Articles tagged with Stem Cell Research
Researchers are testing a new combination of cirmtuzumab and ibrutinib to eradicate leukemias and other blood cancers. The trial aims to determine the safety and effectiveness of the duo's treatment, which could potentially lead to complete remissions without continuous therapy.
A study by McMaster University researchers has pinpointed a gene responsible for neurodevelopmental disorders, including autism. The study found that alterations of the thousand and one amino-acid kinase 2 (TAOK2) gene play a direct role in these disorders.
Researchers at the Wellcome Sanger Institute discovered that SMAD2/3 proteins coordinate unexpected pathways with finely tuned gene expression, allowing cells to switch on and off genes rapidly. This mechanism could be essential for rapid responses in other processes like organ repair or cancer growth.
A low-calorie diet has been shown to enhance intestinal regeneration after injury in mice, with reserve stem cells playing a key role. The study found that calorie restriction expanded reserve stem cells five-fold and improved their ability to regenerate tissue, implicating them as critical players in this process.
Research at EMBL shows that synchronization between Wnt and Notch pathways enables embryo segmentation. Changing their relative timing prevents segment formation.
Researchers develop method to grow tiny brain models from human cells, revealing physical forces behind brain folding and potential links to microcephaly, epilepsy, and schizophrenia.
Researchers at Boston Children's Hospital used stem cell technology to create Purkinje cells from patients with tuberous sclerosis complex, a genetic syndrome often linked to autism. The lab-grown cells showed structural abnormalities and impaired development of synapses, which may help explain how autism develops at the molecular level.
A team of researchers from Osaka University has identified adult endothelial stem cells capable of generating fully functional blood vessels. The discovery was made by isolating a population of endothelial cells expressing the glycoprotein CD157 and testing their ability to form new blood vessels in injured mice.
Researchers created an open-source data atlas of human kidney development, providing detailed molecular and cellular information. The dataset will accelerate stem cell-based technologies for kidney replacement and regeneration therapies.
A stem cell vaccine created from induced pluripotent stem cells (iPSCs) has been shown to elicit strong immune responses in lab mice, effectively eliminating breast, lung, and skin cancers. The vaccine also prevented relapses in animals with removed tumors.
A team of researchers has discovered a chemical compound that converts patient-derived stem cells into blood vessels, offering new hope for treating achromatopsia and cone-rod dystrophy. The compound, AA147, successfully directed the stem cells to develop primarily into endothelial cells that can form blood vessels.
Researchers have successfully transplanted human lung stem cells into damaged lungs, regenerating bronchial and alveolar structures. The study shows promising results in treating chronic pulmonary diseases such as bronchiectasis.
Researchers observed stem cell divisions in the adult mouse hippocampus for the first time, showing that most stem cells divide only briefly before maturing. This process explains why newborn cells dramatically decline in number with advancing age.
Researchers have developed a method for marking dividing stem cells with three different labels, increasing accuracy and speed of analysis. This allows study of new populations of stem cells, including those in the brain and other tissues.
Researchers have successfully generated Tasmanian devil stem cells, offering a potential treatment for the deadly transmissible cancer. The development provides hope for saving the species from extinction, which is estimated to occur within 20-30 years.
Researchers have developed a method to selectively mark multipotent stromal cells in mice using the CD73 gene, allowing for the analysis of their distribution pattern and function in living organisms. This breakthrough enables the study of these stem cells in their original state, providing insights into their role in regenerative medi...
Researchers at UCLA have uncovered a gene network that promotes the formation of spinal motor neurons in chicken and mouse embryos. The study sheds light on how embryonic development is orchestrated for motor neuron formation, with implications for stem cell-based therapies to repair or study neurodegenerative diseases.
Researchers found that manipulating culture environment and 'priming' stem cells can enhance their function, optimizing therapeutic potential for diseases in humans and animals. The study's results demonstrate a significant enhancement of reparative capacity in stem cells treated with interferon gamma.
The Mesp1 gene plays a crucial role in cardiovascular lineage segregation and regional specification of the heart. Single-cell molecular profiling identified distinct populations of cardiac progenitors with unique molecular features associated with early lineage restriction and region-specific identity.
Scientists have discovered a protein called Setd7 that regulates stem cell growth and differentiation. Inhibiting this protein allows stem cells to remain undifferentiated, facilitating tissue regeneration and improved muscle function.
Researchers at Tohoku University have successfully cultured human placenta stem cells for the first time, opening up new avenues for studying fetal development and maternal health. The study, led by Takahiro Arima, has shed light on the crucial role of trophoblast cells in supporting fetal growth and development.
