Articles tagged with Stem Cell Research
Human embryonic stem cell therapy has been shown to significantly reduce MS disease severity in animal models, offering a promising new treatment for the debilitating disease. The therapy also provides an unlimited source of high-quality mesenchymal stem cells, which can be propagated indefinitely in lab cultures.
Scientists at Johns Hopkins Medicine have successfully created a three-dimensional complement of human retinal tissue in the laboratory, including functioning photoreceptor cells that can respond to light. The achievement offers new opportunities for vision-saving research and may ultimately lead to technologies that restore vision in ...
Researchers at Mount Sinai Hospital discovered that a protein called Sirtuin1 (SIRT1) is essential for maintaining healthy aging of blood stem cells. The study found that loss of SIRT1 leads to impaired regeneration and resembles aged, defective stem cells in mouse models.
Researchers found that fasting can replenish stem cells in the blood, combating chemotherapy-induced and aging-related changes in immune cell function. Fasting has also been shown to rejuvenate the immune system of old mice and protect against white blood cell loss in human patients.
Researchers at Case Western Reserve University have identified a new class of genetic switches, called seed enhancers, that guide the development of pluripotent stem cells. These enhancers play roles from before birth to adulthood and hold promise for regenerative medicine and disease prevention.
A study published in Cell Stem Cell shows that prolonged fasting cycles can induce immune system regeneration by shifting stem cells into a state of self-renewal. This process involves the depletion of white blood cells, which are then replaced by new ones, leading to improved immune function.
Researchers at the University of Missouri have successfully transplanted and grown human stem cells in genetically modified pigs. The breakthrough paves the way for future research on stem cell therapies and could lead to new treatments for debilitating human diseases.
Duke researchers discovered a novel neuron population in the adult brain that instructs stem cells to produce new neurons. The finding opens up possibilities for brain repair and regeneration through neural circuits.
University of Illinois researchers develop new technique to induce mouse embryonic stem cells to form three distinct germ layers, a crucial step towards regenerative medicine. The study provides insights into the biological process controlling tissue development and opens doors for efficient organ generation.
Researchers at Stanford University School of Medicine have identified a new cell-cycle phase in resting stem cells, dubbed an 'alert' state, which enables them to rapidly respond to tissue damage. This systemic response is distinct from fully resting or activated stem cells and has been observed in various types of injuries.
Leading scientists from the U.S., Canada, and Belgium discussed cancer stem cells, highlighting their challenges in targeted cancer treatments. The symposium aimed to spark productive dialogues among researchers attending, according to Paul Frenette, director and chair of Einstein's Stem Cell Institute.
A new study challenges the use of stem cells in heart attack patients, finding that they do not regenerate damaged heart tissue at high enough rates. The study suggests that any potential benefit from injecting c-kit-positive cells into the hearts of patients may come from improving circulation rather than generating new cardiomyocytes.
Researchers at Mount Sinai identified a new technique to expand hematopoietic stem cells in cord blood, making them more useful for adult patients. This study has important implications for patients battling blood cancers and the success of life-saving stem cell transplants.
Exosomes secreted by cardiac stem cells carry messages that reduce cell death, promote growth of new heart muscle cells and encourage development of healthy blood vessels. The researchers pinpointed one microRNA as responsible for some of the benefits, suggesting it may be an attractive alternative to living-cell transplantation.
GDF11 protein improves the exercise capability of aging mice by making their brains and skeletal muscles more like those of young health mice. The protein also restores DNA damage associated with aging in muscle stem cells, leading to improved function in unmanipulated muscle.
Johns Hopkins researchers have successfully used stem cells derived from human body fat to deliver biological treatments directly to the brains of mice with glioblastoma, a deadly form of brain tumor. The treatment extended the mice's lives by an average of 24 days, offering new hope for treating aggressive brain cancer in humans.
Researchers successfully coaxed induced pluripotent stem cells from infertile men into producing sperm cell precursors after transplantation into mice testes. This breakthrough helps explain genetic causes of male infertility and holds potential for clinical applications.
Researchers at Stanford University and Montana State University have successfully transplanted stem cells from infertile men into mice, resulting in the formation of primordial germ cells. The study provides a valuable model for understanding the earliest stages of human reproduction, which varies significantly from that of common labo...
Researchers at the University of Adelaide have discovered that stem cells taken from teeth can grow to resemble brain cells, suggesting they could be used as a therapy for stroke. These cells have the potential to form complex networks and communicate like normal neurons, offering hope for new treatments.
Researchers at NYSCF and Columbia University Medical Center have successfully created the first disease-specific human embryonic stem cell line using somatic cell nuclear transfer (SCNT). The achievement marks a major step towards developing personalized cell therapies for life-threatening diseases like type 1 diabetes. By reprogrammin...
