Articles tagged with Dementia
The Baycrest Memory Clinic will pool anonymous medical records from clinics across Toronto to accelerate dementia research and provide access to better integrated care for patients. The database will allow TDRA researchers to share research data across institutions and access a greater pool of volunteer research participants.
Mutations in progranulin protein result in obsessive-like behaviors and immune system alterations, implicating TNF as a potential therapeutic target for FTD. Targeting NF-B activity in microglia may also prevent excessive grooming and improve social behavior.
A review of eight studies found no link between low-dose aspirin and reduced cognitive decline. Researchers are calling for more research on the potential benefits of long-term aspirin use at younger ages.
Research found that drinking at least one artificially sweetened beverage a day increased the risk of developing ischemic stroke by three times and Alzheimer's disease dementia by 2.9 times compared to less frequent consumption. The study highlights the need for more research into this area.
Researchers have discovered an antibody that can detect tau in the serum of patients with tauopathies, a neurodegenerative disorder characterized by toxic protein clumps. The antibody, HJ8.5, has shown promise in increasing tau levels in human patients and mouse models, potentially paving the way for new treatments.
Yuna Ayala's research team discovers how TDP-43 protein causes damaging plaque buildup in neurodegenerative diseases like ALS and frontotemporal dementia. They found that phosphorylation regulates TDP-43's activity, location, and processing, which may be crucial for cellular metabolism.
A new study led by Jennifer Tjia found that training nursing home staff to recognize unmet needs of cognitively impaired residents significantly reduced antipsychotic medication use. The OASIS program shifted care planning from focusing on limitations to meeting resident needs, resulting in a 7% drop in antipsychotic prescriptions.
Scientists identify a common mechanism in two forms of neurodegeneration affecting young adults and the elderly, linked to progranulin protein mutations. The discovery advances efforts to find better treatments and cures for these diseases, including frontotemporal dementia and neuronal ceroid lipofuscinosis.
A study published in the Journal of Alzheimer's Disease found that individuals with a genetic predisposition to Alzheimer's disease had difficulty distinguishing novel figures called Greebles, even when others could not. This method may allow for earlier detection and potential treatment of the disease.
Researchers found a 30% increased risk of pneumonia in patients with Alzheimer's disease taking benzodiazepines, particularly within the first 30 days of treatment. The study suggests that benzodiazepines' sedative nature may increase the risk of pneumonia by increasing saliva or food aspiration into the lungs.
Researchers found that SuperAgers' brains shrink more slowly than peers', resulting in greater resistance to memory loss and dementia. The study suggests that age-related cognitive decline is not inevitable, contradicting traditional approaches to Alzheimer's research.
A new study analyzing over 50,000 patients with prostate cancer reveals a significant link between androgen deprivation therapy and dementia risk, suggesting that long-term use of this therapy may impact brain function. The findings also hint at a possible association between the treatment and Alzheimer's disease.
A US study reveals that the annual cost of neurological diseases in the US is nearly $800 billion, with an estimated $600 billion to be spent on stroke and dementia treatment by 2030. The study emphasizes the need for increased funding to develop treatments and cures for these conditions.
A new study found that individual Cognitive Stimulation Therapy (iCST) delivered at home by family caregivers has no effect on dementia patients' cognition but improves their relationship with caregivers. The therapy also enhances the caregiver's quality of life.
Researchers have found that synapses in brain cells display unusual properties before disease progression, pointing to a new approach for treating dementia. The study highlights the importance of synaptic stability in the development of the condition.
The most common neurological diseases in the US pose a substantial financial burden, totaling $789 billion in 2014 dollars. The report emphasizes the need for increased investment in neurological research and clinical management to reduce this burden.
A leading dementia expert emphasizes the importance of cognitive rehabilitation for people with dementia, sharing similarities with physical rehabilitation. Rehabilitation aims to enable individuals to participate meaningfully in everyday life and family/family activities.
Researchers Claudia Kawas and Kristine Yaffe received the 2017 Potamkin Prize for their work on Alzheimer's disease epidemiology in the oldest-old population. Their studies highlight the critical role of modifiable risk factors in dementia prevention.
Researchers found that unsaturated fatty acids were significantly decreased in Alzheimer's brains compared to healthy patients, contradicting previous assumptions. The study suggests a crucial role for fats in dementia onset and progression, with surprising findings on omega-3s and their impact on the disease.
A recent study published in JAMA Neurology found that vitamin E and selenium supplements did not prevent dementia in asymptomatic older men. The study involved over 7,500 participants who took the supplements for an average of five years, but showed no significant reduction in dementia incidence among the groups.
