these diseases.
SourceAmerican Society for Cell Biology·DateDec 9, 2009
A novel framework encourages adult stem cells to differentiate into heart cells by mimicking the elasticity alterations that occur in protein scaffolds. More cardiomyocytes were formed on this framework than with conventional techniques, suggesting improved cardiac differentiation.
SourceAmerican Society for Cell Biology·DateDec 8, 2009
Researchers from UCLA demonstrate that human blood stem cells can be engineered into cells that target and kill HIV-infected cells. This approach, similar to a genetic vaccine, could be effective against other chronic viral diseases. The study provides proof-of-principle for using this strategy in the human body.
SourceUniversity of California - Los Angeles·JournalPLOS ONE·DateDec 7, 2009
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Researchers found that stem cells from flies lacking SOCS protein had more integrin, allowing them to stick to the niche better than neighboring germline stem cells. This model can be applied to other stem cell niches such as cancer, where cancer stem cells become a danger when they become sticky.
SourceJohns Hopkins Medicine·JournalScience·DateDec 4, 2009
Researchers at Helmholtz Munich have discovered a new source of nerve cell generation in the adult brain, specifically in the olfactory bulb. This discovery may lead to new therapeutic approaches for Alzheimer's disease, where nerve cell degeneration plays a crucial role.
SourceHelmholtz Munich (Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH))·JournalNature Neuroscience·DateDec 1, 2009
Researchers at Hebrew University have developed a novel stem cell technology, immuno-isolation, to treat complicated bone fractures. The technology has been successfully used to treat seven patients with a combination of their own MSCs and blood products, offering a promising alternative to standard treatment methods.
SourceThe Hebrew University of Jerusalem·JournalStem Cells·DateNov 30, 2009
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A team of scientists led by Dr. Bernard Thébaud has demonstrated that stem cells protect and repair the lungs of newborn rats, boosting the power of healthy lung cells and preventing further damage. This research offers real hope for a new treatment for babies with chronic lung disease.
SourceAlberta Heritage Foundation for Medical Research·JournalAmerican Journal of Respiratory and Critical Care Medicine·DateNov 26, 2009
Researchers discovered that the peptide C3a regulates nerve cell maturation and migration in mice, which could lead to treating stroke, Parkinson's disease, and other neurological disorders. The study found that molecules similar to C3a can boost nerve cell formation and replace damaged cells.
SourceUniversity of Gothenburg·JournalStem Cells·DateNov 23, 2009
Scientists have demonstrated that stem cells found in amniotic fluid can form three-dimensional aggregates of cells known as embryoid bodies, which suggests they may be useful for treating a wider array of diseases and conditions. The findings suggest that the amnion cells have greater potential than thought and may be able to form man...
SourceAtrium Health Wake Forest Baptist·JournalOncogene·DateNov 23, 2009
Researchers at I-STEM Institute have made significant breakthrough in stem cell research by recreating a whole epidermis from human embryonic stem cells. The goal is to provide an unlimited resource of cells as an alternative treatment for victims of third-degree burns and patients with genetic diseases affecting the skin.
SourceINSERM (Institut national de la santé et de la recherche médicale)·JournalThe Lancet·DateNov 19, 2009
Researchers at Rice University and the Texas Heart Institute will label stem cells with gadonanotubes to track their effectiveness in regenerating damaged heart tissue. The team aims to use MRI to steer the cells in vivo with an external magnetic field.
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Researchers found that transplanted stem cells restored learning and memory to normal levels in rats four months after radiotherapy. The treatment showed promise in reversing radiation-induced damage of healthy tissue in the brain.
SourceUniversity of California - Irvine·JournalProceedings of the National Academy of Sciences·DateNov 9, 2009
A new treatment approach using a radiolabeled antibody to deliver targeted doses of radiation followed by a stem cell transplant has been shown to be effective in treating advanced leukemia. Forty percent of patients achieved remission, with approximately 35% surviving three years.
SourceFred Hutchinson Cancer Center·JournalBlood·DateNov 5, 2009
Rhode Island Hospital has received a $11 million NIH grant to study stem cell biology and tissue regeneration in lung and marrow diseases. The research will focus on determining the true phenotype of marrow stem cells and their fate as tissue.
A Stanford study reveals that a gene linked to human longevity impacts the brain's ability to generate new neurons. Researchers found that mice without this gene had fewer neural stem cells and more rapidly churned out nerve cell precursors, leading to brain weight increases.
SourceStanford Medicine·JournalCell Stem Cell·DateNov 5, 2009
Researchers have detected distinct molecular disparities between induced pluripotent stem cells and their parental cells, including differences in epigenetic signatures. These findings provide new insights into the fundamental nature of stem cells and may inform therapeutic applications.
SourceJohns Hopkins Medicine·JournalNature Genetics·DateNov 4, 2009
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Adult stem cells from bone marrow have shown promise in preventing and treating acute lung injury by repairing damaged endothelial cells. Researchers found that these progenitor stem cells, named Flk-1 and CD34, can repair lung damage and improve survival when administered to mice with ALI.
SourceUniversity of Illinois Chicago·JournalStem Cells·DateOct 28, 2009
Physician-researchers at USC have received a nearly $16 million grant to develop a stem cell-based treatment for age-related macular degeneration. The four-year study aims to replace damaged retinal cells with healthy ones derived from human embryonic stem cells.
A team of Cedars-Sinai Heart Institute researchers, led by Eduardo Marbán, received a $5.5 million grant to develop cardiac stem cell therapies for strengthening and healing damaged heart muscle caused by cardiac arrest. The goal is to create new treatments for heart attack patients in four years or less.
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Researchers have developed two experimental treatments that restored some vision to people with blinding eye diseases. A retinal prosthesis and fetal tissue transplant showed promise in human studies, improving visual acuity in several individuals with retinitis pigmentosa and age-related macular degeneration.
Scripps Research scientists have made a breakthrough in creating stem cells from adult human tissue using three small drug-like chemicals. The new technique is 200 times more efficient and twice as fast than conventional methods, solving two major challenges in the development of stem-cell-based medicine.
SourceScripps Research Institute·JournalNature Methods·DateOct 18, 2009
Embryonic stem cells exhibit sensitivity to localized cyclic forces due to their softness, affecting gene expression and differentiation. The study suggests that applying controlled mechanical forces could be a new method for directing cell behavior, with implications for therapeutic cloning and regenerative medicine.
SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalNature Materials·DateOct 18, 2009
Researchers at Case Western Reserve University are developing a novel approach to building vascular networks in engineered tissues using custom-designed synthetic molecules and embryonic stem cells. Their goal is to produce networks that can grow and maintain themselves like natural blood vessels, paving the way for improved human lives.
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Researchers at the University of California, San Diego, have developed a new high-throughput cellular array technology that can identify the biological components leading to or alleviating liver disease. By controlling the environment surrounding star-shaped liver cells, they found critical proteins regulating HSC activation.
SourceUniversity of California - San Diego·JournalIntegrative Biology·DateOct 9, 2009
A study published in Stem Cells reveals human stem cells can immunize against colon cancer by tricking the immune system. The discovery builds upon a century-old theory and opens up new possibilities for cancer vaccine research.
Researchers at MDC Berlin-Buch show that DNA methylation regulates the development of blood cells from hematopoietic stem cells, with implications for cancer. The study found that manipulating DNA methylation levels can control the formation of specific blood cell lineages.
SourceHelmholtz Association·JournalNature Genetics·DateOct 6, 2009