Researchers found that electrically stimulating implanted adult stem cells led to increased production of the animal's own stem cells and faster stroke recovery. The study suggests a promising approach for using stem cells to treat patients after stroke.
Researchers at Gladstone Institutes have successfully created induced pluripotent stem cells using CRISPR technology, simplifying a key step in the process. This breakthrough offers new possibilities for treating currently incurable conditions and studying diseases.
Children's National Hospital researchers aim to develop a treatment using human stem cells to address hypoxia, which can severely impair brain development in infants born with CHD. The goal is to reverse or halt injury and promote neurogenesis in affected brains.
Researchers have successfully coaxed human stem cells into becoming sensory interneurons, responsible for relaying information from throughout the body to the central nervous system. This breakthrough could lead to a cell-based treatment that restores sensation in paralyzed people without immune suppression.
Researchers at North Carolina State University have developed a new approach to improve cardiac stem cell therapy, which shows promise in targeting heart attack injuries and enhancing treatment effectiveness.
A new study by Duke University researchers found that stem cell transplant significantly improves survival and reduces the need for immune suppressant drugs in patients with severe scleroderma. The regimen, which includes chemotherapy and radiation, showed a highly significant benefit compared to conventional drug therapy.
Scientists tagged bone marrow cells with a genetic label to track their family tree as they form naturally. The study reveals differences in how stem cells behave in their native environment versus laboratory settings, with implications for blood cell transplantation and gene therapy.
New research reveals obesity causes durable and harmful changes to hematopoietic stem cell compartment, potentially impacting blood cancer development. The study also suggests lifestyle choices like diet may durably impact blood formation.
Researchers discovered that a medication used to treat joint and skin conditions can help people with cancer survive by increasing the survival of transplanted blood stem cells. The drug etanercept blocks TNF-a, which kills healthy cells, allowing human blood stem cells to thrive in new hosts.
Researchers at Helmholtz Munich have discovered a specific subset of pluripotent embryonic stem cells that can transform into totipotent-like cells in culture. This breakthrough could pave the way for new treatments and therapies for various diseases, including diabetes and lung conditions.
A new study by researchers at Sanford Burnham Prebys Medical Discovery Institute describes the biology behind why muscle stem cells respond differently to aging or injury. Adult muscle stem cells are essential for repairing and regenerating muscle throughout life, but their ability to cope with different stimuli varies depending on the...
Researchers at UCLA discovered that high glucose levels in pregnant women can lead to premature heart cell maturation, increasing the risk of congenital heart disease. The study found that targeting the pentose phosphate pathway could help generate more mature cells for regenerating heart tissue.
A new harvesting method has been developed by the Massachusetts General Hospital team, which rapidly produces superior stem cells for bone marrow transplantation. The procedure, which combines GRO-beta and AMD3100 injections, mobilizes stem cells in just 15 minutes, making it less painful and disruptive for donors.
Researchers discovered that TOR signaling becomes activated in stem cells during regenerative responses, leading to the loss of stem cell status. Inhibiting TOR with rapamycin prevented this loss and reversed age-related decline in mouse trachea and muscle tissues.
A series of studies by Monash University researcher Jose Polo have unveiled new evidence in the decade-long mystery of cell reprogramming. The researchers found that the route to pluripotency depended on the original cell type, with different cell types requiring different approaches. This breakthrough has important implications for re...
A new digital platform provides lay summaries of hot-topic articles from leading international academics, bridging the gap between researchers and individuals outside academia. The ultimate aim is to stimulate conversations in all sectors on the impact of regenerative medicine on society.
UC San Diego researchers receive nearly $8 million to develop and test stem cell-based treatments for acute myeloid leukemia (AML). The funding will support testing of novel therapeutic approaches targeting cancer stem cells in AML, which is responsible for a high relapse rate in the disease.
Scientists in Canada converted adult mouse respiratory tract cells into large populations of induced progenitor-like cells using an interrupted reprogramming strategy. These cells retained a residual memory of their parental cell lineage and showed potential as a cell replacement therapy in mice with cystic fibrosis.
Researchers from USC discovered that the levels of Hedgehog protein determine whether cells form bone or cartilage in developing ribs. High Hh concentrations favor bone formation, while lower concentrations promote cartilage growth.
Researchers have successfully treated paraplegic rats using human stem cells, which have shown significantly improved mobility and sensory perception after spinal cord injury. The engineered tissue containing stem cells also demonstrated some degree of spinal cord healing.