A new study has estimated that one in four Australian women over 70 will develop dementia. Researchers used a unique technique called capture-recapture to provide an up-to-date estimate for dementia in the Australian population.
Researchers have discovered a new potential predictor of early dementia through abnormal brain activity in older adults with no noticeable communication problems. Brain regions that process speech were found to be more resilient to Alzheimer's disease, but showed changes that predicted mild cognitive impairment and dementia.
A trial in UK general practices found encouraging patients with potential memory deficits to seek GP advice did not change their behavior or lead to earlier dementia diagnoses. The intervention did increase the proportion of patients consulting GPs with suspected memory problems.
Research suggests that temporary episodes of dizziness upon standing may cause lasting damage to the brain, increasing the risk of cognitive decline and dementia. Middle-aged individuals with orthostatic hypotension were 40% more likely to develop dementia than those without it.
A retrospective analysis of 30,112 home-care clients with dementia found that chronic comorbidities significantly increase the risk of hospitalizations and emergency department visits. The study suggests that targeting high-risk individuals may help prioritize healthcare resources.
A study of 1566 community-dwelling Japanese elderly found elevated dementia risks in individuals with fewer remaining teeth. Individuals with 10-19 and no teeth had significantly higher risks compared to those with more teeth.
A study published in PLOS Medicine found a significant increase in dementia diagnoses among older adults in the Netherlands over two decades. The researchers analyzed data from primary care networks and estimated an annual growth rate of 2.1% for dementia incidence, with women being more likely to develop the condition.
A large-scale study found a significant association between autoimmune diseases and increased risk of dementia, particularly Alzheimer's. People admitted to hospital for autoimmune diseases were 20% more likely to be readmitted for dementia compared to those with other conditions.
Scientists from Plymouth University Peninsula Schools of Medicine and Dentistry are investigating a potential new drug therapy for dementia diseases. They aim to understand how impaired autophagy, or cellular recycling, contributes to neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease.
Research presented at American Stroke Association's International Stroke Conference 2017 found that people with middle age heart disease risks, such as diabetes, high blood pressure or smoking, are at higher risk for dementia later in life. The study, which enrolled 15,744 participants, revealed that the risk of dementia was significan...
A study found that people who sleep for over nine hours each night have smaller brain volumes and double the risk of developing dementia in ten years. Early detection of cognitive impairment and dementia can lead to better healthcare decisions and improved quality of life.
A new study called Latino Core aims to learn about the aging process and risk factors for Alzheimer's disease in older Latino adults. The study will enroll over 300 participants and include yearly visits, memory exams, and brain donation to understand the pathophysiology of dementia in this population.
Research followed 695 bleeding stroke survivors for five years, finding 40% developed depression during follow-up, with high risk of dementia among those who also developed depression. Risk factors associated with hemorrhagic stroke also predicted depression risk.
Rhoda Au's e-cognitive health initiative collects data from over 2,200 participants using wearable devices, smartphone apps, and in-home devices to detect subtle changes in daily behavior that may indicate cognitive decline. The goal is to identify early signs of Alzheimer's and dementia, improving diagnosis and treatment options.
Researchers found that children of parents with C9orf72 mutations are more likely to develop frontotemporal dementia and ALS at a younger age, without accelerated disease progression. The study suggests that the length of the C9orf72 repeat is determinative for the age of onset of the disease.
A research team discovered that Tdp-43 cryptic exons are highly variable between cell types, potentially leading to early diagnosis and therapeutic agents for neurological diseases. This finding may elucidate the causes of Frontotemporal Dementia and Lou Gehrig's Disease.
A study has identified CTE pathology in four former soccer players, exceeding the average background rate of CTE found in a previous survey. All six brains also showed signs of Alzheimer's disease, highlighting a potential link between playing football and degenerative brain pathologies.
Researchers call for a shift from animal experiments to human-focused research on Alzheimer's disease and related dementias. Population studies suggest that dietary changes and other modifiable lifestyle factors can reduce the risk of developing dementia.
Researchers at University of Bristol and UCLan uncover new type of LTP controlled by kainate receptors, promising therapeutic strategies for dementia and epilepsy. The study's findings have far-reaching implications for understanding memory and neurodegenerative disorders.
USC-led study finds that older women living in areas with high PM2.5 levels are 81% more at risk for global cognitive decline and 92% more likely to develop dementia, including Alzheimer's disease. Exposure to air pollution particles may accelerate brain aging and promote Alzheimer's disease.
