Articles tagged with Stem Cell Research
Researchers identified a protein signal that prevents neural stem cells from becoming neurons, shedding light on the maturation process of stem cells. The discovery could simplify stem cell isolation and potentially have implications for treating nervous system damage.
Researchers developed a method to create cardiac muscle cells from embryonic stem cells, which then survived and thrived in damaged rat hearts. The treatment showed promise in improving heart function and thickness of walls after a heart attack.
HIV/AIDS interferes with stem cells in the adult brain, preventing new nerve cells from forming, which is a key feature of AIDS dementia. The researchers discovered a novel molecular mechanism that inhibits stem cell proliferation, possibly triggered in other neurodegenerative diseases as well.
Researchers found that high-dose chemotherapy and blood stem cell transplantation can result in long-term survival for patients with primary systemic light chain (AL) Amyloidosis. The median survival for all 80 patients was 57 months, with 18 still alive 10+ years after treatment.
Two NIH-approved embryonic stem cell lines were found to generate distinct types of neurons, differing in synapse formation and neurotransmitter usage. The discovery highlights the influence of culture conditions on human ES cells' developmental properties.
A UCF team led by Kiminobu Sugaya has discovered a compound, phenserine, that reduces plaque buildup in Alzheimer's disease. This combination with stem cell transplantation triggers neuron regeneration, offering hope for patients. Further research, including clinical trials, is needed to confirm its effectiveness.
Researchers used genetic analysis to determine the origin of a widely disputed stem cell line. The study found that the cell line was derived from a parthenogenetic embryo, not somatic nuclear transfer as previously claimed.
Researchers at Boston Children's Hospital and the Harvard Stem Cell Institute used genetic techniques to compare embryonic stem cells from different sources. They discovered that parthenogenetic embryonic stem cells have a distinct genetic signature reflecting their biological origins, setting the historical record straight for a now-d...
Researchers are developing a new system to analyze beating heart stem cells, which could lead to more detailed information on their electrical activity and potentially facilitate their use in regenerating damaged hearts. The team aims to engineer a novel system for real-time analysis of cardiomyocytes during early development.
A University of Michigan study has identified the Sox17 gene, which regulates blood-forming fetal stem cells. The discovery may lead to new insights into childhood leukemias and the development of bone marrow transplantation from human embryonic stem cells.
Scientists at McMaster University have made a groundbreaking discovery about human embryonic stem cells, finding they can generate fuel to sustain themselves. This breakthrough has significant implications for future clinical therapy, as it could lead to the development of new treatments for diseases such as Parkinson's and diabetes.
Researchers found that transplanted stem cells triggered the brain's self-repair mechanisms by boosting nerve survival and blood vessel development. The study suggests that stem cells may be more effective at repairing damaged brain tissue than previously thought.
Researchers from Boston University Medical Center successfully treat patients with immunoglobulin-light chain amyloidosis who did not respond to initial treatment. A tandem approach of high-dose chemotherapy and blood stem cell transplantation shows improved overall survival and quality of life for these patients.
A $2.5M NIH grant supports research using adult stem cells to engineer soft tissue for facial reconstruction after injuries or surgery. The Columbia University team aims to develop a process that allows patients to use their own stem cells to create long-lasting implants.
Researchers found that cord blood infusions significantly reduced insulin requirements and improved blood sugar control in children with type 1 diabetes. The treatment also increased regulatory immune cells, suggesting potential immunotherapy benefits.
Nicholas Tan Xue-Wei, an 18-year-old Singaporean student, will present his research paper on stem cells at two international conferences in the US and UK. He was nominated for a Best Paper Award at WCE 2007 for his work on growing Mesenchymal Stem Cells in a serum-free medium.
A study by researchers at Duke University Medical Center and Johns Hopkins University found that 60% of infertile couples would be likely to donate unused embryos for stem cell research. The number of available embryos could be 10 times higher than previous estimates, resulting in a potential 100-fold increase in stem cell lines.
Researchers at Children's Hospital Boston have found a new way to increase stem cells in blood, suggesting a possible treatment to help patients recover their immune function more quickly. The discovery uses a small-molecule drug that enhances the blood-forming system.
A survey of over 1,000 infertility patients found 60% willing to donate their frozen embryos for stem cell research. This could lead to 2000-3000 new stem cell lines, exceeding initial estimates.
A team of Canadian scientists has identified 1,155 genes under the control of Oct4, a master regulator of the stem cell state. These genes help maintain stem cells in a flexible state by controlling DNA packaging, cell division, and signaling pathways.
