Articles tagged with Stem Cell Research
The new cell lines, derived from private funds by Harvard University researchers, offer a robust and easy-to-handle alternative to existing human embryonic stem cells. The availability of these cell lines is expected to quicken the pace of discovery in stem cell biology, particularly in research related to type 1 diabetes.
Researchers at Scripps Research Institute have identified a compound called cardiogenol C that can selectively differentiate embryonic stem cells into heart muscle cells. This breakthrough could potentially lead to the development of new treatments for repairing damaged heart tissue.
Researchers at Rockefeller University have developed a feeder-free system for maintaining pluripotency in human embryonic stem cells, overcoming the need for mouse feeder cells. The system uses a synthetic compound derived from a marine mollusk to activate the Wnt signaling pathway, keeping stem cells in an active, undifferentiated state.
Researchers tracked the movement of transplanted stem cells, revealing that they drift throughout the body and settle in specific locations. The study's findings could lead to improved techniques for transplanting bone-marrow stem cells and new therapies for cancer and immunodeficiencies.
A new system has been developed to identify and isolate stem cells, providing a key to understanding regenerative medicine. The discovery offers promise for treating skin injuries, hair loss, and other conditions by identifying stem cells that can create tissue as needed.
Researchers discovered that a growth factor, granulocyte colony stimulating factor (G-CSF), can increase the number of stem cells in the heart, which may help repair damaged heart tissue. After six weeks, patients showed significant improvements in heart function and metabolic recovery.
Researchers have successfully treated heart attack patients with stem cells harvested from their own bone marrow, resulting in improved cardiac function and increased blood flow to the damaged area. This breakthrough therapy could potentially lead to a new treatment for heart attacks.
Researchers found that human bone marrow-derived multipotent stem cells can differentiate into both vessels and heart muscle, regenerating essential tissues of the heart. The study shows promise for treating acute and chronic heart failure and other blood vessel diseases.
Researchers found that Bmi-1 is essential for self-renewal in two types of adult stem cells: neural stem cells from the central nervous system and hematopoietic stem cells. This discovery may lead to a better understanding of cancer development, as Bmi-1's overexpression can promote uncontrolled growth.
A new study found that treating hematopoietic stem cells with parathyroid hormone increases their numbers and improves bone marrow transplantation outcomes. The research team discovered a cellular-signaling pathway called Notch that is involved in the process, which they believe can be exploited to enhance stem cell populations.
Researchers at the Stowers Institute have identified a key component of the hematopoietic stem cell niche, which supports their self-renewal and production of blood cells. The study found that interrupting a specific signaling pathway can increase the size of the niche and the number of stem cells produced.
Researchers at MIT have developed a new method for creating tissues from human embryonic stem cells by seeding them onto biodegradable polymer scaffolds. The resulting tissues showed characteristics of developing human cartilage, liver, nerves, and blood vessels.
Researchers have made significant progress in isolating skin stem cells, with the discovery that these cells can be found in the basal epidermis layer. This breakthrough has the potential to treat wounds, including burns, by transplanting stem cells directly onto the damaged area.
Researchers control the development of stem cells in the inner ears of embryonic chickens by introducing new genes, leading to the growth of balance-related hairs instead of sound-detecting ones. This breakthrough could potentially improve our understanding of inner ear disorders and lead to therapies for deafness and vertigo.
Adult stem cells have been shown to regenerate damaged lung tissue, offering a promising new treatment for devastating lung diseases. The study's findings suggest that circulating stem cells can repair damage in organ tissue, which could have a huge impact on the treatment of conditions like emphysema and cystic fibrosis.
Researchers developed a gene therapy technique that uses an oncoretrovirus to transfer MGMT into normal bone marrow cells, allowing for the enrichment of healthy cells. The treatment showed promising results in mice with beta-thalassemia, achieving successful in vivo selection in 66% of cases.
A study published in JCI finds that PlGF-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity, suggesting a potential therapeutic agent for the condition. Additionally, researchers identify Fgl2/fibroleukin as a critical prothrombinase involved in the pathophysiology of viral hepatitis.
The European Society of Human Reproduction and Embryology's new chairman, Professor Arne Sunde, argues against a total ban on embryo-based research. He suggests that alternative stem cell sources, such as those derived from amniotic fluid or adult tissues, may become important for research and treatment in the future.
The Tulane center will prepare and distribute a continuous supply of marrow stromal cells (MSCs) using standardized protocols, addressing the need for standard MSC preparations. The center's availability will allow scientists to better understand the capabilities of these cells for potential therapeutic uses.
University Health Network researchers have identified a new class of human stem cells that rapidly rebuild the blood system, allowing for faster recovery from cancer treatment. The discovery holds significant implications for transplant patients who are vulnerable to infections during their weakened state.
