Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Scientists at the University of Cambridge have successfully generated key life event in artificial mouse embryo created from stem cells. The team used three types of stem cells to reconstruct the process of gastrulation, a crucial step in embryonic development.
The NYSCF Research Institute has developed a novel bioengineering technique called Segmental Additive Tissue Engineering (SATE), allowing for the creation of large-scale, personalized bone grafts. This technology overcomes limitations of current treatments, such as immune rejection and limited size and shape options.
Researchers at NUS have successfully reprogrammed mature cells into pluripotent stem cells by confining them in a defined geometric space for an extended period. By the 10th day, the cells expressed genes associated with embryonic stem cells and iPSCs, indicating complete transition into re-deployable stem cells.
Researchers found that adult stem cells in the intestines are replaced by fetal growth genes after parasite injury, enabling rapid wound repair. This discovery could lead to new treatments for internal wounds and improve understanding of mammalian body repair mechanisms.
Researchers identified adventitial CD90+ and mesenchymal stem cells in human arteries for the first time, providing a clear link to vascular diseases like coronary artery disease. These cells appear to play a key role in mediating vascular diseases.
A team of scientists from McGill University discovered a key role for the GRIN2B gene in early neural stem cell development and autism. They used genetic engineering to reprogram skin cells into brain cells with the patient's mutation, showing how improper protein production leads to impaired brain development.
Lund University researchers have developed a fluorescent variant of salinomycin to understand its mechanism against cancer stem cells. The molecule rapidly passes through the outer cell membrane and acts as an ion transporter in the endoplasmic reticulum, leading to a reduction in cancer stem cells
Researchers at Harvard University have discovered that the 'blood stem cell niche' evolved to protect blood stem cells from ultraviolet (UV) rays in sunlight. This finding has significant implications for improving the safety of blood stem cell transplants, a procedure used to treat patients with blood diseases and cancers.
Researchers from Newcastle University discovered that human embryonic stem cells travel back and forth in a line, revealing subtle patterns to their movement. This finding has important implications for the development of computer models to predict and control stem cell evolution.
A first-in-human phase I clinical trial using neural stem cells to treat chronic spinal cord injuries showed measurable improvement in three of four participants. No serious adverse effects were observed, suggesting the approach can be performed safely.
Scientists have developed a method to track biological samples using RFID chips, which can withstand extreme conditions and identify organoids grown from stem cells. This technology has the potential to advance drug testing and transplantation by providing real-time data on organoid health.
Researchers discovered that blood stem cells with a genetic mutation can be compensated by normal stem cells producing specific types of immune cells. Key findings suggest these highly productive stem cells proliferate dramatically and maintain a balanced immune system when transplanted into mice.
Researchers at Duke-NUS Medical School have identified CK1 as the priming kinase that 'switches on' the biological clock's phosphorylation process, shedding light on circadian rhythm regulation. This discovery may lead to treatments for circadian clock disorders and improve sleep-wake cycles.
Researchers at Helmholtz Zentrum München discovered that cerebrospinal fluid flow stimulates neural stem cell division through ENaC channel protein. The study highlights a new mechanism controlling neural stem cell proliferation and has implications for brain function and treatment.
Researchers at the University of Washington School of Medicine developed a robotic system to rapidly produce human mini-organs derived from stem cells, expanding basic research and drug discovery capabilities. The new technology enables mass production of organoids, which resemble rudimentary organs and behave similarly.
Researchers successfully convert mature skin cells into immature muscle cells using a simple approach, promoting muscle regeneration in injured mice. The induced myogenic progenitor cells (iMPCs) engrafted in damaged tissue and contributed to sustained muscle regeneration.
Researchers at University of Illinois Chicago have created atrial cells from pluripotent stem cells using vitamin A. This breakthrough enables better study of atrial fibrillation and potential personalized treatments.
A 24-hour fast can reverse age-related decline in intestinal stem cells' regenerative capacity. Fasting induces a metabolic switch that enhances stem cell function, which can be reproduced by activating PPARs with a molecule.
A UMD researcher has discovered mechanisms dictating germline stem cell development and epigenetic markers associated with diseases such as cancers, viral infections, and male infertility. These findings provide insight into treatments for these conditions and unlock future animal and human health research.
A new study has identified a critical stage in human embryonic development that may contribute to infertility and miscarriage. The research, led by UCLA biologist Amander Clark, reveals that epigenomic changes in early embryonic stem cells play a crucial role in determining embryo viability.
