Articles tagged with Stem Cell Research
Researchers at the University of Cambridge have successfully grown a model embryo with a brain, beating heart, and all other organs using mouse stem cells. This breakthrough could help understand why some pregnancies fail and develop a new approach for repairing synthetic human organs.
Researchers have developed a model mouse embryo that has beating hearts, foundations for a brain, and all the organs in a mouse body. This breakthrough could help understand why some embryos fail and provide insights into repairing synthetic human organs.
Researchers have identified a group of latent stem cells in the central nervous system of mice that respond to injury by dividing, migrating towards damaged areas, and differentiating into astrocytes. If similar cells exist in humans, they could provide a new therapeutic approach for treating spinal cord injuries.
Researchers found that cells in diseased connective tissue lose their ability to reorder DNA information correctly, leading to cell dysfunction. The study suggests that epigenetic treatments could restore healthy genome organization and may be effective treatments for conditions affecting dense tissues.
Researchers have successfully engineered human immune cells to model an infection common among immunocompromised people, paving the way for new drug testing and treatments. The immune cell type created played a key role in infection, inflammation, and regeneration, but also served as a natural host for germs.
Researchers have developed a tiny EEG cap for brain organoids, enabling 3D recording from the entire surface. This innovation expands what can be accomplished with organoids and holds promise for reducing animal testing in chemical toxicity studies.
A new study reveals a previously unrecognized level of heterogeneity and specialization of endothelial and mesenchymal cells in the bone marrow. By integrating single-cell gene expression data, researchers identified 14 endothelial and 11 mesenchymal subclusters, providing insights into blood stem cell self-renewal and differentiation
A new study published in Nature reveals that microglia cells change their molecular state to match neighboring neurons, influencing neural circuit function. The researchers found that different types of cortical neurons recruit specific numbers of microglia, which then adapt to the neuron's environment.
Researchers developed a new technique to track single blood stem cells in live organisms and describe their ultrastructure using electron microscopy. This allows for better understanding of cell-cell interactions and potential therapeutics for blood diseases and cancers.
Researchers generated rat sperm cells inside sterile mice using blastocyst complementation, achieving a proof-of-principle for producing gametes from one animal species in another. This breakthrough may speed up the production of transgenic rats for biomedical research and potentially support animal species conservation efforts.
A study published in Stem Cell Reports found that manipulating two signaling pathways, MAPK and PI3K-AKT, enhances the maturation of human-induced pluripotent stem cell-derived cardiomyocytes. This breakthrough discovery has significant implications for the development of cell therapy for heart disease.
Scientists have identified a critical source of essential molecules that enables the intestine's self-renewal and regeneration after injury. The study reveals that lymphatic endothelial cells play a key role in maintaining stem cell activity and tissues in the intestine.
Researchers from FSU College of Medicine and FAMU-FSU College of Engineering have developed a promising strategy to produce therapeutic particles in stem cells, which could help patients with neurological diseases such as stroke or multiple sclerosis. The new technique combines three-dimensional growing platforms with wave motion, lead...
Scientists at Cincinnati Children's develop a 'plug-and-play' method to consistently produce large numbers of lab-grown small intestines, colons, and stomachs. The new process overcomes the bottleneck of inconsistent organoid production, enabling faster and more accessible research.
Researchers investigate astrocyte production in the brain, discovering distinct dynamics in different parts of the cortex. The study suggests that early exposure to specific genes regulates stem cell behavior, leading to variations in astrocyte generation.
Scientists reprogrammed stem cells to create models of diseased eye cells, analyzing DNA, RNA, and proteins to pinpoint genetic signatures. The study identified 439 molecular signatures associated with AMD, including potential new gene variants that target mitochondrial proteins.
Researchers have identified a key chemical controlling hair follicle cell division and death, shedding light on a potential cure for baldness. The discovery also holds promise for speeding up wound healing by harnessing the regenerative properties of stem cells found in hair follicles.
A team of researchers has discovered a protein called NOVA1 that displays pathological characteristics in ALS patients at an early stage. This finding could lead to the development of new therapy concepts and potentially enable early detection of the disease.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
Researchers at UCLA have developed a roadmap detailing how stem cells become sensory interneurons, which enable sensations like touch and pain. The study identifies protocols for producing all types of sensory interneurons in the laboratory, paving the way for cell therapies to restore sensation in people with spinal cord injuries.
