Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Researchers at UT Houston are conducting a Phase I safety trial using patient's own stem cells to treat strokes. The study aims to reduce disability in patients and could be an exciting new therapeutic approach.
Researchers have made a groundbreaking discovery in the treatment of bone injuries, using teriparatide to jumpstart the body's natural healing process. The study shows significant healing and pain control in patients with unhealed bone fractures, offering new hope for those with no effective treatment options.
A study by Pitt researchers found that injecting human corneal stem cells into mice with scarred and hazy eyes restored transparency. The cells were able to remodel scar-like tissue back to normal, suggesting a potential treatment for corneal blindness and vision impairment.
Researchers discovered the JunB gene's role in regulating hematopoietic stem cells, which produce blood cells. The study suggests that JunB can help prevent leukemia by limiting cell proliferation and differentiation.
Research led by David Hess identified how to use bone marrow stem cells to grow new blood vessels in mice with ligated leg arteries. These pro-angiogenic stem cells have a natural ability to induce blood vessel repair and improve blood flow in ischemic limbs.
Researchers develop novel method to identify stem cells in pancreas, showing acinar cells produce digestive enzymes and may have carcinogenic properties. The breakthrough paves the way for further study on proliferation mechanisms and potential dangers of these cells.
A new dual therapy approach generates new blood vessels and improves cardiac function following a heart attack, overcoming current stem-cell-mobilizing therapies' ineffectiveness in humans. This strategy stabilizes SDF-1 and enhances the recruitment of EPCs to damaged heart tissue.
Researchers at Helmholtz Munich have discovered the last step leading to blood cell formation, which has important implications for the development of new therapies. The study found that a special type of endothelial cell can transform into blood cells, providing a key insight into the mechanisms of hematopoiesis.
A team of American researchers has developed a genetic switch that allows mutations or light signals to be turned on in muscle stem cells, enabling monitoring of muscle regeneration in living mammals. This breakthrough could lead to the creation of a genetic switch or drug for humans to grow new muscle cells and treat muscular dystrophy.
Researchers at St. Jude Children's Research Hospital have found that cells isolated from the eye are not retinal stem cells, contradicting previous findings. Instead, they suggest that re-engineering stem cells to develop photoreceptor cells could be a promising approach to restore vision in people with retinal degeneration.
A team of scientists has developed a new method to create stem cells with embryonic-like properties without using viruses, which can trigger cancer. This approach imports necessary genes on a small DNA circle and naturally disappears from the cell population over time.
Researchers at USC have identified a key mechanism that guides the migration of blood-forming stem cells to the bone marrow. The finding may lead to improved efficiency in bone marrow transplants by activating a specific signaling pathway.
A breakthrough study has revealed that blood stem cells produce chemical signals of their own that influence their attachment to the bone marrow or migration into the circulatory system. This discovery holds implications for improving leukemia treatment and artificially culturing infection-fighting immune cells.
Researchers have successfully isolated human auditory stem cells from fetal cochleae and found they can differentiate into sensory hair cells and neurons. This breakthrough has the potential to develop a new treatment for deafness, with implications for studying ear development and modeling drug screening.
Researchers at Rensselaer will investigate the role of specific genes and biological molecules in human stem cell function. They aim to understand how to control stem cell development using a range of new technologies.
Researchers have discovered that the Shp2 protein plays a critical role in controlling the pathways that decide whether human and mouse embryonic stem cells differentiate or self-renew. The study found that Shp2 acts as a coordinator to fine-tune signal strength, providing insight into fundamental signaling mechanisms.
A newly identified molecular pathway directed stem cells to produce glial cells, providing insights into the neurobiology of Down's syndrome and central nervous system disorders. The study found that synaptojanin-1 is essential for glia production, which may lead to the development of drugs that inhibit glial proliferation.
Researchers reported on eight patients with spinal cord injury (SCI) who received multiple route bone marrow stem cell injections, showing functional improvements such as bladder control. The study demonstrated the safety and feasibility of multiple route administration of bone marrow-derived stem cells for SCI treatment.
The Empire State Stem Cell Board has awarded Albert Einstein College of Medicine $12.7 million to support promising medical advancements, including treatments for sickle cell anemia and obesity. The new grants will help create technologies for cancer, heart and liver disease, as well as age-related diseases.
Researchers have successfully tracked and confirmed the survival of stem cells in the body using a firefly-like bioluminescence imaging agent. This innovative technique enables precise targeting of stem cell delivery to specific blood vessels, opening new hope for treating peripheral arterial disease.
