Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Baylor College of Medicine researchers found that long-term exposure to IFNγ exhausts blood stem cells by triggering proliferation and excessive differentiation. Modulating BST2 expression on these cells may provide a means to regulate their activation during chronic infections.
Researchers have discovered that brain stem cells in the hippocampus of mice can divide repeatedly over several months, leading to new insights into the formation of nerve cells. This finding has significant implications for future therapeutic approaches to conditions such as depression and Alzheimer's disease.
Researchers at Kyushu University identified eight transcription factors that can convert mouse stem cells directly into oocyte-like cells. These findings offer a simple route for generating specialized substances unique to oocytes for use in reproductive biology and medicine.
New research from the University of Exeter's Living Systems Institute has found that human embryonic stem cells do not acquire cancer-causing mutations when grown in their most primitive state. The study provides a significant breakthrough in understanding the genetic stability of human pluripotent stem cells.
A team of researchers has successfully grown structures similar to parts of a mouse embryo using a special gel and 3D cell culturing technique. This allows for the investigation of pharmacological agents on a scale that would not be possible in living organisms.
Researchers have discovered a protein that can expand typically scarce blood stem cells, potentially leading to new methods for growing a large quantity of these cells inside and outside the human body. The findings could benefit patients with inherited blood disorders and certain types of blood cancers.
New research suggests that testing for tumor DNA in DLBCL patients' stem cells or blood can help predict relapse risk. Patients with positive results may benefit from alternative treatments like CAR T cell therapy and prompt interventions to prevent relapse.
Scientists have identified a key gene mechanism controlling cellular aging and rejuvenation in mesenchymal stem cells. The GATA6/SHH/FOXP1 pathway regulates MSC aging and rejuvenation, offering insights into developing treatments for age-related diseases.
Scientists create a system to quickly and easily convert human stem cells into various cell types, including neurons and blood vessels. The researchers identified 290 DNA-binding proteins that reprogram stem cells into target cells within four days.
Researchers used genome-wide profiling to study the epigenetic landscape of human stem cells, revealing important information about gene regulation. They found differences in chromatin structures between long-term and short-term stem cells, which could improve understanding of cancer cell behavior and stem cell therapy.
A new study by Crick researchers reveals that stem cells protect their chromosome ends through a unique t-loop structure, distinct from the TRF2-dependent mechanism in somatic cells. This discovery opens up new questions about the evolution of telomere protection and its implications for premature aging and cancer.
Researchers identified Sestrin as a key regulator of stem cell function and lifespan in response to dietary amino acids. Increasing Sestrin levels extended fruit fly lifespan and protected against negative diet effects.
Scientists have developed a novel approach to reprogram T cells into long-lived, highly active 'super immune cells' that can fight multiple types of cancer. This breakthrough could lead to more effective and durable anti-cancer responses with existing treatments.
A new study from UCLA researchers found that smoking cigarettes causes more severe COVID-19 infection in the airways by blocking immune system messenger proteins. The study used a model of airway tissue created from human stem cells to understand how SARS-CoV-2 virus affects smokers.
Researchers at Duke University have discovered a mechanism by which mesenchymal stem cells (MSCs) modulate the inflammatory response, extending their beneficial effects even after being cleared from the system. The study sheds light on how MSCs suppress T cell activation and reprogram disease-fighting cells to promote healing.
Researchers describe a rare case of frosted branch angiitis, a unique presentation of florid retinal vasculitis, in a woman treated for leukemia-lymphoma with allogeneic human stem cell transplant. The condition led to immune activation and required corticosteroids to suppress inflammation.
Researchers discovered that stem cells have smaller and weaker centromeres compared to differentiated cells. This finding highlights a possible mechanism for the errors in cell division that limit the potential of stem cells in regenerative medicine.
A study published in STEM CELLS revealed that fibulin 5 plays a crucial role in the development of Schwann cells, which produce the myelin sheath surrounding neuronal axons. The research suggests that fibulin 5 may be used to treat Charcot-Marie-Tooth disease and other demyelinating disorders.
Scientists have identified a subgroup of stem cells that retains regenerative capacity well beyond geriatric age, suggesting new avenues for improving muscle health in elderly individuals. The discovery provides insight into the FoxO signalling pathway and its role in maintaining youthful gene expression.
Scientists successfully created airway basal stem cells in vitro from induced pluripotent stem cells, which may lead to new treatments for airways and lungs damaged by various diseases. The study's findings could also enable the development of disease models and targeted drug approaches.
The New York Stem Cell Foundation (NYSCF) has announced the 2020 class of NYSCF - Robertson Investigators, recognizing six outstanding stem cell researchers and neuroscientists. The program provides critical seed funding to support cutting-edge research with the potential to accelerate treatments and cures.
