Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The University of Texas at Arlington hosts weekly 1 Million Cups meetings, bringing together students, faculty, and local entrepreneurs to share ideas, network, and support startups. The program is part of the global 1MC network, which aims to facilitate community engagement and innovation.
A new machine learning approach developed by UCR researchers enables the detection of environmental patterns in large datasets generated by LIGO, improving data quality and reducing noise. This technology has potential applications in particle accelerator experiments and complex industrial systems.
Researchers at Memorial Sloan Kettering Cancer Center have made a breakthrough in creating allogeneic CAR T cells that can persist in fighting cancer without being rejected by patients. By modifying donor cells with the HIV protein Nef, the cells can survive and remain potent in treating various types of cancer.
A team of researchers at Duke University has developed a novel AI-based platform that can design and match small peptides with complex proteins, previously considered unreachable. The PepPrCLIP platform utilizes generative large language models to create peptide guide proteins and an algorithm framework to screen and test the peptides.
Researchers at Monash University have discovered how microbes consume huge amounts of carbon monoxide and reduce its levels in the atmosphere. By using a special enzyme called CO dehydrogenase, microbes extract energy from CO, powering their own survival while also cleaning the air.
The OSIRIS-REx mission returned a large sample from asteroid Bennu, which Japanese collaborators detected includes all five nucleobases required for life. The analysis revealed high concentrations of ammonia and nitrogen-rich organic matter.
Scientists at Tel Aviv University successfully transport mRNA-based drugs to the immune system of small and large intestines without passing through the liver. The breakthrough could enable treatments for inflammatory diseases such as Crohn's and colitis.
Berkeley Lab scientists analyzed asteroid Bennu samples using advanced tools, revealing a telltale set of salts formed by evaporation that illuminate the asteroid's watery past. The findings suggest Bennu may have delivered water and essential chemical building blocks of life to Earth in the distant past.
Researchers at Mayo Clinic developed patient-derived organoid models to study uveal melanoma, a common type of eye cancer. These 3D models accurately represent the disease's genetic and biological characteristics, enabling better understanding and treatment development.
Researchers found a genetic change, pR552*, that could give the RB1 gene a new function leading to cancer growth. This challenges the common belief that both copies of the RB1 gene must be damaged for cancer to develop.
Researchers gained insight into the early history of the solar system through well-preserved asteroid samples. The analysis revealed a variety of salts, including sodium carbonates, phosphates, sulphates, and chlorides, which formed from evaporation of brines. These findings may provide clues about the presence of life on distant icy b...
A predictive model developed by Ochsner Health researchers uses data-driven insights to determine whether urgent carotid-intervention patients will regain functional independence. The model has been shown to have a 93% accuracy rate and can help physicians tailor treatment plans and optimize intervention timing.
Researchers at Kyungpook National University have developed a new approach to map and engineer enzymes for enhanced plastic recycling. They employ landscape profiling to identify efficient biocatalysts for recycling polyethylene terephthalate (PET), producing high-purity monomers under mild conditions.
A deadly ciliate parasite has decimated sea urchin populations in the Caribbean, Red Sea, and Indian Ocean, with mortality rates reaching over 90%. The International team of researchers is working to track the disease and preserve sea urchins, which play a crucial role in maintaining coral reef health.
The foundation has awarded eight recipients of the 2025 Damon Runyon-Rachleff Innovation Award, including five early-career researchers with initial grants of $400,000 over two years. The awardees aim to develop novel cancer therapies using innovative approaches such as engineered skin bacteria and small molecule-boosted drug delivery.
A team led by biologist Thomas Mayer found that a small binding-pocket on cyclin B helps regulate the sequence of cell division events. Without this pocket, malformations occur due to incorrect kinase phosphorylation, leading to potential tumours or infertility.
A recent study published in JAMA Network Open found that heavy cannabis users exhibited reduced brain activity during working memory tasks, associated with worse performance. Abstaining from cannabis before cognitive tasks may help improve performance.
The ISS National Lab sponsored over 100 payloads to the orbiting laboratory, achieving the second-highest annual total. The lab also published a record 51 peer-reviewed articles in FY24, advancing scientific discovery and innovation.
Scientists found evidence of relatively recent geological activity on the moon's far side, contradicting previous assumptions about its 'geological dead' status. The team used advanced dating methods to track changes and found small ridges formed within the last 200 million years.
A global study will explore structural changes in the brains of people with bipolar disorder and compare them to major depression. The project aims to develop new tools for diagnosis and treatment, leveraging unprecedented sample sizes from over 3,500 individuals with BD and 9,000 healthy controls.