A study by Johns Hopkins researchers found that when a certain kind of stem cell is killed off experimentally, another group of non-stem cells can replace them naturally. The discovery may help explain how stem cells in tumors replenish themselves and could offer new targets for controlling cancer growth.
Scientists studying fetal stem cells that facilitate scarless wound healing aim to develop cell-based approaches to minimize scarring in adult wounds. Researchers have identified a new stem cell capable of participating in this process.
Researchers have developed a new method to generate bone tissue using the body's own stem cells, which could replace traditional bone grafting techniques. The process, known as biodegradable polymer scaffolding material and BMP, has been successful in lab experiments and shows promise for future clinical trials.
Researchers at UC Irvine's Sue & Bill Gross Stem Cell Research Center found that bone marrow stem cells significantly improved multiple outcome measures in animal studies of stroke. The effects were robust regardless of dosage, timing, or method of administration.
A recent study published in Stem Cell Reports has found no evidence of complete heart regeneration in newborn mice after apex resection. The researchers, led by Ditte Andersen, were unable to replicate the findings of a previous 2011 study that suggested complete regeneration was possible.
A new human trial demonstrates the effectiveness of injecting bone marrow-derived stem cells into the heart muscle to improve heart function in patients with severe ischemic heart disease. The treatment improved heart pump function by 8.2 milliliters, compared to an increase of 6 milliliters in the placebo group.
Researchers discovered that the p53 gene is hyperactive in stem cells when cellular damage is present, but not in other cells. This finding suggests that p53's tumor suppression ability may have evolved from its original role in regulating stem cell growth.
Researchers have developed a new technique to generate large concentrations of skeletal muscle cells and muscle progenitors directly from human pluripotent stem cells. This method, described in Stem Cells Translational Medicine, uses growth factors to guide the stem cells towards a muscle fate, avoiding genetic modification.
Researchers at UC Davis successfully coax laboratory cultures of human stem cells into the specialized, unique cells needed to repair a patient's defective or diseased bladder. The breakthrough provides a pathway to regenerate replacement bladder tissue for patients whose bladders are too small or do not function properly.
Scientists at A*STAR's IMCB develop a method to generate human induced pluripotent stem cells from a single drop of finger-pricked blood. This technique enables donors to collect their own blood samples, potentially boosting recruitment and diversities of donors for large-scale hiPSC banks.
A recent study published in Stem Cell Reports identified the earliest arising hematopoietic stem cell (HSC) precursors based on their ability to generate all major blood cell types. This discovery may be beneficial for creating purer, cleaner populations of these precursor cells for clinical treatments.
Two proteins, HIF1α and HIF2α, play a key role in the formation of human stem cells through reprogramming. The findings advance understanding of stem cell development and suggest potential targets for new cancer therapies.
Researchers have successfully identified two chemical compounds that can maintain functional human leukemic stem cells alive for at least seven days in vitro. This major breakthrough paves the way for the development of new cancer drugs to fight acute myeloid leukemia, a form of blood cancer.
Scientists at the University of Washington have successfully created a line of human embryonic stem cells that can develop into various tissues. The new 'naive' cells retain their natural ability to differentiate into all types of human cells without artificial genes, opening up possibilities for regenerative medicine and transplantation.
Scientists have successfully studied protein synthesis in adult stem cells, finding that precise protein production is essential to their function. The discovery opens up new avenues of cellular biology and may lead to a better understanding of diseases associated with protein synthesis mutations.
A team of researchers at Brigham and Women's Hospital has generated stem cells from skin biopsies of living family members with a genetic predisposition to early-onset Alzheimer's. The study found that the APPV7171 mutation alters amyloid-beta protein generation, Tau protein expression, and phosphorylation, providing new insights into ...
Researchers developed a set of 64 parameters to evaluate stem cell-derived cardiac myocytes, providing a standardized method to test cell function. This approach addresses critical quality control issues in the industry, enabling more reliable and reproducible tests for cell function.
Researchers found that human umbilical cord blood cells transplanted into rats with simulated myocardial infarction improved left ventricular heart function and preserved myocardial fiber structure. The study showed long-term benefits for the treated rats, suggesting a potential therapy for MIs.
Researchers at the University of Edinburgh's Roslin Institute have created working nerve cells from horse stem cells, paving the way for cell therapies targeting neurological conditions. The breakthrough could also benefit horses affected by grass sickness, a previously untreatable condition.
Researchers at Caltech have shown that bone marrow cells are sensitive to infection-related molecules and respond rapidly. They detect invasion and mount an inflammatory response, producing cytokines that stimulate the differentiation of immune cells.
Researchers have discovered a method for restoring strength to damaged skeletal muscles in the elderly using stem cell therapy. The treatment involves treating cells outside the body with a drug that prevents protein modification and culturing them on soft biomaterials, allowing aged cells to grow and self-renew.
