Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Researchers successfully recreate a functional stem-cell niche in adult mice, enabling further study of stem cell development and fate. The discovery has potential implications for leukemia treatment and bone healing.
A UC Riverside study reveals that harm-reduction cigarette smoke retains toxicity and can adversely affect reproductive development in mice and may pose risks to human pregnancies. The research found that both mainstream and sidestream smoke from traditional and harm-reduction brands are toxic to pre-implantation embryos.
A new clinical trial has demonstrated the safety of expanding umbilical cord blood stem cells before transplanting them to patients with advanced leukemias or lymphomas. The study found that expanded stem cell technique is comparable to standard double-cord transplant and shows promise for improved engraftment and survival.
Two studies examine the impact of cord blood, peripheral blood, and bone marrow on transplant success rates in adults with acute leukemia. The research reveals that mismatched cord blood transplants can be a suitable alternative to bone marrow or peripheral blood transplants.
Researchers at M.D. Anderson Cancer Center analyzed over 1,100 blood stem cell transplantations and found that older patients (65+) do not have poorer outcomes compared to younger patients. The study also showed that disease type and status at transplant are key prognostic variables for survival.
UC Davis researchers are exploring a new gene therapy approach to cure AIDS by replacing HIV-infected immune cells with HIV-resistant ones. They plan to conduct safety and efficacy trials using a mouse model before moving on to human clinical trials.
The Linheng Li Lab has identified the precise location of the bone marrow stem cell niche, building on previous discoveries. The findings reveal a special zone that includes both osteoblastic and endothelial components, which maintains HSCs in their resting state and promotes expansion in response to stressors.
Researchers at UCLA have discovered that blood stem cells are made by endothelial cells during mid-gestational embryonic development. This finding has significant implications for the treatment of blood disorders and cancers, as it could lead to new therapies for conditions such as leukemia.
Researchers at Tufts University have discovered that changes in membrane voltage control the timing of differentiation in adult human stem cells. The study found that hyperpolarization is a characteristic of differentiated cells and acts as an instructive signal to induce or inhibit differentiation.
Researchers have effectively repaired damaged heart muscle using a novel population of stem cells derived from human skeletal muscle tissue. The transplanted myoendothelial cells improved heart function and reduced scar tissue, showing promise for regenerative medicine therapies.
Researchers successfully produce pure insulin-producing cells from mouse embryonic stem cells, showing efficacy in treating diabetes in lab models. The findings provide proof of principle for applying this strategy to human ESCs and offer avenues for further research.
Researchers at the University of Utah are enrolling patients in a clinical trial using their own bone marrow cells to regenerate heart muscle and improve blood flow. The study aims to improve heart function and quality of life for those with congestive heart failure.
Researchers from Cedars-Sinai Heart Institute will share findings on regenerating heart tissue using stem cells, a mutant gene therapy strategy to protect against heart disease, women's rapid onset of heart disease, and the effectiveness of new medication prasugrel in preventing ischemic complications.
Researchers at Yerkes National Primate Research Center discovered dental pulp stem cells can stimulate growth of neural cells, showing therapeutic potential for diseases like Huntington's and Parkinson's. The study suggests dental pulp stem cells may be used in cell therapy and regenerative medicine.
Researchers at USC have identified Ryk protein as a key regulator of neural stem cell differentiation into neurons. The study provides insight into potential therapies for neurodegenerative disorders and cancers, with implications for regenerative medicine and cancer treatments.
Researchers at Stanford University School of Medicine discovered that Wnt-responsive cells in embryoid bodies spontaneously form a primitive streak, which is a hallmark of gastrulation. The study suggests that understanding this process can help direct the differentiation of embryonic stem cells for therapy.
Researchers have identified two small molecule compounds, BIX and BayK, that can replace conventional reprogramming genes, enabling the selective reprogramming of general cells into pluripotent stem cells. This breakthrough technology offers a more precise control over the process and has distinct advantages over genetic manipulation.
Scientists at Karolinska Institutet discovered skin stem cells can divide actively and transport themselves through skin tissue, contradicting previous assumptions. The study's findings also suggest a link between hedgehog signaling and the development of basal cell carcinoma, the most common form of skin cancer.
Research reveals a connection between mitochondrial activity and stem cell differentiation, with high-metabolism cells more prone to forming tumors. Administering a mitochondrial inhibitor reduced teratoma capacity in these cells, suggesting a potential therapeutic strategy.
Researchers at Stanford University School of Medicine have pinpointed the crucial role of Rb proteins in regulating blood stem cell division, finding that blocking their function leads to abnormal proliferation and immune system disruption.
