Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
A study of 90 patients reveals 50% experienced delirium, with distinct clusters of symptoms including psychotic problems, cognitive impairment, and mood disturbance. Early recognition is crucial to prevent poor outcomes, as delirium can lead to increased risk of falls, infections, and mortality.
Researchers at Dana-Farber Cancer Institute found that the loss of hair color is caused by the gradual dying off of adult stem cells, which become depleted and make errors. This discovery may lead to a better understanding of the underlying mechanism of graying and potentially inform treatment for malignant melanoma.
Scientists have successfully cloned primates up to the blastocyst stage, a developmental milestone for embryonic stem cell research and potential treatments for diseases such as diabetes and Parkinson's. The breakthrough could pave the way for deriving human embryonic stem cells from nonhuman primate templates.
Researchers transplanted BM-SP stem cells into mice with cardiomyopathy, but found that only 2 muscle fibers expressed restored sarcoglycan levels. The study suggests alternative approaches should be investigated for regenerative medicine.
A new study found that transplanted stem cells from bone marrow cannot become functional heart muscle cells due to their inability to produce the protein sarcoglycan. The researchers tested bone marrow side population cells in mice with a receptor deficiency, but the results were disappointing.
Researchers have developed a treatment for urinary stress incontinence using patients' own stem cells. After a 15-20 minute outpatient procedure, many patients experience no urinary leakage within 24 hours, with increased muscle mass and contractility of the sphincter and thicker urethra.
The National Center for Regenerative Medicine will enable groundbreaking research discoveries using non-embryonic stem cells to treat thousands of patients annually. The center's education programs will train personnel in performing innovative research and delivering world-class patient care.
Researchers have found that stem cells can preserve vision in mice with damaged retinas, holding hope for treatments of macular degeneration and other retinal diseases. The transplanted cells were found to migrate to the damaged area and regain or retain function in cone cells.
Researchers at Johns Hopkins Medicine have successfully replicated heart stem cells using a new technique, producing over 100 million cells in four weeks. The resulting cardiospheres contain cells that can regenerate and develop into specialized heart cells.
Researchers at the University of Pennsylvania School of Veterinary Medicine have identified key growth factors essential for sustaining spermatogonial stem cells in culture. By understanding these factors, scientists hope to develop new fertility therapies and create sperm in vitro.
Scientists have successfully grown sperm progenitor cells in a laboratory culture, paving the way for potential new treatments for male infertility. The breakthrough, led by Hiroshi Kubota, could also enable the creation of genetically modified animals and extend the reproductive life of endangered species.
Scientists at Sick Kids Research Institute have identified a new source of stem cells found in adult skin that can transform into neurons, offering hope for treating brain disorders. The discovery was made using mice and has similar findings in human cells.
Researchers have developed blood cells without animal serum, paving the way for potential human applications. The new method uses specific growth factors to guide cell differentiation, avoiding contamination risks associated with animal serum.
Researchers found that stem cells in mice with Alzheimer's disease were attracted to abnormal protein bundles called amyloid plaques. This could lead to the development of plaque-busting treatments using adult olfactory bulb stem cells.
Researchers successfully transplanted human retinal stem cells into light-sensing photoreceptor cells and retinal pigment epithelial cells in animal models. The study's findings have implications for future treatment of degenerative eye diseases such as retinitis pigmentosa and macular degeneration.
Researchers have successfully engineered mice with alveolar rhabdomyosarcoma, a particularly deadly childhood muscle cancer. The studies provide insights into the genetic events that cause the disease, paving the way for potential new therapies.
Scientists have identified four critical stages in generating B cells from stem cells, involving regulatory proteins and signaling pathways that guide the cell's development. The study paves the way for creating customized immune cells with specific functions.
International society agrees on fat stem cell clinical applications for repairing bone defects, promoting blood vessel growth in tissues and treating cardiac diseases. The best use of this technology is expected to be developing therapies using patients' own cells.
Researchers identified a mechanism for beta-cell growth during insulin resistance, which occurs as a normal protective response to delay type 2 diabetes onset. PDX-1 plays a crucial role in regulating this growth, and modulating key proteins involved may enhance beta cell replication or transplantation
Researchers develop methodology to efficiently pinpoint mutations in mitochondrial respiratory chain, identifying new cause of lethal neonatal disease. The technique uses cell-fusion experiments and bioinformatics analyses to categorize mutation types, revealing complex genetic backgrounds.
A team of UBC scientists aims to use stem cells to regenerate bone cells and improve the success rate of artificial joint replacements. By combining minerals and slow-release growth factors, they hope to create a strong, organic environment to secure prosthetic joints.
