Articles tagged with Stem Cell Research
Scientists have identified a crucial protein called DE-cadherin-mediated cell adhesion, or 'cell glue', which enables stem cells to locate their niche and receive essential instructions for survival. The discovery sheds light on the importance of microenvironment in determining stem cell fate.
Researchers have discovered that adult blood stem cells can function to make blood vessels, a breakthrough that could lead to new treatments for circulatory diseases. The discovery was made using genetically engineered mice with green glowing stem cells, which were able to form new capillary beds in the eyes.
Duke University researchers have successfully transformed adult stem cells taken from fat into cells that resemble nerve cells. The new cells were grown in the laboratory using chemicals and growth factors, and showed promise as a potential treatment for central nervous system disorders. While further research is needed to determine th...
A new bioreactor-based technique has improved stem cell cultivation, allowing for large-scale production and higher efficiency. This breakthrough could lead to significant advancements in regenerative medicine and tissue engineering.
A recent study published in JCI Journals reveals that a versatile stem cell can be repurposed to enhance tissue repair and regeneration in various tissues. The researchers discovered that the stem cell can differentiate into multiple cell types to facilitate the healing process.
The NIH has granted $3.5 million in funding to four institutions to enhance their human embryonic stem cell (hESC) research infrastructure. The funds will support the expansion, testing, quality assurance, and distribution of existing cell lines, enabling basic scientists to access these cells for research.
Researchers at the University of Minnesota have successfully transplanted stem cells into laboratory animals with stroke, restoring brain function. The study demonstrates that bone marrow-derived stem cells can differentiate into neurons, astrocytes, and oligodendroglia, offering hope for future clinical trials.
Scientists have successfully generated primate stem cells from an unfertilized embryo through parthenogenesis, demonstrating the ability to produce various cell types, including midbrain dopamine neurons. This breakthrough could lead to new treatments for diseases such as Parkinson's and Huntington's, heart disease, and diabetes.
Researchers found that adult bone marrow stem cells can differentiate into blood vessels, potentially treating cancer tumors, wounds, and atherosclerosis. The discovery of multipotent adult progenitor cells (MAPCs) may lead to new clinical therapies.
Researchers at Duke University Medical Center found that stem cell transplants performed within the first 28 days of life have a 95 percent success rate in treating newborn babies with severe combined immunodeficiency (SCID). The early transplants also stimulate a more robust and effective immune system, with reduced stresses on the th...
Researchers found that proliferating germline stem cells, which divide continuously, affect aging by influencing a steroid hormone. The discovery suggests that these stem cells are master control cells controlling both reproduction and aging.
Scientists have successfully genetically altered human blood stem cells to selectively activate genes in developing immune cells, providing a potential breakthrough for gene therapy. The research uses a lentivirus to transfer a fluorescent protein gene into stem cells, which then express the gene only in specific immune cells called an...
Scientists discover that the Math1 gene triggers the differentiation of three types of intestinal cells from stem cells, including goblet, enteroendocrine, and Paneth cells. This finding provides significant insights into the regulatory control of intestinal stem cells and their role in disease treatment.
Carl Picconatto, a chemist from Wisconsin, has been named a congressional fellow by the American Chemical Society to work in Rep. Connie Morella's office on science and technology issues. He previously interned at the National Academy of Sciences and holds degrees from Columbia University and the University of Notre Dame.
Researchers have successfully converted adult human bone marrow stem cells into functional brain cells in the lab, using a combination of growth factors and nutrients. The breakthrough could potentially lead to new treatments for neurodegenerative diseases like Parkinson's disease.
A unique gene has been identified as a regulator of stem cell growth, suggesting that embryonic and adult stem cells share key genes and properties. This discovery could lead to the development of new therapies for cancer patients in need of stem cell transplants.
Researchers at McGill University have isolated novel stem cells from the dermis of adult rodents that can differentiate into various cell types, including neurons and muscle cells. These multipotent stem cells, known as SKPs, hold promise for treating Parkinson's disease and other neural disorders.
John D. Gearhart praises the policy as a good starting point for expanding stem cell research, despite limitations in funding and oversight. He emphasizes the potential of federal funding to accelerate progress and improve human health through advances in understanding and treating various diseases.
The use of embryonic stem cells is a contentious issue, with proponents arguing that they hold promise for medical breakthroughs. However, opponents claim that destroying an embryo is tantamount to infanticide. Scientists generally favor the use of embryonic stem cells due to their versatility.
