Articles tagged with Stem Cell Research
Researchers discovered that DNA damage in moss Physcomitrella patens causes cells to reprogram into stem cells, producing an entire plant body. This phenomenon is a new adaptive strategy for plants under harsh environments.
Scientists have identified stem cells in the optic nerve that help preserve vision and may lead to new therapeutic strategies for disorders causing blindness. The discovery presents a new theory on why glaucoma develops and provides potential ways to treat this leading cause of blindness in American adults.
A nationwide survey of academic neurologists reveals that bad outcomes from stem cell tourism are much more common than realized, with complications including infections, strokes, spinal tumors, seizures, and even deaths. Many neurologists feel ill-equipped to warn patients about the dangers of unproven treatments.
The study found that a delicate equilibrium between stem cells and airway cells is necessary for proper lung regeneration. In the aging process, this balance is disrupted, leading to increased cancer risk and other diseases.
Researchers have found that embryonic stem cells use a self-eating process called chaperone-mediated autophagy (CMA) to maintain pluripotency, but switch to a related metabolite when differentiating into specialized cells. This discovery could lead to new regenerative therapies for tissue and organ repair.
Scientists have identified unique de novo DNA methylation targets for DNMT3 enzymes during mammalian development. Dnmt3a exclusively regulates differentiation-related genes, while dnmT3b regulates X-chromosome genes. The study's findings may lead to a novel therapeutic approach for patients with DNMT3 mutations.
Researchers at the University of Tsukuba found that epidermal stem cells undergo a change in their complex sugar repertoire with age, which could serve as a biological marker of aging. This 'glycome shift' is characterized by an increase in sialylated complex type N-glycans and a decrease in mannose-type N-glycans.
A strong cellular lining is essential for a healthy gut, and damage to it can cause painful symptoms. Monash University researchers have identified a key biomolecule, Neuregulin-1, that accelerates the repair of damaged tissue by prompting stem cells to regenerate.
Researchers found that the sympathetic nerve connects to hair follicle stem cells, bridging the gap between nervous system control and hair regeneration. The muscle facilitates this connection, allowing the nerve to directly regulate stem cell behavior and promote new hair growth in response to temperature changes.
University of Minnesota researchers successfully 3D printed a functioning centimeter-scale human heart pump using real human cells. The discovery allows for studying heart function and disease at the cell and molecular level, creating a valuable tool for tracking blood movement and testing treatments.
Researchers at Newcastle University have discovered a new technique that can improve the function of 'marginal' kidneys, increasing urine production and improving blood flow to damaged cells. The treatment uses a type of stem cell called MultiStem to deliver anti-inflammatory molecules.
A new study found that special filter glasses enhance color vision for those with red-green color vision deficiency, and the effect persists even when not worn. The filters increased chromatic contrast response in individuals with anomalous trichromacy.
A new NIH study suggests that deactivating certain genes in the human genome may play a role in controlling the differentiation of stem cells into neurons. The research found that these genes, which were once thought to be inactive 'junk DNA', may help regulate the maturation process of stem cells, leading to improved understanding of ...
Researchers at Boston University and Boston Medical Center have assembled the largest repository of patient-derived stem cells from AATD patients. The cells can be used to study genetic diseases and potentially find new treatment approaches for AATD.
A new protocol enhances stem cells' ability to differentiate into adult cells, improving their quality and efficiency for therapeutic purposes. The study identified microRNA 203 as a key molecule to boost stem cell differentiation, opening doors to improved treatments for degenerative diseases.
Researchers have successfully reprogrammed three types of mouse cells into induced hair cell-like cells, offering a potential solution for identifying causes and treatments of hearing loss. The new cells possess characteristics similar to naturally occurring hair cells and are vulnerable to an antibiotic known to cause hearing loss.
Researchers at Lund University have developed a 3D model of human hippocampal tissue from induced pluripotent stem cells, allowing for the study of early cellular dysfunction in Alzheimer's disease. The study found that patient-specific pathology differs between individuals with extreme symptomatology.
Researchers at CNRS and Delft University of Technology have developed acoustical tweezers to control microbubbles, enabling highly localized drug delivery. This breakthrough opens up new possibilities for controlled medicine delivery and tissue engineering using stem cells.
Researchers used a 'disease in a dish' stem cell model to examine the mechanism behind retinal ganglion cell degeneration in glaucoma. The study found that cells from individuals with a genetic risk allele for glaucoma were stalled at an immature stage, making them more vulnerable to degeneration.
Children's Cancer Institute researchers have discovered a new approach to treating acute myeloid leukaemia (AML) by targeting leukemia stem cells. The therapy disrupts the ability of these cells to self-renew, markedly reducing leukaemia amounts and preventing new cells from growing.