Researchers at the University of Queensland have identified a new henipavirus, Camp Hill virus, in shrews in Alabama, USA. The discovery suggests these viruses may be more globally distributed than previously thought, with implications for human health and vaccine development.
Borealis Mud Volcano provides a hard substrate for various species like anemones and octocoral colonies, sustaining local fish populations. The volcano's carbonates also offer shelter and feeding opportunities.
The collaboration aims to develop advanced 3D mini-brain models for replicating human brain architecture, enabling researchers to explore neurological diseases and screen drug candidates. The platform offers a high-throughput screening method for rapid testing of potential drug candidates.
Researchers at Yale University have made a groundbreaking discovery about the human ear, revealing two previously unknown sets of modes that govern sound detection and amplification. These modes, which include low-frequency mechanical responses, place constraints on how hair cells respond to incoming sound waves.
Researchers at Johannes Gutenberg University Mainz discovered altermagnetism, a new concept in physics that combines the characteristics of ferromagnets and antiferromagnets. The discovery has the potential to increase data storage capacity by utilizing the magnetic moment of electrons for dynamic random-access memory.
The project leverages super-radiance to enhance the brightness and emission rate of fluorophores, enabling high-throughput imaging and tracking of molecular processes. This could lead to breakthroughs in fields like cell biology, materials science, and nanotechnology.
Laboratory experiments corroborate the theory that Titan maintains its nitrogen-rich atmosphere through internal heating of organic materials. The study found significant amounts of carbon gases like methane and nitrogen, supporting the existence of a geologically short-lived atmosphere.
The study establishes a consensus nomenclature and characterization framework to advance mitochondria transfer and transplantation biology. It defines types of mitochondrial transfers and reviews methods to define and enforce these processes.
A therapeutic HPV vaccine targeting HPV16 could potentially eliminate precancerous cervical lesions, according to a phase II clinical trial. The vaccine showed significant regression and reduced lesion size in patients with HPV16-positive high-grade cervical intraepithelial neoplasia.
A new study published in Nature Medicine shows a promising approach to preventing metastases in breast cancer patients. Researchers found that administering digoxin reduced circulating tumour cell clusters by an average of 2.2 cells, significantly decreasing the risk of metastasis.
Researchers identified an unknown family of microbes uniquely adapted to tropical peatlands, with a dual role in the carbon cycle. These microbes can either stabilize or intensify climate change by releasing greenhouse gases like CO2 and methane.
Researchers have developed a groundbreaking approach using specially designed peptides to improve drug formulations, significantly enhancing anti-tumor efficacy in leukemia models. The innovative method achieves high drug loadings and optimizes delivery to targeted areas, holding significant potential for treating various diseases.
A new study from the University of Southern Denmark reveals that the brain's self-healing abilities are hindered by inflammation after a stroke. The researchers mapped specific cells that play a central role in rebuilding myelin, but found gender differences in how men and women respond to injuries.
A research team led by Associate Professor Ding P led a breakthrough discovery regarding the complex reaction mechanisms of carbon dioxide in supercritical water. They found that pyrocarbonate is a stable and important reaction intermediate in nanoconfined environments, which was previously overlooked.
A research team led by Ohio University's Sabrina Curran has discovered new evidence of early hominin activity in Europe, suggesting that hominins were present on the continent at least 1.95 million years ago. This finding pushes back previous timelines and provides valuable insights into the behavior of early human ancestors.
A cognitive science professor at UC Merced proposes a suite of video games to accelerate cancer research using artificial intelligence and gamified citizen science. The 'Cancer Wars' initiative aims to harness the collective problem-solving power of millions of gamers to tackle complex scientific problems.
Researchers have discovered a complex mechanism that allows bacteria to build resistance to antibiotics, involving a KorB-KorA regulatory system. This finding offers a fresh insight into long-range gene silencing in bacteria and provides a potential target for novel therapeutics.
A new study from the Salk Institute has discovered that a protein called BCL6 plays a crucial role in maintaining healthy muscle mass. Increasing BCL6 levels successfully reversed muscle losses in mice, suggesting that pairing GLP-1 medications with a BCL6-boosting drug could help counteract unwanted muscle loss.
Dale Gary, a distinguished professor of physics at NJIT's Center for Solar-Terrestrial Research, has been named an American Astronomical Society Fellow. He is recognized for his national and international leadership in solar radio engineering and physics, advancing our understanding of solar energetic processes.
A new study aims to characterize the human virome, exploring its role in health and disease. The project will investigate nonpathogenic viruses and their potential impact on human phenotypes over time. Researchers hope to discover novel biomarkers for health and disease, as well as new therapeutic approaches.
