A new compound called OSU 111 has been developed to target both cancer cells and the formation of new blood vessels that feed them. In laboratory experiments, it was found to be highly effective in killing prostate cancer tissue cells within three days.
Researchers create synthetic transcription factors, mimicking natural regulators to probe gene regulation and explore new treatment approaches. The artificial activation domains developed in Mapp's lab were as effective as a natural activation domain at turning on genes.
Researchers studied sediments from two contaminated rivers and found that bacteria in Hudson River sediment were faster at digesting PCBs compared to those in Grasse River sediment. The team aims to identify nutrients or factors that can accelerate PCB breakdown in sediments without dredging.
A recent simulation study revealed that damaged DNA becomes more susceptible to bending due to a reorganization of its sugar-phosphate backbone. This change allows the molecule to bend easily, which is recognized by enzymes as a damaged site.
Scientists identify ZIC1 and ZIC4 genes linked to Dandy-Walker, a condition affecting the cerebellum. The discovery may lead to prenatal diagnosis and better understanding of autism.
Researchers have developed a new method to enhance the conductivity of polymer nanowires by injecting extra negative or positive charges using high-energy electrons. This allows for the observation of charge movement across the wire, a key step toward developing good conductors.
A study from the Ludwig Institute for Cancer Research has uncovered a fundamental mechanism of lymphatic vessel formation, revealing abnormally shaped vessels covered in smooth muscle cells. The findings may lead to better treatments for lymphedema, which affects people worldwide and can be inherited or caused by tumor removal.
Textile researchers are uncovering secrets about ancient lives through chemical and physical analysis. Fragments of prehistoric fabric provide clues about the status, wealth, and cultural practices of individuals buried in North American archaeological sites. By studying these textiles, experts can gain a deeper understanding of the te...
Researchers found that individuals in a positive mood tend to have unreliable memories and poor critical thinking skills, while those in a negative mood provide more accurate eyewitness accounts. In contrast, a negative mood state triggers more systematic information processing, leading to superior thinking and communication skills.
The Masters of Chemistry Education program at Penn enables high school teachers to learn chemistry from researchers while working full-time. The 26-month program includes three summers, providing tuition scholarships and expanding a teacher's knowledge of chemistry.
Researchers discovered a link between aneurysm formation and the activation of an asthma inflammation gene. Blocking this pathway may prevent or slow aneurysm progression, potentially using anti-inflammatory drugs used in cardiovascular disease treatment.
Researchers at Johns Hopkins University have developed a new class of nitroxyl-releasing compounds that seem to strengthen cardiac contractions and relaxation in dogs with heart failure. These compounds, which produce nitric oxide (HNO), have shown promising results in early studies.
A University of Toronto study discovered precursor cells within the adult pancreas that can make new pancreatic cells, potentially providing a plentiful supply of beta cells for transplant treatments. The research also found that these cells can generate both beta cells and neurons, challenging existing dogma on development.