Researchers found that certain chemotherapeutic agents can promote tissue overgrowth in normal tissues, while an innate immune signaling pathway in fibroblasts causes stem cells to proliferate. This discovery has broad implications for diseases associated with the immune system, including psoriasis and cancer.
Researchers from Kyoto University and Tokai University have developed a new apparatus to study terahertz radiation's effects on human stem cells. The findings reveal that terahertz pulses activate genes involved in motor neuron survival and mitochondrial function, while deactivating those involved in cell differentiation.
A research team at Pohang University of Science & Technology has developed a technology that allows for the rapid harvesting of human bone marrow-derived mesenchymal stem cell sheets using poly(N-isopropylacrylamide) (PNIPAAm) nanotopography. This breakthrough reduces the harvest time from one week to just two days, making it possible ...
Forsyth researchers discovered a way to reverse periodontal disease by stimulating stem cells with Maresin-1 and Resolvin-E1, two synthetic lipid mediators. This finding offers new therapeutic possibilities for treating systemic diseases associated with inflammation.
Researchers at Karolinska Institutet discovered that stem cells in the mouse spinal cord can form new oligodendrocytes, essential for neuronal signal transmission, to help repair damaged tissue. This finding indicates a conceptually new strategy for stimulating repair after nervous system damage.
A new study from Kanazawa University finds that combining antibiotics with antibiotic-laden stem cells effectively treats implant-related bone infections. The researchers used mesenchymal stem cells to deliver ciprofloxacin, which showed strong antimicrobial effects and improved outcomes in animal models of osteomyelitis.
A US survey of 430 Americans found 82% supportive of at least some parts of human-animal chimeric embryo research. Support varied by organ type, with highest for heart and liver, while concerns about animal welfare and human dignity were cited.
Researchers have designed a multifunctional cell therapy system to treat ulcerative colitis, with encouraging results obtained in animal models. The system incorporates stem cells, biomaterials, and microparticles that release interferon, aiming to improve cell persistence and biosafety.
A new material has been developed to transplant bone-forming stem cells into severe bone fractures and speed up the healing process. The bone-like bandage is coated in a protein used for growth and repair, allowing it to enhance the natural ability of bones to heal.
The UK Research and Innovation has partnered with the Japan Agency for Medical Research and Development to support eight new regenerative medicine research projects. The funding will focus on developing novel therapies for a range of disorders, including Parkinson's disease, blood disorders, and liver diseases.
Researchers have discovered that HSCs from early human embryos can multiply approximately 200-500 times more than those from umbilical cord blood, potentially revolutionizing blood cancer treatment. This breakthrough could lead to advances in expanding HSCs from bone marrow and cord blood, increasing the available blood supply.
A new discovery in regenerative medicine may lead to new treatments for placenta complications during pregnancy. Researchers at Monash University and Duke-NUS have developed a method to create induced trophoblast stem cells (iTSCs) that can be used to make placenta cells.
Researchers have developed a method to genetically edit out proteins on human pluripotent stem cells that trigger immune rejection. This approach could generate universally compatible 'off-the-shelf' cell grafts without the need for immune suppression, offering a promising solution for regenerative medicine.
Research finds that high androgen levels can cause intestinal stem cells to divide excessively and produce fewer mature epithelial cells, increasing the risk of tumor formation. The study's findings may have implications for treating or preventing colon cancers through androgen regulation.
Researchers at UC Davis Health have made a breakthrough in using stem cell treatments for heart disease. By blocking an enzyme linked with inflammation, they were able to increase the survival of transplanted stem cells and improve cardiac function. This discovery could lead to a cellular-based treatment for heart failure.
Researchers have successfully grown human intestinal grafts using stem cells from patient tissue, paving the way for personalized transplants for children with intestinal failure. The mini-organs can digest and absorb nutrients, reducing the risk of complications associated with parenteral nutrition.
Researchers discovered that DNA damage in moss Physcomitrella patens causes cells to reprogram into stem cells, producing an entire plant body. This phenomenon is a new adaptive strategy for plants under harsh environments.
Scientists have identified stem cells in the optic nerve that help preserve vision and may lead to new therapeutic strategies for disorders causing blindness. The discovery presents a new theory on why glaucoma develops and provides potential ways to treat this leading cause of blindness in American adults.
A nationwide survey of academic neurologists reveals that bad outcomes from stem cell tourism are much more common than realized, with complications including infections, strokes, spinal tumors, seizures, and even deaths. Many neurologists feel ill-equipped to warn patients about the dangers of unproven treatments.