Gene expression is found to be highly variable in cloned mice, with imprinted genes showing widespread aberrant regulation. This variability may contribute to the large offspring and respiratory problems commonly seen in clones.
Researchers at Harvard University have created a powerful new tool to combat diabetes, identifying crucial genes responsible for pancreatic development. The discovery sheds light on the role of NGN3 and Pdx-1 in pancreatic development, offering hope for potential therapeutic usage.
A study led by Dr. William Bensinger found that patients undergoing stem-cell transplantation lived longer than those receiving marrow transplants, especially for high-risk blood cancers. The study also showed lower rates of acute and chronic graft-versus-host disease with stem cells.
A team of researchers at The Hospital for Sick Children has discovered two distinct types of stem cells within the blood system, short-term repopulating and long-term repopulating stem cells. These stem cells have different functions and could lead to improved cancer treatment and gene therapy outcomes.
Scientists at Johns Hopkins have engineered a new type of cell that can develop into various tissues, overcoming drawbacks that limited hPSCs for disease therapy. The embryoid body derived cells (EBDs) reproduce readily and are easily maintained, eliminating the need for fetal tissues.
Two new studies show that bone marrow cells transplanted into mice can migrate into the brain and develop into cells resembling neurons. These findings have significant implications for treating conditions such as Parkinson's disease and traumatic brain injury, potentially using patients' own cells that would not be rejected by the imm...
Researchers at Imperial College will examine the science behind stem cells and their potential for regenerative medicine, including treatments for various diseases. The symposium will feature world leaders in stem cell science, providing a comprehensive background to the field.
The conference will examine the latest research efforts towards understanding and treating neurodegenerative diseases. Novel approaches using stem cells, vaccines, gene therapy and hormone modulation will be discussed.
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) has awarded five new grants to support research on osteogenesis imperfecta. These grants will focus on developing treatments, such as gene therapies and drug treatments, to improve diagnosis and treatment options for people with OI.
OHSU researchers successfully used bone marrow stem cells to repair liver damage in mice with genetic disease Tyrosinemia. The study shows that hematopoietic stem cells are required for liver cell regeneration, offering hope for new therapies using stem cells.
Scientists at Johns Hopkins Medicine used stem cells to treat paralysis in rodents infected with an animal virus that damages motor neurons. Fifty percent of treated rodents regained hind leg function, suggesting potential for improved treatments for ALS and spinal motor atrophy.
Researchers at ZymoGenetics have identified a novel Interleukin, IL-21, and its receptor, which play a crucial role in regulating the immune system. The discovery was made using an integrated genomics approach and has shown promising results in promoting the activation of immune cells.
Researchers at Ohio State University have made a breakthrough discovery that may lead to a new therapy for patients who suffer from heart attacks. The study shows that blood-derived cells called monocytes can create tunnels in damaged heart tissue, which can potentially be used to grow new blood vessels.
A new patented device co-developed by Ohio State University engineers helps scientists separate cells in the laboratory for transplant and cancer research. The device refines existing magnetic cell separation techniques to better measure how well cells are labeled and magnetized.
The human organs shortage is raising complex questions about who should receive transplants, how to balance costs against medical needs, and the ethics of extending individual lives. A forum on 'Reinventing the Human: The Six Million Dollar Body' will explore these issues and provide a platform for public debate.
Researchers have identified regulatory cells that govern the behavior of stem cells in Drosophila, revealing a specialized cellular environment known as a niche. The niche environment provides support needed for stem cell self-renewal, and its characteristics may offer insights into human stem cell regulation.
Researchers at UCSF Comprehensive Cancer Center are testing an immunotherapy treatment that involves collecting stem cells from a patient's sibling to attack the cancer. The trial aims to confirm previous NIH study results and explore its potential in treating solid cancers, including prostate and melanoma.
Researchers have successfully transplanted neuronal stem cells into a diseased rat retina, which integrated into the eye and extended into the optic nerve. This breakthrough could lead to the development of a new therapy to restore vision in millions of people affected by retinal damage.
A Phase I/II study found substantial and occasional complete regression of widespread tumors in patients with treatment-resistant metastatic renal cell carcinoma treated with blood stem cell transplants. Three patients achieved total regression, while seven showed partial regression of disease.
Researchers found that high-dose immune suppression and stem-cell transplantation can lead to long-term remission in lupus patients. The treatment approach has implications for the treatment of other immune disorders, including multiple sclerosis and some types of cancers.
Researchers at NYU Langone Health and the University of Pennsylvania School of Medicine have discovered that hair follicles are the source of new cells for the skin's outermost layer, the epidermis. These stem cells reside in a protected area called the bulge, which migrates to the epidermis, replenishing the skin throughout life.
