Articles tagged with Stem Cell Research
Researchers found that suppressing interferon-gamma can prevent damage to myelin-producing cells in the nervous system. Transgenic mice with SOCS1 gene showed reduced symptoms and cell loss compared to those without it.
Researchers developed a new type of immature support cell from embryonic glial stem cells that can regenerate nerve fibers and promote healing. The study showed over 60% of sensory nerve fibers regenerating and more than two-thirds growing through the injury site in rats.
Researchers have successfully isolated and cultured sperm-producing stem cells from mouse testes, providing valuable insights into the development of a culture system for human spermatogenic stem cells. The study also reveals the importance of growth factors GDNF and FGF in enhancing cell growth and survival.
Researchers at Beth Israel Deaconess Medical Center have discovered that bone marrow-derived stem cells can repair damaged kidney tissue in a mouse model of Alport syndrome, leading to improved kidney function and structure. The study offers a promising therapeutic opportunity for children and adults with the disease.
Researchers at Ohio State University Comprehensive Cancer Center identified the four stages of natural killer cell maturation in secondary lymphoid tissue, such as tonsils and lymph glands. This discovery could lead to new therapies for cancer, infection, and immune deficiencies, advancing our understanding of the human immune system.
The J. David Gladstone Institutes will develop and implement a three-year, stem cell-specific curriculum for 10 postdoctoral fellows using the first third of $2.4 million grant. The program aims to educate scholars from various scientific backgrounds in stem cell biology and disease.
The brittlestar model provides a realistic approach to studying stem cells in living organisms, shedding light on the recovery of the nervous system after regeneration. This breakthrough could lead to a better understanding and treatment of neurodegenerative diseases.
Researchers administered stem cells to animals with significant mobility loss after stroke, showing a 25% greater improvement in motor function compared to controls. In another model of cerebral palsy, rodent stem cells improved recovery by at least 25% within two weeks.
Research reveals a significant gap in publications between US and non-US groups, with the US trailing behind in human embryonic stem cell research. The study suggests that federal policies may be contributing to this disparity, which could impact competitiveness in the biotechnology industry.
Researchers at Duke University Medical Center have developed a novel growth factor that significantly improves the ability of human fat-derived stem cells to be transformed into cartilage cells. The growth factor, BMP-6, stimulates the production of key biochemical markers of cartilage cell proliferation, suggesting potential for tissu...
Researchers have successfully induced neotendon formation in mesenchymal stem cells using the Smad8 signaling pathway. This breakthrough could lead to new cell-based therapeutic approaches for musculoskeletal injuries.
Researchers have discovered two new sources of stem cells with high cardiomyogenic potential, derived from menstrual blood and umbilical cord blood. These findings suggest that these cells may be able to repair or replace damaged cardiac muscle, offering a promising treatment option for heart dysfunctions.
University of Wisconsin-Madison researchers have created a liquid crystal-based cell culture system to control the uncontrolled differentiation of human embryonic stem cells. The system uses mechanical strain to guide stem cells along well-defined lineages, enabling real-time monitoring and reducing the mixture of cells of little medic...
A radical proposal suggests that California's CIRM could accelerate the development of stem cell therapies by implementing a patent pool and a shared prize system. This approach aims to stimulate innovation, make treatments more affordable, and establish a new medical innovation model for the 21st century.
The article highlights the need for researchers to navigate intricate legal, ethical, and political issues surrounding human embryonic stem cell research. The author, Henry T. Greely, emphasizes that these concerns will significantly impact researchers, institutions, and science as a whole.
The Broad Institute will be a pivotal hub for integrative biomedical research, bringing together researchers and biologists in one place. The institute will support the development of novel platforms in imaging, bioengineering, and nanotechnology for stem cell research.
University of Minnesota researchers identify a new population of cord blood stem cells that can regenerate nerve tissue after stroke. The discovery shows promise for treating neurological disorders such as stroke, which affects nearly 750,000 people in the US each year.
A study of 50 patients with treatment-resistant lupus found an overall 5-year survival rate of 84% after autologous hematopoietic stem cell transplantation (HSCT). The longest continuous duration of remission was 7.5 years, with a 2% treatment-related death rate.
Researchers discovered that PrP protein plays a crucial role in maintaining healthy human stem cells, particularly in the brain. The findings suggest that PrP's positive function is essential for preventing prion-related neurodegenerative diseases.
Researchers found that genetically engineered muscle-derived stem cells (MDSC-B4) improved cartilage repair in rats, with well-integrated repaired tissue at 8, 12, and 24 weeks after surgery. The study also showed that MDSC-B4 could differentiate into chondrogenic cells depending on the type of medium they grew in.
