Articles tagged with Stem Cell Research
A study published in PNAS found that delivering stem cells on a polymer scaffold to treat large areas of missing bone leads to improved bone formation. However, the therapeutic effect is limited by the migration of stem cells away from the injury site, highlighting the need for improved delivery methods.
Scientists from University of Wisconsin-Madison present a new model of stem cell regulation in Caenorhabditis elegans, balancing stem cell maintenance and differentiation. The regulatory network defines two states - stem cell state and differentiated state - and regulates their balance.
Scientists at Queen Mary University of London have discovered that medulloblastomas, the most common type of children's brain cancer, can arise from a specific type of stem cell. This breakthrough finding may lead to new ways to tackle the disease and improve treatment outcomes for patients.
Chinese researchers have become a leading contributor to peer-reviewed scientific literature on clock-reversing regenerative medicine, with over 1,100 publications in 2008. New regulations aim to improve patient safety and restore China's global reputation.
Researchers found that MyoD activates CDC6 expression to promote rapid proliferation of muscle stem cells. The study suggests a new mechanism for muscle regeneration and highlights the importance of transcription factors in controlling cell cycle progression.
A recent study developed a straightforward technique to determine the ethnic origin of stem cells, finding that Caucasian and East Asian populations are overrepresented in current cell lines. The team created a new stem cell line with a West African Yoruba genetic profile, which could lead to more diverse research and safer therapies.
Researchers have identified a critical component, Jarid2, of the delicate balancing act between stem cell specialization and cellular chaos. The study reveals how Jarid2 recruits PRC2 to genes important in differentiation and modulates its activity to keep it poised for action.
Researchers found that vitamin C accelerates gene expression changes and promotes efficient iPSC generation. The study suggests a simple way to improve iPSC production, which can be considered a reversal of the aging process at the cellular level.
Researchers at the University of Pittsburgh School of Medicine have found that umbilical cord tissue contains a plentiful supply of stem cells that could be used to treat various muscle and bone disorders. The study reveals that these cells can be easily harvested from the tissue, expanded in number, and are remarkably stable.
A University of Michigan research team analyzed 47 embryonic stem cell lines and found they lacked genetic diversity, with most derived from northern and western European ancestry. The lack of diversity raises concerns about unequal access to therapies for certain groups.
The University of Maryland School of Medicine will coordinate a consortium of national experts in stem cell research, with a focus on regenerative therapy and new clinical therapies. The seven-year grant aims to advance the field at a faster pace and realize potential for new treatments sooner.
Researchers at the Broad Stem Cell Research Center found that tissue-specific genes are indeed marked by transcription factors, potentially crucial for stem cell function. The study suggests that faithful marking of these genes may be essential for pluripotency and efficient differentiation of stem cells.
Researchers discuss consent, privacy and clinical translation issues in iPS cell study. The emergence of iPS cells adds new challenges to the legal and social debates in stem-cell science.
Researchers at the North East England Stem Cell Institute have developed a successful stem cell therapy to treat Limbal Stem Cell Deficiency (LSCD), a painful and blinding disease. The treatment, which uses patients' own stem cells without immunosuppression, shows promise for restoring sight in hundreds of people.
Researchers have created human stem cell-derived neurons to model Alzheimer's disease and Niemann-Pick Type C, revealing early transport defects as a key factor in severe neuronal dysfunction. The study aims to understand how genetic differences affect cellular transport and behavior in these diseases.
A novel framework encourages adult stem cells to differentiate into heart cells by mimicking the elasticity alterations that occur in protein scaffolds. More cardiomyocytes were formed on this framework than with conventional techniques, suggesting improved cardiac differentiation.
Researchers from UCLA demonstrate that human blood stem cells can be engineered into cells that target and kill HIV-infected cells. This approach, similar to a genetic vaccine, could be effective against other chronic viral diseases. The study provides proof-of-principle for using this strategy in the human body.
Researchers found that stem cells from flies lacking SOCS protein had more integrin, allowing them to stick to the niche better than neighboring germline stem cells. This model can be applied to other stem cell niches such as cancer, where cancer stem cells become a danger when they become sticky.
Researchers at Helmholtz Munich have discovered a new source of nerve cell generation in the adult brain, specifically in the olfactory bulb. This discovery may lead to new therapeutic approaches for Alzheimer's disease, where nerve cell degeneration plays a crucial role.
Researchers at Hebrew University have developed a novel stem cell technology, immuno-isolation, to treat complicated bone fractures. The technology has been successfully used to treat seven patients with a combination of their own MSCs and blood products, offering a promising alternative to standard treatment methods.