A breakthrough study by Dr. Xinglong Wang has linked ALS and dementias to TDP-43 toxicity in mitochondria, offering new hope for treatment. His team discovered a small-molecule peptide that can reverse symptoms of ALS in mice, paving the way for potential therapeutic approaches.
A new study published in JAMA Psychiatry found that delirium can accelerate dementia-related cognitive decline, with severe changes in memory observed among those with both conditions. The research highlights the importance of recognizing delirium in hospital settings to prevent brain injury and potentially delay or reduce dementia.
Recent preclinical research suggests microinfarcts can induce prolonged dysfunction in brain areas estimated 12-times larger than the visible injury site, contributing to cognitive decline and dementia. The study used a mouse model to examine the effects of individual cortical microinfarcts on surrounding tissue function in vivo.
The new guidelines provide a revised conceptual model of VCI and its subtypes, aiming to clarify diagnosis and facilitate collaboration among researchers. The study's findings have the potential to speed up research in this vital area and bring much-needed help to people with vascular cognitive impairment.
Delirium is an often-undiagnosed syndrome affecting nearly 18% of long-term care residents, characterized by disorganized thinking and attention deficits. Prevention strategies include avoiding non-essential surgery, maintaining hydration, and minimizing medication exposure.
Researchers found tablet use to be safe and engaging for nearly all patients with dementia, reducing symptoms of agitation. The tablets demonstrated significant effectiveness in improving mood and behavior, particularly among patients with milder forms of dementia.
A study of over 6.5 million Ontario residents found that those living within 50 meters of high-traffic roads had a seven percent higher likelihood of developing dementia compared to those further away. The risk increased with proximity, but not for Parkinson's disease or multiple sclerosis.
Scientists have developed a new technique to examine blood vessels in the brain using 3D Image Analysis, allowing for greater understanding of how diseases like dementia, brain cancer, and stroke affect veins and capillaries. This innovative method could help identify early warning signs of these illnesses, potentially saving lives.
A study of 6.6 million people found that those living within 50 meters of a major road had a small increased risk of developing dementia, with up to 7-11% cases potentially attributed to traffic exposure. The study also found no link between traffic exposure and Parkinson's disease or multiple sclerosis.
Researchers confirm the use of a simple sniff test as a supplementary tool for diagnosing mild cognitive impairment and Alzheimer's dementia. The study found that combining the sniff test with a standard cognitive assessment significantly improved diagnostic accuracy, particularly in identifying people at high risk of worsening.
A 20-year study found that men taking a sauna 4-7 times a week were 66% less likely to be diagnosed with dementia. The study also showed a significant reduction in the risk of Alzheimer's disease.
Rates of dementia and Alzheimer's disease are higher among older kidney transplant recipients than in the general population. Older patients with kidney failure who receive a kidney transplant are at increased risk of developing these conditions, which can threaten both their transplanted organ and survival.
A meta-analysis published in Neurology found that people with protein in their urine are 35% more likely to develop cognitive impairment or dementia. Chronic kidney disease shares many risk factors with dementia, including high blood pressure, diabetes, and high cholesterol.
A recent study from the University of Eastern Finland found that hip fracture risk is higher among those with Alzheimer's disease. Regular assessments of medications and targeted interventions such as exercise, home safety assessment and modification, and medication reviews are proposed as feasible approaches to reduce this risk.
A national cohort study found that patients using more than one health system had significantly higher rates of potentially unsafe medication prescribing compared to those using the Department of Veterans Affairs (VA) only. The prevalence of such prescribing was particularly high among dual users, suggesting a need for improved coordin...
Research reveals women with dementia have fewer visits to the GP, receive less health monitoring, and take more potentially harmful medication than men. Women are at particular risk of staying on antipsychotic or sedative medication for longer due to fewer check-ups.
A randomized trial involving 180 Alzheimer's patients found that occupational therapy did not slow the loss of physical function, despite tailored to individual patient needs. The results underscore the burden on caregivers and highlight the need for additional support strategies, such as home modifications and assistive devices.
A new study finds that dementia rates are decreasing in the US, particularly among those with more years of education. However, three risk factors – diabetes, high blood pressure, and obesity – are on the rise and could offset these gains.
A decline in dementia prevalence was reported in the US between 2000-2012, affecting an estimated 4-5 million older adults annually. The decline may be attributed to factors such as increased education levels and improved cardiovascular treatment, leading to a 24% reduction in dementia prevalence.
A randomized clinical trial found that long-term collaborative care and occupational therapy did not slow functional decline in persons with Alzheimer disease. The study suggests that new assistive devices, home modifications, and technologies are needed to support patients and families at home.