Researchers have made a breakthrough in treating liver disease by using bone marrow stem cells from matched donors. The study found that these stem cells can form liver-like cells in damaged livers, producing human albumin and showing promise as a potential treatment for liver disease.
A study found that mice genetically engineered to lack a molecule called Stem Cell Antigen-1 (Sca-1) experienced normal bone development but exhibited decreased bone mass and brittle bones as they aged. The researchers believe that defective maintenance of stem cells may contribute to age-related osteoporosis in humans.
Researchers at the University of Pennsylvania have successfully produced mouse eggs from embryonic stem cells outside the body, showcasing their totipotent capabilities. This breakthrough could lead to new methods for producing embryonic stem cells artificially, potentially sidestepping ethical concerns.
Researchers have purified Wnt protein, a potent trigger of development and cell proliferation, to activate blood-forming stem cells. The discovery offers novel ways to enhance stem cells for cancer patients whose immune systems are compromised by chemotherapy.
Researchers at Stanford Medicine have successfully isolated a key protein that helps maintain the youthful state of hematopoietic stem cells. The discovery, led by Irving Weissman and Roeland Nusse, reveals how this protein, Wnt, triggers stem cell division and expansion.
Researchers successfully transplanted adult stem cells into mice, which then developed into various brain cell types, including nerve cells and glial cells. This breakthrough study suggests that these cells can potentially be used to treat neurodegenerative diseases such as Parkinson's and Alzheimer's.
Researchers have identified a new source of stem cells in human teeth, known as SHED (Stem cells from Human Exfoliated Deciduous Teeth), which can grow rapidly in culture and differentiate into specialized cells. This discovery may lead to breakthroughs in tooth repair, bone regeneration, and neural injury treatment.
Researchers found that bone marrow stem cells from healthy mice contribute to regeneration of nervous and muscle tissue affected by ALS. A five-fold increase in newly generated neuronal cells was observed in the central nervous system of ALS mice.
Scientists have discovered that bone marrow-derived stem cells can fuse with liver cells to form healthy, functional cells. This process, called cell fusion, reverses liver damage in mice with a genetic disease, paving the way for potential human treatments.
A team of scientists at the National Institutes of Health reports finding cheek cells with a male Y chromosome, indicating that some transplanted stem cells had differentiated into cheek cells. The study provides strong evidence for transdifferentiation and offers insights into its potential therapeutic applications.
Scientists have discovered two signaling molecules, Wnt and noggin, that influence immature stem cells to form hair follicles. These findings may lead to new ways to promote or inhibit hair growth, as well as insights into the development of other tissues like teeth and lungs.
Researchers have identified two natural proteins, Wnt and noggin, that promote the development of hair follicles in stem cells. These proteins work together to change the stem cell's shape and separate from adjoining cells, a crucial step for hair growth.
Argonne researchers have created powerful stem cells that can morph into various cell types, offering a practical alternative to embryonic stem cells. The breakthrough allows for the production of pluripotent stem cells from adult blood cells, which can potentially treat diseases such as cancer and neurodegenerative disorders.
Researchers at Duke University Medical Center have found that oxygen levels play a crucial role in transforming adult stem cells from fat into cartilage cells. Under low-oxygen conditions, the stem cells differentiate into chondrocytes, which can potentially repair damaged cartilage.
Scientists at Cold Spring Harbor Laboratory develop a new method to set the level of gene activity in stem cells using RNA interference, revealing distinct forms of lymphoma based on p53 levels. The study establishes RNAi as a convenient alternative to traditional gene knockout strategies.
The National Institute of Arthritis and Musculoskeletal and Skin Diseases has awarded five new grants to researchers studying stem cells and their potential in treating various musculoskeletal diseases. These studies aim to investigate growth factors, muscle regeneration, connective tissue repair, bone disease treatment, and the develo...
Researchers successfully differentiated stem cells from whole adult bone marrow into central nervous system cells. These cells may be used to treat various neurological conditions by replacing damaged brain cells.
The AAAS Top Ten Science Policy List for 2002 highlights concerns over new American security policies impacting scientific research. Human cloning, stem cell science, and sustainable development are among the top issues, with scientists facing a balancing act between global security and scientific progress.
Researchers found that bone marrow cells can repair damaged vessels to reduce atherosclerosis in mice. The study suggests a potential new approach to treating coronary artery disease and could lead to the development of stem cell-based therapies.
Researchers have successfully restored sperm production in infertile mice by transplanting healthy Sertoli cells. The technique, developed by Dr. Ralph L. Brinster, may provide a new way to replace defective Sertoli cells and initiate normal spermatogenesis.