A team of scientists led by Dr. Bernard Thébaud has demonstrated that stem cells protect and repair the lungs of newborn rats, boosting the power of healthy lung cells and preventing further damage. This research offers real hope for a new treatment for babies with chronic lung disease.
Researchers discovered that the peptide C3a regulates nerve cell maturation and migration in mice, which could lead to treating stroke, Parkinson's disease, and other neurological disorders. The study found that molecules similar to C3a can boost nerve cell formation and replace damaged cells.
Scientists have demonstrated that stem cells found in amniotic fluid can form three-dimensional aggregates of cells known as embryoid bodies, which suggests they may be useful for treating a wider array of diseases and conditions. The findings suggest that the amnion cells have greater potential than thought and may be able to form man...
Researchers at I-STEM Institute have made significant breakthrough in stem cell research by recreating a whole epidermis from human embryonic stem cells. The goal is to provide an unlimited resource of cells as an alternative treatment for victims of third-degree burns and patients with genetic diseases affecting the skin.
Researchers at Rice University and the Texas Heart Institute will label stem cells with gadonanotubes to track their effectiveness in regenerating damaged heart tissue. The team aims to use MRI to steer the cells in vivo with an external magnetic field.
Researchers found that transplanted stem cells restored learning and memory to normal levels in rats four months after radiotherapy. The treatment showed promise in reversing radiation-induced damage of healthy tissue in the brain.
Rhode Island Hospital has received a $11 million NIH grant to study stem cell biology and tissue regeneration in lung and marrow diseases. The research will focus on determining the true phenotype of marrow stem cells and their fate as tissue.
A Stanford study reveals that a gene linked to human longevity impacts the brain's ability to generate new neurons. Researchers found that mice without this gene had fewer neural stem cells and more rapidly churned out nerve cell precursors, leading to brain weight increases.
A new treatment approach using a radiolabeled antibody to deliver targeted doses of radiation followed by a stem cell transplant has been shown to be effective in treating advanced leukemia. Forty percent of patients achieved remission, with approximately 35% surviving three years.
Researchers have detected distinct molecular disparities between induced pluripotent stem cells and their parental cells, including differences in epigenetic signatures. These findings provide new insights into the fundamental nature of stem cells and may inform therapeutic applications.
A team of Cedars-Sinai Heart Institute researchers, led by Eduardo Marbán, received a $5.5 million grant to develop cardiac stem cell therapies for strengthening and healing damaged heart muscle caused by cardiac arrest. The goal is to create new treatments for heart attack patients in four years or less.
Adult stem cells from bone marrow have shown promise in preventing and treating acute lung injury by repairing damaged endothelial cells. Researchers found that these progenitor stem cells, named Flk-1 and CD34, can repair lung damage and improve survival when administered to mice with ALI.
Physician-researchers at USC have received a nearly $16 million grant to develop a stem cell-based treatment for age-related macular degeneration. The four-year study aims to replace damaged retinal cells with healthy ones derived from human embryonic stem cells.
Researchers have developed two experimental treatments that restored some vision to people with blinding eye diseases. A retinal prosthesis and fetal tissue transplant showed promise in human studies, improving visual acuity in several individuals with retinitis pigmentosa and age-related macular degeneration.
Embryonic stem cells exhibit sensitivity to localized cyclic forces due to their softness, affecting gene expression and differentiation. The study suggests that applying controlled mechanical forces could be a new method for directing cell behavior, with implications for therapeutic cloning and regenerative medicine.
Scripps Research scientists have made a breakthrough in creating stem cells from adult human tissue using three small drug-like chemicals. The new technique is 200 times more efficient and twice as fast than conventional methods, solving two major challenges in the development of stem-cell-based medicine.
Researchers at Case Western Reserve University are developing a novel approach to building vascular networks in engineered tissues using custom-designed synthetic molecules and embryonic stem cells. Their goal is to produce networks that can grow and maintain themselves like natural blood vessels, paving the way for improved human lives.
Researchers at the University of California, San Diego, have developed a new high-throughput cellular array technology that can identify the biological components leading to or alleviating liver disease. By controlling the environment surrounding star-shaped liver cells, they found critical proteins regulating HSC activation.
A study published in Stem Cells reveals human stem cells can immunize against colon cancer by tricking the immune system. The discovery builds upon a century-old theory and opens up new possibilities for cancer vaccine research.
Researchers at MDC Berlin-Buch show that DNA methylation regulates the development of blood cells from hematopoietic stem cells, with implications for cancer. The study found that manipulating DNA methylation levels can control the formation of specific blood cell lineages.