Researchers developed artificial blood vessels from muscle-derived stem cells and a biodegradable polymer, exhibiting extensive remodeling and blockage-free performance in rat models. The findings have significant implications for treating heart and kidney disorders with 'off-the-shelf' vascular grafts.
Research at the University of Pittsburgh School of Medicine suggests that chemotherapy must target a subset of cancer stem cells to be effective in treating lung cancers. Cancer stem cells, similar to normal stem cells, can resist multiple drug resistance transporters, making them resistant to conventional therapies.
Two studies show that defects in the bone marrow microenvironment can lead to pre-cancerous conditions in mice, contradicting previous assumptions about the root cause of myeloproliferative syndromes. The findings highlight the importance of environmental considerations for stem cell therapies.
Researchers develop computational method to better understand protein networks and their regulation through phosphorylation. This approach aims to target human diseases by identifying aberrant genes in kinase-controlled processes.
Researchers identify complex regulatory network controlling epithelial stem cell proliferation in mouse incisors. Spatial differences in gene expression levels contribute to characteristic asymmetry of rodent incisors.
Researchers at UCLA successfully reprogrammed normal tissue cells into cells with unlimited properties as embryonic stem cells, offering a promising alternative to current cloning methods. The breakthrough could lead to the creation of immune-compatible cells for disease treatment and regenerative therapies.
A study by University of Pennsylvania researchers discovered that deleting a gene essential for DNA repair leads to premature aging and loss of stem cells in adult mice. This accelerated aging process results from the exhaustion of tissue renewal mechanisms.
Researchers at Whitehead Institute successfully reprogrammed mature skin cells into pluripotent cells, identical to embryonic stem cells, without using eggs or destroying embryos. These cells can give rise to live mice and transmit their genetic material to subsequent generations.
Researchers found that blood-forming stem cells in mice accumulate DNA damage with age, leading to reduced ability to produce new blood and immune system cells. This finding may explain the origin of blood cancer and immune dysfunctions that occur as people age.
The California Institute for Regenerative Medicine awarded $3.79 million to the Burnham Institute for the development of a shared laboratory and expansion of its training courses in human embryonic stem cell research. This funding will support the Institute's partner institutes and researchers, including those at the San Diego Consorti...
USC and Childrens Hospital Los Angeles will receive $6.4 million in Shared Research Laboratory Grants from the California Institute for Regenerative Medicine (CIRM) to build shared laboratory space for researchers. The grants will fund dedicated lab space, equipment, and training programs for stem cell research.
UCI will receive $3.9 million to enhance its core embryonic stem cell research laboratory and expand a training program for young scientists on research techniques involving human embryonic stem cells. The grant is part of $50 million in funding awarded to 17 institutions by the California Institute for Regenerative Medicine.
Researchers at Stanford University School of Medicine have successfully tracked human neural stem cells transplanted into the brains of rats, which migrated towards damaged areas and matured into functional neurons. The study used iron particles to track the cells in real-time, paving the way for potential human clinical trials.
The article highlights protocols for characterizing epigenetic marks in native chromatin, investigating embryogenesis in Xenopus laevis, and cloning techniques. These methods provide insights into gene activity, cellular reprogramming, and disease states.
Researchers at UC San Diego report that grafting human spinal stem cells into paralyzed rats restored ambulatory function within six weeks. The study demonstrates the potential of stem cell therapy to reconstruct neural circuitry and treat debilitating muscle spasticity.
Researchers have made significant breakthroughs in stem cell treatment options, including isolation of human spermatoogonial stem cells and use of autologous adipose-derived stem cells. Studies also show promise for engineered bladder tissue and muscle-derived cell injection in treating stress urinary incontinence.
A FSU engineering professor is developing technologies to generate bone cells in a lab that can be transplanted into human patients. The goal is to replace lost bone mass due to osteoporosis and treat traumatic injuries. Research has shown promising results, but significant hurdles remain before the technology is ready for medical use.
A study led by researchers at the University of Pittsburgh School of Medicine found that muscle-derived stem cell injections strengthened sphincter muscles, improving bladder control and quality of life for women with stress urinary incontinence. The treatment was safe and effective, with long-term improvements observed.
Researchers at University of Cincinnati have found that bone marrow stem cells can differentiate into keratocan-producing cells, potentially treating abnormal corneal cell growth. The study showed that injected stem cells altered the shape and healed abnormal corneas in animal models within a week
The California Institute for Regenerative Medicine (CIRM) regulates $3 billion stem cell research with 'high ethical standards' and five objectives. CIRM-developed regulations include informed consent processes for human embryonic stem cell research, protecting oocyte donors' rights.
Janet Rossant and Anne McLaren receive March of Dimes Prize in Developmental Biology for their pioneering work on mammalian reproduction and development using the mouse model. Their research has significantly advanced understanding of birth defects, genetic predispositions, and reproductive technology.
