Research on stem cells and regenerative medicine. Covers engineered T cells, scalable manufacturing, blood-cancer research, and stem-cell training programs.
Johns Hopkins Medicine researchers have developed a 3D map of blood vessels and stem cells in a mouse skull, revealing previously unknown niches for stem cell residence. The map provides precise locations of blood vessels and stem cells, which could be used to repair wounds and generate new bone tissue.
The Lef1 gene is found to suppress the development and growth of colorectal cancer by restricting cancer stem cell niches. Blocking this gene leads to increased tumor stem cell niches and accelerated tumor growth.
Researchers produce large quantities of powerful cancer-fighting iNKT cells using stem cell engineering and organoid technology, offering a potential solution for mass-producing an off-the-shelf immune cell therapy. The therapy, which uses hematopoietic stem cell-engineered iNKT cells, has been shown to be effective in killing multiple...
Researchers found that blood stem cells, which are among the smallest cells in the body, lose their ability to perform their normal function — replenishing the body’s blood cells — as they grow larger. However, when the cells were restored to their usual size, they behaved normally again.
Researchers at Mount Sinai have developed a diverse library of well-characterized human induced pluripotent stem cell lines from clinically healthy individuals, offering valuable resources for studying normal human biology, evaluating drug responses, and disease modeling.
A study suggests that suppressing the protective mechanisms of rogue blood stem cells can help curb clonal hematopoiesis and prevent leukemia. The researchers used zebrafish with colored 'barcodes' to track the dominance of cancerous clones, revealing a connection between anti-inflammatory genes and resistance to inflammation.
A US study found that businesses selling non-FDA-approved stem cell products grew four-fold in five years, with California, Texas, and Florida leading the nation. Patients spend thousands of dollars on unproven treatments, posing significant risks to their health, while the industry's lack of regulation endangers public health.
Researchers developed a method to image lithium in living cells, finding that neurons from bipolar disorder patients accumulate higher levels of lithium than healthy controls. This new tool could help optimize lithium dosage and improve treatment outcomes for patients with bipolar disorder.
A recent study published in PLOS ONE found that combining copper ions with a drug once used for treating alcoholism kills medulloblastoma cancer cells and prevents new ones from forming. The therapy also curtails the creation of cancer stem cells, which initiate tumor growth and recurrence.
A study to investigate stem cell therapy as a potential treatment for glaucoma, the world's second leading cause of blindness, has received $6.7M in NEI funding. The research team will explore ways to make stem cell-derived neurons survive and integrate into the eye.
A team of scientists developed a drug-like molecule that can counteract the effects of mutated epigenetic regulators, which are known to drive certain types of cancer. The molecule targets the 'reader' CBX8, which is critical for the proliferation of cancer cells, but more dispensable in healthy cells.
A genome-wide screening technique reveals the interrelated activities of genes controlling pluripotency and apoptosis in human embryonic stem cells. The study provides new insights into cancer genetics and a novel approach for regenerative medicine research, enabling the systematic mapping of genetic networks involved in tissue formation.
Scientists from the University of Johannesburg found that shining two lasers on adult stem cells accelerates their transformation into different types of cells. The consecutive irradiation increases proliferation and differentiation under laboratory conditions, paving the way for potential therapies to repair damaged tissues.
Scientists at Lewis Katz School of Medicine discovered that reintroducing the protein LIN28 into adult heart stem cells improves their chances of survival. This breakthrough could lead to new treatments for heart disease using stem cell therapy.
Researchers at University of Cambridge have developed lab-grown mini brains that can mimic the development of motor neurone disease and frontotemporal dementia. The models, grown for up to 340 days, provide valuable insights into early stages of these devastating conditions.
Researchers have made a breakthrough in spermatogonial stem cell research, successfully generating functional sperm cells using primate embryonic stem cells. The study, published in Fertility and Sterility Science, shows promise for future clinical therapies to treat male infertility.
A recent study highlights the negative effects of misinformation on stem cell therapies for COVID-19, including exaggerated claims and unregulated sales. The researchers advocate for increased enforcement of laws and regulations to protect patients and promote responsible science communication.
Researchers report that 90% of patients who received gene therapy between 2009 and 2012 remain disease-free, with significant immune system differences observed among those treated. The therapy is most effective in younger children, but further work is needed to achieve high levels of gene correction in all patients.
Researchers from Aarhus University have developed a method to cultivate millions of plasmacytoid dendritic cells, a rare immune cell crucial in fighting diseases. This breakthrough could lead to new treatments for cancers and viral infections, with clinical trials expected within the next few years.
A USC-led study has improved lizard tail regeneration through stem cell-based therapy, leading to the creation of tails with skeletal and nerve tissue on both sides for the first time in history. This breakthrough informs efforts to improve wound healing in humans, particularly for injuries that don't naturally regenerate.