Researchers at Tokyo Institute of Technology have revealed that zinc (Zn) content is essential for the methionine-mediated regulation of pluripotent stem cells (PSCs). The team developed a protocol to convert PSCs into insulin-producing β cells, overcoming diabetes treatment challenges.
A groundbreaking study by Hebrew University researchers has discovered the most primitive blueprint for embryo cell creation. The team identified 14,000 sites in the DNA that control the development of all embryonic organs.
Researchers used human heart muscle cells and machine learning to predict arrhythmias in patients, achieving over 90% accuracy. The study lays the foundation for safer and more effective medicines by generating patient risk profiles and drug toxicity testing.
Research by Jeremy Wang at the University of Pennsylvania has discovered that DOT1L, a stem cell self-renewal factor, is essential for mice to produce sperm throughout their adult lives. The team found that mice lacking DOT1L fail to maintain spermatogonial stem cells and lose the ability to continuously produce sperm.
Scientists uncovered a biophysical mechanism steering stem cells in the intestine, shedding light on their behavior and renewal process. The findings suggest that location plays a crucial role in determining which cells act as stem cells, with more frequent movements in the small intestine leading to increased stem cell activity.
Researchers generated simple kidney-like structures called organoids and used them to identify potential drugs for adult-onset polycystic kidney disease. They found nine compounds that inhibited cyst growth without stunting overall growth.
Researchers using 'blastoids' - in vitro models of the blastocyst - discovered that early embryonic signals induce placental development and prepare the uterus. The findings may contribute to a better understanding of human fertility and potentially improve IVF procedures, fertility drugs, and contraceptives.
A new strategy using nanoparticles restores damaged stem cells, enabling them to grow new tissues again. The approach, which uses specially formulated 'backpacks' to deliver medicine, shows promise for treating gestational diabetes and other pregnancy complications.
Researchers have discovered that Schwann Cell Precursors are the origin of tuberous sclerosis complex tumours in the kidney. Lab-grown 'mini-kidneys' were used to create a genetic profile similar to TSC tumours, revealing the diversity in tumour size and cellular makeup within patients.
Researchers have created stem cell models that mimic the genetic disorder, revealing the role of WASP protein in regulating RNA splicing and finding potential therapeutic targets. These findings could lead to new treatments for Wiskott-Aldrich syndrome, a devastating immune deficiency disorder.
A KAUST-developed nanotechnology platform uses tiny iron wires that bend in response to magnetic fields to accelerate bone cell formation. Bone-forming stem cells grown on the moving substrate transform into mature bone much faster than usual, potentially paving the way for more efficient regeneration of bone.
A joint research group developed a robotic AI system that autonomously determines optimal conditions for growing replacement retina layers. The system achieved a 90% rate of differentiation efficiency in 185 days, compared to months of work by humans.
Scientists studied embryonic development in fish and cartilaginous fish, revealing that the jaw shares a common developmental origin with the gill. The findings support the theory that the jaw evolved by modification of an ancestral gill, which was previously considered controversial.
Researchers have discovered that human urine-derived stem cells have the ability to regenerate tissue and become various cell types, making them a promising source for stem cell therapy. The study also highlights the importance of telomerase activity in maintaining regenerative potential.
Izpisua Belmonte's work on cellular rejuvenation programming has the promise to improve aging and age-associated diseases, with potential therapies for new treatments. He was recognized for his innovations leading to discoveries that can reset a cell's aging clock, allowing organs to regenerate.
A new molecule called embigin has been discovered to regulate sebaceous gland progenitor cell function. Embigin binds to fibronectin and directs transport proteins for lipid synthesis, playing a crucial role in sebum production.
Researchers have developed a unique 3D printed system to harvest mesenchymal stem cells from bioreactors, which can be used for various treatments. The system combines microfluidics and 3D printing to process adult stem cells, potentially making stem cell therapies more widely available.
Researchers at EMBL discovered how messenger RNA molecules bind to and regulate the enzyme ENO1, which breaks down glucose. This riboregulation process can determine cell growth and differentiation, with potential implications for understanding cancer.
Researchers have developed a new protocol for differentiating human embryonic stem cells into retinal pigment epithelial (RPE) cells, which can be used to treat age-related macular degeneration. The study shows that the protocol produces a pure population of RPE cells that can continue maturing after transplantation, paving the way for...
Researchers have discovered an alternative route that pluripotent and endoderm extra-embryonic stem cells can use to form intestinal organs in the lab. This finding could lead to improved cell development and potentially treat diseases, but further function testing is needed.
