Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Researchers from Penn Medicine found that increased activity of the Wnt pathway leads to expansion of lung stem cells. This discovery could hold promise for therapies to repair lung tissue after injury or disease.
Researchers developed a method to track mesenchymal stem cells in tumors using noninvasive molecular imaging technology. The technique offers promise for personalized medicine and gene-modified stem cell therapies to fight cancer.
Researchers at UNC have shown that transplantation of adult stem cells can improve healing of fractures in animal models. The study provides a scientific foundation for future clinical trials and could lead to a new treatment for millions of people suffering from bone union failure.
Researchers identified two key pathways controlling adult stem cells' repair and replacement abilities. By tweaking these pathways, they revived the ability of old mice's muscle tissue to repair itself nearly as well as younger counterparts.
Researchers at UT Southwestern Medical Center have created a small molecule, Isx-9, that can stimulate nerve stem cells to mature into nerve cells. This breakthrough could lead to new treatments for diseases such as Huntington's disease and brain cancer.
Researchers at the Genome Institute of Singapore have identified over 3,000 genomic hotspots critical for maintaining embryonic stem cell state. These findings may lead to the development of an inexhaustible source of clinically useful cells for regenerative medicine.
Researchers discover at least one or two additional types of adult stem cells beyond Bmi1-expressing cells, found primarily in the upper third of the intestine. This finding complicates stem cell therapy for diseases such as Parkinson's and heart disease, requiring recognition of organ-specific stem cell complexity.
Public attitudes toward embryonic stem cell research are influenced more by religious values and deference to scientific authority than scientific knowledge. For highly religious audiences, understanding the science has no effect on their views, while for less religious individuals, it is linked to more positive attitudes.
Researchers at Rush University Medical Center present pre-clinical data on a CD26 Inhibitor that increases the efficiency and responsiveness of umbilical cord blood for bone marrow transplants. The technology may improve treatment outcomes for blood cancer patients who require stem cell transplantation.
Scientists at Schepens Eye Research Institute have identified specific molecules that awaken dormant brain stem cells, which can transform into neurons and repair damaged brain tissue. The findings suggest that tapping the brain's regenerative potential may be a promising approach for treating neurodegenerative diseases.
The study found that the UK and Israel produced substantially more research in human embryonic stem cells than other fields. In contrast, Australia showed a modest result due to its mixed policy on stem cell research. The US is still the largest producer of research in this field but lags behind when compared to other similar fields.
Researchers at Johns Hopkins have established a human cell-based system for studying sickle cell anemia by reprogramming somatic cells to an embryonic stem cell-like state. The new method improves reprogramming efficiency and increases the total number of reprogrammed cells, enabling future studies on blood diseases.
Researchers at UCLA identified a type of leukemia stem cell and uncovered the genetic mechanisms that cause normal blood stem cells to become cancerous. This discovery may lead to new therapies targeting these stem cells, potentially curing certain cancers.
Researchers at OHSU have developed new antibodies that can recognize pancreatic cancer and gastrointestinal cancers. These antibodies show promise in early detection and treatment of pancreatic cancer, which is the fourth-leading cause of cancer death in the US.
Researchers at USC have discovered a method to keep embryonic stem cells undifferentiated by shielding them from differentiation signals. This breakthrough could lead to the large-scale production of specialized cells for future therapeutic use.
Researchers have identified a specific gene expression profile of prostate cancer stem cells, revealing key pathways and potential therapeutic targets. The study's findings offer new hope for treatments targeting the rare but aggressive cancer stem cells.
Researchers have identified an embryonic pathway that confers adult stem cell properties to both normal and cancer cells undergoing epithelial-to-mesenchymal transition, offering a potential route to generate unlimited numbers of stem cells. This discovery has major implications for regenerative medicine and cancer treatment.
The study identifies GATA4 and GATA6 as crucial proteins controlling heart cell formation. Without these proteins, embryonic stem cells fail to develop normal hearts. The findings have significant implications for the production of heart cells from stem cells and may help unravel the mechanisms behind congenital heart disease.
Researchers at Hebrew University of Jerusalem demonstrate the exact mechanism by which embryonic stem cells develop into specific cell types. The study reveals that ES cells express a large proportion of their genome in an 'open and active' state, enabling them to become any cell type before undergoing global genetic silencing.
The University of California, Santa Barbara will receive a $3.2 million grant from the California Institute for Regenerative Medicine to develop a state-of-the-art stem cell research facility. The center aims to foster interdisciplinary research and translation of stem cell-based therapeutics for human diseases.