Researchers at Stanford Medicine found that isolated stem cells have a different gene-expression profile than their counterparts in the body. The study suggests that conclusions about stem cell function may need to be reconsidered due to changes in cell biology during isolation.
Researchers used CRISPR-Cas9 to pinpoint epigenetic signals driving cocaine addiction and shed light on rare genetic disorders. They also developed a cellular disease model to probe the neurobiological causes of schizophrenia and identified changes in neural stem cells caused by Zika virus.
Researchers at OHSU have successfully performed stem transplants on monkeys, offering a critical tool to explore the Berlin patient's unexpected cure. The findings provide hope for improving stem cell transplant outcomes for human patients with blood-related conditions.
Researchers have developed a method to prolong the survival of stem cells, which could aid in tissue regeneration after blood flow obstruction. By attaching vascular endothelial growth factor to microscopic particles, they increased stem cell lifespan and improved their ability to form new blood vessels.
Cristina Lo Celso, a rising star in biomedical research, has been awarded the Foulkes Foundation Medal for her groundbreaking work on leukemia. Her research focuses on understanding how leukaemia cells develop and relapse, with the ultimate goal of improving treatments and preventing disease recurrence.
A recent study published in Cell Stem Cell has discovered a mechanism to prevent genetic chaos caused by transposons in early human development. The research found that endosiRNAs, a type of small interfering RNA, play a crucial role in regulating transposon activity during epigenetic reprogramming.
The New York Stem Cell Foundation (NYSCF) has selected six promising researchers and neuroscientists to join the NYSCF - Robertson Investigators program, providing critical seed funding of $1.5 million over five years. The program supports high-risk/high-reward research that aims to accelerate treatments and cures for various diseases.
Dr. Paul Tesar receives the 2017 NYSCF Robertson Stem Cell Prize for his pioneering work on pluripotent epiblast stem cells, which holds promise for treating neurological disorders like multiple sclerosis and pediatric leukodystrophies.
Researchers review the effectiveness of stem cells and emerging agents in preventing and treating neurodegenerative pathologies. They discuss potential advantages and obstacles of using different types of stem cells and present evidence for further study of certain compounds.
Researchers created synthetic hydrogels that allowed human intestinal cells to grow and differentiate in a 3D environment, forming normal tissue structures. The hydrogels can be easily modified to support various cell types, offering a promising approach for treating gut injuries and potentially other organ damage.
Researchers have found that interaction between mesenchymal and adult neural stem cells can strongly promote oligodendrogenesis, potentially leading to improved treatment options for Multiple Sclerosis. The study's results demonstrate conservation across species, offering hope for clinical translation.
German researchers have made significant advancements in human gene therapy, including virotherapy capable of destroying tumor cells and engineered hematopoietic stem cell delivery systems. These innovations hold promise for treating immunodeficiencies and genetic diseases.
A team of researchers used stem cell technology to generate motor neurons from ALS patients with FUS mutations, revealing axonal transport defects. Genetic correction and pharmacological inhibition of HDAC6 restored axonal transport, suggesting a potential therapeutic approach for ALS.
Researchers at McMaster University have discovered that bolstering fat cells in the bone marrow can suppress leukemia cells while also regenerating healthy red blood cells. This innovative approach presents a new potential therapeutic strategy for treating acute myeloid leukemia, which often leads to anemia and infection.
Researchers developed improved mini brain organoids from stem cells, closely mimicking human brain structure. They found critical similarities between the organoids and real brain tissue and identified effective drugs to block Zika's entry into the brain, offering new avenues for studying neurological disorders
The National Eye Institute (NEI) awarded $90,000 to a team led by Erin Lavik for their innovative approach to creating a living model of the human retina. The award aims to develop next-generation models to study blinding diseases and test therapies.
Researchers found that altering stem cell volume changes its internal dynamics and influences the cell's fate, with removing water making it stiff pre-bone cells and adding water forming soft pre-fat cells. This study adds a new tool to understanding stem cell biology for regenerative medicine.
A new study published in Circulation Research found that umbilical cord-derived stem cells improved heart muscle function and quality of life for patients with stable heart failure. The treatment was safe and showed significant improvements over placebo, paving the way for a promising new therapy.
Researchers have discovered that Prostaglandin E1 (PGE1) can inhibit leukemia stem cells, which are resistant to chemotherapy and targeted therapies. Combining PGE1 with standard chemotherapy may improve treatment outcomes for patients with chronic myeloid leukemia.