Scientists have successfully replaced damaged brain tissue in rats with stem cells, filling cavities within 7 days. The new tissue interacts with the host brain and can be gradually replaced by natural processes.
Penn Vet researchers identified colony stimulating factor 1 (Csf1) as a growth factor that enhances sperm stem cell self-renewal. The study reveals that Leydig cells secrete Csf1, which interacts with the microenvironment to support stem cell function.
Researchers have discovered a new pathway that prompts stem cells to specialize into blood cells, providing hope for regenerating the blood system in patients with leukemia or undergoing cancer treatments. The Canadian Cancer Society funded this research, which could lead to more efficient production of blood cells.
Researchers have developed a world-first procedure to regrow muscles in a mouse model, which could be applied to human tissue-based illnesses such as liver or brain diseases. The technique strengthens adult stem cells' ability to regenerate damaged tissue by making them resistant to chemotherapy.
Scientists at McMaster University have identified a key communication pathway that triggers stem cells to specialize and become blood cells in humans. The noncanonical Wnt pathway works by organizing cells to respond to signals for blood development, providing an efficient way to produce blood cells.
Researchers at McGill University Health Centre discover a new pathway that controls bone remodelling with interferon gamma. Interferon gamma may become an efficient drug-target for treating osteoporosis.
Researchers at Stanford University School of Medicine have developed a technique to generate solid organs using stem cells. By utilizing microcirculatory beds and a bioreactor, the team can keep tissue healthy enough for reimplantation into a second animal, overcoming the major hurdle of blood supply in tissue engineering. The techniqu...
Dr. Nagy's method uses a novel wrapping procedure to deliver specific genes, overcoming major hurdles for personalized stem cell therapies. The breakthrough accelerates stem cell technology and provides a road map for new clinical approaches to regenerative medicine.
A new approach to generate induced pluripotent stem (iPS) cells has been developed by Austin Smith's team. They used a single reprogramming factor called Klf4 and a transposable element called Piggybac to persuade partly specialised mouse cells to reprogram into iPS cells.
Researchers have successfully used stem cells to grow on a scaffold made from tissue extract, overcoming two key challenges for organ transplantation. This breakthrough enables the creation of bioengineered organs that can be transplanted without rejection.
Researchers at UCR identified all the genes expressed in plant stem cells, providing a global view of which genes are expressed and where within the shoot apical meristem. This discovery can help scientists develop better varieties of crops and understand why stem cells give rise to specialized cells.
A Johns Hopkins engineer is working on coaxing human stem cells to form new blood vessels that could replace damaged tissue in people with heart disease and other illnesses. The researcher, Sharon Gerecht, aims to understand the molecular signals that cause stem cells to differentiate into blood vessels.
A rare case of a boy with Ataxia Telangiectasia developed abnormal growths in his brain and spinal cord four years after receiving human fetal stem cell therapy. The tumors were found to be benign neural tumors that could not have arisen from the patient's own tissues, highlighting the need for caution in stem cell therapy.
Researchers at UT Houston are launching a Phase I study to treat acute stroke victims with their own stem cells, harvested from bone marrow. The goal is to assess the safety and potential benefits of this treatment in reducing disability.
Researchers have discovered a signaling pathway involved in normal pancreatic development is also associated with type 2 diabetes. The Wnt signaling pathway is up-regulated in insulin-producing cells of pancreases from adults with type 2 diabetes.
Researchers at the University of Wisconsin-Madison have made a breakthrough in growing functional heart cells from induced pluripotent stem cells, paving the way for potential therapies for heart failure patients. The discovery uses a virus to reprogram skin cells into embryo-like states and could potentially lead to new treatments.
Researchers at Baylor College of Medicine have identified two critical genes, Scl and Lyl1, that work together to maintain a pool of hematopoietic stem cells. These 'sister' genes are essential for the survival and function of blood-system stem cells, and their dysfunction can lead to severe consequences.
Scientists have discovered a chemical that prevents stem cells from turning into other cell types, allowing researchers to grow larger stocks of these cells. This breakthrough has huge potential for treating diseases and injuries without current cures.
UT Southwestern researchers discovered that mice without the AGPAT2 enzyme accumulated excessive liver fat, leading to metabolic complications. A fat-free diet reduced liver triglycerides by approximately 50% in these mice.
Researchers at UC San Diego have developed a novel method to accelerate bone growth using nanotubes and stem cells, which could lead to quicker recovery times for patients undergoing orthopedic surgery. The new method uses mesenchymal stem cells placed on top of titanium oxide nanotubes to control cell differentiation into osteoblasts.