Researchers at Einstein and Montefiore will focus on developing new therapies for Alzheimer's, diabetes, Parkinson's, ALS, and other conditions. They aim to create unique stem cells derived from patients with blood diseases like sickle cell anemia and hemophilia.
Research shows corneal epithelium contains stem cells that generate two different epithelial tissues, contradicting prevailing opinion. These cells are activated in everyday renewal, while limbal stem cells respond to serious injuries.
The Broad Institute will create comprehensive epigenomic maps of human cells, including embryonic stem cells and adult stem cells. The five-year grant aims to transform the understanding of gene expression control using cutting-edge technologies like ChIP-Seq and HTBS.
A recent survey found that most infertility patients support using leftover embryos for stem cell research, with 73% in favor. However, there is a growing demand from patients who want to sell their extra embryos to others, with 56% approving of the practice.
Researchers at Indiana University discovered that healthy endothelial cells lining blood vessels can reduce the tendency of precursor cells to develop into fat cells. This finding could lead to new treatment options for cardiovascular diseases and obesity.
Two UC San Diego faculty members, Karen Christman and Seth J. Field, received $1.5 million grants from the NIH to support their cutting-edge research in tissue engineering and lipid signaling molecules. Their projects aim to improve human health through regenerative medicine approaches.
Researchers at Children's Hospital of Pittsburgh have identified pericytes as a promising source of multipotent adult stem cells. These cells can be extracted easily from blood vessels and grown in culture to produce various types of tissues, including bone, cartilage, and muscle.
Scientists have identified distinct gene combinations that define different stem cell types, revealing a single key factor controlling their behavior. This breakthrough has significant implications for manipulating and engineering stem cells to treat human degenerative disorders.
Scientists have made a breakthrough in treating spinal cord injuries by manipulating stem cells to promote nerve regeneration. The research focused on astrocytes and found two distinct sub-types with robustly different effects when transplanted into injured adult nervous systems, offering hope for victims of paralysis.
Researchers have found a gene in flatworms that is highly similar to the human gene PTEN, which is frequently mutated in cancer. Disruption of this pathway leads to abnormal growths and cell death, making it an important model for studying human stem cells and cancer.
Researchers at Stanford University School of Medicine confirmed that satellite cells harbor an elusive muscle stem cell, which can self-renew and give rise to specialized progeny. This discovery has profound therapeutic implications for disorders like muscular dystrophy and muscle wasting due to aging.
Studies in mice reveal that women who have children young have fewer mammary stem cells, which could contribute to lower breast cancer risk. Researchers plan to investigate further to determine the mechanism behind this protective effect and explore potential treatments.
Researchers at Mayo Clinic have successfully used stem cells to regenerate heart tissue and repair dilated cardiomyopathy, a genetic defect. The treatment improved heart performance, synchronized electrical impulses, and halted deterioration in genetically altered mice with heritable dilated cardiomyopathy.
Researchers have isolated cancer stem cells using a specific protein that only appears in these cells, opening the door for new therapy targeting them. This could lead to a reduction in cancer recurrence by killing stem cells before they can divide.
Researchers have developed a drug-inducible system to generate human induced pluripotent stem (iPS) cells with high efficiency. The new method requires less time than previous approaches and shows promise for development of cell therapies.
Researchers developed a novel method using human embryonic stem cell secretions to reduce tissue injury after a heart attack. The approach significantly improved heart function and reduced tissue death by 60%, offering a promising therapeutic option for heart attack patients.
Researchers at Tel Aviv University have developed a new classification system for identifying pluripotent stem cells in human tissue. By analyzing global gene expression profiles from 150 human stem cell samples, the team discovered a protein-protein network common to pluripotent cells, pointing to a key building block of their transfo...
Researchers at Durham University have developed two synthetic molecules that can direct stem cells to 'differentiate' into specific tissue types, improving the reliability of experiments and potentially reducing animal use. The new molecules, EC23 and EC19, are more stable than natural compounds currently used in laboratory research.
Scientists discovered the earliest form of human blood stem cells, called hemangioblasts, which can be replicated in unlimited supply using ACE as a marker. This breakthrough could lead to new treatments for heart diseases, anemias, leukemia and autoimmune diseases by mass-producing progenitor blood cells.
Research reveals that certain adult stem cells are more active than previously thought, actively controlling their behavior through the interaction between laminin A and integrins. This interaction enables follicle stem cells to remain in place, primed for division, by laying down laminin A to build their own niche.
Five UCSF faculty members have received $13.7 million in funding from the California Institute for Regenerative Medicine to explore fundamental questions about embryonic stem cells and develop treatment strategies for conditions such as cancer and liver disease. The researchers will investigate molecular mechanisms, cell specialization...