The University of Southern California will establish a five-story laboratory building with 53,000 assignable square feet to carry out stem cell research in three categories. The new facility will facilitate basic and clinical research, accelerating the pace of research toward clinical application and patient care.
The UCI Sue and Bill Gross Stem Cell Research Center will house up to 26 researchers, a master's program in biotechnology, and programs educating patients and the public. The facility is expected to advance stem cell therapies for treating spinal cord injuries and other diseases.
A new study by UC Davis researchers provides evidence that methods using human bone marrow-derived stem cells to deliver gene therapy do not cause the development of tumors or leukemia. The study tested the safety of gene transfer into bone marrow stem cells in over 600 mice, with none developing leukemia or solid tumors.
Researchers at Baylor College of Medicine found that the association between Nanog and Oct4 proteins with transcription repression complexes determines embryonic stem cell fate. The complex, called NODE, contains histone deacetylases that control gene expression.
A new study by researchers at the University of California, San Francisco found that brief exposure to secondhand smoke can cause blood vessel injury in young and healthy nonsmokers. The study also showed that smoke exposure impairs the body's natural repair mechanisms, leading to persistent effects on vascular health.
StemCyte's move to New Jersey is driven by collaboration with Rutgers and a desire for proximity to groundbreaking research. The company will house its executive management and therapeutics team at the new office, which will support its northeast US operations.
Researchers have found a new model to explain how signals between cells in the embryo control limb development. Growth factors at the distal tip of the embryonic limb act as instructive molecules controlling bone pattern along the limb length in an animal model.
Researchers identified adult stem cells in the pituitary gland of mice that can adapt to traumatic stress or normal life changes. These cells are distinct from embryonic stem cells and have a more limited repertoire, but still play a crucial role in maintaining the organ's function.
Researchers at University Medical Center Utrecht have successfully grown large numbers of stem cells from adult human hearts into new heart muscle cells. The stem cells can be used to study cardiac arrhythmia, test new medicines, and potentially repair damaged heart tissue. This breakthrough in stem cell research could move forward res...
Researchers have identified menstrual blood as a valuable source of multipotential stem cells, which can differentiate into various cell lineages. The study found that these cells exhibit self-renewal and multipotency properties, making them suitable for regenerative transplantation therapies.
Researchers at UT Southwestern Medical Center used a drug-treated blood stem cell compound to transform human blood stem cells into immature heart cells. This helped improve the function of injured rodent hearts and may lead to new treatments for heart attacks.
Researchers have identified a cell that can produce enough of a person's own cartilage to treat cartilage lesions and mark the onset of osteoarthritis. This breakthrough could lead to effective transplantation of transplanted cells into damaged joints, overcoming current limitations in treating arthritis.
Researchers are investigating whether embryonic stem cell-derived tissues can be accepted by the immune system, paving the way for new treatments. The study suggests that ES cells display an underlying immune privilege, which could be harnessed to promote regulatory T-cell activity and suppress immune activation.
Researchers aim to understand the mechanisms that regulate stem cell function, which may contribute to malignant brain tumor formation. The study finds similarities in stem cell regulation and cancer tumor maintenance, potentially paving the way for targeted therapies.
Researchers have found that a key gene called Apc plays a crucial role in controlling adult stem cells and preventing tumours. The study suggests that when this gene is lost or damaged, the normal function of adult stem cells breaks down, leading to cancer. This research has important implications for using adult stem cells for therapy.
Researchers have uncovered a complex signaling system that instructs adult stem cells to contribute to tissue repair in response to chemical signals. The study, funded by the Medical Research Council, holds promise for developing techniques to control adult stem cells for therapeutic use.
Researchers are developing cell-scaffold combinations to provide a framework for neural stem cells to regenerate lost brain tissue after stroke. The approach aims to support the growth of new tissue and promote functional repair, paving the way for potential clinical applications in stroke and neurodegenerative diseases.
A team of scientists at the Joslin Diabetes Center has identified a key regulator of hematopoietic stem cell migration and proliferation, which could lead to improved bone marrow and blood cell transplants. The discovery also holds promise for treating type 1 diabetes and enhancing recovery from infections after transplantation.
Dame Anne McLaren was a pioneer in embryonic germ cells and contributed to IVF treatments. Prof Christine Mummery will honor her memory with a keynote lecture on advances in stem cell research, highlighting its potential for treating diseases like heart damage.
New study finds blood-forming stem cells can survive without Notch signals, allaying fears of damage during chemotherapy. The findings have implications for a high-profile breast-cancer drug trial combining chemotherapy with a Notch inhibitor.
