Research on dementia and cognitive decline. Covers Alzheimer's screening, brain injury recovery, attention training, and gaps in diagnosis and care.
A recent study analyzing 12 peer-reviewed epidemiologic studies found a substantial benefit of late-in-life cognitive activities in reducing the incidence of Alzheimer's disease and other forms of dementia. The bias analysis suggested that potential confounding factors may not account for the observed associations, lending support to a...
A study published by the American Academy of Neurology found a link between calcium supplement use and increased dementia risk in older women with cerebrovascular disease. Women who took calcium supplements were twice as likely to develop dementia, particularly those with white matter lesions.
A study published in JAMA found that the proportion of US nursing home residents with advanced dementia receiving feeding tubes decreased by approximately 50% between 2000 and 2014. Feeding tube use declined across racial groups, but remained higher among black residents.
A recent study published in JAMA found that the proportion of advanced dementia patients receiving feeding tubes decreased from 11.7% to 5.7% between 2000 and 2014. The decline was observed across both white and black patient groups, with significant racial disparities initially present.
The Michigan Alzheimer's Disease Core Center will support researchers and clinicians from three major universities in developing new treatments and understanding the causes of dementia. The center aims to provide training opportunities across many areas of research and facilitate collaboration among experts.
A systematic review and meta-analysis of brain training exercises found that speed of processing training can significantly reduce the risk of dementia. The study, which included 2,832 participants, showed a 48% reduction in dementia risk over 10 years with this specific exercise.
A review suggests that acupuncture improves subtle memory loss before dementia development, with potential benefits when combined with drug treatment. However, more rigorous clinical trials are required to confirm its effectiveness and safety.
The University of Pennsylvania's Alzheimer's Disease Core Center has been awarded $8.8 million over five years from the National Institute on Aging to investigate Alzheimer's disease and related dementias. The center will focus on recruiting, studying subjects with early-stage AD, and expanding its bioinformatics infrastructure.
Researchers found an association between low physical activity and a higher risk for dementia in older individuals, with regular exercise potentially leading to higher brain volumes and reduced dementia risk. The protective effect was strongest in people aged 75 and older.
Researchers have identified novel expression sites in the hippocampus and olfactory bulb of mouse brains where the C9orf72 gene is strongly expressed. This discovery provides an important resource for studying animal models of ALS and FTD, with hopes of developing new treatments and eventually cures.
Researchers have unveiled a new diagnostic tool that can identify Alzheimer's disease long before the onset of symptoms using a non-invasive eye scan. The tool, developed by Professor Melanie Campbell, uses polarized light to highlight amyloid protein deposits in the retina.
Researchers have identified the first case of Alzheimer's disease in an HIV-positive individual, challenging existing knowledge about dementia in people with HIV. The discovery highlights the need for timely diagnosis and treatment of Alzheimer's disease in this population.
Researchers found a link between poor physical performance tests and increased dementia risk in people aged 90 and older. The study suggests that testing walking and standing balance may help predict dementia risk among the 'oldest-old'.
A recent study by University of Kentucky researchers found that nearly half of patients with early dementia or mild cognitive impairment reported positive scores on the Silver Lining Questionnaire, indicating improved personal relationships and increased appreciation for life. The results challenge the stereotype of depression and desp...
Researchers found a significant association between delirium and long-term cognitive decline in older surgical patients. The study, published in Alzheimer's & Dementia, suggests that delirium may serve as a marker for seniors with poor cognitive reserve.
Researchers found that pre-stroke risk factors, including high blood pressure, diabetes, and smoking, significantly influence future stroke and dementia risk. After one year post-stroke, survivors retain a high risk of recurrent strokes or dementia for at least five years.
A new $13 million study will revisit patients first screened between the 1960s and 1980s to evaluate how early life risk factors affected brain health and dementia risk. Researchers aim to explore racial and ethnic differences in dementia rates and risk factors.
Researchers found that an FDA-approved cancer drug increased brain dopamine and reduced toxic proteins linked to Parkinson's disease progression. The study showed significant signs of benefit for patients with neurodegenerative diseases, including improved cognitive and motor functions.
Research found no association between traumatic brain injury and dementia or Alzheimer disease, but increased risk of Parkinson's disease, progression of parkinsonism, and microinfarcts were observed. The study analyzed data from over 7,000 participants with a history of traumatic brain injury.
Researchers found poor standing balance and 4-meter walk test performances strongly associated with late-age dementia. The study suggests that impaired physical performance may be an early sign of developing late-age dementia.