Rutgers University has received a $3.2 million grant from the NSF to equip experts in fields such as cell and molecular biology, computational modeling and biomaterials to move stem-cell breakthroughs from the biology lab into practical therapies. The program will also support training for underrepresented minorities and enhance divers...
Scientists have identified a crucial protein called Lnk that regulates the growth of stem cells in the bone marrow. The findings may aid in improving the success of bone marrow transplants and developing better treatments for blood disorders such as aplastic anemia and severe combined immunodeficiency disorders.
Dr. Edwin Monuki will study choroid plexus epithelial cells, which produce cerebrospinal fluid to promote normal nervous system health and function. Success in generating these cells could lead to clinical therapies and screens for new drugs for neurological disorders.
Researchers have created disease-specific stem cell lines for ten genetic disorders, including muscular dystrophy and Parkinson's disease. These lines will enable scientists to model human diseases in a laboratory setting, making it possible to study the development of various tissues relevant to these conditions.
Researchers at Boston Children's Hospital have developed 20 disease-specific stem cell lines for conditions such as Parkinson's Disease, Down Syndrome, and Muscular Dystrophy. These lines were created using the iPS technique and will be made available to researchers worldwide.
The University of Georgia has been awarded a $9.2 million grant to explore the molecular underpinnings of human embryonic stem cell differentiation, aiming to identify genetic and protein modification patterns that accompany this process.
Researchers have successfully differentiated pluripotent stem cells from a patient with ALS into motor neurons and glia featuring an ALS genotype, offering new avenues for drug discovery and understanding the disease process.
Dr. Kevin Eggan's breakthrough discovery marks the first time scientists have replicated specific human cells affected by ALS in a laboratory setting. The New York Stem Cell Foundation funded his work and will continue to support him.
Researchers at the University of California-Irvine have discovered that adult stem cells in the mammalian brain originate from ependymal cells lining the ventricles. These cells can be coaxed into dividing, providing a promising approach to treating neurological disorders and injuries such as Parkinson's disease and stroke.
New research funded by the Economic and Social Research Council explores standards in stem cell research, balancing scientist autonomy with data comparability. The study suggests that standardizing practices could lead to automation technologies, but also raises concerns about exclusivity and robustness.
The California Institute for Regenerative Medicine has awarded a planning grant to Cedars-Sinai Heart Institute to support regenerative stem cell-based approaches for treating heart attacks, congestive heart failure, and pacing abnormalities. Researchers will use autologous stem cells derived from patients to replace damaged heart cells.
Researchers have shown that purified stem cells isolated from adult skeletal muscle can restore healthy muscle and improve muscle function in mice with muscular dystrophy. The injected cells also replenished the pool of regenerative cells normally found in muscle, allowing the treated muscle to undergo subsequent rounds of injury repair.
A new report by scientists shows that relationships between scientists and journalists are now smoother than previously thought. The study found that most scientists view their media interactions as mostly positive, with only 6% reporting an unfavorable experience.
Researchers at Joslin Diabetes Center have successfully transplanted muscle stem cells into mice with muscular dystrophy, improving muscle function and replenishing the stem cell population. This breakthrough study demonstrates the potential of stem cell therapy for treating degenerative muscle diseases like Duchenne muscular dystrophy.
A recent study published in Science found that 57% of researchers were 'mostly pleased' with their media interaction, while only 6% were 'mostly dissatisfied'. The survey, conducted among 1354 scientists, suggests that science-journalist interactions are more positive than previously thought.
Researchers successfully developed human embryonic stem cells from a single cell of a 4-cell stage embryo, reducing the need for destruction of the embryo. This breakthrough could lead to more efficient production of hESCs at an earlier stage and alleviate ethical concerns surrounding the technology.
Scientists at WashU Medicine have successfully directed mouse embryonic stem cells to build the heart using the Mesp1 gene, a crucial discovery that may lead to new therapies using human stem cells. The study found that Mesp1 regulates cardiovascular fate restriction and epithelial-mesenchymal transition in differentiating ES cells.
Researchers at the Salk Institute have made a groundbreaking discovery by reprogramming adult brain stem cells into support cells in their natural environment. This achievement opens up new avenues for treating neurological diseases such as multiple sclerosis, stroke, and epilepsy.
Researchers at Baylor College of Medicine have discovered a novel cellular regulator called Ronin, which maintains embryonic stem cells in their undifferentiated state. This finding suggests an alternative control mechanism to the previously identified proteins Oct4, Sox2, and Nanog.