Researchers at Children's Hospital of Philadelphia achieved immune tolerance in mice through prenatal stem cell transplants, enabling donor cells to multiply without toxic side effects. The technique could greatly broaden the use of cell and organ transplants for genetic diseases detected before birth.
Researchers discussed potential breakthroughs in understanding Alzheimer's disease, with one expert suggesting genetic testing could aid early diagnosis. Another speaker addressed the need for public education on vaccine risks and the challenges of bioterrorism preparedness.
A study published by University of Pennsylvania School of Medicine reveals the Foxd3 gene plays a vital role in maintaining stem cells' pluripotency. The findings suggest that Foxd3 is essential for embryonic development and has diagnostic significance for human embryonic stem cells.
Researchers identified 216 'stemness' genes that are active in embryonic, neural, and hematopoietic stem cells. These genes are involved in coping with stress, signaling, and self-renewal, and can aid in developing techniques to induce stem cells to differentiate into specific adult cells.
Researchers at Princeton University identified a core set of genes responsible for regulating stem cell behavior and unique activities. The study also uncovered over 4,000 genes active in surrounding tissues that influence stem cell behavior.
A Stanford study found that a single adult stem cell could only repopulate blood and immune cells in mice, casting doubt on its ability to form all adult tissues. The research suggests that embryonic stem cells remain the most promising option for tissue formation.
Researchers at Johns Hopkins University have successfully created cartilage-like tissue using adult stem cells in a minimally invasive procedure. The technique involves injecting a fluid filled with stem cells and nutrients into damaged tissue, where it hardens into a stable gel that can be replaced by new bone or cartilage.
Researchers created four new mouse embryonic germ cell lines to investigate imprinting and its control. They found that the mother's copy of a paternally imprinted gene was active instead of the expected father's copy.
Researchers found that human embryonic germ cells and their specialized daughter cells maintain correct 'imprinting,' a way cells determine gene expression. This is critical information for the safe clinical use of these cells in treating diseases.
Researchers have successfully used gene therapy to treat two young children with ADA-SCID, a rare form of SCID that requires regular injections of the bovine form of ADA enzyme. The new method involves removing bone marrow cells and engineering them to produce healthy immune cells, offering a potentially lower-risk alternative to bone ...
Researchers discovered that degradation of SDF-1 protein is crucial for stem cell mobilization in bone marrow transplants. G-CSF growth factor triggers this process by reducing SDF-1 levels, allowing stem cells to flow into the bloodstream. The findings may lead to improved collection of stem cells for clinical transplantations.
A new program will bring together experts to discuss criteria for selecting stem cell lines and address concerns over safety, transplant rejection, privacy, genetic diversity, and public access. The project aims to anticipate emerging issues and provide a reasoned backdrop for policy decisions.
Researchers at Georgetown University Medical Center have developed a germ cell line derived from spermatogonia, offering a basic tool for studying male infertility and testicular cancer. This cell line exhibits characteristics of normal adult spermatogonial stem cells and differentiates into advanced germ cell types upon stimulation.
Scientists have identified a crucial protein called DE-cadherin-mediated cell adhesion, or 'cell glue', which enables stem cells to locate their niche and receive essential instructions for survival. The discovery sheds light on the importance of microenvironment in determining stem cell fate.
Researchers have discovered that adult blood stem cells can function to make blood vessels, a breakthrough that could lead to new treatments for circulatory diseases. The discovery was made using genetically engineered mice with green glowing stem cells, which were able to form new capillary beds in the eyes.
Duke University researchers have successfully transformed adult stem cells taken from fat into cells that resemble nerve cells. The new cells were grown in the laboratory using chemicals and growth factors, and showed promise as a potential treatment for central nervous system disorders. While further research is needed to determine th...
A new bioreactor-based technique has improved stem cell cultivation, allowing for large-scale production and higher efficiency. This breakthrough could lead to significant advancements in regenerative medicine and tissue engineering.
A recent study published in JCI Journals reveals that a versatile stem cell can be repurposed to enhance tissue repair and regeneration in various tissues. The researchers discovered that the stem cell can differentiate into multiple cell types to facilitate the healing process.
The NIH has granted $3.5 million in funding to four institutions to enhance their human embryonic stem cell (hESC) research infrastructure. The funds will support the expansion, testing, quality assurance, and distribution of existing cell lines, enabling basic scientists to access these cells for research.
Researchers at the University of Minnesota have successfully transplanted stem cells into laboratory animals with stroke, restoring brain function. The study demonstrates that bone marrow-derived stem cells can differentiate into neurons, astrocytes, and oligodendroglia, offering hope for future clinical trials.