The NIH has launched a three-year, $100 million pilot project to explore cancer genomics through The Cancer Genome Atlas (TCGA) Pilot Project. This initiative aims to create a systematic framework for identifying and characterizing genetic mutations and genomic changes associated with cancer.
Researchers used in vivo cell fate mapping to study the role of TGFbeta signaling in congenital eye disorders. They found that NC-derived cells contribute to various eye structures, and TGFbeta signaling is essential for their proper differentiation and morphogenesis.
Researchers at Georgia Tech are developing silicon-germanium microchips that can operate in ultra-sophisticated radar systems and new generations of NASA spacecraft. These chips offer cost savings, compact size, and improved efficiency, making them ideal for phased-array radar systems.
Researchers at Emory University Health Sciences Center found that administering neuregulin-1 reduces cell death by 90% and protects neurons from damage after surgically induced strokes. The compound's therapeutic window is longer than existing treatments, offering potential for new stroke therapies.
Researchers at Children's Hospital of Philadelphia found that parents of children with cancer often suffer from post-traumatic stress symptoms, including intrusive thoughts, avoidance behaviors, and heightened arousal. The studies suggest that these symptoms can be just as severe as those experienced by patients themselves.
Researchers have discovered a new drug that raises the level of endocannabinoids, providing measurable antidepressant effects. The study found similar results to commonly prescribed antidepressants, suggesting URB597 as a safer, non-addictive alternative for pain and depression treatment.
Researchers have discovered that transforming growth factor beta (TGF-ß) regulates bone matrix properties, which affect bone elasticity, toughness, and resistance to fracture. The study suggests that targeting TGF-ß signaling could improve bone quality, potentially preventing osteoporosis and improving bone repair.
Scientists have discovered 142 human disease genes in the flatworm planarian Schmidtea mediterranea, which may provide insights into human diseases. The findings suggest that flatworms could be a valuable complementary model for studying gene function and developing new treatments.
Researchers at institutions in developing countries can now access the scientific subset of the web using Scirus and TEK, reducing connectivity charges. The collaboration between Elsevier and MIT aims to provide a robust and user-friendly service to researchers globally.
Researchers found L1 in large quantities exclusively in aggressive colon cancer cells, enabling them to invade and metastasize more effectively. The discovery may have important implications for diagnosing colon cancer and designing new therapies.
Researchers found encouraging preliminary findings in four patients with CLL who improved after taking EGCG, an extract of green tea. However, more studies are needed to determine the optimal dose and side effects before recommending widespread use.
Researchers discovered that TRAF3 is essential for producing type I interferons and IL-10, a protein preventing inflammation. Cells lacking TRAF3 over-produce inflammatory proteins, highlighting its role in controlling the immune response to viruses.
Researchers discover that mutant lamin A proteins interfere with key controls of gene expression and cell cycle, leading to rapid aging in HGPS patients. The study suggests that similar missteps may be part of normal human aging.
A high-fiber diet from whole plant foods, but not isolated to cereal consumption, has been related to lower risks of chronic conditions such as heart disease and diabetes. However, a pooled analysis of 13 prospective cohort studies found no association between dietary fiber intake and reduced risk of colorectal cancer.
Researchers will use a tumor biopsy or blood examination to identify a 'gene signature' that indicates aggressive prostate cancer, allowing patients to make informed treatment decisions. The study aims to improve outcomes for up to 30% of men with prostate cancer who do not require radical treatments.
A team of researchers has successfully engineered a drought-resistant gene into tomato plants, resulting in stronger root systems that can better utilize limited water. The technology could be applied to all crops, addressing the global concern of water scarcity and potentially increasing food production.
A Swedish study found that peacetime grenade stockpiling leads to environmental harm from metal mining and explosive residues. Replacing plastic with copper could make grenades more environmentally friendly, according to the authors.
Harvard researcher Martin Nweeia discovers that the narwhal's tooth has hydrodynamic sensor capabilities, allowing it to detect salinity and particle gradients in Arctic waters. This unique adaptation enables the whales to survive in their icy environment and potentially discern prey.
A team of researchers assembled ancient gourd remnants across the Americas and found they matched modern gourds in Asia, suggesting a pre-pottery Asian origin. The findings indicate that people arrived in the New World with domesticated plants and tools, changing our understanding of the founding of the Americas.
Researchers isolated Sirius B's light using Hubble Space Telescope, measuring its mass based on gravitational redshift. The result indicates Sirius B has a diameter less than Earth's but is denser and has a surface temperature of 25,000 degrees C.
A new study using an animal model suggests that anabolic steroids can be addictive. Hamsters showed a marked preference for testosterone, nandrolone or drostanolone, indicating the drugs' potential for addiction. The research highlights the need for awareness among coaches and mental health professionals about this risk.
A new study found that Fezl is necessary for proper development of neural connections to the spinal cord. In developing mice lacking the Fezl gene, normal connections failed to form, and brain cells made inappropriate connections instead.
Researchers found that up to half of Amazon's oldest trees are over 300 years old, with some reaching 1,000 years. This challenges previous studies suggesting the Amazon can absorb more carbon dioxide than predicted.
Researchers discover that disturbances in norepinephrine levels lead to breathing problems in RTT mice. Increasing norepinephrine helps normalize breathing patterns, suggesting a potential therapeutic approach for the disorder.
Scientists have discovered that Streptococcus mutans, a decay-causing organism, can survive without the SRP pathway. The bacteria altered to lack SRP components were able to adapt and survive gradual increases in acid resulting from their own metabolism.
Research at St. Jude Children's Research Hospital found that cocaine exposure alters brain chemistry, making neurons more susceptible to damage from environmental toxins. The study suggests a potential link between cocaine use and the development of Parkinson's disease in both adults and their offspring.
Researchers identify the breathing center in the medulla as the source of erratic breathing in Rett Syndrome, finding a significant decrease in norepinephrine. Adding norepinephrine can normalize breathing patterns, suggesting potential treatment options for the condition.
A cohort study found that higher insulin concentrations and insulin resistance were associated with an increased risk of pancreatic cancer in male smokers. The study suggests that lifestyle changes to decrease glucose and insulin levels may help prevent pancreatic cancer development.
A new study finds that the herbal supplement NAC can help reduce cocaine cravings in individuals undergoing treatment for cocaine addiction. The research, conducted at the ACNP Annual Meeting, showed that NAC-treated subjects had reduced brain activity in the prefrontal cortex and reported less craving for cocaine.
Despite extensive research and calls for reform, US hospitals' patient safety systems have made only modest progress. The study found that while some areas, like surgery, have implemented effective safety measures, others, such as medication management, have seen improvements but are already at high baseline levels.
Researchers are developing intelligent systems to monitor seniors' daily lives and detect changes in health. The ORCATECH center is creating technologies for in-home monitoring of mobility, cognition, and medication management.
A £6m grant has been awarded to develop new methods for processing, forming, joining, and surface engineering of aluminium, titanium, and magnesium. The project aims to create lighter, more environmentally-friendly vehicles using these materials.
A new clinical trial found that using minimal residual disease (MRD) measurements, doctors can accurately assess treatment response and adjust therapy, leading to a high remission rate and low treatment-related mortality. This breakthrough approach improved outcomes for pediatric AML patients by identifying slow responders and intensif...