A new drug candidate, TG101348, has been developed to treat a rare class of blood diseases called myeloproliferative disorders (MPD). The drug, which targets the JAK2 protein that causes overproduction of red blood cells, shows promise in halting disease progression and reversing excessive production of red blood cells.
Researchers have discovered that stem cells isolated from hair follicles can differentiate into smooth muscle cells that grow new vasculature, making them ideal for engineering cardiovascular tissue regeneration. This breakthrough may lead to the development of new treatments for vascular grafts and cardiac tissue regeneration.
Researchers at Yale University have successfully created new neurons using uterine stem cells, which increased dopamine levels and partially corrected Parkinson's disease symptoms in mice. This breakthrough has significant implications for the development of a potential human treatment.
A Northwestern University team has developed a method to assemble polymer and small molecule into flexible but strong sacs that can grow human stem cells. The sacs have been shown to survive for weeks in culture, allow proteins to pass through the membrane, and even self-repair damaged membranes.
Researchers from UCLA used high-resolution technique array CGH to examine the genome of two human embryonic stem cell lines, finding differences in gene numbers that could impact disease susceptibility and therapeutic applications. These differences can provide a unique genetic fingerprint for each line, enabling researchers to choose ...
Researchers at Memorial Sloan-Kettering Cancer Center have successfully used therapeutic cloning to treat Parkinson's disease in mice. The method involves generating customized dopamine neurons from the patient's own skin cells and transplanting them into the mouse, resulting in neurological improvement.
Researchers are exploring stem cell transplants to provide insulin cells for a bioartificial pancreas, addressing the shortage of human pancreatic islet tissue. They also aim to target and destroy cancer stem cells to improve therapies and develop reversible immortalized cell lines.
Injecting human umbilical cord blood cells (UCBC) into aged laboratory animals rejuvenates the hippocampus region of their brains by reducing inflammation and increasing neurogenesis. This study presents a potential cell therapy approach to improve brain function in aging individuals.
A new stem cell technique has been developed by UC Irvine researchers, which blends two existing methods to improve cell survival rates and increase the efficiency of inserting DNA into cells. This approach is up to 100 times more efficient than current methods at producing human embryonic stem cells with desired genetic alterations.
Researchers have made a groundbreaking discovery about the origin of blood stem cells, finding that they are generated in the placenta. The study's findings may allow for the growth of blood stem cells in cell culture, potentially leading to new treatments for diseases like leukemia and aplastic anemia. By understanding how blood stem ...
Recent research suggests adult stem cells from blood or marrow may provide treatment benefits for certain autoimmune diseases and cardiovascular disorders. The studies indicate that these cells can contribute to modest improvement in cardiac function, but more clinical trials are needed to determine their effectiveness.
Researchers are developing a new approach to treat conditions like osteoarthritis and trauma injuries using patient-derived stem cells. The 'bioactive scaffold' protects the stem cells, simulating their growth into bone or cartilage in the affected area.
ASU researcher Daniel Sarewitz argues that excessive direct democracy in science funding can result in abuse and a loss of credibility. He suggests that representative democracy is more effective, allowing for informed decision-making and consideration of complex issues.
UCLA stem cell scientists have successfully reprogrammed human skin cells into embryonic stem cells without using embryos or eggs. This breakthrough uses genetic alteration to turn back the clock on human skin cells and create cells nearly identical to human embryonic stem cells, which can become every cell type in the human body.
Researchers have developed a transparent zebrafish that allows direct observation of internal organs and processes like tumor metastasis and blood production. The study reveals cancer cells' ability to 'home' to specific locations, enabling scientists to better understand disease progression.
A recent study from Rockefeller University has discovered the protein NFATc1, which regulates hair growth and maintains stem cell potency. The research suggests that these stem cells do not need prolonged resting periods to maintain their abilities.
Researchers have designed an implantable cell retriever and reprogrammer that can isolate and manipulate specific cell populations with great efficiency. The device uses the mechanics of blood flow to capture viable stem cells, which are rare in the bloodstream.
The University of Southern California (USC) has been selected for a major funding round to establish a new institute for stem cell research. The grant, worth up to $262 million, will support the construction of a facility for basic and discovery stem cell research, as well as preclinical and clinical studies.
A study by UCI researchers has identified the Lhx2 gene as the long-sought cortical creator gene, instructing stem cells in the developing brain to form the cerebral cortex. This finding could potentially be used in stem cell research efforts to grow new cortical neurons to replace damaged ones.
Researchers at USC have identified a novel signaling mechanism that coordinates stem cell activity and regulates hair regeneration in large populations of hairs in animal models. The study found that periodic expression of bone morphogenetic protein (Bmp) in the skin macro-environment is key to coordinated hair stem cell activation.