Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Influenza A virus particles can change shape from spheres to larger filaments to favor infection efficiency, according to a new NIH study. The researchers developed a method to observe real-time structure formation and found that filament shape requires more energy, helping the virus evade immune responses.
Researchers identified a link between Alzheimer's disease, cell function, and cholesterol in the brain. Lowering oxysterol levels freed trapped ABCA1, restoring its healthy state, and showed potential as a new treatment approach.
Researchers at Hokkaido University have successfully cultivated an ultrasmall bacterial strain that parasitizes methanogenic archaea, inhibiting their growth. This discovery represents the first successful cultivation of such bacteria and proposes a new phylum Minisyncoccota, advancing our understanding of microbial ecology.
Researchers at MD Anderson Cancer Center have made significant advancements in treating oligometastatic prostate cancer, advanced urothelial cancer, and triple-negative breast cancer. Personalized risk-based screening is also being explored as a tool to reduce cancer deaths.
Scientists have discovered a scrawny star and its fast-moving super-Neptune world, which sets a new record for the fastest exoplanet system. The planetary system is thought to move at least 1.2 million miles per hour.
Thousands of proteins rely on their tails to become successfully embedded within the cellular membrane. Researchers discovered a protein called YidC that helps short tails cross the fatty membrane, enabling functional protein-tail integration.
UD researchers found significant differences in gene expression in adipose tissue, a vital endocrine organ linked to cardiovascular and metabolic diseases. The study identified four genes related to metabolism, calcium handling, and inflammation that warrant further investigation.
The Terasaki Institute for Biomedical Innovation has announced the recipients of its inaugural Keith Terasaki Mid-Career Innovation Award. Dr. Liangfang Zhang and Dr. Aydogan Ozcan were recognized for their innovative approaches to translating groundbreaking research into real-world impact.
Researchers found that glioblastoma stem cells are co-localized with myeloid-derived suppressor cells, promoting tumor growth and aggressiveness. The study identified key molecules, such as IL-6 and IL-8, that attract and activate MDSCs, providing new potential therapeutic targets.
A new study compares the allosteric regulation of Escherichia coli and Mycobacterium tuberculosis cAMP receptor proteins, revealing distinct regulatory mechanisms despite structural resemblance. The findings suggest species-specific control over bacterial gene regulation and have potential implications for drug development.
Researchers aim to identify key mechanisms and molecular targets to prevent tumor progression in Rhabdomyosarcoma patients. The study focuses on the TAK1 protein, which plays a significant role in regulating cell growth, and its potential inhibition as a therapeutic approach.
Researchers at Texas A&M University have developed a low-cost technology using curcumin to curb bacterial resistance. The study shows that photodynamic inactivation can trigger deleterious reactions within bacteria, killing them and reducing the number of antibiotic-resistant strains.
A University of Ottawa neuroscientist has led a Canadian research team to discover how neural stem cells integrate signals from different cell types and decode them. The study found that low daughter cell numbers trigger activation, while high numbers keep them in quiescence, offering new insights into cellular relationships and potent...
A new genetic mutation, RUFY1-RET fusion, was discovered in a patient with stage IV CD-74-ROS1 fusion NSCLC who developed resistance to lorlatinib. The finding highlights the importance of ongoing genetic testing to guide therapy decisions.
The ISSCR International Symposium will commemorate the 20th anniversary of iPSC discovery, highlighting breakthrough achievements and new research advances. The event aims to celebrate the transformative power of scientific curiosity and its potential to unlock cures for previously untreatable diseases.
Researchers mapped the precise brain mechanisms that enable animals to overcome instinctive fears, revealing two key components in this learning process. The study found that a brain structure called the ventrolateral geniculate nucleus (vLGN) stores learning-induced memories and is triggered by the release of endocannabinoids.
Researchers at TUM found that cystic fibrosis causes changes in the immune system as early as birth, leading to frequent inflammation and infections. These changes are not affected by CFTR modulator therapies.
Researchers used CRISPR/Cas9 to study the gene function of adenine phosphoribosyl transferase in beans. They found two functional mutants with distinct roles: one affects adenine recycling and the other regulates cytokinins, essential for root growth and nodules.
A Virginia Tech research team has made significant progress in understanding the role of physical properties in tuning the body's immune responses. By modifying biomaterials' size, shape, and stiffness, they aim to enhance immune cell behavior and stimulate antitumor immune responses.
A team of researchers at Mass General Brigham has discovered that granzyme K activates the complement system against own tissues, driving inflammation and tissue damage. Inhibiting this pathway could preserve anti-microbial functions while targeting chronic inflammatory diseases.