The study found that a delicate equilibrium between stem cells and airway cells is necessary for proper lung regeneration. In the aging process, this balance is disrupted, leading to increased cancer risk and other diseases.
Researchers have found that embryonic stem cells use a self-eating process called chaperone-mediated autophagy (CMA) to maintain pluripotency, but switch to a related metabolite when differentiating into specialized cells. This discovery could lead to new regenerative therapies for tissue and organ repair.
Scientists have identified unique de novo DNA methylation targets for DNMT3 enzymes during mammalian development. Dnmt3a exclusively regulates differentiation-related genes, while dnmT3b regulates X-chromosome genes. The study's findings may lead to a novel therapeutic approach for patients with DNMT3 mutations.
Researchers at the University of Tsukuba found that epidermal stem cells undergo a change in their complex sugar repertoire with age, which could serve as a biological marker of aging. This 'glycome shift' is characterized by an increase in sialylated complex type N-glycans and a decrease in mannose-type N-glycans.
A strong cellular lining is essential for a healthy gut, and damage to it can cause painful symptoms. Monash University researchers have identified a key biomolecule, Neuregulin-1, that accelerates the repair of damaged tissue by prompting stem cells to regenerate.
Researchers found that the sympathetic nerve connects to hair follicle stem cells, bridging the gap between nervous system control and hair regeneration. The muscle facilitates this connection, allowing the nerve to directly regulate stem cell behavior and promote new hair growth in response to temperature changes.
University of Minnesota researchers successfully 3D printed a functioning centimeter-scale human heart pump using real human cells. The discovery allows for studying heart function and disease at the cell and molecular level, creating a valuable tool for tracking blood movement and testing treatments.
Researchers at Newcastle University have discovered a new technique that can improve the function of 'marginal' kidneys, increasing urine production and improving blood flow to damaged cells. The treatment uses a type of stem cell called MultiStem to deliver anti-inflammatory molecules.
A new study found that special filter glasses enhance color vision for those with red-green color vision deficiency, and the effect persists even when not worn. The filters increased chromatic contrast response in individuals with anomalous trichromacy.
A new NIH study suggests that deactivating certain genes in the human genome may play a role in controlling the differentiation of stem cells into neurons. The research found that these genes, which were once thought to be inactive 'junk DNA', may help regulate the maturation process of stem cells, leading to improved understanding of ...
A new protocol enhances stem cells' ability to differentiate into adult cells, improving their quality and efficiency for therapeutic purposes. The study identified microRNA 203 as a key molecule to boost stem cell differentiation, opening doors to improved treatments for degenerative diseases.
Researchers at Boston University and Boston Medical Center have assembled the largest repository of patient-derived stem cells from AATD patients. The cells can be used to study genetic diseases and potentially find new treatment approaches for AATD.
Researchers have successfully reprogrammed three types of mouse cells into induced hair cell-like cells, offering a potential solution for identifying causes and treatments of hearing loss. The new cells possess characteristics similar to naturally occurring hair cells and are vulnerable to an antibiotic known to cause hearing loss.
Researchers at Lund University have developed a 3D model of human hippocampal tissue from induced pluripotent stem cells, allowing for the study of early cellular dysfunction in Alzheimer's disease. The study found that patient-specific pathology differs between individuals with extreme symptomatology.
Researchers at CNRS and Delft University of Technology have developed acoustical tweezers to control microbubbles, enabling highly localized drug delivery. This breakthrough opens up new possibilities for controlled medicine delivery and tissue engineering using stem cells.
Researchers found that thorns in citrus plants arise from stem cells, which undergo a programmed arrest to create the sharp pointy end. This discovery may lead to safer fruit harvesting and more fruitful orchards.
Researchers at the University of Houston have identified three different stem cell types in Crohn's biopsies, with two variants contributing to inflammation and fibrosis. The team is developing new drug therapies to selectively destroy these rogue cells and create new treatments for pediatric and adult Crohn's disease.
Researchers used a 'disease in a dish' stem cell model to examine the mechanism behind retinal ganglion cell degeneration in glaucoma. The study found that cells from individuals with a genetic risk allele for glaucoma were stalled at an immature stage, making them more vulnerable to degeneration.
Children's Cancer Institute researchers have discovered a new approach to treating acute myeloid leukaemia (AML) by targeting leukemia stem cells. The therapy disrupts the ability of these cells to self-renew, markedly reducing leukaemia amounts and preventing new cells from growing.
Researchers used stem cells to study the developmental effects of Neandertal DNA, finding that archaic DNA contributes to skin and hair color traits prevalent in Europeans. The study provides a proof-of-principle for using organoids to track Neandertal-derived RNA across developmental processes.