Researchers developed a mouse model that mimics human Alzheimer's disease, showing that beta-amyloid accumulation is insufficient to trigger tau clumping alone. The study suggests combination therapy targeting both processes may be effective in preventing the disease.
Researchers from Rush University Medical Center found that diseased blood vessels in the brain may contribute more significantly to Alzheimer's disease dementia than previously believed. The study analyzed medical and pathologic data on 1,143 older individuals and found an association between worsening brain vessel diseases and higher ...
Scientists from the University of Sheffield have discovered a novel function of the C9orf72 protein, which is linked to amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The study found that the C9orf72 protein regulates the initiation of autophagy, a vital process for nerve cell survival.
The study found that families reported better quality of end-of-life care for patients with cancer or dementia compared to those with end-stage renal disease (ESRD), cardiopulmonary failure, or frailty. Palliative care consultations, do-not-resuscitate orders, and setting of death were associated with improved quality of care.
A study of patients who died at VA hospitals found that family-reported end-of-life care was significantly better for those with cancer or dementia than for those with other serious illnesses. Increasing access to palliative care may improve quality of end-of-life care for patients dying of heart, lung, and kidney diseases.
A new study investigates the effects of early dementia screening on family members of older adults, exploring potential benefits and harms. The EFECT study aims to inform optimal care for at-risk individuals and impact the lives of caregivers, measuring knowledge, caregiver preparedness, and mental health outcomes.
Researchers found that people with probable dementia who had not been diagnosed were more likely to engage in potentially dangerous activities. Healthcare practitioners can better address safety concerns by asking older adults about their activities.
Research at University of Plymouth investigates potential therapy for dementia with Lewy bodies, a condition caused by alpha-synuclein protein deposits in nerve cells. The project aims to understand mitochondrial damage and its impact on DLB, potentially leading to new treatments.
A study published in JAMA Neurology found that larger hematoma size and location are associated with an increased risk of dementia after intracerebral hemorrhage. The research also identified educational level, mood symptoms, and white matter disease as risk factors for delayed post-ICH dementia.
A recent study published in Journal of the American Geriatrics Society found that older adults with probable dementia but without a diagnosis are more likely to perform potentially hazardous tasks, such as driving and managing finances. This suggests that early diagnosis can help address safety concerns and plan for the future.
A new study found that video consultation technology brings together nursing home staff and hospital-based clinical experts to manage behavioral challenges associated with dementia. The program, Project ECHO-AGE, resulted in significant reductions in the use of physical restraints and antipsychotic medication among patients.
A Johns Hopkins study found that undiagnosed dementia patients are nearly twice as likely to engage in potentially unsafe activities, such as driving and cooking. Those without a diagnosis, however, were less frequently engaging in these activities compared to those with possible or no dementia.
Researchers found progranulin levels in cerebrospinal fluid differ from those in blood, challenging its use as a biomarker for neurodegenerative diseases. This discovery sheds new light on the biological processes underlying Alzheimer's and other common neurodegenerative diseases.
A recent study found that genetic modifications, such as differential gene expression and alternative splicing, contribute to the development of Parkinson's disease. The research identifies specific genes implicated in the disease, suggesting new avenues for diagnosis and treatment.
A study of over 20,000 patients with heart failure found that flu vaccination was associated with a 35% lower risk of developing dementia. Those who received the flu vaccine more than three times had a 55% lower risk. The researchers suggest that vaccination may reduce inflammation and prevent brain damage
Researchers propose Spherical Brain Mapping (SBM) to detect Alzheimer's disease, achieving 91% accuracy in differential diagnosis. The framework projects three-dimensional MR brain images onto two-dimensional maps, revealing statistical characteristics of tissue, and can be visually assessed for diagnosis.
A study published in the Journal of Neurology found that brain scans of dementia patients with coprophagia showed significant neurodegeneration, particularly in the medial temporal lobe and amygdala. The researchers also noted that behavioral modifications and antipsychotic medication were effective in treating the behavior.
Researchers propose an out-of-control immune system as a common cause of neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's. The theory suggests that prolonged activation of the innate immune system leads to brain cell death, contributing to the decline in these diseases.
Research found chronic use of proton pump inhibitors (PPIs) accelerates vascular aging in humans, leading to increased cardiovascular disease, vascular dementia, and renal failure. PPIs like esomeprazole are widely used but not approved for long-term use.
A new study of over 10,000 patients with atrial fibrillation (AF) and those without found that AF patients treated with warfarin had higher rates of dementia, Alzheimer's disease, and vascular dementia. The study suggests that the efficacy of therapy is strongly associated with dementia risk.