Researchers used stem cells to study the developmental effects of Neandertal DNA, finding that archaic DNA contributes to skin and hair color traits prevalent in Europeans. The study provides a proof-of-principle for using organoids to track Neandertal-derived RNA across developmental processes.
Researchers found that thorns in citrus plants arise from stem cells, which undergo a programmed arrest to create the sharp pointy end. This discovery may lead to safer fruit harvesting and more fruitful orchards.
Researchers at the University of Houston have identified three different stem cell types in Crohn's biopsies, with two variants contributing to inflammation and fibrosis. The team is developing new drug therapies to selectively destroy these rogue cells and create new treatments for pediatric and adult Crohn's disease.
Two genes, MTG8 and MTG16, regulate stem cell differentiation in the small intestine, supporting its fast replacement process. This discovery could help understand how the body maintains a healthy gut and inform research on stem cell differentiation outside of the small intestine.
Using human stem cell models, researchers identified deficits within cells damaged by glaucoma and found that correcting genetic mutations could slow disease progression. They also discovered dysfunction in autophagy, a process that removes damaged cells, which correlated with neurodegeneration.
Researchers at A*STAR in Singapore have identified a potential biomarker, GSTT1, to screen the quality of donor's stem cells before harvesting. This biomarker can help determine the growth capacity and potency of MSCs, which is crucial for effective stem cell therapies.
The study mapped the molecular characteristics of the aortic microenvironment where Hematopoietic Stem Cells (HSCs) form. Researchers identified conserved regulators, such as ADM and RAMP2, involved in HSC production in vivo.
Researchers at Indiana University School of Medicine have successfully grown hairy skin from human stem cells using a 3D cell culture method. The study shows that skin generated from pluripotent stem cells can integrate into mouse skin, leading to potential applications in skin reconstruction and disease modeling.
Researchers at Lund University have identified CXCR4 as essential for the survival of leukemia stem cells, which can be controlled by cutting off the gene using CRISPR technology. This discovery reveals a fundamental difference in how leukemia stem cells and normal blood stem cells are regulated.
A study published in Cell Reports reveals that human acute myeloid leukemia (AML) stem cells are dependent on the transcription factor RUNX1, which could lead to lasting remissions or even cures. The researchers used induced pluripotent stem cells from a patient with AML to recreate leukemia stem cell biology in the lab.
A study by NYSCF Research Institute creates human stem-cell-derived astrocytes that become toxic to neurons in disease-like environments. This phenomenon could lead to effective treatments for neurodegenerative diseases such as multiple sclerosis, Parkinson's, and Alzheimer's.
Researchers found that stem cells collected from human amniotic membrane can slow the progression of scarring in pulmonary fibrosis by controlling immune cell activity. This pre-clinical study could lead to new treatments for this deadly disease, affecting 13-20 out of every 100,000 people worldwide.
Researchers have found that reprogrammed stem cells between days 15 and 28 of maturation can successfully restore heart tissue. This 'window of opportunity' makes it possible to use stem cells that the body recognizes as its own, allowing for more effective regenerative medicine.
Researchers at the University of Sheffield have discovered ways to reduce DNA damage and mutations in pluripotent stem cells, a crucial step for regenerative medicine. The findings may allow for safer use of these cells in patients and significantly reduce the risk of genetic mutations.
After allogeneic stem cell transplantation, a critical window of vulnerability exists for re-infection with HIV. New T-cell responses to HIV proteins from donor cells develop after this time, indicating a weak point that may explain incomplete removal of the virus.
Researchers mapped out how gene networks change as muscle cells mature from embryonic development to adulthood. The roadmap could lead to better methods for creating muscle stem cells from stem cells, potentially treating muscular dystrophies and sarcopenia.
Researchers demonstrate a potential solution to corneal scarring by using stem cells to regenerate the cornea's stroma. The study shows improved corneal transparency and vision with minimal inflammatory response.
Researchers have found that stem cells in planarians can postpone their own death to respond to an injury, allowing them to gather around the site of the wound and mount a response. This unique ability has implications for cancer research and therapies, particularly when examining chemotherapy and surgery options.
Researchers at the University of Illinois used nanostimulators to boost stem cells' regenerative powers, increasing blood flow and oxygen levels in ischemic limbs. The treatment showed improvements in mobility and strength, offering a promising approach for muscle repair.
A UCLA-led research team has developed a new method for delivering DNA into stem cells and immune cells safely, rapidly and economically. The technique uses high-frequency acoustic waves to manipulate cells and insert cargo without damaging them, enabling the creation of gene therapies for various diseases.