The final synthetic chromosome unlocks new possibilities in metabolic engineering and strain optimisation, enabling the generation of genetic diversity on demand. The achievement represents a major milestone in synthetic biology and has important implications for future genome engineering projects.
Researchers found that white-faced capuchin monkeys who showed a stronger stress response were more likely to survive extreme droughts. The study, led by UCLA's Susan Perry, used natural experiment of an El Niño drought in Costa Rica to investigate the adaptive nature of stress response.
UVA researchers analyzed 300 blood serum samples from babies who died from SIDS and identified specific biological indicators linked to their deaths. The study found 35 predictors of SIDS, including ornithine and a lipid metabolite critical for brain and lung health.
A POSTECH research team found that EGF/EGF-like domains interact with GlcNAc-based biopolymers to achieve strong underwater adhesion without oxidation, leading to durable and reversible bonds.
Researchers discovered that removing arginase-II gene can slow down muscle aging in mice, leading to improved muscle health and reduced inflammation. This finding suggests targeting the Arg-II gene could help maintain muscle strength and mobility in older adults.
The Chris Chang Lab develops a copper-detection tool to uncover how copper regulates cell growth in lung cancer. The probe identifies cells with elevated copper levels and reveals a connection between copper and the antioxidant response mediated by NRF2.
A new method can detect tiny amounts of SARS-CoV-2 virus in blood, stool, and saliva from patients with acute COVID-19 infections. The technology has potential for guiding treatment of long COVID and monitoring viral loads for future infectious diseases.
A research team from the University of Minnesota Medical School received a $1.2 million grant to study the use of TMS in addition to CBIT as a treatment for children with Tourette syndrome. The trial found that this new treatment improved brain circuits involved in tics, and the researchers hope it could lead to a future treatment option.
The Aging Research and Drug Discovery Meeting (ARDD2025) will feature Nobel laureates Morten Meldal and Michael Levitt. Their groundbreaking discoveries have had a lasting impact on drug development and molecular design, highlighting the conference's pivotal role in advancing healthspan and longevity science.
Researchers have created a detailed structural map of GABA A receptors in the human brain, revealing how they assemble and interact with drugs. The study provides new insights into treating epilepsy, anxiety, depression, and insomnia, and paves the way for customized therapies.
UCSF researchers found that when brain cells of female mice express only a maternal X chromosome, their memory and cognitive skills deteriorate faster. This study could explain the variation in brain aging between the sexes and individual women.
Researchers developed efficient tin-based catalysts for electrochemical CO2 reduction, enabling the production of high-value formic acid with improved selectivity and activity. The study's findings provide critical insights into the reaction mechanism, highlighting the importance of structural and kinetic factors in catalyst design.
Researchers developed mucoadhesive films combining xyloglucan and green tea extract to treat oral mucositis, a painful inflammation caused by cancer treatment. The films demonstrated high strength and adhesion forces comparable to commercial products, showing promise as a novel treatment for oral mucositis.
Researchers tracked spur-winged lapwings in urban and rural areas, finding that city-dwellers are more mobile, especially during nesting season. The study also reveals seasonal differences in exploration patterns between males and females, highlighting the complex impact of human presence on bird behavior.
UCSF researchers identify a molecular timer controlling mouse birth timing, which could lead to new tests for human preterm labor risk and interventions. DNA packaging during pregnancy plays a crucial role in regulating gene expression, with KDM6B working as a 'timer' that winds down over time.
Researchers identify Fam102a as a key regulator of both osteoclast and osteoblast differentiation, leading to enhanced osteoblast formation and bone volume. The study reveals significant protein-protein interactions involving Fam102a and Kpna2, shedding light on the critical molecular interactions involved in bone remodeling.
Researchers have identified a key protein called Apex1 as a potential therapeutic target for stopping the immune system from attacking itself. By inhibiting this protein, harmful T cells that cause autoimmune diseases and allergies can be eliminated.
Researchers used a new method to precisely locate a fast radio burst, finding it in the outskirts of an old elliptical galaxy. This discovery raises questions about how energetic events occur in regions without new star formation, and challenges existing theories about FRB origins.
A study found that a simple blood test could predict breast cancer risk in older women by measuring biological aging via DNA methylation changes. Lifestyle factors, such as obesity and hormone replacement therapy, also influenced epigenetic aging and breast cancer risk.
Scientists discovered that dry museum skulls of long-dead birds can provide surprisingly detailed information on their brain structures. The study found a nearly 1:1 correlation between the brain's volume and digital imprints, allowing researchers to gather insight into elusive species without seeing their brains.