Mammary stem cells from dairy cows may help heal damaged tissue and combat bacterial infections, potentially reducing antibiotic use and improving milk quality. The secreted factors of these cells have been shown to promote tissue regeneration, form new blood vessels, and protect epithelial cells from damage.
A new review concludes that stem cells derived from adult body tissues can differentiate into mature body cells with similar efficiency to those from younger donors. This validates induced pluripotent stem cells (iPSCs) as a viable alternative to embryonic stem cells in regenerative medicine.
Scientists from Brigham and Women's Hospital have developed 3D mini-brains from human stem cells to investigate the effects of a specific gene mutation tied to major mental illnesses. The results show that the mutated mini-brains exhibit structural disruptions, suggesting a potential new target pathway for therapies.
Researchers at Stockholm University discovered a new mechanism regulating stem cells in the fruit fly's intestine and found that a specific protein can slow tumour growth. The study sheds light on how intestinal diseases occur and may contribute to the development of new medicine to prevent and cure them.
Researchers at Washington University in St. Louis have developed a new process to generate NP-like cells from human induced pluripotent stem cells (hiPSCs). The team mimicked the embryonic development process to produce nucleus pulposus cells, which could potentially be used to treat degenerative disc disease.
Researchers at CU Anschutz are working on stem cell-created skin grafts to treat Epidermolysis Bullosa, a debilitating inherited skin disease. The $3.8M grant from the DoD will help move technology into clinical trials, bringing hope for potential cures.
Researchers at the University of Iowa have discovered glandular myoepithelial cells that can regenerate airways after severe injury. These reserve stem cells can develop into new replacement cells in both submucosal glands and the lining of the airway, offering a potential therapeutic target for lung diseases.
CReM researchers engineered two new categories of lung epithelial cells in vitro using pluripotent stem cells. The study used single-cell RNA sequencing to generate comprehensive profiles of air sack-like and airway-like cells, which can be used to create lung tissue in vitro.
A research team at Lund University has discovered a crucial mechanism regulating protein production in hematopoietic stem cells. The enzyme PUS7 and pseudouridine modification play a vital role in controlling protein synthesis machinery. This control ensures the correct amount of proteins is made, preventing unbalanced stem cell growth.
Scientists at the University of Cambridge have discovered a new type of 'sleeping' stem cell in the brain that has a high potential for repair following brain injury or disease. The G2 quiescent stem cell can awaken and produce key brain cells, such as neurons and glia, faster than previously identified quiescent stem cells.
Researchers have found that older adults can produce thousands of new hippocampal neurons, similar to younger individuals, which may suggest that senior citizens remain more cognitively intact than believed. However, they also had less vascularization and reduced connections between new neurons.
Researchers at Duke-NUS Medical School have identified key regulators of the intestinal stem cell niche, including hormones R-spondins and Wnts. The team's study shows that subepithelial myofibroblasts are essential sources of these hormones, highlighting the close interaction between epithelial stem cells and their niche.
Evan Y. Snyder, a leading researcher on stem cells and neural development, has been elected to the Association of American Physicians for his groundbreaking contributions to human health. He will be inducted at the AAP annual meeting on April 21, 2018.
A new study by the University of Nottingham found that lower temperatures can activate the formation of 'good' brown adipose tissue (BAT) in adults. This discovery could lead to new ways of controlling diseases such as diabetes and obesity.
Researchers at UCSB developed a specially engineered retinal patch using stem cells to treat people with sudden severe sight loss from wet AMD. The study showed improvements in vision, enabling patients to read and perform daily tasks.
Researchers have successfully treated two participants with stem cells, increasing estrogen levels and alleviating menopausal symptoms. The treatment has also led to the resumption of menses and potentially restored fertility in these patients.
Researchers have developed remote-controlled nanospears that can pierce membrane walls and deliver DNA into selected cells with precision. The technique shows promise for the production of new gene therapies and may lead to more effective and less harmful methods for delivering genetic material.
Researchers are testing a new combination of cirmtuzumab and ibrutinib to eradicate leukemias and other blood cancers. The trial aims to determine the safety and effectiveness of the duo's treatment, which could potentially lead to complete remissions without continuous therapy.
A study by McMaster University researchers has pinpointed a gene responsible for neurodevelopmental disorders, including autism. The study found that alterations of the thousand and one amino-acid kinase 2 (TAOK2) gene play a direct role in these disorders.