The University of California, San Francisco (UCSF) has received tentative approval for a comprehensive stem cell training program, designed to cultivate the next generation of stem cell scientists. The three-year grant, totaling $3.9 million, will support six graduate students, six postdoctoral fellows, and four clinician-scientists.
The University of California, Irvine has received a $3.3 million grant to expand its stem cell training program, which will attract top talent and develop more physician-scientists engaged in stem cell research. The program will train researchers to cross disciplines and develop new disease treatments.
Researchers found that ordinary plant cells can replace lost organs and tissue without the need for stem cells, a function previously thought to be exclusive to stem cells. The study suggests that plants can regenerate without stem cells through a process of reprogramming.
A study found that transplantation of stem cells from the spinal cord lining reverses paralysis in laboratory tests. The transplanted cells regenerated ten times faster than similar cells from healthy control animals.
A therapy developed at UC Irvine will become the world's first embryonic stem cell treatment tested in humans, targeting patients with acute spinal cord injury. The U.S. FDA has approved a clinical trial led by Geron Corp., which aims to restore electrical conduction and mobility in paralyzed individuals.
A study by Ralph Brinster found that males housed with females had a six-month delay in fertility decline, compared to those without companionship. This could have significant implications for male fertility in wildlife and human populations.
Researchers led by Nancy Speck identified the location and developmental timeline of bone marrow stem cell formation in mouse embryos. Understanding this process may help manipulate embryonic stem cells to generate new blood cells for therapy.
Researchers have developed a new technique to mobilize specific types of adult stem cells into the bloodstream using new drug combinations. This method aims to accelerate tissue regeneration and repair in cases of heart disease or sports injuries, potentially treating autoimmune diseases like rheumatoid arthritis.
Researchers at Boston University have created a more efficient way to generate induced Pluripotent Stem (iPS) cells using a single lentiviral vector. This breakthrough reduces the risk of genomic integrations and cancer-causing genes, paving the way for human clinical trials.
A key gene has been identified as a factor in maintaining the potency of various stem cells, preventing them from differentiating into specialized cell types. The scrawny gene modifies chromosomal proteins to silence genes that would cause differentiation, ensuring stem cells remain undifferentiated.
Researchers at Hebrew University have made significant breakthroughs in reversing brain birth defects in animal models by using stem cells to replace defective brain cells. In their study, Prof. Joseph Yanai and his team demonstrated that stem cells can induce the host brain to produce large numbers of stem cells, repairing damage and ...
Scientists have developed a cocktail that can capture and maintain indefinitely the most fundamental of embryonic stem cells from essentially any mammal. The discovery allows researchers to produce genetically altered strains of rats with conditions mimicking human disease in a targeted way, making it easier to study human diseases.
Researchers at USC have successfully derived authentic embryonic stem cells from rats, which will facilitate the creation of animal models for studying human diseases such as cancer and diabetes. This breakthrough finding represents a major advancement in stem cell research.
Researchers have developed a method to create novel types of stem cells, offering opportunities for expanding research and drug discovery. The technique enables the creation of rat and human pluripotent stem cells with characteristics similar to mouse embryonic stem cells.
Thomson's discovery of human embryonic stem cells and development of induced pluripotent stem cells launched the field of stem cell science. His work has the potential to help find the root cause of disease, test new drugs at the human cellular level, and offer regenerative therapies.
Leukemia takes over bone marrow niches, crowding out healthy stem cells. Blocking cancer cell chemical signals could help protect stem cells and improve treatment strategies. Researchers develop approach to blunt leukemia's effect on stem cells, potentially boosting immune system response.
Scientists at St. Jude Children's Research Hospital have discovered that normal stem cells can give rise to tumors in mature solid tissues, including the intestine. The study identifies Prominin1 as a molecular marker for normal stem cells, which can act as the source of cancerous tumors.
A leading British researcher predicts a boom in stem cell drug testing under Obama's administration, offering a viable alternative to animal-based heart cell tests. The UK has already established a special public-private research program to harness the potential of human embryonic stem cells for safer medicine.
A new study from the University of Pennsylvania School of Medicine has identified stem cells in the esophagus that can grow into functional tissue. The researchers found that these stem cells can repair damaged tissue and potentially treat conditions like GERD and Barrett's esophagus, a precursor to esophageal adenocarcinoma.
Researchers successfully monitored transplanted stem cells using bioluminescent imaging and iron oxide, enabling non-invasive tracking. Three different labeling methods were evaluated for their reliability in detecting transplanted mensenchymal stem cells, with DAPI labeling showing promising results.