Researchers from Sanford Burnham Prebys have discovered a new source of stem cells that could help treat people living with Alagille syndrome. These 'outside the box' liver stem cells may offer hope for those with the rare genetic disorder, which causes severe liver damage and death.
Researchers at Lund University discovered a previously overlooked part of our DNA that appears to contribute to the development of human and chimpanzee brains. The study found that humans and chimpanzees use a structural variant of DNA in different ways, which plays a significant role in brain evolution.
A new study by University of Pennsylvania researchers uses human gingiva-derived mesenchymal stem cells to guide nerve growth and regeneration, achieving similar results as traditional autograft procedures. The approach has potential for treating larger nerve gaps, including those resulting from oral cancer surgery.
Researchers identified specific mesenchymal stromal cells within the bronchovascular bundle of lungs that play a crucial role in creating scarring through interaction with epithelial cells. These cells are thought to be triggered by immune cell attacks, leading to fibrotic scarring and rejection.
Researchers have discovered the molecular mechanisms behind stem cell rolling in blood vessels, a complex process that slows down cells using long tethers. The findings offer new insights into improving stem cell transplantations and developing treatments for metastasizing cancers.
The University of California, Riverside has received a $5 million grant from the California Institute for Regenerative Medicine to train young scientists and physicians in stem cell research. The program, named TRANSCEND, will provide training in broad areas of stem cell biology and regenerative medicine.
A team of researchers has identified a cellular mechanism that enables embryonic stem cells to maintain their state as stem cells. The study, published in Cell Reports, reveals the genetic ingredients required for ESCs to decide whether to divide or differentiate.
Researchers have created a human disease model of FCMD using stem cells from a patient, which successfully mimicked the disorder's brain defects. The study found that a small compound called Mannan-007 can restore αDG glycosylation and reduce FCMD-related defects.
A clinical trial conducted by TTUHSC researchers found that corneal epithelial stem cell-derived eye drops significantly improved symptoms of severe dry eye disease, with patients experiencing a 23% improvement in SPEED questionnaire scores and a 17.1% improvement in OSDI scores. No adverse reactions were reported during the 12-week tr...
A new ex vivo drug delivery system has been shown to keep MSCs viable longer and reprogram the peripheral immune response toward organ repair. The study's results suggest that SBI-101 can impact a peripheral immune response that can be transmitted to local tissue damage in vital organs, including the kidney.
The Lundquist Institute has received a prestigious CIRM Scholar Research Training Award to support its PhD students, postdoctoral fellows, and clinical fellows in stem cell biology and regenerative medicine. The grant will enable the institute to create a stem-cell focused program, recruit researchers, and retain talent in the field.
A recent study published at Masonic Medical Research Institute found that electrocution-induced physiological stress can lead to overlapping cardiac conditions in individuals. The research used human induced pluripotent stem cells to investigate the mechanisms behind these conditions, shedding light on potential new treatments.
Caltech researchers have developed a technique to build embryo-like structures from human stem cells, opening up new possibilities for studying early human development. The technology can generate large quantities of these structures without the need for donated embryos.
Researchers link repeated injury to airway stem cells with chronic lung disease, suggesting that biological aging of these cells may contribute to the development of this condition. The study found that injury caused activation of a subset of stem cells, leading to their premature aging and loss of functional capacity.
A study found that treating wounds with mesenchymal stromal cell secretions significantly reduced MRSA viability and stimulated the surrounding skin cells to build a defense. The treatment has potential as an alternative to antibiotics, reducing antibiotic resistance in both veterinary and human medicine.
A new study from Cornell University has found that the antimicrobial properties of certain stem cell proteins can effectively reduce the viability of methicillin-resistant Staphylococcus aureus (MRSA) in skin wounds. The treatment also stimulates the surrounding skin cells to build up a defense against the bacterial invader.
Researchers at Kyushu University successfully reconstitute the ovarian follicle from mouse stem cells, generating functional egg cells and growing viable mice. This breakthrough could lead to new treatments for infertility and help conserve endangered animals through egg cell production.
Aging stem cells in bone marrow lose function due to epigenetic changes that affect bone production. Researchers reverse these changes by adding acetate, rejuvenating the epigenome and improving stem cell activity. This finding holds promise for treating diseases like osteoporosis.
Researchers investigated antibody response to Pfizer-BioNTech vaccine in 117 allogeneic hematopoietic stem cell transplant recipients. The study aimed to assess vaccine safety and immune response in this population. Key findings were not reported in the article.
Researchers developed lab-grown cochlear organoids to screen FDA-approved drugs for hair cell-inducing properties. The study identified Regorafenib as a potent stimulator of hair cell formation, even regenerating lost cells in mouse tissues.