Researchers at Rockefeller University have successfully isolated a single mouse skin cell that can differentiate into various epidermal tissues, including hair and sebaceous glands. The study's findings hold promise for potential future applications in treating human skin and hair conditions.
Researchers have identified stem cells in skin that can self-renew and differentiate into multiple cell types, offering new insights into regenerative medicine. The discovery holds promise for treating hair loss and wound healing.
A University of Toronto study discovered precursor cells within the adult pancreas that can make new pancreatic cells, potentially providing a plentiful supply of beta cells for transplant treatments. The research also found that these cells can generate both beta cells and neurons, challenging existing dogma on development.
International bodies have struggled to agree on separating stem-cell research from reproductive cloning laws. Dr. Carol A Tauer argues that each issue should be argued on its own merits. Scientists shy away from controversial areas due to unclear funding policies, and the EU needs to break its stalemate for progress.
The field of stem-cell research faces challenges in winning public support due to limited clinical benefits. Scientists are urged to step forward and lead a debate about the potential benefits and costs of working with stem cells.
A recent study found that the public's opinions on stem-cell research are heavily influenced by poll questions and messaging, with support for embryonic research being lower than expected. The study suggests that the debate is ongoing, with supporters seeking to capitalize on recent events like Ronald Reagan's death.
Researchers at Johns Hopkins Medicine discovered that adding a single protein, BMP4, induced mouse stem cells to become fat cells. The study suggests that a similar signal is likely involved in humans, too, paving the way for new treatments for obesity and related diseases.
A team of researchers from the University of Washington has identified a gene, ZFP145, that is linked to sperm-producing stem cells in mammals. The study found that this gene plays a crucial role in the decision-making process of these cells, and its mutation can lead to infertility.
Scientists at Johns Hopkins Medicine have discovered that lost sperm-making stem cells in fruit flies can be replaced by reversing their specialized state. The team found that temperature changes can trigger a process called dedifferentiation, where more specialized cells retrace the path taken by stem cells.
A study by Lund scientists has shown that adult stem cells cannot form new heart muscle cells after a heart attack. The transplanted cells retain their identity as blood cells and fuse with heart muscle cells outside the infarcted area.
The UI Hematopoietic Stem Cell Bank provides cord blood stem cells for advancing gene therapy and treating conditions like Parkinson's disease. Nearly 20 mothers have donated their child's umbilical cord blood, supporting scientific and medical advances.
Researchers successfully converted muscle stem cells into cells showing properties of neurons through the use of an artificial gene. This breakthrough suggests that stem cells may be 'flexible' and able to develop into different cell types, paving the way for potential neuroregeneration techniques.
Researchers discovered that gene BMI1 is essential for the multiplication of stem cells in the cerebellum, leading to an enormous growth of these cells. Overexpression of BMI1 was found in 8 of 12 medulloblastomas investigated, suggesting its contribution to brain tumour development.
The Oregon Stem Cell Center aims to develop therapies using adult stem cells for human diseases through a rapid approach from basic research to animal trials and human studies. The center's focus will be on the liver and pancreas, building on OHSU's existing expertise in cell therapy.
Penn researchers have isolated stem cells in adult mice responsible for hair growth, leading to the development of potential treatments. The findings also hold promise for burn treatments, where current skin grafting methods fail to generate hair growth.
Bioethicists Elizabeth Blackburn and Janet Rowley critique two PLoS Biology reports for presenting a biased agenda. They argue that the reports overlook diverse scientific opinions on stem cell research and aging studies.
The new cell lines, derived from private funds by Harvard University researchers, offer a robust and easy-to-handle alternative to existing human embryonic stem cells. The availability of these cell lines is expected to quicken the pace of discovery in stem cell biology, particularly in research related to type 1 diabetes.
Researchers at Scripps Research Institute have identified a compound called cardiogenol C that can selectively differentiate embryonic stem cells into heart muscle cells. This breakthrough could potentially lead to the development of new treatments for repairing damaged heart tissue.
Researchers at Rockefeller University have developed a feeder-free system for maintaining pluripotency in human embryonic stem cells, overcoming the need for mouse feeder cells. The system uses a synthetic compound derived from a marine mollusk to activate the Wnt signaling pathway, keeping stem cells in an active, undifferentiated state.
Researchers tracked the movement of transplanted stem cells, revealing that they drift throughout the body and settle in specific locations. The study's findings could lead to improved techniques for transplanting bone-marrow stem cells and new therapies for cancer and immunodeficiencies.