Research from the University of East Anglia found that eating family-style meals, playing music, and engaging in multisensory exercise can boost nutrition, hydration, and quality of life among people with dementia. The study assessed 56 interventions aimed at improving food or drink intake among over 2,200 people with dementia.
Researchers found that smaller, more interconnected social networks are associated with early signs of cognitive decline. Participants with mild cognitive impairment or dementia had a higher proportion of relatives in their networks and less socialization with friends and neighbors.
A long-term study of 3325 adults aged 55 and over found that depression symptoms that steadily increase in older age are more strongly linked to dementia than any other types of depression. The study suggests that increasing depressive symptoms may indicate the early stages of dementia.
A new study has found a link between rosacea and an increased risk of dementia, with the highest risks seen in older patients. The study published in Annals of Neurology suggests that treating rosacea may also modify patients' risk of developing dementia.
Researchers created a mouse model that closely replicates the symptoms and gene expression patterns of ALS and frontotemporal dementia. The model allows scientists to understand how the C9orf72 gene mutation causes paralysis and dementia, and potentially develop treatments.
Researchers at McGill University find that the combination of amyloid and tau proteins causes brain damage in cognitively intact individuals, offering new insights into Alzheimer's disease progression. The study's findings suggest that therapeutic strategies targeting both proteins may be effective in preventing or stabilizing AD.
A new study from Indiana University reveals that nearly half of all long-stay nursing home residents are sent to the Emergency Department over a year, despite their cognitive status. The study's findings highlight the need for strategies to avoid unnecessary transfers and deliver patient-centered care in long-term care facilities.
A 20-year study found a significant drop in dementia incidence among men in the UK, driven by reduced risk factors such as smoking and improved vascular health. The study suggests that targeted public health measures may help prevent future increases in dementia cases, contradicting global projections of a looming 'dementia tsunami'.
A 71-year-old HIV-positive man was diagnosed with Alzheimer's disease through a PET scan showing amyloid deposition in the brain. This finding suggests that some older HIV-positive patients may be misdiagnosed with HIV-associated neurocognitive disorders and highlights the need for accurate diagnosis to guide treatment.
The Alzheimer's Association has developed recommendations for patient care milestones, including workforce development, timely diagnosis, education, and care guideline measures. Caregiver support strategies include culturally sensitive training, enabling caregivers to balance care with their own well-being, and addressing housing needs.
A new study finds that person-centered dementia care can be effectively provided by an engaged low-cost workforce of care coordinator assistants. These assistants, with limited education, are trained to conduct home visits and support caregivers, extending primary care to older adults' homes.
Researchers at Boston University School of Medicine discovered a new gene, FOXF2, linked to ischemic stroke caused by small vessel disease in the brain. The study suggests that unraveling the mechanisms of small vessel disease could lead to better treatments for this major cause of stroke and dementia.
The University of Stirling has developed an innovative activity toolkit to support people living with dementia. The 'gardens' themed kit provides a group activity pack to prompt conversation and reminiscence, aiming to bring benefits such as constructive conversations, social connections, and engagement with personal histories.
A new Parkinson's disease study has found significant variability in brain signaling that could serve as a predictive marker for identifying patients at highest risk of dementia. Measuring brain signal variability may help identify the best patients to include in trials of new neuroprotective drugs.
A systematic review and meta-analysis published by the International Association for Dental Research reveals an association between tooth loss and reduced cognitive function in adults. Individuals with less than 20 teeth were found to be at a 20% higher risk of developing cognitive decline and dementia compared to those with more teeth.
A study analyzing data on over 1,100 aging adults found that combinations of brain pathologies drive dementia, rather than a single condition. The research suggests that maintaining healthy blood pressure may be key to preventing dementia.
A study published in the Journal of the American Geriatrics Society found that transitions in care for older adults with dementia are linked to medication errors, hospital readmissions, and increased risk of death. Receiving coordinated care and a long-term care plan can help reduce unnecessary transitions.
A recent study found that antipsychotic drug use is associated with higher mortality among all Parkinson's disease patients, not just those with dementia. The researchers compared records of over 15,000 patients and found a significant increase in mortality rates among those who took antipsychotics.
A recent study published in Molecular Brain reveals that dementia risk is higher in women due to changes in proteins present in the brain. The research found that degenerative protein modifications were more pronounced in women than men, particularly in the myelin basic protein.
A comprehensive report by internationally leading researchers calls for concerted efforts to reduce the burden of dementia. The report advocates for public governmental agencies to form large multinational partnerships with academic centers and pharmaceutical companies to deploy capital resources and share risk.