Researchers at MIT have successfully generated blood vessels near damaged tissue using enhanced stem cells equipped with genes producing growth factors. The breakthrough could lead to new treatments for infarctions and induced blood supply for engineered tissues.
Researchers at the Salk Institute have successfully reprogrammed umbilical cord blood cells to function like embryonic stem cells, creating a potential source for patient-specific stem cells. The new method reduces the need for expensive and time-consuming genetic modifications, making it a safer alternative for clinical applications.
Researchers found that moss shares basic development processes with humans and discovered a key component in stem cell programming. This discovery has implications for cancer research and could lead to better reprogramming of implanted stem cells.
University of Michigan researchers have successfully induced embryonic stem cells to differentiate into parathyroid cells producing a hormone essential for maintaining bone density. The goal is to prevent osteomalacia, a severe form of bone loss affecting tens of thousands in the US.
Masitinib targets mast cells and shows greater activity and selectivity against KIT than benchmark TKI imatinib. The study demonstrates masitinib's potential in treating KIT and PDGFR-dependent diseases, including various cancers, inflammatory diseases, and neurological indications.
Researchers at WPI's Life Sciences and Bioengineering Center have received funding from the NIH and NSF to study the bacterium that causes tuberculosis and develop engineered blood vessels. The work aims to create new treatments for infections and heart disease, and could lead to targets for a new class of antibiotics.
The Canadian Stem Cell Foundation has released a charter that unifies supporters of stem cell research, outlining five principles for advancing the field. The charter aims to promote responsible science, protect citizens, and empower the public to speak out on behalf of stem cell research.
UCSF researchers found private cord blood banking to be cost-effective only for families with high likelihood of needing a stem cell transplant. The analysis revealed that the process is more expensive than expected, with an additional $1,374,246 per life-year gained.
Researchers at Penn State College of Medicine have identified a population of cancer stem cells in the liver prior to tumor formation. These malignant stem cells have been found to be resistant to chemotherapy and are thought to play a key role in driving liver cancer formation. The study suggests that targeting these cells could poten...
Scripps Research scientists successfully corrected a genetic defect in mice with cystinosis, a rare and devastating disorder. The treatment involved bone marrow stem cell transplantation, which significantly reduced cystine levels and improved symptoms.
The 2009 Lasker Awards honor pioneering work in cancer and stem cell research, promising new therapies and a $700 million global market. Renowned scientists receive awards for their discoveries in nuclear reprogramming techniques and regenerative medicine.
Researchers identified two proteins, C/EBPα and β, that control the transition from stem cell to skin cell development in mice. Mice lacking these proteins had defective skin formation and died shortly after birth. The study sheds light on the mechanisms involved in skin cancer and other epithelial cancers.
A new study by University of Wisconsin-Madison researchers suggests that many mainstream scientists regularly work with journalists, contradicting the common perception that they are out of touch. The study found that senior researchers tend to interact most frequently with reporters.
The Rome meeting aimed to address the challenges of sharing biological research data and materials, highlighting the negative impact of restrictive licensing on genetically engineered mice and embryonic stem cells. The meeting recommended increasing investment in public databases and mouse repositories to facilitate efficient sharing.
Researchers have identified versatile cells in liposuction leftovers that can be quickly converted into induced pluripotent stem cells (iPS cells), potentially revolutionizing regenerative medicine. The study shows a 20-fold improvement in efficiency compared to skin cells, which are more challenging to reprogram.
Researchers at the University of Toronto have identified a protein called nSR100 that controls alternative splicing events in genes critical to nervous system formation. This discovery could provide new insights into brain complexity and neurodegenerative diseases like Alzheimer's.
Researchers engineered a chimeric protein that increases cell survival, migration and proliferation to improve liver stem cell engraftment. The protein, TAT-Tpr-Met, was shown to increase the number of hepatic stem cells integrated into the liver of mice.
Researchers have successfully modified a human embryonic stem cell line to glow red when it becomes a red blood cell, representing a significant step towards generating mature red blood cells from human stem cells. This breakthrough could aid in tracking the differentiation of embryonic stem cells into specific cell types.
Only two human embryonic stem cell lines, H1 and H9, have been used routinely in research, with the majority of requests coming from these lines. This finding raises concerns about the impact on future research and the need for a more diverse range of cell lines.
Scientists identify key molecular players responsible for reversion of adult cells into a primordial, stem cell state. By reducing activity of Jak and STAT proteins, researchers found fewer cells to revert back to stem cells, with only 60% regaining their stem cell population.