Researchers at ETH Zurich discovered tiny ice quakes deep inside ice streams, explaining the discrepancy between simulations and satellite measurements. The findings impact sea-level rise estimates and may reveal fault planes in ice cores, providing a better understanding of ice stream deformation.
Scientists at KTH Royal Institute of Technology have developed a refined method for measuring and predicting gravity changes as the Nordic region rises. The study found that the Ferroscandinavian peninsula's land mass is more dense than previously known, with an upper mantle density of approximately 3,546 kilograms per cubic meter.
Researchers identified S6K2 as a potential target for treating NRAS MUT melanoma, which accounts for 30% of all melanoma cases. The team found that silencing S6K2 killed cancer cells by disrupting lipid metabolism, and combining treatment with two compounds improved therapeutic outcomes.
A new study reveals that first-generation planetesimals in the inner solar system were rich in moderately volatile elements, which were later lost during violent cosmic collisions. This discovery reshapes our understanding of how planets acquired their ingredients.
Researchers at Tel Aviv University have developed a method to transform graphite into novel materials with controlled atomic layers, enabling the creation of tiny electronic memory units. This process, known as 'Slidetronics,' allows for precise manipulation of material properties, opening doors to innovative applications in electronic...
The KeyScope is a low-cost, robust laparoscope priced at approximately $1,000, making it accessible in low- and middle-income countries. It offers high-resolution images, color accuracy, and low distortion, comparable to standard laparoscopes.
A new study suggests that pre-colonial people in Brazil may have gathered in summer months to feast on migratory fish and share alcoholic drinks. The researchers analyzed pottery fragments dating back to between 2300 and 1200 years ago, which revealed evidence of fermented beverages and processing of fish.
Researchers at MIT and Harvard University have directly measured superfluid stiffness in magic-angle graphene for the first time, shedding light on its remarkable properties. The study suggests that quantum geometry governs the material's superconductivity, a key step toward understanding its exceptional properties.
Researchers at Tokyo University of Science have found that opioid delta-receptor agonists can alleviate stress-induced IBS symptoms in a validated mouse model by targeting the central nervous system. The study suggests that these drugs could provide a more definitive solution for IBS with minimal adverse effects.
Researchers at McGill University found that a protein produced in muscles helps manage the release of follicle-stimulating hormone (FSH), which promotes egg maturation. Lowering myostatin levels delayed puberty and reduced fertility, while restoring it boosted FSH levels.
The Terasaki Institute recognizes Dr. Cato Laurencin's groundbreaking contributions to regenerative engineering, while Dr. Jun Chen is recognized for his innovative technologies in soft bioelectronics and magnetoelastic materials.
The partnership aims to accelerate discoveries and develop life-changing therapies for children with cancer and rare diseases. By combining expertise in pediatric care and cutting-edge technology, the organizations hope to make significant strides in understanding and treating devastating childhood diagnoses.
Researchers have found a new method to remove PFAS from drinking water by heating them with granular activated carbon at 572 degrees Fahrenheit. This process achieves 90% mineralization of the PFAS, breaking them down into harmless inorganic fluorine.
University of Texas at Arlington President Jennifer Cowley has received a national award for her sustained commitment to community engagement. The Richard Guarasci Award for Presidential Leadership honors presidents who demonstrate deep and committed civic engagement throughout their careers.
Researchers at UCSF have discovered how a unique type of virus called a jumbo phage protects itself inside bacteria. The shield works via a set of secret handshakes that allow only useful proteins to pass through, giving the phage an advantage over regular phages when fighting infections.
Researchers at the University of Maryland discovered multiple pathways for dsRNA molecules to enter cells, challenging previous assumptions about RNA transport. They found that a protein called SID-1 plays a key role in regulating genes across generations, which could lead to better targeted treatments for human diseases.
A new tool named retriever extracts disease-specific drug response signatures to predict cancer treatment combinations, improving personalized treatment strategies. The tool refines predictions using single-cell RNA sequencing data and demonstrates its potential in identifying effective treatments for triple-negative breast cancer.
Researchers have created detailed maps of the retina using AI technology to better understand its link to various diseases. The study identified new genetic factors influencing retinal thickness, which may serve as a diagnostic biomarker for disease detection.
Researchers at FAU's Schmidt College of Medicine will explore the use of genetically engineered cells to treat degenerative diseases, with a focus on understanding how hypoxic conditions drive cellular transformation. The study aims to identify novel pathways controlling this process and develop strategies for engineering more complex ...
A recent study published in Communications Biology reveals that the Sudan virus binds to human cells through a specific protein called NPC1, which enables it to attach with nine times greater affinity than Ebola. This discovery may contribute to the high fatality rate of the Sudan virus.
A POSTECH research team developed a novel multidimensional sampling theory to overcome limitations of flat optics. Their study identifies constraints of conventional sampling theories and presents an innovative anti-aliasing strategy, significantly enhancing optical performance.
