Articles tagged with Stem Cell Research
Researchers at Helmholtz Munich used new bioimaging techniques to show that hematopoietic progenitor cells are instructed by cytokines, steering their lineage choice. This discovery confirms the influence of environmental factors on cell differentiation and has important implications for optimizing therapeutic stem cell applications.
Researchers at Newcastle University have successfully created human sperm from embryonic stem cells, allowing them to study the causes of infertility and potentially develop new treatments. The technique uses germline stem cells developed from male embryos, which are then prompted to mature into fully functional sperm.
A gene called Chd1 has been found to be critical in maintaining the pluripotent state of embryonic stem cells. This discovery could lead to a greater understanding of how cells acquire specialized states and provide a strategy for efficiently reprogramming mature cells back into the pluripotent state.
Researchers at Gladstone Institute discovered a key switch, microRNA-145 (miR-145), to turn stem cells into muscle cells that reside in blood vessel walls. This finding suggests restoring miR-145 activity could prevent artery narrowing and vessel disease.
A team of bioethicists is urging the public to engage in open discussions about the research and reproductive use of stem cell-derived gametes. The authors recommend guidelines for the development of these cells, including specific consent requirements and oversight rules.
Researchers at Stanford University School of Medicine have identified a novel connection between the telomerase molecule and the Wnt pathway in stem cell regulation. Overexpression of telomerase's TERT protein enhances Wnt-inducible genes, suggesting a potential new target for cancer therapies.
Case Western Reserve University has received funding to support multiple stem cell and regenerative medicine commercial, emerging, and pilot projects. The $5 million grant will help advance technologies to benefit patients in Ohio, building on previous investments that have brought in $170 million in new commercial development.
Researchers at MU develop method to transform fibroblasts from a pig's connective tissues into induced pluripotent stem cells. The new approach eliminates genetic incompatibility issues and allows for long-term animal models, paving the way for more accurate tests of stem cell therapies.
Scientists found that adult muscle stem cells can regenerate muscles after injury without the two key embryonic muscle cell genes Pax3 and Pax7. This discovery challenges current research on muscular dystrophy and regenerative medicine, suggesting that age-matched stem cells may be more effective for therapy.
Johns Hopkins researchers have made a breakthrough in editing human stem cells, enabling the development of patient-specific therapies for rare blood diseases like paroxysmal nocturnal hemoglobinuria (PNH). The team successfully targeted and edited a gene responsible for causing PNH, improving on standard gene targeting technology.
Researchers have successfully created a line of induced pluripotent stem cells from adult pigs, providing a valuable model for studying therapeutic potential and addressing ethical concerns. The pig iPS cells closely resemble human stem cells, making them an exciting emerging field with rapid progression and multiple applications.
Researchers at the Ottawa Hospital Research Institute have discovered a protein called Wnt7a that increases satellite stem cells in muscle tissue, leading to accelerated growth and repair. This breakthrough may lead to new therapeutic treatments for muscular diseases such as muscular dystrophy and sarcopenia.
Researchers demonstrated a non-invasive procedure that increased myocytes and reduced cardiac tissue injury by 60%, improving heart function by 40%. The therapy also reduced fibrosis, promoting regeneration of heart tissue.
Researchers have discovered that activated stem cells in damaged lungs may lead to rapidly dividing cells that can develop into lung cancer. This finding is significant because it highlights the role of stem cell activation in lung cancer susceptibility, particularly among cigarette smokers.
Researchers at Karolinska Institutet are making rapid progress in stem cell therapy, with a first-in-human study initiated for Parkinson's disease. The study uses the drug product sNN0031, which has shown long-lasting recovery and new cell formation in animal models. Additionally, a treatment for ALS entered clinical trials last year.
The American Society for Neural Therapy and Repair (ASNTR) endorses the new NIH Guidelines, enabling research on human embryonic stem cells derived from IVF embryos. This move aims to facilitate the development of stem cell therapies for central nervous system diseases by reducing restrictions on cell line acquisition.
Researchers successfully transplanted embryonic stem cells into mouse embryos, demonstrating a capacity to recover from cardiac injury in adulthood. The study provides evidence for preventive regenerative medicine to treat myocardial infarction through prophylactic intervention.
Researchers at Hebrew University of Jerusalem neutralized tumor growth in human embryonic stem cells by identifying and inhibiting the survivin gene. This breakthrough paves the way for further progress in stem cell therapy for diseases like diabetes, Parkinson's disease, and heart failure.
Researchers at UBC's Biomedical Research Centre have identified S1P as a molecule that can open the thymic gate for migrating stem cells. This discovery holds promise for increasing the success of blood stem cell transplants, which are currently used to treat diseases such as leukemia and aplastic anemia.