A recent study published in Cell Stem Cell found that nearly half of couples who underwent in vitro fertilization (IVF) chose to donate their surplus embryos for stem cell research. The key factor was a clear explanation of the options, which helped couples navigate the legal situation and address concerns about donation.
A recent study found that stem cell identity in culture is highly dependent on the surrounding environment, challenging traditional views of differentiation. Researchers suggest that this context-dependent approach could lead to more efficient stem cell culture methods and potentially even develop stem cells from differentiated cells.
Dr. Battey's dedication to the chemical senses has led to significant contributions, including leadership in trans-NIH scientific efforts and support of promising young investigators. He will receive the Distinguished Service Award from AChemS for his record of outstanding service.
Recent studies have found that PTEN and HER2 genes regulate self-renewal and invasion of human mammary stem cells, making them potential targets for breast cancer treatment. Additionally, radiation therapy may contribute to leukemia risk by recruiting hematopoietic stem cells into the irradiated bone marrow.
Researchers have developed an in vitro model of ALS using embryonic stem cells, providing insights into the disease's mechanisms. The studies suggest that astrocytes may be toxic to motor neurons in ALS, offering a potential target for new therapies.
Researchers found that astrocytes, carrying a mutated gene, induce motor neuron death in ALS patients. The study suggests that targeting these cells may lead to effective therapies and earlier diagnoses. This discovery could involve transplanting embryonic stem cells to replace damaged neurons.
A study by Pittsburgh scientists found that female stem cells have a greater ability to regenerate skeletal muscle tissue than male cells. The researchers isolated female and male muscle-derived stem cells and tested their regenerative capabilities in dystrophic mice. Female stem cells were more efficient at regenerating skeletal muscl...
Scientists at Case Western Reserve University have isolated cochlear stem cells, which may regenerate damaged hair cells and restore normal hearing. The discovery offers a potential therapy for noise-induced and genetic hearing loss affecting millions worldwide.
Using adult bone marrow stem cells, researchers successfully regenerated healthy liver tissue in patients, doubling the liver growth rate and allowing for earlier surgical resection. This therapy has potential as a treatment for regenerating livers damaged by other chronic and acute diseases.
The San Diego Consortium for Regenerative Medicine has received six grants totaling $16.479588 to conduct life-saving human embryonic stem cell research, including work on brain repair and spinal injuries. The consortium aims to develop cures and therapies for devastating diseases like Parkinson's and Alzheimer's.
Scientists at USC have identified a small molecule, IQ-1, that prevents embryonic stem cells from differentiating into specific cell types. This discovery allows for the potential growth of human stem cells without risk of contamination from mouse feeder cells.
Three UCI projects focus on mitochondria, spinal cord injuries and genetic manipulation of human embryonic stem cells. Researchers aim to develop therapies and treatments for degenerative diseases and cancers.
The California Institute for Regenerative Medicine has awarded $6 million in comprehensive grants to the Burnham Institute for Medical Research to support long-range stem cell studies aimed at developing new treatments for heart disease and brain repair. The funds will enable researchers to develop a supply of nerve cells for brain rep...
The University of Wisconsin is conducting a clinical trial using adult stem cells to treat severe coronary artery disease. The study aims to investigate the efficacy and safety of blood-derived selected stem cells in improving symptoms and clinical outcomes in patients with chronic myocardial ischemia.
The study identifies centrosome asymmetry as a key regulator of asymmetric stem cell division, ensuring the correct differential identity of resulting cells. This complex behavior is precisely regulated, coinciding with the orientation in which the stem cell must divide to guarantee asymmetry.
Mayo Clinic researchers successfully transplanted cardiac preprogrammed embryonic stem cells into diseased hearts, regenerating infarcted heart muscle without tumor formation. The study establishes a tumor-resistant approach to growing new heart tissue from an embryonic stem cell source.
Researchers have developed a technique to encourage survival and growth of adult stem cells, found in many tissues, which hold great promise for treating injuries and some diseases. The study's findings suggest that by manipulating the environment surrounding the cells, certain growth factors can protect them from pro-death signals.
Researchers successfully produced neurons in vitro using stem cells from adult human skin, a breakthrough that could lead to revolutionary advances in treating neurodegenerative diseases like Parkinson's. The method used involves extracting neuron precursor cells from skin samples and cultivating them in an appropriate environment.
Researchers identified Jumonji proteins essential for cellular differentiation, inactivating genes critical to embryogenesis. The study uses C. elegans and mouse embryonic stem cells, with potential applications in cancer treatment using inhibitors.