A study by University of Pennsylvania researchers found that the hair follicle and epidermis may originate from the same cache of cells. The finding suggests that daughter cells in the upper follicle migrate upward to form and maintain the new epidermis, and down to form the hair shaft.
A newly identified protein called palladin is being explored for its influence on biological processes including cancer spread and wound healing. Palladin appears to play a critical role in determining cell shape via the actin cytoskeleton, with different forms of the protein involved in tight adhesion and movement.
UC Davis researchers have successfully restored vision in 10 of 14 patients suffering from severe corneal damage, using a new technique to grow replacement cornea tissue in a laboratory dish. The treatment showed significant improvement in visual acuity, enabling patients to regain their independence.
Researchers discovered that bone marrow-derived stem cells can generate mature liver cells in humans. This groundbreaking finding has the potential to revolutionize treatment options for liver damage and disease.
Scientists have discovered that the bone marrow is a source of mature liver cells, which could be used to develop new treatments for liver diseases. The findings suggest that healthy genes can be inserted into these stem cells to correct metabolic abnormalities.
Researchers find functional liver tissue in human patients, solving organ shortages and rejection issues. The discovery also enables the growth of artificial livers and targets gene therapy for inherited liver diseases.
Dr. Edus H. Warren, an immunologist at the Fred Hutchinson Cancer Research Center, is one of five recipients of a $1.2 million grant to support his research on understanding immune responses in leukemia patients. He aims to develop strategies for selectively enhancing the GVL effect without inducing GVHD.
Researchers have identified over 2,000 genes active in blood stem cells, shedding light on how they replenish themselves and potentially inform treatments for diseases like leukemias. The discovery offers a powerful tool for understanding blood cell production and development.
Researchers will grow functional human heart tissue, aiming for a fully functional heart in 10 years. They'll use scaffolding, stem cells, and patented technology to engineer cardiac muscle and valves.
Researchers at Fred Hutchinson Cancer Research Center have discovered a novel agent that can prevent transplant reactions and promote immunological tolerance. The treatment, using an anti-CD28 antibody, could lead to safer and more effective transplants, reducing the risk of graft-versus-host disease.
Researchers have identified a new strain of antibiotic-resistant salmonella bacteria in the US, prompting concerns over effective treatment options. The bacteria, which is resistant to cephalosporins, has been linked to outbreaks in poultry and other foods, posing a significant threat to public health.
Researchers have discovered retinal stem cells in adult mice, cows, and humans, which can proliferate and differentiate into new neurons when removed from the eye. The study suggests that these cells may be harnessed to regenerate and restore vision in damaged eyes.
Researchers at Massachusetts General Hospital have identified a molecular switch, the protein p21, that controls the development and proliferation of hematopoietic stem cells. The discovery may solve a major limitation to using these stem cells in transplants and gene therapies.
University of Florida researchers have reversed diabetes in mice by injecting cells that produce enough insulin to regulate blood sugar levels effectively. The cells were grown into small, insulin-secreting organs and implanted just beneath the skin, allowing them to function like an endocrine pancreas within days.
Researchers have successfully cloned mice using embryonic stem cells, achieving the highest efficiency to date. The new technology allows for modification of genetic material before cloning, improving understanding of cloning challenges and potential benefits in biomedical research and agriculture.
Researchers at Oregon Health & Science University have successfully cloned an identical monkey named Tetra using embryo splitting. This breakthrough method shows promise for accelerating discoveries in human diseases like Alzheimer's, AIDS, and cancer.
Scientists made significant progress towards controlling human stem cells, which showed promise for treating a range of diseases. Adult stem cells also demonstrated the ability to shed their old identities and adopt new ones, opening up possibilities for important therapies.
Researchers found that stem cells provide a higher two-year survival rate (70%) compared to marrow transplants (45%) for certain high-risk blood cancer patients. The study suggests that stem cell transplants may offer fewer relapses with fewer complications.
The Indiana University Cancer Center has been designated as an NCI-recognized clinical cancer center, bolstering its $33.3 million annual funding for cancer research projects. The grant enhances collaboration between researchers and physicians to target clinical problems and apply findings to new patient treatments.
Researchers from HHMI at Children's Hospital and Harvard Medical School discovered that stem cells can deliver therapeutic genes to diseased organs, potentially remodeling genetically defective tissues. The study suggests that adult stem cells may be manipulated to heal genetic defects in various organs and tissues.