A study led by Brigham and Women's Hospital investigators has revealed that alpha-synuclein plays a dual role in Parkinson's disease, interacting with both vesicles and P-body structures. This new understanding may lead to targeted treatments for the disease, with ongoing genetic studies aiming to identify optimal therapeutic targets.
A new platform mimics live cellular environment to guide stem cell differentiation outside the body. Researchers from Chung-Ang University developed a novel platform based on metal-organic frameworks, which offers advantages over conventional methods for in vitro stem cell differentiation.
Researchers at Cedars-Sinai have discovered that zinc, a common mineral, plays an important role in reversing lung damage and improving survival for patients with idiopathic pulmonary fibrosis (IPF). By identifying a molecular pathway involving zinc, the team hopes to develop new therapies to reverse IPF-related lung damage.
A Rutgers study analyzing brain stem cells of autism patients found irregularities in early brain development, supporting the concept that ASD arises from poor control of brain cell proliferation. The study discovered that some patients had NPCs producing too many brain cells while others had underproduced cells.
A new study has identified over 300 novel genetic features in retinal ganglion cells affected by primary open-angle glaucoma. The research provides a detailed genetic roadmap that will help researchers develop new therapies to prevent vision loss and potentially reverse damage caused by the disease.
Researchers used stem-cell models to uncover hidden genetic markers of glaucoma, a leading cause of permanent blindness. The study identified 312 genetic variants associated with retinal cells and 97 genetic clusters linked to damage caused by glaucoma.
A new study found that patients with multiple myeloma who received a three-drug combination therapy had improved progression-free survival if they underwent an autologous stem cell transplant soon after treatment. The use of maintenance lenalidomide also conferred substantial clinical benefit.
Researchers discovered that leukemia-initiating cells in MLL-rearranged B-ALL can switch between two metabolic states, which makes them difficult to target. Targeting the quiet, stem cell-like state curbs the leukemia by forcing the cells back to an active proliferation state.
Researchers developed an in vitro stem cell model to map disease risk variants in human neurons, which could provide insights into the biological mechanisms underlying neuropsychiatric disorders. The study focuses on mapping cis-regulatory elements linked to psychiatric disease heritability.
Researchers discovered that ancient retroviruses embedded in human genome can undergo retrotransposition into iPS cells, potentially posing a risk for regenerative medicine. The study found that HERV-K is expressed in SOX2-expressing cells and may cause cancer and neurological diseases by altering gene expression profiles.
Researchers studied meiotic cohesin complexes' effect on chromosome structure and genomic integrity in embryonic stem cells. Maintaining adequate levels of REC8 and STAG3 factors ensures chromosomal stabilization and sister chromatid cohesion.
A study published in Nature Communications reveals that the type of macrophage present in a person's body may determine how likely they are to develop severe inflammation in response to COVID-19. The research found that an aggressive subset of macrophages, known as M1 macrophages, can cause a cascade of events leading to multi-organ fa...
Scientists found that lithium chloride can cause X-inactivation loss in female hESCs, leading to cell death. The study suggests a possible new model for regulating X-inactivation and warns against using GSK-3 inhibitors like lithium.
Researchers have developed a novel therapeutic strategy for treating glioblastoma using allogenic stem cells that can target and kill tumor cells. The therapy demonstrated profound efficacy in preclinical models, with 100% of mice living over 90 days after treatment.
A Johns Hopkins Medicine study found that a protein called STING responds to clean-up signals in brain cells damaged by Parkinson’s disease by creating a cycle of inflammation that accelerates the disease’s progression. In mice with deactivated STING proteins, there was less microglial activity and brain cell death.
A recent study published in NPJ Regenerative Medicine found that large bone injuries trigger a repair strategy recapitulating elements of skeletal formation in utero. The gene Sonic hedgehog (Shh) plays a necessary role in healing central regions, while small-scale fractures heal through a distinct program.
Researchers studied naked mole-rats' skin using single-cell RNA-seq to understand its remarkable stability against aging. They found no changes in epidermal gene expression with age and a unique keratinocyte differentiation trajectory that remained intact.
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
A receptor protein called insulin receptor is pivotal for brain stem cell longevity, according to a Rutgers study. The researchers also found that the same protein plays a crucial role in sustaining brain cancer cells.
Researchers have developed a process to convert non-neuronal cells into functioning neurons that can take up residence in the brain and restore capacities undermined by Parkinson's destruction of dopaminergic cells. In a proof-of-concept study, one group of experimentally engineered cells performs optimally in terms of survival, growth...