A master determinant was identified to generate dopamine neurons from embryonic stem cells, promising advances in cell replacement therapy for Parkinson's disease. The discovery also highlights the importance of understanding developmental processes for producing authentic cells from stem cells.
Australian researchers have made a groundbreaking discovery in stem cell research, producing the country's first human embryonic stem cell line without using animal products. The new line, named 'Endeavour 1', has the potential to lead to safer treatments for conditions such as diabetes and Parkinson's disease.
Researchers have discovered a way to multiply adult stem cells 30-fold, offering promise for treating blood diseases and gene therapies. This breakthrough could address the limited availability of stem cells from donors.
Treena Arinzeh, a NJIT engineer, has received two new grants to develop stem cell therapies for spinal cord and cartilage injuries. Her research aims to regenerate nerve tissue and promote bone growth using nano-scaffolds.
In a double-blind, placebo-controlled study, administering bone marrow stem cells to patients with acute myocardial infarction resulted in a significant reduction of the infarct size and improved regional left ventricle function. The findings suggest potential benefits for targeted clinical and pre-clinical research.
Wisconsin scientists have developed a culture system free of animal cells, growing two new human embryonic stem cell lines. The new lines survive for over seven months in the defined medium, showing promise for therapeutic use. However, further work is needed to understand chromosome stability during long-term culture.
Researchers at Oregon Health & Science University (OHSU) have identified a critical gene, Brg-1, that regulates the differentiation of stem cells into neurons and glial cells in the brain. This discovery could lead to new therapies for brain injuries, Parkinson's disease, and other conditions affecting brain function.
Feather stem cells are distributed in a ring configuration around the inner wall of the vase-shaped feather follicle. This unique arrangement allows for continuous growth, shedding, and regeneration of feathers.
Scientists have discovered 142 human disease genes in the flatworm planarian Schmidtea mediterranea, which may provide insights into human diseases. The findings suggest that flatworms could be a valuable complementary model for studying gene function and developing new treatments.
Researchers found that hair follicle stem cells quickly mobilize to generate new cells that migrate into the wound area, contributing to wound healing. The study suggests a therapeutic target for developing drugs to enhance wound healing and treat patients with wounds.
Researchers at UT Southwestern have developed methods to keep sperm precursor cells from differentiating into sperm, allowing them to freeze and thaw the cells. This breakthrough could lead to alternative sources for embryonic stem cells and enable the development of new male contraceptives. The study's findings also pave the way for g...
A Florida State University research team has developed a biomedical device called a perfusion bioreactor that allows for the large-scale growth of adult stem cells from bone marrow. The device mimics the body's circulatory system and delivers nutrients to stem cells, enabling controlled differentiation into various tissue types.
Researchers will focus on understanding human stem cells, transplanting them into patients for leukemia and lymphoma treatment, and using natural killer cells to fight cancer. The funding also aims to apply what has been learned about the use of natural killer cells in fighting diseases including leukemia and breast cancer.
Researchers at the University of Toronto have identified a key component blocking stem cell growth and developed a system to expand cord blood stem cells, potentially treating adult patients with leukemia. The discovery may lead to clinical trials within the next year.
A new stem cell technology allows HLA-mismatched and haploidentical donors into the donor pool, improving stem cell transplantation outcomes. Researchers identified genetic risk factors for acquired aplastic anemia affecting immune response and hematopoietic cell number and function.
Scientists have successfully developed a proof-of-concept for Altered Nuclear Transfer (ANT), an alternative to somatic cell nuclear transfer (SCNT) that enables the creation of genetically altered embryos without implantation. The method uses RNA interference to disable genes in donor nuclei, producing stem cells with disabled Cdx2 fu...
A recent survey of over 2,200 Americans found broad support for human embryonic stem cell (ESC) research, with two-thirds approving or strongly approving its use. The study's findings contradict the deeply polarized debate seen in Congress and newspapers, highlighting a more nuanced public opinion landscape.
Researchers at the University of Minnesota have successfully generated natural killer cells from human embryonic stem cells that can target and destroy cancer cells. The breakthrough research suggests a potential new approach to treating cancers such as leukemia and lymphoma, and may also lead to treatments for infections.
Researchers at EPFL discover that stem cells within hair follicles can develop into various cell types needed for hair growth and follicle replacement. This breakthrough has significant implications for regenerative medicine and could potentially be used to regenerate hair on patients with severe burns.