A study by American University researchers found that understanding public opinion goes beyond partisanship to address differences in people's perceptions about the social implications of science. Four distinct groups, including 'Scientific Optimists' and 'Disengaged', were identified as influencing opinions on stem cell research.
Researchers have found that aging muscle stem cells become less able to regenerate new fibers and self-renew. However, they discovered a process to rejuvenate old muscle stem cells using a drug and soft hydrogel substrate, enabling them to repair muscle damage in mice.
Cancer researchers have discovered a pre-leukemic stem cell that may initiate disease and trigger relapse in patients with acute myeloid leukemia (AML). This finding offers a potential tool for earlier diagnosis and targeted therapy, as the pre-leukemic stem cell can survive chemotherapy and be found in the bone marrow at remission.
Scientists have discovered how the prostate gland develops for the first time, identifying 80 genes and a signalling pathway involved in its growth. The finding provides potential targets for new therapies to combat common prostate diseases, including prostate cancer.
A Cedars-Sinai research team led by Paul W. Noble is developing a novel approach to treat idiopathic pulmonary fibrosis, a disease that destroys the lungs and damages vital organs. The two-year study aims to build upon preliminary research and uncover the precise way normal lung stem cell repair occurs.
Researchers from RIKEN in Japan have identified a duo of histone proteins, TH2A and TH2B, that dramatically enhance the generation of induced pluripotent stem cells (iPSCs). The study demonstrates that these proteins function as substitutes for two Yamanaka factors and increase iPSC cell generation by twentyfold and speed up the process.
Researchers at Boston Children's Hospital have developed a new pathway to reverse lung diseases in mice by coaxing the production of healthy cells. By enhancing the natural signaling pathway, they successfully increased the production of alveolar epithelial cells, which line the small sacs where gas exchange takes place.
Two UC Irvine research teams will use the grants to investigate the fundamental structure and function of stem cells, with potential applications for treating cancer, neurological diseases, and injuries. The funded projects aim to uncover specific properties of human stem cells used in transplants.
Researchers at Johns Hopkins Medicine have developed human induced-pluripotent stem cells that can repair damaged retinal vascular tissue in mice without using viruses. These non-viral, human retinal iPSCs were grown using a safer method and showed comparable ability to human embryonic-derived iPSCs.
Researchers at UT Southwestern Medical Center found that estrogen increases proliferation of blood-forming stem cells in females, leading to increased red blood cell production. This discovery raises possibilities for treating blood cancers and reducing chemotherapy toxicity by considering estrogen levels.
Researchers have discovered two types of breast cancer stem cells, each playing a crucial role in metastasis. The findings highlight the need for targeted therapies that can tackle both forms of stem cells, offering new hope for patients with metastatic breast cancer.
Azim Surani receives the McEwen Award for Innovation for pioneering epigenetics research; Valentina Greco wins the ISSCR-BD Biosciences Outstanding Young Investigator Award for her noninvasive method to visualize skin stem cell division. Paolo Bianco, Elena Cattaneo, and Michele De Luca receive the ISSCR Public Service Award for their ...
Scientists have identified a key gene receptor and signaling pathway essential to maintaining human embryonic stem cells (hESCs) in an undifferentiated state. By blocking the WNT signaling pathway and its encoded receptor FZD7, researchers were able to keep hESCs in their pluripotent state.
Researchers successfully transplanted skin-derived stem cells into collagen tubes to bridge gaps in injured nerves, resulting in functional recovery and saving the upper arms from amputation. The study provides a promising new avenue for treating peripheral nerve injuries.
Scientists have identified fourteen genes that may be implicated in Alzheimer's disease and one gene that shows inflammation plays a crucial role in the brain of Alzheimer's patients. The study provides new insight into the cause of the disease, offering potential targets for drug discovery.
Researchers at NYSCF and Columbia University Medical Center successfully generated iPS cells from frozen brain tissue, allowing for the study of Alzheimer's disease at a cellular level. The new stem cell lines will enable drug testing on cells from patients with confirmed diagnoses.
A research team at the University of California, San Diego has discovered how calcium phosphate-based materials encourage stem cells to differentiate into bone-forming cells. The findings could lead to the development of new biomaterials that can be used to treat bone defects and diseases.
A study by Johns Hopkins Medicine found that patients overwhelmingly support stem cell research with induced pluripotent stem cells (iPSCs), despite ethical concerns. Patients prioritize full disclosure of anticipated uses and informed consent to alleviate concerns about privacy and commercialization.
Researchers at UCLA discovered a mechanism by which certain adult stem cells suppress their ability to initiate skin cancer during dormancy. The study found that PTEN gene plays a crucial role in tumor suppression via quiescence in hair follicle stem cells.