Researchers have found that human foetal stem cells can effectively treat back leg ischaemic ulcers in a model of type 1 diabetes. The culture mimics the wound-healing ability of the cells, suggesting they could be used as a 'factory' of wound-healing substances.
Scientists have successfully reprogrammed blood cells into cells that mimic embryonic stem cells, opening up new avenues for research and potential treatment of diseases. The discovery provides an accessible source of stem cells, which can be used to study various diseases and develop new therapies.
A team from IRIC has successfully produced a large quantity of laboratory stem cells from a small number of blood stem cells. This breakthrough could lead to major implications in fields with no current treatment, such as transplantation and organ rejection prevention.
Researchers have developed a new culture system to isolate and proliferate liver stem cells from bone marrow cells, achieving six passages of the stem cells. The method uses a selecting culture system containing cholestatic serum to purify the stem cells, providing an easy and efficient way to separate them.
Researchers at UT Houston are conducting a Phase I safety trial using patient's own stem cells to treat strokes. The study aims to reduce disability in patients and could be an exciting new therapeutic approach.
Researchers have made a groundbreaking discovery in the treatment of bone injuries, using teriparatide to jumpstart the body's natural healing process. The study shows significant healing and pain control in patients with unhealed bone fractures, offering new hope for those with no effective treatment options.
A study by Pitt researchers found that injecting human corneal stem cells into mice with scarred and hazy eyes restored transparency. The cells were able to remodel scar-like tissue back to normal, suggesting a potential treatment for corneal blindness and vision impairment.
Researchers discovered the JunB gene's role in regulating hematopoietic stem cells, which produce blood cells. The study suggests that JunB can help prevent leukemia by limiting cell proliferation and differentiation.
Research led by David Hess identified how to use bone marrow stem cells to grow new blood vessels in mice with ligated leg arteries. These pro-angiogenic stem cells have a natural ability to induce blood vessel repair and improve blood flow in ischemic limbs.
Researchers develop novel method to identify stem cells in pancreas, showing acinar cells produce digestive enzymes and may have carcinogenic properties. The breakthrough paves the way for further study on proliferation mechanisms and potential dangers of these cells.
A new dual therapy approach generates new blood vessels and improves cardiac function following a heart attack, overcoming current stem-cell-mobilizing therapies' ineffectiveness in humans. This strategy stabilizes SDF-1 and enhances the recruitment of EPCs to damaged heart tissue.
Researchers at Helmholtz Munich have discovered the last step leading to blood cell formation, which has important implications for the development of new therapies. The study found that a special type of endothelial cell can transform into blood cells, providing a key insight into the mechanisms of hematopoiesis.
A team of American researchers has developed a genetic switch that allows mutations or light signals to be turned on in muscle stem cells, enabling monitoring of muscle regeneration in living mammals. This breakthrough could lead to the creation of a genetic switch or drug for humans to grow new muscle cells and treat muscular dystrophy.
Researchers at St. Jude Children's Research Hospital have found that cells isolated from the eye are not retinal stem cells, contradicting previous findings. Instead, they suggest that re-engineering stem cells to develop photoreceptor cells could be a promising approach to restore vision in people with retinal degeneration.
A team of scientists has developed a new method to create stem cells with embryonic-like properties without using viruses, which can trigger cancer. This approach imports necessary genes on a small DNA circle and naturally disappears from the cell population over time.
A breakthrough study has revealed that blood stem cells produce chemical signals of their own that influence their attachment to the bone marrow or migration into the circulatory system. This discovery holds implications for improving leukemia treatment and artificially culturing infection-fighting immune cells.
Researchers at USC have identified a key mechanism that guides the migration of blood-forming stem cells to the bone marrow. The finding may lead to improved efficiency in bone marrow transplants by activating a specific signaling pathway.
Researchers at Rensselaer will investigate the role of specific genes and biological molecules in human stem cell function. They aim to understand how to control stem cell development using a range of new technologies.
Researchers have successfully isolated human auditory stem cells from fetal cochleae and found they can differentiate into sensory hair cells and neurons. This breakthrough has the potential to develop a new treatment for deafness, with implications for studying ear development and modeling drug screening.
Researchers have discovered that the Shp2 protein plays a critical role in controlling the pathways that decide whether human and mouse embryonic stem cells differentiate or self-renew. The study found that Shp2 acts as a coordinator to fine-tune signal strength, providing insight into fundamental signaling mechanisms.
A newly identified molecular pathway directed stem cells to produce glial cells, providing insights into the neurobiology of Down's syndrome and central nervous system disorders. The study found that synaptojanin-1 is essential for glia production, which may lead to the development of drugs that inhibit glial proliferation.