The National Stem Cell Bank (NSCB) will provide comprehensive characterization of human embryonic stem cell lines and distribute them to investigators at a lower cost. This move aims to increase the use of stem cells in research and potentially lead to therapies for diseases, with WiCell handling technical support and training.
A study published in the Journal of Clinical Oncology found that patients who underwent stem-cell transplantation have similar rates of hospitalization, diseases, and psychological health as those who did not receive a transplant. However, they reported higher incidence of musculoskeletal problems and poor long-term sexual health.
The Keck School's grant will train graduate students and post-doctoral fellows across 27 departments, developing courses on bioethics and cutting-edge gene-transfer technology. The program aims to create a pipeline of highly trained researchers for CIRM-funded projects.
The Gladstone Institutes will develop a core curriculum of required and elective courses spanning various stem cell research disciplines. The CIRM Scholars Training Program aims to advance regenerative medicine by focusing on understanding the fundamental mechanisms related to stem cells.
A team of researchers has identified three key transcription factors that enable human embryonic stem cells to maintain pluripotency. By understanding the regulatory circuitry controlling these cells, scientists can now develop strategies to coax them into specific cell types for regenerative medicine applications.
Researchers have made significant progress in understanding stem cells and their role in reproduction and the nervous system. Studies suggest that therapeutic cloning may become unnecessary once body cells can be re-programmed into stem cells.
Researchers found that most human embryonic stem cell lines exhibit gross genetic changes after a year to three years of growth in the lab. These changes can affect chromosome numbers, gene expression, and mitochondrial DNA sequences. The study highlights the need for close monitoring and further investigation into the effects of these...
Scientists have devised a new technique for creating human stem cells by fusing somatic cells with embryonic stem cells. The hybrid cells exhibit characteristics of human embryonic stem cells and can be induced to mature into various specialized cell types. However, technical hurdles remain before this method can be widely adopted.
A trans-Atlantic team of researchers has successfully created embryonic-like stem cells from umbilical cord blood, a breakthrough that could revolutionize the treatment of serious diseases. The new cell type shares characteristics with both adult and embryonic stem cells, making it an attractive alternative for stem cell therapies.
Neural stem cells in the subventricular zone of the forebrain give rise to malignant astrocytoma in genetically engineered mice. The study challenges current dogma that tumors arise from glial cells throughout the brain.
A new study by Christof Westenfelder's team found that stem cells improve kidney function and reduce tissue injury in acute renal failure. The benefits are primarily mediated by paracrine mechanisms, not differentiation, and are induced by the release of growth factors and cytokines.
The Mount Sinai School of Medicine has been awarded significant NIH funding to support its stem cell research efforts. Researchers will focus on developing methods to genetically modify stem cells and studying the molecular signals that cause them to differentiate into red blood cells.
The Burnham Institute was selected by NIH to receive a $3M grant for exploratory center in hESC research. The center will support pilot projects, core facilities, and training for scientists.
The National Institute of General Medical Sciences (NIGMS) has funded three new Exploratory Centers for Human Embryonic Stem Cell Research. The centers will establish core facilities to support scientists and advance fundamental knowledge of human embryonic stem cell properties and functions.
A recent study found that circulating stem cells contribute less than 1% to lung repair, while most contributions come from lung-resident stem cells. The study also suggests a link between the number of Y-chromosome containing pneumocytes and acute cellular rejection in lung tissue.
Researchers at University of Cincinnati have developed a new chemical compound that can accelerate adult stem cell mobilization, enabling easier harvesting. The findings reveal the RAC GTPase family plays a crucial role in regulating stem cells' movement into bone marrow and blood stream.
Researchers discovered that the protein CrebA single-handedly controls the entire set of events leading to secretion in the fruit fly's salivary gland, improving understanding of how cells become specialized for secretion. This finding could potentially help fix problems with pancreatic cells in juvenile (type I) diabetes.
A panel of experts published recommendations to minimize the risk of altering non-human primates' cognitive capacity, focusing on grafting human stem cells into their brains. The panel concluded that healthy adult members of species distantly related to humans are least likely to experience morally significant changes.
Research involving human stem cells in nonhuman primate brains may be necessary and effective, but oversight boards must consider six key factors to ensure ethics are maintained. The number of human cells used and animal brain size are among the factors considered.
The American Academy of Neurology has supported a bill that would expand funding scope for National Institutes of Health support of embryonic stem-cell research. This move is expected to significantly advance the field while ensuring strong ethical safeguards.
Researchers at U of MN identified 14 genes that regulate blood stem cell development, which could lead to new treatments for blood disorders and cancers. The discovery provides insight into understanding how to stimulate blood stem cells to multiply in the laboratory.