The study found that a specific type of glycosaminoglycan in the scaffold led to greater blood vessel development and immune cell activation. Researchers aim to further understand these interactions to develop biomaterials for bone repair.
Researchers at KAUST have developed an in vitro model of early human embryogenesis using extended pluripotent stem cells, overcoming ethical concerns. The model, called EPS-blastoids, is a faithful representation of the earliest moments of human development and holds promise for studying developmental defects and regenerative medicine.
Researchers at Kyoto University have made a groundbreaking discovery by creating functional sperm cells from mouse pluripotent stem cells. The breakthrough has significant implications for male fertility and reproduction, providing a new model for generating male germ cells in a test tube.
Researchers have genetically engineered cells that can deliver a biologic drug in response to inflammation, reducing inflammation and preventing bone damage in mice with rheumatoid arthritis. This approach could provide personalized treatments for arthritis patients, limiting side effects associated with current therapies.
Researchers from Nara Institute of Science and Technology and Nanjing University discovered a small protein, KNUCKLES, that plays multiple roles in ensuring the correct timing of floral development. This discovery reveals a regulatory pathway where KNUCKLES supports the completion of floral meristem development within a short time window.
Researchers found that astrocytes carrying the AD-associated APOE4 gene released more cholesterol, leading to increased beta-amyloid production in neurons. This study suggests modulating brain cholesterol could be a potential treatment option for Alzheimer's disease.
Using human stem cells and small molecules, researchers successfully differentiated them into insulin-producing pancreatic beta cells. This breakthrough could lead to a personalized treatment option for type 1 diabetes, reducing costs and increasing accessibility for those affected.
Researchers at Masonic Medical Research Institute are using human induced pluripotent stem cells (hiPSCs) to create scientific models for studying cardiac arrhythmias and testing therapeutics. The integration of mathematical modeling tools enables the prediction of drug efficacy with minimal adverse effects.
Researchers have discovered that the TRPV4 gene plays a crucial role in regulating cartilage growth, which could lead to more effective treatments for osteoarthritis and other cartilage diseases. The study also suggests that TRPV4 may be used to accelerate stem cell differentiation for bioengineering cartilage.
Researchers at UCLA developed brain organoids that mimic human brain structure and function, allowing for the study of neurological disorders like Rett syndrome. The organoids showed organized waves of activity similar to those found in living brains and responded to treatment with an experimental drug.
A USC-led study has mapped the developmental blueprint of human kidneys, shedding light on how cells interact to form filtering units. The research provides a foundation for creating synthetic mini kidneys and could lead to new treatments for kidney diseases.
Researchers at Massachusetts General Hospital have discovered the molecular changes triggered by converting skin cells into immature muscle cells. The findings may lead to generating patient-matched muscle cells for treating muscle injuries and conditions like muscular dystrophy.
A new clinical study reveals that treatment with mesenchymal stromal cells reduces inflammation in patients with chronic obstructive pulmonary disease (COPD). The study provides insights into the therapeutic potential of MSCs as a novel treatment for COPD, which is a leading cause of morbidity and mortality worldwide.
Researchers generated brain organoids containing functional optic cups from human induced pluripotent stem cells (iPSCs), demonstrating intrinsic self-patterning ability. The optic cups exhibited light sensitivity, diverse retinal cell types, and connectivity to brain regions.
Researchers used autologous adipose micrografts to treat tendon injuries in sheep, achieving similar diameter and hardness to healthy tendons within two months. The study suggests a safe, reliable, and relatively fast way to promote tendon healing, with potential for human treatment.
Scientists at University of California San Diego School of Medicine have developed a method to keep cultured hematopoietic stem cells healthy, positive news for patients seeking stem cell transplants. The findings also hint at a new way to ward off aging by super-activating the heat shock pathway.
Researchers created the first detailed cell-by-cell description of how the coronal suture develops, identifying new genes and cell types involved in generating stem cells that grow skull bones. The study aims to advance new interventions for patients with craniosynostosis.
A study confirmed the safety of a novel stem cell therapy for knee pain caused by osteoarthritis. The treatment, which involves transplanting patient's own mesenchymal stem cells into the affected knee, showed no serious side effects over five years.
Researchers at the University of Helsinki have identified short non-coding RNA molecules in human ova and embryos, shedding light on embryonic development. The study's findings may lead to improved infertility treatments and a deeper understanding of early miscarriages.
Researchers from USC Stem Cell discovered a latent regenerative potential in the inner ear's sensory cells. They found that epigenetic modifications regulate hair cell development and identified a key histone decoration, H3K4me1, that keeps supporting cells primed for transdifferentiation.