The hospital was ranked highly among healthcare professionals in the US and globally, reflecting its commitment to compassionate care and innovative research. UH Cleveland Medical Center is affiliated with several top medical schools and institutions, further solidifying its reputation as a leading Academic Medical Center.
Researchers discovered that a topical ABT-263 treatment effectively reduces aged skin senescence markers, priming the skin for improved subsequent wound healing. The treatment also triggered inflammation, which surprisingly helped the healing process by 'waking up' the skin's repair systems.
Dr. Kerry Ressler's research bridges the gap between molecular neuroscience and clinical psychiatry to understand PTSD's genetic architecture. Recent breakthroughs have identified over 100 significant genetic loci, representing a major step toward translating scientific discoveries into effective treatments.
A team of engineers from the University of Texas at Austin used x-ray, infrared, and other imaging technologies to investigate battery degradation in wireless earbuds. They found that temperature gradients, caused by clashes between critical components and the battery, led to damage and reduced battery life.
The Neuro-Oncology Translational Research Training Program aims to bridge laboratory discoveries and clinical applications in neuro-oncology, targeting glioblastoma and brain metastases. The program provides predoctoral and postdoctoral trainees with cutting-edge lab experience and mentorship across multiple disciplines.
Researchers at UCSF describe how to curb MYC levels by disrupting the protein assembly line controlled by RBM42. Disrupting RBM42 in pancreatic cancer cells stopped them from growing, suggesting drugs could be developed to do the same for other fast-growing cancers.
A recent study introduces an innovative method for analyzing body composition, providing accurate assessments of body fat and muscle distribution. The approach utilizes deep, nonlinear methods to enhance estimation accuracy, surpassing previous linear models.
Researchers developed a computer model called MANAscore to identify tumor-fighting immune cells in lung cancer patients treated with immune checkpoint inhibitors. The three-gene model helped find differences associated with patient response to immunotherapy, including the presence of stem-like memory T cells.
ApoB100 protein structure revealed for the first time, allowing for more precise testing and treatment of high cholesterol and heart disease. The discovery may lead to new drugs targeting LDL particles, reducing side effects of statin drugs.
Researchers at Virginia Tech have discovered a new solid lubricating mechanism that can reduce friction in machinery at extremely high temperatures. The novel coating has the potential to make components from rockets to semiconductors more safe, durable, and cost-effective.
Researchers have developed a new gene therapy that targets aggressive brain cancer, glioblastoma, with a precise delivery system. The treatment uses a novel virus to deliver a targeting drug to cancer cells, achieving cure rates of up to 90% in mouse models.
Researchers developed a novel microscopy technique to study metabolic changes in individual cancer cells at the single-cell level. They found that radiation treatment caused significant metabolic shifts in head and neck squamous cell carcinoma cells, particularly through the activation of HIF-1α.
Filipino researchers have discovered that Taal volcanic ash can be used as a sustainable and lightweight alternative to expensive materials like concrete and lead. The natural presence of iron-rich minerals in the ash gives it strong radiation attenuation properties, making it effective for shielding against harmful X-rays and gamma rays.
Researchers at University of Hawaii at Manoa shed light on the transformation of supercooled water into ice, mimicking Earth's atmosphere conditions. The study provides valuable insights into cloud formation and precipitation, tying into a $26 million project to develop sustainable refrigerant technologies.
Researchers at Lancaster University have developed a new method to detect Alzheimer's disease by analyzing changes in brain oxygenation dynamics and neuronal function. The study found that individuals with Alzheimer's disease exhibit altered respiratory frequency, which may be an early indicator of the condition.
A new Weizmann Institute study identified all proteins in a stool sample – those from the microbiome, human body, and food – revealing secrets of the intestines and their impact on human disease. The method, dubbed IPHOMED, decodes microbiome activity by showing which proteins come from bacterial strains and amounts.
Researchers at the University of Surrey have discovered a unique mix of lipids in polar bear fur that drastically reduces ice adhesion, paving the way for safer and more sustainable anti-freezing solutions. The study found that specific lipids, such as cholesterol and diacylglycerols, exhibit low adsorption energies on ice.
Researchers at the University of Melbourne have identified a rare type of immune cell, called stem-like T cells, that holds the key to maintaining powerful, long-term immune responses. ID3+ T cells have the remarkable ability to resist burnout and maintain a powerful immune response over time.
Researchers at La Trobe University's Olivia Newton-John Cancer Research Institute have developed a novel pre-clinical model expressing an enhanced version of the Cas12a enzyme, which can delete multiple genes simultaneously with high efficiency. This breakthrough enables complex genetic disorders to be modeled and interrogated.