Researchers successfully reversed diabetes in mice by using genetically edited stem cells derived from patients with a rare genetic form of insulin-dependent diabetes. The CRISPR-Cas9 gene-editing tool corrected a genetic defect that caused the disease, allowing the human stem cells to normalize blood sugar levels.
A team of researchers at the Francis Crick Institute identified early-commitment genes that trigger irreversible cell specialization in human embryos. These genes, which include GATA3, activate a positive feedback loop, ensuring cells remain differentiated and do not reverse back to a stem cell state.
Abnormal stem cells in COPD patients drive key features of the disease, including mucins that block airways and fibrosis and inflammation. Researchers have identified specific cells responsible for COPD pathology and are screening them against drug libraries to discover new treatments.
Scientists have discovered a way to directly reprogram skin cells into light-sensing rod photoreceptors, enabling blind mice to detect light after transplantation. The technique, which took only 10 days to produce functional cells, has the potential to model eye disease and advance therapies for age-related macular degeneration.
Researchers discovered that microscopic alterations in stem cell niche can predict Crohn's disease recurrence. A therapeutic approach using dichloracetate (DCA) restored intestinal stem cell functionality and maintained the intestinal barrier.
A Stanford study found that exercise restores youthful properties to muscle stem cells of old mice, improving their repair capabilities. The researchers identified a molecular pathway involved in this process and suggest that drugs targeting this pathway could be an effective substitute for exercise.
Researchers at UC San Diego Health are developing a dedicated space stem cell orbital research laboratory within the International Space Station (ISS) to study microgravity's effects on human biology. The studies aim to understand aging, degenerative diseases, and cancers in space, with potential applications for therapeutics on Earth.
Scientists successfully incorporated noncanonical amino acids into human hematopoietic stem cells, enabling the production of ncAA-containing proteins in living organisms. The modified stem cells provided a tool for studying human proteins in cell culture and living systems.
Scientists identified a new control mechanism that enables stem cells to adapt their activity in emergency situations by modifying protein blueprints. Alternative polyadenylation regulates the amount of protein produced and controls protein isoform formation, affecting stability and localization.
A team of researchers has developed a groundbreaking 'cardiac patch with bioink' to repair heart damage. The patch uses genetically engineered stem cells and 3D bioprinting technology to enhance vascular regeneration and improve myocardiocyte survival. The innovative method has shown promising results in treating myocardial infarction.
Researchers at Karolinska Institutet have developed a new method to refine the production of retinal cells from embryonic stem cells using CRISPR/Cas9 gene editing. The modified cells can hide from the immune system, reducing the risk of rejection and potentially leading to a new treatment for age-related macular degeneration.
Researchers at University College London have developed a new way to increase the functionality of umbilical cord blood stem cells, making them more suitable for transplantation. This breakthrough could improve treatment options for patients with blood cancers and other blood disorders.
A new stem cell delivery system using mussel adhesive protein has been developed to efficiently deliver mesenchymal stem cells to damaged cardiac muscular tissues. The system enables prolonged transplantation and promotes rapid integration of transplanted stem cells into surrounding tissues.
Scientists at the Wellcome Sanger Institute discovered that astrocytes in mouse brains are organized into distinct layers with molecular forms depending on their location, redefining brain structure. This knowledge will have implications for understanding neurological disorders like Alzheimer's, multiple sclerosis, and autism.
Researchers discovered that blood stem cells can drive a rapid and efficient immune response if previously exposed to LPS, mimicking an infection. The cells store immune response circuits in their DNA using C/EBP? factor, enabling a more efficient response upon subsequent infections.
Researchers have uncovered mechanisms of healing after a heart attack using human cardiopoietic cells, which restored cardiac muscle to its pre-attack state. The study found that these cells reversed two-thirds of the changes caused by a heart attack, with 85% of cellular functional categories responding favorably to treatment.
Researchers aim to investigate leukaemia stem cells to gain a better understanding of acute myeloid leukaemia (AML) causes and therapies. The study will use isolated single cells from patient samples to analyze characteristic markers, mutations, functional data, and metabolic pathways.
Scientists have successfully turned back the biological hands of time by coaxing adult human cells to revert to a primitive state, unlocking their potential to replace and repair damaged blood vessels in the retina. The findings advance regenerative medicine techniques aimed at reversing diabetic retinopathy.
Researchers at UConn School of Dental Medicine have discovered a population of stem cells residing along vascular channels in bone that can generate new bone-forming cells. These perivascular cells may regulate bone formation and participate in bone mass maintenance.
A new computer model developed by MIT cognitive scientists can quickly generate a detailed scene description from an image, similar to the brain's ability. The model, known as efficient inverse graphics (EIG), reverses the steps used in computer graphics programs to generate images, allowing it to infer underlying features of a scene. ...