A new system has been developed to identify and isolate stem cells, providing a key to understanding regenerative medicine. The discovery offers promise for treating skin injuries, hair loss, and other conditions by identifying stem cells that can create tissue as needed.
Researchers discovered that a growth factor, granulocyte colony stimulating factor (G-CSF), can increase the number of stem cells in the heart, which may help repair damaged heart tissue. After six weeks, patients showed significant improvements in heart function and metabolic recovery.
Researchers have successfully treated heart attack patients with stem cells harvested from their own bone marrow, resulting in improved cardiac function and increased blood flow to the damaged area. This breakthrough therapy could potentially lead to a new treatment for heart attacks.
Researchers found that human bone marrow-derived multipotent stem cells can differentiate into both vessels and heart muscle, regenerating essential tissues of the heart. The study shows promise for treating acute and chronic heart failure and other blood vessel diseases.
Researchers found that Bmi-1 is essential for self-renewal in two types of adult stem cells: neural stem cells from the central nervous system and hematopoietic stem cells. This discovery may lead to a better understanding of cancer development, as Bmi-1's overexpression can promote uncontrolled growth.
A new study found that treating hematopoietic stem cells with parathyroid hormone increases their numbers and improves bone marrow transplantation outcomes. The research team discovered a cellular-signaling pathway called Notch that is involved in the process, which they believe can be exploited to enhance stem cell populations.
Researchers at the Stowers Institute have identified a key component of the hematopoietic stem cell niche, which supports their self-renewal and production of blood cells. The study found that interrupting a specific signaling pathway can increase the size of the niche and the number of stem cells produced.
Researchers at MIT have developed a new method for creating tissues from human embryonic stem cells by seeding them onto biodegradable polymer scaffolds. The resulting tissues showed characteristics of developing human cartilage, liver, nerves, and blood vessels.
Researchers have made significant progress in isolating skin stem cells, with the discovery that these cells can be found in the basal epidermis layer. This breakthrough has the potential to treat wounds, including burns, by transplanting stem cells directly onto the damaged area.
Researchers control the development of stem cells in the inner ears of embryonic chickens by introducing new genes, leading to the growth of balance-related hairs instead of sound-detecting ones. This breakthrough could potentially improve our understanding of inner ear disorders and lead to therapies for deafness and vertigo.
Adult stem cells have been shown to regenerate damaged lung tissue, offering a promising new treatment for devastating lung diseases. The study's findings suggest that circulating stem cells can repair damage in organ tissue, which could have a huge impact on the treatment of conditions like emphysema and cystic fibrosis.
Researchers developed a gene therapy technique that uses an oncoretrovirus to transfer MGMT into normal bone marrow cells, allowing for the enrichment of healthy cells. The treatment showed promising results in mice with beta-thalassemia, achieving successful in vivo selection in 66% of cases.
A study published in JCI finds that PlGF-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity, suggesting a potential therapeutic agent for the condition. Additionally, researchers identify Fgl2/fibroleukin as a critical prothrombinase involved in the pathophysiology of viral hepatitis.
The European Society of Human Reproduction and Embryology's new chairman, Professor Arne Sunde, argues against a total ban on embryo-based research. He suggests that alternative stem cell sources, such as those derived from amniotic fluid or adult tissues, may become important for research and treatment in the future.
The Tulane center will prepare and distribute a continuous supply of marrow stromal cells (MSCs) using standardized protocols, addressing the need for standard MSC preparations. The center's availability will allow scientists to better understand the capabilities of these cells for potential therapeutic uses.
University Health Network researchers have identified a new class of human stem cells that rapidly rebuild the blood system, allowing for faster recovery from cancer treatment. The discovery holds significant implications for transplant patients who are vulnerable to infections during their weakened state.
Researchers have made a breakthrough in treating liver disease by using bone marrow stem cells from matched donors. The study found that these stem cells can form liver-like cells in damaged livers, producing human albumin and showing promise as a potential treatment for liver disease.
Researchers at the University of Pennsylvania have successfully produced mouse eggs from embryonic stem cells outside the body, showcasing their totipotent capabilities. This breakthrough could lead to new methods for producing embryonic stem cells artificially, potentially sidestepping ethical concerns.
A study found that mice genetically engineered to lack a molecule called Stem Cell Antigen-1 (Sca-1) experienced normal bone development but exhibited decreased bone mass and brittle bones as they aged. The researchers believe that defective maintenance of stem cells may contribute to age-related osteoporosis in humans.