Researchers reported on eight patients with spinal cord injury (SCI) who received multiple route bone marrow stem cell injections, showing functional improvements such as bladder control. The study demonstrated the safety and feasibility of multiple route administration of bone marrow-derived stem cells for SCI treatment.
The Empire State Stem Cell Board has awarded Albert Einstein College of Medicine $12.7 million to support promising medical advancements, including treatments for sickle cell anemia and obesity. The new grants will help create technologies for cancer, heart and liver disease, as well as age-related diseases.
Researchers have successfully tracked and confirmed the survival of stem cells in the body using a firefly-like bioluminescence imaging agent. This innovative technique enables precise targeting of stem cell delivery to specific blood vessels, opening new hope for treating peripheral arterial disease.
Scientists have successfully replaced damaged brain tissue in rats with stem cells, filling cavities within 7 days. The new tissue interacts with the host brain and can be gradually replaced by natural processes.
Penn Vet researchers identified colony stimulating factor 1 (Csf1) as a growth factor that enhances sperm stem cell self-renewal. The study reveals that Leydig cells secrete Csf1, which interacts with the microenvironment to support stem cell function.
Researchers have discovered a new pathway that prompts stem cells to specialize into blood cells, providing hope for regenerating the blood system in patients with leukemia or undergoing cancer treatments. The Canadian Cancer Society funded this research, which could lead to more efficient production of blood cells.
Researchers have developed a world-first procedure to regrow muscles in a mouse model, which could be applied to human tissue-based illnesses such as liver or brain diseases. The technique strengthens adult stem cells' ability to regenerate damaged tissue by making them resistant to chemotherapy.
Scientists at McMaster University have identified a key communication pathway that triggers stem cells to specialize and become blood cells in humans. The noncanonical Wnt pathway works by organizing cells to respond to signals for blood development, providing an efficient way to produce blood cells.
Researchers at McGill University Health Centre discover a new pathway that controls bone remodelling with interferon gamma. Interferon gamma may become an efficient drug-target for treating osteoporosis.
Researchers at Stanford University School of Medicine have developed a technique to generate solid organs using stem cells. By utilizing microcirculatory beds and a bioreactor, the team can keep tissue healthy enough for reimplantation into a second animal, overcoming the major hurdle of blood supply in tissue engineering. The techniqu...
Dr. Nagy's method uses a novel wrapping procedure to deliver specific genes, overcoming major hurdles for personalized stem cell therapies. The breakthrough accelerates stem cell technology and provides a road map for new clinical approaches to regenerative medicine.
A new approach to generate induced pluripotent stem (iPS) cells has been developed by Austin Smith's team. They used a single reprogramming factor called Klf4 and a transposable element called Piggybac to persuade partly specialised mouse cells to reprogram into iPS cells.
Researchers have successfully used stem cells to grow on a scaffold made from tissue extract, overcoming two key challenges for organ transplantation. This breakthrough enables the creation of bioengineered organs that can be transplanted without rejection.
Researchers at UCR identified all the genes expressed in plant stem cells, providing a global view of which genes are expressed and where within the shoot apical meristem. This discovery can help scientists develop better varieties of crops and understand why stem cells give rise to specialized cells.
A Johns Hopkins engineer is working on coaxing human stem cells to form new blood vessels that could replace damaged tissue in people with heart disease and other illnesses. The researcher, Sharon Gerecht, aims to understand the molecular signals that cause stem cells to differentiate into blood vessels.
A rare case of a boy with Ataxia Telangiectasia developed abnormal growths in his brain and spinal cord four years after receiving human fetal stem cell therapy. The tumors were found to be benign neural tumors that could not have arisen from the patient's own tissues, highlighting the need for caution in stem cell therapy.
Researchers at UT Houston are launching a Phase I study to treat acute stroke victims with their own stem cells, harvested from bone marrow. The goal is to assess the safety and potential benefits of this treatment in reducing disability.
Researchers have discovered a signaling pathway involved in normal pancreatic development is also associated with type 2 diabetes. The Wnt signaling pathway is up-regulated in insulin-producing cells of pancreases from adults with type 2 diabetes.
Researchers at the University of Wisconsin-Madison have made a breakthrough in growing functional heart cells from induced pluripotent stem cells, paving the way for potential therapies for heart failure patients. The discovery uses a virus to reprogram skin cells into embryo-like states and could potentially lead to new treatments.
Researchers at Baylor College of Medicine have identified two critical genes, Scl and Lyl1, that work together to maintain a pool of hematopoietic stem cells. These 'sister' genes are essential for the survival and function of blood-system stem cells, and their dysfunction can lead to severe consequences.