Researchers at the Wellcome Sanger Institute discovered that SMAD2/3 proteins coordinate unexpected pathways with finely tuned gene expression, allowing cells to switch on and off genes rapidly. This mechanism could be essential for rapid responses in other processes like organ repair or cancer growth.
A low-calorie diet has been shown to enhance intestinal regeneration after injury in mice, with reserve stem cells playing a key role. The study found that calorie restriction expanded reserve stem cells five-fold and improved their ability to regenerate tissue, implicating them as critical players in this process.
Research at EMBL shows that synchronization between Wnt and Notch pathways enables embryo segmentation. Changing their relative timing prevents segment formation.
Researchers develop method to grow tiny brain models from human cells, revealing physical forces behind brain folding and potential links to microcephaly, epilepsy, and schizophrenia.
Researchers at Boston Children's Hospital used stem cell technology to create Purkinje cells from patients with tuberous sclerosis complex, a genetic syndrome often linked to autism. The lab-grown cells showed structural abnormalities and impaired development of synapses, which may help explain how autism develops at the molecular level.
Researchers created an open-source data atlas of human kidney development, providing detailed molecular and cellular information. The dataset will accelerate stem cell-based technologies for kidney replacement and regeneration therapies.
A stem cell vaccine created from induced pluripotent stem cells (iPSCs) has been shown to elicit strong immune responses in lab mice, effectively eliminating breast, lung, and skin cancers. The vaccine also prevented relapses in animals with removed tumors.
A team of researchers from Osaka University has identified adult endothelial stem cells capable of generating fully functional blood vessels. The discovery was made by isolating a population of endothelial cells expressing the glycoprotein CD157 and testing their ability to form new blood vessels in injured mice.
A team of researchers has discovered a chemical compound that converts patient-derived stem cells into blood vessels, offering new hope for treating achromatopsia and cone-rod dystrophy. The compound, AA147, successfully directed the stem cells to develop primarily into endothelial cells that can form blood vessels.
Researchers have successfully transplanted human lung stem cells into damaged lungs, regenerating bronchial and alveolar structures. The study shows promising results in treating chronic pulmonary diseases such as bronchiectasis.
Researchers have developed a method for marking dividing stem cells with three different labels, increasing accuracy and speed of analysis. This allows study of new populations of stem cells, including those in the brain and other tissues.
Researchers have successfully generated Tasmanian devil stem cells, offering a potential treatment for the deadly transmissible cancer. The development provides hope for saving the species from extinction, which is estimated to occur within 20-30 years.
Researchers observed stem cell divisions in the adult mouse hippocampus for the first time, showing that most stem cells divide only briefly before maturing. This process explains why newborn cells dramatically decline in number with advancing age.
Researchers at UCLA have uncovered a gene network that promotes the formation of spinal motor neurons in chicken and mouse embryos. The study sheds light on how embryonic development is orchestrated for motor neuron formation, with implications for stem cell-based therapies to repair or study neurodegenerative diseases.
Researchers have developed a method to selectively mark multipotent stromal cells in mice using the CD73 gene, allowing for the analysis of their distribution pattern and function in living organisms. This breakthrough enables the study of these stem cells in their original state, providing insights into their role in regenerative medi...
Researchers found that manipulating culture environment and 'priming' stem cells can enhance their function, optimizing therapeutic potential for diseases in humans and animals. The study's results demonstrate a significant enhancement of reparative capacity in stem cells treated with interferon gamma.
The Mesp1 gene plays a crucial role in cardiovascular lineage segregation and regional specification of the heart. Single-cell molecular profiling identified distinct populations of cardiac progenitors with unique molecular features associated with early lineage restriction and region-specific identity.
Scientists have discovered a protein called Setd7 that regulates stem cell growth and differentiation. Inhibiting this protein allows stem cells to remain undifferentiated, facilitating tissue regeneration and improved muscle function.
Researchers at Tohoku University have successfully cultured human placenta stem cells for the first time, opening up new avenues for studying fetal development and maternal health. The study, led by Takahiro Arima, has shed light on the crucial role of trophoblast cells in supporting fetal growth and development.
Researchers found that electrically stimulating implanted adult stem cells led to increased production of the animal's own stem cells and faster stroke recovery. The study suggests a promising approach for using stem cells to treat patients after stroke.
Researchers at Gladstone Institutes have successfully created induced pluripotent stem cells using CRISPR technology, simplifying a key step in the process. This breakthrough offers new possibilities for treating currently incurable conditions and studying diseases.